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Avanzi, C., Lécorché, E., Rakotomalala, F. A., Benjak, A., Rapelanoro Rabenja, F., Ramarozatovo, L. S., Cauchoix, B., Rakoto-Andrianarivelo, M., Tió-Coma, M., Leal-Calvo, T., Busso, P., Boy-Röttger, S., Chauffour, A., Rasamoelina, T., Andrianarison, A., Sendrasoa, F., Spencer, J. S., Singh, P., Dashatwar, D. R., Narang, R., Berland, J.-L., Jarlier, V., Salgado, C. G., Moraes, M. O., Geluk, A., Randrianantoandro, A., Cambau, E. and Cole, S. T. (2020). Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros. Frontiers in Microbiology 11, URL: https://www.frontiersin.org/article/10.3389/fmicb.2020.00711 [Accessed March 2022].
BRUUT! (2020). Loulou. 6 March 2020, URL: https://www.youtube.com/watch?v=jPwFWmY271A [Accessed October 2022].
Cambau, E. and Poljak, M. (2020). Sniffing animals as a diagnostic tool in infectious diseases. Clinical Microbiology and Infection 26, 431–435, http://doi.org/10.1016/j.cmi.2019.10.036.
Chauffour, A., Robert, J., Veziris, N., Aubry, A., Pethe, K. and Jarlier, V. (2020). Telacebec (Q203)-containing intermittent oral regimens sterilized mice infected with Mycobacterium ulcerans after only 16 doses. PLOS Neglected Tropical Diseases 14, e0007857, http://doi.org/10.1371/journal.pntd.0007857.
Cox, V., McKenna, L., Acquah, R., Reuter, A., Wasserman, S., Vambe, D., Ustero, P., Udwadia, Z., Triviño-Duran, L., Tommasi, M., Skrahina, A., Seddon, J. A., Rodolfo, R., Rich, M., Padanilam, X., Oyewusi, L., Ohler, L., Lungu, P., Loveday, M., Khan, U., Khan, P., Hughes, J., Hewison, C., Guglielmetti, L. and Furin, J. (2020). Clinical perspectives on treatment of rifampicin-resistant/multidrug-resistant TB. The International Journal of Tuberculosis and Lung Disease 24, 1134–1144, http://doi.org/10.5588/ijtld.20.0330.
Daley, C. L., Iaccarino, J. M., Lange, C., Cambau, E., Wallace, R. J., Jr, Andrejak, C., Böttger, E. C., Brozek, J., Griffith, D. E., Guglielmetti, L., Huitt, G. A., Knight, S. L., Leitman, P., Marras, T. K., Olivier, K. N., Santin, M., Stout, J. E., Tortoli, E., van Ingen, J., Wagner, D. and Winthrop, K. L. (2020). Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline. Clinical Infectious Diseases 71, e1–e36, http://doi.org/10.1093/cid/ciaa241.
Guglielmetti, L., Low, M. and McKenna, L. (2020). Challenges in TB regimen development: preserving evidentiary standards for regulatory decisions and policymaking. Expert Review of Anti-infective Therapy 18, 701–704, http://doi.org/10.1080/14787210.2020.1756776.
Guglielmetti, L., Huerga, H., Khan, U. and Varaine, F. (2020). WHO 2019 guidelines on drug-resistant tuberculosis treatment: based on evidence or expert opinion? Eur Respir J 55, 1901935, http://doi.org/10.1183/13993003.01935-2019.
Guglielmetti, L., Chiesi, S., Eimer, J., Dominguez, J., Masini, T., Varaine, F., Veziris, N., Ader, F. and Robert, J. (2020). Bedaquiline and delamanid for drug-resistant tuberculosis: a clinician’s perspective. Future Microbiology 15, 779–799, http://doi.org/10.2217/fmb-2019-0309.
Jaffré, J., Aubry, A., Maitre, T., Morel, F., Brossier, F., Robert, J., Sougakoff, W., Veziris, N. and the CNR-MyRMA (Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux) (2020). Rational Choice of Antibiotics and Media for Mycobacterium avium Complex Drug Susceptibility Testing. Frontiers in Microbiology 11, URL: https://www.frontiersin.org/article/10.3389/fmicb.2020.00081 [Accessed March 2022].
Jaspard, M., Butel, N., Helali, N. E., Marigot-Outtandy, D., Guillot, H., Peytavin, G., Veziris, N., Bodaghi, B., Flandre, P., Petitjean, G., Caumes, E. and Pourcher, V. (2020). Linezolid-Associated Neurologic Adverse Events in Patients with Multidrug-Resistant Tuberculosis, France. Emerg Infec Dis 26, http://doi.org/10.3201/eid2608.191499.
Kort, F., Ray, L. F. L., Chauffour, A., Jarlier, V., Lounis, N., Andries, K., Aubry, A., Guglielmetti, L. and Veziris, N. (2020). Fully weekly antituberculosis regimen: a proof-of-concept study. European Respiratory Journal 56, http://doi.org/10.1183/13993003.02502-2019.
Lan, Zhiyi, Ahmad, Nafees, Baghaei, Parvaneh, Barkane, Linda, Benedetti, Andrea, Brode, Sarah K., Brust, James C. M., Campbell, Jonathon R., Chang, Vicky Wai Lai, Falzon, Dennis, Guglielmetti, Lorenzo, Isaakidis, Petros, Kempker, Russell R., Kipiani, Maia, Kuksa, Liga, Lange, Christoph, Laniado-Laborín, Rafael, Nahid, Payam, Rodrigues, Denise, Singla, Rupak, Udwadia, Zarir F., Menzies, Dick, Ahmad, N., Baghaei, P., Barkane, L., Benedetti, A., Brode, S. K., Brust, J. C. M., Campbell, J. R., Chang, V. W. L., Falzon, D., Guglielmetti, L., Isaakidis, P., Kempker, R. R., Kipiani, M., Kuksa, L., Lan, Z., Lange, C., Laniado-Laborín, R., Nahid, P., Rodrigues, D., Singla, R., Udwadia, Z. F. and Menzies, D. (2020). Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis. The Lancet Respiratory Medicine 8, 383–394, http://doi.org/10.1016/S2213-2600(20)30047-3.
Lecorche, E., Pean de Ponfilly, G., Mougari, F., Benmansour, H., Poisnel, E., Janvier, F. and Cambau, E. (2020). Disseminated Mycobacterium chimaera Following Open-Heart Surgery, the Heater–Cooler Unit Worldwide Outbreak: Case Report and Minireview. Frontiers in Medicine 7, URL: https://www.frontiersin.org/article/10.3389/fmed.2020.00243 [Accessed March 2022].
Lerolle, N., Laanani, M., Galicier, L., Rivière, S., Meynard, J.-L., Azoulay, E., Jeblaoui, A., Lalande, V., Mougari, F., Fardet, L., Coppo, P., Goujard, C., Molina, J.-M. and Lambotte, O. (2020). Factors associated with tuberculosis-associated haemophagocytic syndrome: a multicentre case-control study. The International Journal of Tuberculosis and Lung Disease 24, 124–130, http://doi.org/10.5588/ijtld.19.0856.
Lopes, A., Mougari, F., Chopin, D., Pogliaghi, M., Munier, A., Delcey, V., Simoneau, G., Raskine, L., Evans, J., Mouly, S., Cambau, E., Bergmann, J. and Sellier, P. (2020). Prospective study comparing the conventional and same-day strategies to diagnose pulmonary tuberculosis - ScienceDirect. Med Mal Infect 50, 36–42, URL: https://www.sciencedirect.com/science/article/pii/S0399077X18301343?via%3Dihub [Accessed March 2022].
Marsollier, L., Aubry, A., Carbonnelle, E., Canaan, S., Laencina, L., Cambau, E. and Herrmann, J. (2020). Mycobactérioses cutanées dues à Mycobacterium ulcerans, Mycobacterium marinum, Mycobacterium abscessus, Mycobacterium chelonae et autres mycobactéries non tuberculeuses. EM-Consulte, http://doi.org/10.1016/S1166-8598(19)81974-9.
Méchaï, F., Cordel, H., Guglielmetti, L., Aubry, A., Jankovic, M., Viveiros, M., Santin, M., Goletti, D. and Cambau, E. (2020). Management of Tuberculosis: Are the Practices Homogeneous in High-Income Countries? Frontiers in Public Health 8, URL: https://www.frontiersin.org/article/10.3389/fpubh.2020.00443 [Accessed March 2022].
Morel, F., Jaffré, J., Sougakoff, W., Aubry, A. and Véziris, N. (2020). Place de la biologie moléculaire dans le diagnostic de la tuberculose. Revue des Maladies Respiratoires 37, 412–416, http://doi.org/10.1016/j.rmr.2019.09.004.
Ong, C. W. M., Migliori, G. B., Raviglione, M., MacGregor-Skinner, G., Sotgiu, G., Alffenaar, J.-W., Tiberi, S., Adlhoch, C., Alonzi, T., Archuleta, S., Brusin, S., Cambau, E., Capobianchi, M. R., Castilletti, C., Centis, R., Cirillo, D. M., D’Ambrosio, L., Delogu, G., Esposito, S. M. R., Figueroa, J., Friedland, J. S., Ho, B. C. H., Ippolito, G., Jankovic, M., Kim, H. Y., Klintz, S. R., Ködmön, C., Lalle, E., Leo, Y. S., Leung, C.-C., Märtson, A.-G., Melazzini, M. G., Fard, S. N., Penttinen, P., Petrone, L., Petruccioli, E., Pontali, E., Saderi, L., Santin, M., Spanevello, A., Crevel, R. van, Werf, M. J. van der, Visca, D., Viveiros, M., Zellweger, J.-P., Zumla, A. and Goletti, D. (2020). Epidemic and pandemic viral infections: impact on tuberculosis and the lung: A consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Mycobacterial Infections (ESGMYC). European Respiratory Journal 56, http://doi.org/10.1183/13993003.01727-2020.
Phillips, R. O., Robert, J., Abass, K. M., Thompson, W., Sarfo, F. S., Wilson, T., Sarpong, G., Gateau, T., Chauty, A., Omollo, R., Ochieng Otieno, M., Egondi, T. W., Ampadu, E. O., Agossadou, D., Marion, E., Ganlonon, L., Wansbrough-Jones, M., Grosset, J., Macdonald, J. M., Treadwell, T., Saunderson, P., Paintsil, A., Lehman, L., Frimpong, M., Sarpong, N. F., Saizonou, R., Tiendrebeogo, A., Ohene, S.-A., Stienstra, Y., Asiedu, K. B., van der Werf, T. S., Osei Mireku, S., Abotsi, J., Adu Poku, J. K., Asamoah-Frimpong, R., Osei-Wusu, B., Sarpong, E., Konadu, B., Opoku, E., Forson, M., Ndogyele, M., Ofori, E., Aboagye, F., Berko, T., Amofa, G., Nsiah, A., Mensah-Bonsu, J., Ofori Nyarko, J., Amoako, Y. A., Koranteng Tannor, E., Boakye-Appiah, J., Dzibordzi Loglo, A., Sarpong-Duah, M., Agbavor, B., Ardent, M. F., Yamadjako, A., Adanmado Gersande, N., Adeye, A., Kindjinou, M., Akpolan, Kiki, M., Sodjinou, E., Guegnard, C., Klis, S.-A., Velding, K., Omansen, T., Ofori-Adjei, D., Eyangoh, S., Knell, A. and Faber, W. (2020). Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial. The Lancet 395, 1259–1267, http://doi.org/10.1016/S0140-6736(20)30047-7.
Rousset, L., Sokal, A., Vignon-Pennamen, M.-D., Pagis, V., Rybojad, M., Lecorche, E., Mougari, F., Bagot, M., Bouaziz, J.-D. and Jachiet, M. (2020). Association d’une lèpre borderline tuberculoïde et d’une tuberculose : un cas et revue de la littérature. Annales de Dermatologie et de Vénéréologie 147, 886–891, http://doi.org/10.1016/j.annder.2020.09.571.
Schön, T., Köser, C. U., Werngren, J., Viveiros, M., Georghiou, S., Kahlmeter, G., Giske, C., Maurer, F., Lina, G., Turnidge, J., Ingen, J. van, Jankovic, M., Goletti, D., Cirillo, D. M., Santin, M. and Cambau, E. (2020). What is the role of the EUCAST reference method for MIC testing of the Mycobacterium tuberculosis complex? Clinical Microbiology and Infection 26, 1453–1455, http://doi.org/10.1016/j.cmi.2020.07.037.
Schön, T., Werngren, J., Machado, D., Borroni, E., Wijkander, M., Lina, G., Mouton, J., Matuschek, E., Kahlmeter, G., Giske, C., Santin, M., Cirillo, D. M., Viveiros, M. and Cambau, E. (2020). Antimicrobial susceptibility testing of Mycobacterium tuberculosis complex isolates – the EUCAST broth microdilution reference method for MIC determination. Clinical Microbiology and Infection 26, 1488–1492, http://doi.org/10.1016/j.cmi.2020.07.036.