NTM – Non-tuberculous mycobacteria
Seules les publications les plus récentes sont présentées – Pour voir plus de publications aller à la page de recherche : toutes les publications
Only the most recent publications are displayed – to see more, go to the search page : all publications
1368488
Nontuberculous mycobacteria
1
heidelberg-university-faculty-of-medicine
300
date
desc
1
266
https://cnrmyrma.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22S3S73Y3G%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22B%5Cu00e9mer%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EB%26%23xE9%3Bmer%2C%20P.%2C%20Aubry%2C%20A.%2C%20Schramm%2C%20F.%2C%20Koebel%2C%20C.%2C%20Revillet%2C%20H.%2C%20Baltes%2C%20V.%2C%20Brun%2C%20C.%20L.%2C%20Chazerain%2C%20P.%2C%20Zeller%2C%20V.%2C%20Hamdad%2C%20F.%2C%20Morand%2C%20P.%20C.%2C%20Guillouzouic%2C%20A.%2C%20Piau%2C%20C.%2C%20Roux%2C%20A.-L.%2C%20Soueges%2C%20S.%2C%20Martin%2C%20C.%2C%20Gaudart%2C%20A.%2C%20H%26%23xFC%3Bssler%2C%20S.%2C%20Fihman%2C%20V.%2C%20Carricajo%2C%20A.%2C%20Caruba%2C%20C.%20G.%2C%20Bador%2C%20J.%2C%20Dauchy%2C%20F.-A.%2C%20Dutronc%2C%20H.%2C%20Vignals%2C%20C.%20and%20Peuchant%2C%20O.%20%282024%29.%20%3Cb%3EClinical%20features%20and%20treatment%20outcomes%20of%20bone%20and%20joint%20nontuberculous%20mycobacterial%20infections%20according%20to%20immune%20status%3A%20a%209-year%20retrospective%20observational%20cohort%3C%5C%2Fb%3E.%20International%20Journal%20of%20Infectious%20Diseases%20%3Ci%3E146%3C%5C%2Fi%3E%2C%20107122%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2024.107122%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2024.107122%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20features%20and%20treatment%20outcomes%20of%20bone%20and%20joint%20nontuberculous%20mycobacterial%20infections%20according%20to%20immune%20status%3A%20a%209-year%20retrospective%20observational%20cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascale%22%2C%22lastName%22%3A%22B%5Cu00e9mer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Schramm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christelle%22%2C%22lastName%22%3A%22Koebel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Revillet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginie%22%2C%22lastName%22%3A%22Baltes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9cile%20Le%22%2C%22lastName%22%3A%22Brun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Chazerain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Zeller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farida%22%2C%22lastName%22%3A%22Hamdad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%20C.%22%2C%22lastName%22%3A%22Morand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Guillouzouic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Piau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Soueges%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alice%22%2C%22lastName%22%3A%22Gaudart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22H%5Cu00fcssler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Fihman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Carricajo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christelle%20Guillet%22%2C%22lastName%22%3A%22Caruba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Bador%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric-Antoine%22%2C%22lastName%22%3A%22Dauchy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herv%5Cu00e9%22%2C%22lastName%22%3A%22Dutronc%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Vignals%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivia%22%2C%22lastName%22%3A%22Peuchant%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2209%5C%2F2024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ijid.2024.107122%22%2C%22ISSN%22%3A%2212019712%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1201971224001930%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-10-18T16%3A21%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22V6NG839V%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Loebinger%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELoebinger%2C%20M.%20R.%2C%20Aliberti%2C%20S.%2C%20Haworth%2C%20C.%2C%20Jankovic%20Makek%2C%20M.%2C%20Lange%2C%20C.%2C%20Lorent%2C%20N.%2C%20Papavasileiou%2C%20A.%2C%20Polverino%2C%20E.%2C%20Rohde%2C%20G.%2C%20Veziris%2C%20N.%2C%20Wagner%2C%20D.%20and%20Van%20Ingen%2C%20J.%20%282024%29.%20%3Cb%3EPatients%20at%20risk%20of%20nontuberculous%20mycobacterial%20pulmonary%20disease%20who%20need%20testing%20evaluated%20using%20a%20modified%20Delphi%20process%20by%20European%20experts%3C%5C%2Fb%3E.%20ERJ%20Open%20Res%20%3Ci%3E10%3C%5C%2Fi%3E%2C%2000791%26%23x2013%3B02023%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F23120541.00791-2023%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F23120541.00791-2023%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patients%20at%20risk%20of%20nontuberculous%20mycobacterial%20pulmonary%20disease%20who%20need%20testing%20evaluated%20using%20a%20modified%20Delphi%20process%20by%20European%20experts%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20R.%22%2C%22lastName%22%3A%22Loebinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Aliberti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Haworth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mateja%22%2C%22lastName%22%3A%22Jankovic%20Makek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalie%22%2C%22lastName%22%3A%22Lorent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Apostolos%22%2C%22lastName%22%3A%22Papavasileiou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eva%22%2C%22lastName%22%3A%22Polverino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gernot%22%2C%22lastName%22%3A%22Rohde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22Van%20Ingen%22%7D%5D%2C%22abstractNote%22%3A%22Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Identifying%20patients%20at%20risk%20of%20nontuberculous%20mycobacterial%20pulmonary%20disease%20%28NTM-PD%29%20is%20challenging.%20Delays%20in%20NTM-PD%20identification%20and%20management%20are%20associated%20with%20declining%20lung%20function%20and%20increased%20morbidity%20and%20mortality.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Study%20design%20and%20methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20European%20NTM-PD%20experts%20%28n%3D12%29%20participated%20in%20a%20three-round%20modified%20Delphi%20process%20to%20score%20symptoms%20and%20comorbidities%20potentially%20associated%20with%20NTM-PD%20as%20reasons%20to%20test%20for%20nontuberculous%20mycobacteria.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Experts%20reached%20a%20consensus%20on%20the%20symptoms%20and%20comorbidities%20that%20should%20and%20should%20not%20prompt%20testing%20for%20nontuberculous%20mycobacteria.%20Requirements%20for%20testing%20were%20scored%20as%20high%20%28mean%20%5Cu22657%29%2C%20medium%20%28mean%20%5Cu22654%5Cu2013%3C7%29%20or%20low%20%28mean%20%3C4%29.%20Nontuberculous%20mycobacteria%20testing%20should%20be%20undertaken%20when%20multiple%20suggestive%20symptoms%20are%20present%20simultaneously%20in%20all%20patients%20except%20those%20with%20cancer%20%287.3%5Cu20138.8%29%2C%20or%20when%20radiology%20is%20indicative%20of%20NTM-PD%20%28%5Cu22658.9%29.%20Symptoms%20of%20persistent%20sputum%20production%2C%20recurrent%20respiratory%20infection%20and%20haemoptysis%20should%20prompt%20testing%20for%20nontuberculous%20mycobacteria%2C%20particularly%20in%20those%20with%20underlying%20respiratory%20diseases.%20Symptomatic%20patients%20with%20bronchiectasis%20or%20previous%20tuberculosis%5C%2FNTM-PD%20or%20those%20being%20prescribed%20or%20undergoing%20long-term%20macrolide%20therapy%20for%20a%20respiratory%20condition%20should%20also%20be%20tested.%20Testing%20is%20not%20warranted%20in%20patients%20without%20an%20underlying%20respiratory%20disorder%20or%20in%20those%20without%20a%20history%20of%20respiratory%20disorders%20unless%20presenting%20with%20multiple%20symptoms.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Assessing%20patients%5Cu2019%20risk%20of%20NTM-PD%20is%20challenging.%20This%20Delphi%20consensus%20process%20provides%20insight%20into%20symptoms%20and%20clinical%20characteristics%20that%20should%20prompt%20NTM-PD%20assessment.%20Timely%20testing%20and%20diagnosis%20would%20enable%20initiation%20of%20appropriate%20management.%22%2C%22date%22%3A%2209%5C%2F2024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1183%5C%2F23120541.00791-2023%22%2C%22ISSN%22%3A%222312-0541%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fopenres.ersjournals.com%5C%2Flookup%5C%2Fdoi%5C%2F10.1183%5C%2F23120541.00791-2023%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-10-17T10%3A17%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22RQ6UZII8%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tagliani%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ETagliani%2C%20E.%2C%20Kohl%2C%20T.%20A.%2C%20Ghodousi%2C%20A.%2C%20Groenheit%2C%20R.%2C%20Holicka%2C%20Y.%2C%20Niemann%2C%20S.%2C%20Maurer%2C%20F.%20P.%2C%20Cirillo%2C%20D.%20M.%20and%20Cambau%2C%20E.%20%282024%29.%20%3Cb%3EAppeal%20from%20the%20European%20tuberculosis%20reference%20laboratory%20network%20%28ERLTB-Net%29%20for%20improving%20the%20diagnosis%20of%20infections%20due%20to%20nontuberculous%20mycobacteria%3C%5C%2Fb%3E.%20Clinical%20Microbiology%20and%20Infection%20%3Ci%3E30%3C%5C%2Fi%3E%2C%204%26%23x2013%3B6%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2023.06.005%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2023.06.005%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Appeal%20from%20the%20European%20tuberculosis%20reference%20laboratory%20network%20%28ERLTB-Net%29%20for%20improving%20the%20diagnosis%20of%20infections%20due%20to%20nontuberculous%20mycobacteria%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Tagliani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20A.%22%2C%22lastName%22%3A%22Kohl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arash%22%2C%22lastName%22%3A%22Ghodousi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%22%2C%22lastName%22%3A%22Groenheit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yen%22%2C%22lastName%22%3A%22Holicka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%20P.%22%2C%22lastName%22%3A%22Maurer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%20Maria%22%2C%22lastName%22%3A%22Cirillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2201%5C%2F2024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2023.06.005%22%2C%22ISSN%22%3A%221198743X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1198743X2300280X%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-12-31T15%3A03%3A48Z%22%7D%7D%2C%7B%22key%22%3A%223QIW9WA9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Heid-Picard%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHeid-Picard%2C%20B.%2C%20Awad%2C%20Z.%2C%20Mougari%2C%20F.%20and%20Cambau%2C%20E.%20%282023%29.%20%3Cb%3EMycobact%26%23xE9%3Brioses%20non%20tuberculeuses%20hors%20mycobact%26%23xE9%3Brioses%20cutan%26%23xE9%3Bes%3C%5C%2Fb%3E.%20EM-Consulte%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1166-8598%2823%2944823-5%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1166-8598%2823%2944823-5%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobact%5Cu00e9rioses%20non%20tuberculeuses%20hors%20mycobact%5Cu00e9rioses%20cutan%5Cu00e9es%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%22%2C%22lastName%22%3A%22Heid-Picard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Z%22%2C%22lastName%22%3A%22Awad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Mycobact%5Cu00e9rioses%20non%20tuberculeuses%20hors%20mycobact%5Cu00e9rioses%20cutan%5Cu00e9es%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22fr%22%2C%22DOI%22%3A%2210.1016%5C%2FS1166-8598%2823%2944823-5%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.em-consulte.com%5C%2Farticle%5C%2F1627622%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-01-04T16%3A58%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22THH9Q9E6%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chiron%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EChiron%2C%20R.%2C%20Hoefsloot%2C%20W.%2C%20Van%20Ingen%2C%20J.%2C%20Marchandin%2C%20H.%2C%20Kremer%2C%20L.%2C%20Morisse-Pradier%2C%20H.%2C%20Charriot%2C%20J.%2C%20Mallet%2C%20J.-P.%2C%20Herrmann%2C%20J.-L.%2C%20Caimmi%2C%20D.%2C%20Moreau%2C%20J.%2C%20Dumont%2C%20Y.%2C%20Godreuil%2C%20S.%2C%20Bergeron%2C%20A.%2C%20Drevait%2C%20M.%2C%20Bouzat-Rossigneux%2C%20E.%2C%20Terrail%2C%20N.%2C%20Andrejak%2C%20C.%2C%20Veziris%2C%20N.%2C%20Grenet%2C%20D.%2C%20Coudrat%2C%20A.%20and%20Catherinot%2C%20E.%20%282022%29.%20%3Cb%3EAmikacin%20Liposomal%20Inhalation%20Suspension%20in%20the%20Treatment%20of%20Mycobacterium%20abscessus%20Lung%20Infection%3A%20A%20French%20Observational%20Experience%3C%5C%2Fb%3E.%20Open%20Forum%20Infect%20Dis%20%3Ci%3E9%3C%5C%2Fi%3E%2C%20ofac465%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofac465%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofac465%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Amikacin%20Liposomal%20Inhalation%20Suspension%20in%20the%20Treatment%20of%20Mycobacterium%20abscessus%20Lung%20Infection%3A%20A%20French%20Observational%20Experience%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raphael%22%2C%22lastName%22%3A%22Chiron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wouter%22%2C%22lastName%22%3A%22Hoefsloot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22Van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Marchandin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Kremer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Morisse-Pradier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Charriot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mallet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Herrmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Davide%22%2C%22lastName%22%3A%22Caimmi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johan%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Dumont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Godreuil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Bergeron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margot%22%2C%22lastName%22%3A%22Drevait%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Bouzat-Rossigneux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Terrail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Grenet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Coudrat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Catherinot%22%7D%5D%2C%22abstractNote%22%3A%22A%20French%20observational%20cohort%20study%20investigated%20amikacin%20liposome%20inhaled%20suspension%20as%20an%20adjunct%20to%20antibiotic%20regimen%20for%20M%20abscessus%20lung%20infection.%20Sputum%20culture%20conversion%20was%20achieved%20in%2054%25%20%2814%5C%2F26%29%20of%20patients%20with%20acceptable%20safety%20profile%20after%206%20months%20of%20treatment.%22%2C%22date%22%3A%222022-9-11%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fofid%5C%2Fofac465%22%2C%22ISSN%22%3A%222328-8957%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9578164%5C%2F%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-12-28T16%3A03%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22AM4AMZDJ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chaptal%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EChaptal%2C%20M.%2C%20Andrejak%2C%20C.%2C%20Bonifay%2C%20T.%2C%20Beillard%2C%20E.%2C%20Guillot%2C%20G.%2C%20Guyomard-Rabenirina%2C%20S.%2C%20Demar%2C%20M.%2C%20Trombert-Paolantoni%2C%20S.%2C%20Jacomo%2C%20V.%2C%20Mosnier%2C%20E.%2C%20Veziris%2C%20N.%2C%20Djossou%2C%20F.%2C%20Epelboin%2C%20L.%20and%20Group%2C%20F.%20G.%20P.%20working%20%282022%29.%20%3Cb%3EEpidemiology%20of%20infection%20by%20pulmonary%20non-tuberculous%20mycobacteria%20in%20French%20Guiana%202008%26%23x2013%3B2018%3C%5C%2Fb%3E.%20PLOS%20Neglected%20Tropical%20Diseases%20%3Ci%3E16%3C%5C%2Fi%3E%2C%20e0010693%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0010693%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0010693%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Epidemiology%20of%20infection%20by%20pulmonary%20non-tuberculous%20mycobacteria%20in%20French%20Guiana%202008%5Cu20132018%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mil%5Cu00e8ne%22%2C%22lastName%22%3A%22Chaptal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timoth%5Cu00e9e%22%2C%22lastName%22%3A%22Bonifay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Beillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genevi%5Cu00e8ve%22%2C%22lastName%22%3A%22Guillot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Guyomard-Rabenirina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magalie%22%2C%22lastName%22%3A%22Demar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Trombert-Paolantoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronique%22%2C%22lastName%22%3A%22Jacomo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Mosnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%22%2C%22lastName%22%3A%22Djossou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lo%5Cu00efc%22%2C%22lastName%22%3A%22Epelboin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22French%20Guiana%20PNTM%20working%22%2C%22lastName%22%3A%22Group%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%20Unlike%20diseases%20caused%20by%20Mycobacterium%20tuberculosis%2C%20M.%20leprae%20and%20M.%20ulcerans%2C%20the%20epidemiology%20of%20pulmonary%20non-tuberculous%20mycobacteria%20%28PNTM%29%20has%20not%20received%20due%20attention%20in%20French%20Guiana.%20The%20main%20objective%20of%20the%20current%20study%20was%20to%20define%20the%20incidence%20of%20these%20PNTM%20infections%3A%20NTM%20pulmonary%20diseases%20%28NTM-PD%29%20and%20casual%20PNTM%20isolation%20%28responsible%20of%20latent%20infection%20or%20simple%20colonization%29.%20The%20secondary%20objectives%20were%20to%20determine%20species%20diversity%20and%20geographic%20distribution%20of%20these%20atypical%20mycobacteria.%20Methods%20A%20retrospective%20observational%20study%20%282008%5Cu20132018%29%20of%20French%20Guiana%20patients%20with%20at%20least%20one%20PNTM%20positive%20respiratory%20sample%20in%20culture%20was%20conducted.%20Patients%20were%20then%20classified%20into%20two%20groups%3A%20casual%20PNTM%20isolation%20or%20pulmonary%20disease%20%28NTM-PD%29%2C%20according%20to%20clinical%2C%20radiological%20and%20microbiological%20criteria%20defined%20by%20the%20American%20Thoracic%20Society%20%5C%2F%20Infectious%20Disease%20Society%20of%20America%20%28ATS%20%5C%2F%20IDSA%29%20in%202007.%20Results%20178%20patients%20were%20included%2C%20out%20of%20which%20147%20had%20casual%20PNTM%20isolation%20and%2031%20had%20NTM-PD.%20Estimated%20annual%20incidence%20rate%20of%20respiratory%20isolates%20was%206.17%20%5C%2F%20100%2C000%20inhabitants%20per%20year%20while%20that%20of%20NTM-PD%20was%201.07%20%5C%2F%20100%2C000%20inhabitants%20per%20year.%20Among%20the%20178%20patients%2C%20M.%20avium%20complex%20%28MAC%29%20was%20the%20most%20frequently%20isolated%20pathogen%20%2838%25%29%2C%20followed%20by%20M.%20fortuitum%20then%20M.%20abscessus%20%2819%25%20and%206%25%20of%20cases%20respectively%29%2C%20the%20latter%20two%20mycobacteria%20being%20mainly%20found%20in%20the%20coastal%20center%20region.%20Concerning%20NTM-PD%2C%20two%20species%20were%20mainly%20involved%3A%20MAC%20%2881%25%29%20and%20M.%20abscessus%20%2816%25%29.%20Discussion%5C%2FConclusion%20This%20is%20the%20first%20study%20on%20the%20epidemiology%20of%20PNTM%20infections%20in%20French%20Guiana.%20PNTM%5Cu2019s%20incidence%20looks%20similar%20to%20other%20contries%20and%20metropolitan%20France%20and%20NTM-PD%20is%20mostly%20due%20to%20MAC%20and%20M.abscessus.%20Although%20French%20Guiana%20is%20the%20French%20territory%20with%20the%20highest%20tuberculosis%20incidence%2C%20NTM%20should%20not%20be%20overlooked.%22%2C%22date%22%3A%229%20sept.%202022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0010693%22%2C%22ISSN%22%3A%221935-2735%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.plos.org%5C%2Fplosntds%5C%2Farticle%3Fid%3D10.1371%5C%2Fjournal.pntd.0010693%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A15%3A19Z%22%7D%7D%2C%7B%22key%22%3A%223SA6SQXF%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kilin%5Cu00e7%20et%20al.%22%2C%22parsedDate%22%3A%222022-06-24%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKilin%26%23xE7%3B%2C%20G.%2C%20Walburg%2C%20K.%20V.%2C%20Franken%2C%20K.%20L.%20M.%20C.%2C%20Valkenburg%2C%20M.%20L.%2C%20Aubry%2C%20A.%2C%20Haks%2C%20M.%20C.%2C%20Saris%2C%20A.%20and%20Ottenhoff%2C%20T.%20H.%20M.%20%282022%29.%20%3Cb%3EDevelopment%20of%20Human%20Cell-Based%20In%20Vitro%20Infection%20Models%20to%20Determine%20the%20Intracellular%20Survival%20of%20Mycobacterium%20avium%3C%5C%2Fb%3E.%20Front%20Cell%20Infect%20Microbiol%20%3Ci%3E12%3C%5C%2Fi%3E%2C%20872361%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcimb.2022.872361%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcimb.2022.872361%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20of%20Human%20Cell-Based%20In%20Vitro%20Infection%20Models%20to%20Determine%20the%20Intracellular%20Survival%20of%20Mycobacterium%20avium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00fcl%22%2C%22lastName%22%3A%22Kilin%5Cu00e7%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kimberley%20V.%22%2C%22lastName%22%3A%22Walburg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kees%20L.%20M.%20C.%22%2C%22lastName%22%3A%22Franken%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Merel%20L.%22%2C%22lastName%22%3A%22Valkenburg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mari%5Cu00eblle%20C.%22%2C%22lastName%22%3A%22Haks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anno%22%2C%22lastName%22%3A%22Saris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%20H.%20M.%22%2C%22lastName%22%3A%22Ottenhoff%22%7D%5D%2C%22abstractNote%22%3A%22The%20Mycobacterium%20avium%20%28Mav%29%20complex%20accounts%20for%20more%20than%2080%25%20of%20all%20pulmonary%20diseases%20caused%20by%20non-tuberculous%20mycobacteria%20%28NTM%29%20infections%2C%20which%20have%20an%20alarming%20increase%20in%20prevalence%20and%20vary%20in%20different%20regions%2C%20currently%20reaching%200.3%5Cu20139.8%20per%20100%2C000%20individuals.%20Poor%20clinical%20outcomes%2C%20as%20a%20result%20of%20increasing%20microbial%20drug%20resistance%20and%20low%20treatment%20adherence%20due%20to%20drug-toxicities%2C%20emphasize%20the%20need%20for%20more%20effective%20treatments.%20Identification%20of%20more%20effective%20treatments%2C%20however%2C%20appears%20to%20be%20difficult%2C%20which%20may%20be%20due%20to%20the%20intracellular%20life%20of%20NTM%20and%20concomitant%20altered%20drug%20sensitivity%20that%20is%20not%20taken%20into%20account%20using%20traditional%20drug%20susceptibility%20testing%20screenings.%20We%20therefore%20developed%20human%20cell-based%20in%20vitro%20Mav%20infection%20models%20using%20the%20human%20MelJuSo%20cell%20line%20as%20well%20as%20primary%20human%20macrophages%20and%20a%20fluorescently%20labeled%20Mav%20strain.%20By%20testing%20a%20range%20of%20multiplicity%20of%20infection%20%28MOI%29%20and%20using%20flow%20cytometry%20and%20colony-forming%20unit%20%28CFU%29%20analysis%2C%20we%20found%20that%20an%20MOI%20of%2010%20was%20the%20most%20suitable%20for%20Mav%20infection%20in%20primary%20human%20macrophages%2C%20whereas%20an%20MOI%20of%2050%20was%20required%20to%20achieve%20similar%20results%20in%20MelJuSo%20cells.%20Moreover%2C%20by%20monitoring%20intracellular%20bacterial%20loads%20over%20time%2C%20the%20macrophages%20were%20shown%20to%20be%20capable%20of%20controlling%20the%20infection%2C%20while%20MelJuSo%20cells%20failed%20to%20do%20so.%20When%20comparing%20the%20MGIT%20system%20with%20the%20classical%20CFU%20counting%20assay%20to%20determine%20intracellular%20bacterial%20loads%2C%20MGIT%20appeared%20as%20a%20less%20labor-intensive%2C%20more%20precise%2C%20and%20more%20objective%20alternative.%20Next%2C%20using%20our%20macrophage%20Mav%20infection%20models%2C%20the%20drug%20efficacy%20of%20the%20first-line%20drug%20rifampicin%20and%20the%20more%20recently%20discovered%20bedaquiline%20on%20intracellular%20bacteria%20was%20compared%20to%20the%20activity%20on%20extracellular%20bacteria.%20The%20efficacy%20of%20the%20antibiotics%20inhibiting%20bacterial%20growth%20was%20significantly%20lower%20against%20intracellular%20bacteria%20compared%20to%20extracellular%20bacteria.%20This%20finding%20emphasizes%20the%20crucial%20role%20of%20the%20host%20cell%20during%20infection%20and%20drug%20susceptibility%20and%20highlights%20the%20usefulness%20of%20the%20models.%20Taken%20together%2C%20the%20human%20cell-based%20Mav%20infection%20models%20are%20reliable%20tools%20to%20determine%20the%20intracellular%20loads%20of%20Mav%2C%20which%20will%20enable%20researchers%20to%20investigate%20host%5Cu2013pathogen%20interactions%20and%20to%20evaluate%20the%20efficacy%20of%20%28host-directed%29%20therapeutic%20strategies%20against%20Mav.%22%2C%22date%22%3A%222022-6-24%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffcimb.2022.872361%22%2C%22ISSN%22%3A%222235-2988%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9263196%5C%2F%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A31%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22EBWEL99Z%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Daniau%20et%20al.%22%2C%22parsedDate%22%3A%222022-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDaniau%2C%20C.%2C%20Lecorche%2C%20E.%2C%20Mougari%2C%20F.%2C%20Benmansour%2C%20H.%2C%20Bernet%2C%20C.%2C%20Blanchard%2C%20H.%2C%20Robert%2C%20J.%2C%20Berger-Carbonne%2C%20A.%20and%20Cambau%2C%20E.%20%282022%29.%20%3Cb%3EAssociation%20of%20Healthcare%20and%20Aesthetic%20Procedures%20with%20Infections%20Caused%20by%20Nontuberculous%20Mycobacteria%2C%20France%2C%202012%26%23x2012%3B2020%3C%5C%2Fb%3E.%20Emerg%20Infect%20Dis%20%3Ci%3E28%3C%5C%2Fi%3E%2C%20518%26%23x2013%3B526%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2803.211791%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2803.211791%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20Healthcare%20and%20Aesthetic%20Procedures%20with%20Infections%20Caused%20by%20Nontuberculous%20Mycobacteria%2C%20France%2C%202012%5Cu20122020%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00f4me%22%2C%22lastName%22%3A%22Daniau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanaa%22%2C%22lastName%22%3A%22Benmansour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claude%22%2C%22lastName%22%3A%22Bernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herv%5Cu00e9%22%2C%22lastName%22%3A%22Blanchard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Berger-Carbonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22We%20describe%20nontuberculous%20mycobacteria%20%28NTM%29%20infections%20during%202012%5Cu20132020%20associated%20with%20health%20care%20and%20aesthetic%20procedures%20in%20France.%20We%20obtained%20epidemiologic%20data%20from%20the%20national%20early%20warning%20response%20system%20for%20healtcare-associated%20infections%20and%20data%20on%20NTM%20isolates%20from%20the%20National%20Reference%20Center%20for%20Mycobacteria.%20We%20compared%20clinical%20and%20environmental%20isolates%20by%20using%20whole-genome%20sequencing.%20The%2085%20original%20cases%20were%20reported%20after%20surgery%20%2848%2C%2056%25%29%2C%20other%20invasive%20procedures%20%2828%2C%2033%25%29%20and%20other%20procedures%20%289%2C%2011%25%29.%20NTM%20isolates%20belonged%20to%20rapidly%20growing%20%2873%2C%2086%25%29%20and%20slowly%20growing%20%2810%2C%2012%25%29%20species%3B%20in%202%20cases%2C%20the%20species%20was%20not%20identified.%20We%20performed%20environmental%20investigations%20for%2038%20%2845%25%29%20cases%3B%20results%20for%2012%20%2832%25%29%20were%20positive%20for%20the%20same%20NTM%20species%20as%20for%20the%20infection.%20In%2010%20cases%20that%20had%20environmental%20and%20clinical%20samples%20whose%20genomes%20were%20similar%2C%20the%20infection%20source%20was%20probably%20the%20water%20used%20in%20the%20procedures.%20NTM%20infections%20could%20be%20preventable%20by%20using%20sterile%20water%20in%20all%20invasive%20procedures.%22%2C%22date%22%3A%222022-3%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3201%5C%2Feid2803.211791%22%2C%22ISSN%22%3A%221080-6040%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC8888244%5C%2F%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T21%3A35%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22WWYPJGM4%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lange%20et%20al.%22%2C%22parsedDate%22%3A%222022-01-25%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELange%2C%20C.%2C%20B%26%23xF6%3Bttger%2C%20E.%20C.%2C%20Cambau%2C%20E.%2C%20Griffith%2C%20D.%20E.%2C%20Guglielmetti%2C%20L.%2C%20van%20Ingen%2C%20J.%2C%20Knight%2C%20S.%20L.%2C%20Marras%2C%20T.%20K.%2C%20Olivier%2C%20K.%20N.%2C%20Santin%2C%20M.%2C%20Stout%2C%20J.%20E.%2C%20Tortoli%2C%20E.%2C%20Wagner%2C%20D.%2C%20Winthrop%2C%20K.%2C%20Daley%2C%20C.%20L.%2C%20Lange%2C%20C.%2C%20Andrejak%2C%20C.%2C%20B%26%23xF6%3Bttger%2C%20E.%2C%20Cambau%2C%20E.%2C%20Griffith%2C%20D.%2C%20Guglielmetti%2C%20L.%2C%20van%20Ingen%2C%20J.%2C%20Knight%2C%20S.%2C%20Leitman%2C%20P.%2C%20Marras%2C%20T.%20K.%2C%20Olivier%2C%20K.%20N.%2C%20Santin%2C%20M.%2C%20Stout%2C%20J.%20E.%2C%20Tortoli%2C%20E.%2C%20Wagner%2C%20D.%2C%20Wallace%2C%20R.%20J.%2C%20Winthrop%2C%20K.%20and%20Daley%2C%20C.%20%282022%29.%20%3Cb%3EConsensus%20management%20recommendations%20for%20less%20common%20non-tuberculous%20mycobacterial%20pulmonary%20diseases%3C%5C%2Fb%3E.%20The%20Lancet%20Infectious%20Diseases%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2821%2900586-7%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2821%2900586-7%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Consensus%20management%20recommendations%20for%20less%20common%20non-tuberculous%20mycobacterial%20pulmonary%20diseases%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%20C%22%2C%22lastName%22%3A%22B%5Cu00f6ttger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20E%22%2C%22lastName%22%3A%22Griffith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shandra%20L%22%2C%22lastName%22%3A%22Knight%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodore%20K%22%2C%22lastName%22%3A%22Marras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20N%22%2C%22lastName%22%3A%22Olivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Santin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%20E%22%2C%22lastName%22%3A%22Stout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrico%22%2C%22lastName%22%3A%22Tortoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Winthrop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20L%22%2C%22lastName%22%3A%22Daley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22B%5Cu00f6ttger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Griffith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shandra%22%2C%22lastName%22%3A%22Knight%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Leitman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodore%20K.%22%2C%22lastName%22%3A%22Marras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20N.%22%2C%22lastName%22%3A%22Olivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Santin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%20E.%22%2C%22lastName%22%3A%22Stout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrico%22%2C%22lastName%22%3A%22Tortoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Wallace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Winthrop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Daley%22%7D%5D%2C%22abstractNote%22%3A%22The%202020%20clinical%20practice%20guideline%20for%20the%20treatment%20of%20non-tuberculous%20mycobacterial%20pulmonary%20disease%20%28NTM-PD%29%20by%20the%20American%20Thoracic%20Society%2C%20European%20Respiratory%20Society%2C%20European%20Society%20of%20Clinical%20Microbiology%20and%20Infectious%20Diseases%2C%20and%20Infectious%20Diseases%20Society%20of%20America%3B%20and%20the%202017%20management%20guideline%20by%20the%20British%20Thoracic%20Society%20covered%20pulmonary%20diseases%20in%20adults%20caused%20by%20Mycobacterium%20avium%20complex%2C%20Mycobacterium%20kansasii%2C%20Mycobacterium%20xenopi%2C%20and%20Mycobacterium%20abscessus.%20In%20order%20to%20provide%20evidence-based%20recommendations%20for%20the%20treatment%20of%20less%20common%20non-tuberculous%20mycobacterial%20%28NTM%29%20species%20in%20adult%20patients%20without%20cystic%20fibrosis%20or%20HIV%20infection%2C%20our%20expert%20panel%20group%20performed%20systematic%20literature%20searches%20to%20provide%20management%20guidance%20for%20pulmonary%20diseases%20caused%20by%20seven%20additional%20organisms%3A%20Mycobacterium%20chelonae%2C%20Mycobacterium%20fortuitum%2C%20Mycobacterium%20genavense%2C%20Mycobacterium%20gordonae%2C%20Mycobacterium%20malmoense%2C%20Mycobacterium%20simiae%2C%20and%20Mycobacterium%20szulgai.%20Treatment%20recommendations%20were%20developed%20by%20a%20structured%20consensus%20process.%20The%20evidence%20from%20the%20scientific%20literature%20published%20in%20English%20for%20treatment%20recommendations%20for%20pulmonary%20diseases%20caused%20by%20other%20NTM%20species%20was%20of%20very%20low%20quality%2C%20with%20the%20exception%20of%20M%20malmoense%2C%20and%20based%20on%20the%20evaluation%20of%20case%20reports%20and%20case%20series.%20For%20M%20malmoense%2C%20results%20from%20two%20randomised%20controlled%20trials%20and%20three%20retrospective%20cohort%20studies%20provided%20a%20better%20evidence%20base%20for%20treatment%20recommendations%2C%20although%20the%20evidence%20was%20still%20of%20low%20quality.%22%2C%22date%22%3A%222022-01-25%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2FS1473-3099%2821%2900586-7%22%2C%22ISSN%22%3A%221473-3099%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1473309921005867%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-16T14%3A15%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22JTCH47MP%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vongthilath-Moeung%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EVongthilath-Moeung%2C%20R.%2C%20Plojoux%2C%20J.%2C%20Poncet%2C%20A.%2C%20Renzi%2C%20G.%2C%20Veziris%2C%20N.%2C%20Schrenzel%2C%20J.%20and%20Janssens%2C%20J.-P.%20%282022%29.%20%3Cb%3ENontuberculous%20Mycobacteria%20under%20Scrutiny%20in%20the%20Geneva%20Area%20%282015%26%23x2013%3B2020%29%3C%5C%2Fb%3E.%20RES%20%3Ci%3E101%3C%5C%2Fi%3E%2C%20367%26%23x2013%3B375%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1159%5C%2F000520033%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1159%5C%2F000520033%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nontuberculous%20Mycobacteria%20under%20Scrutiny%20in%20the%20Geneva%20Area%20%282015%5Cu20132020%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rechana%22%2C%22lastName%22%3A%22Vongthilath-Moeung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Plojoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Poncet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gesuele%22%2C%22lastName%22%3A%22Renzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Schrenzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Paul%22%2C%22lastName%22%3A%22Janssens%22%7D%5D%2C%22abstractNote%22%3A%22%3Cb%3E%3Ci%3EBackground%3A%3C%5C%2Fi%3E%3C%5C%2Fb%3E%20Nontuberculous%20mycobacteria%20%28NTM%29%20are%20increasingly%20identified%20in%20industrialized%20countries%2C%20and%20their%20role%20as%20pathogens%20is%20more%20frequently%20recognized.%20The%20relative%20prevalence%20of%20NTM%20strains%20shows%20an%20important%20geographical%20variability.%20Thus%2C%20establishing%20the%20local%20relative%20prevalence%20of%20NTM%20strains%20is%20relevant%20and%20useful%20for%20clinicians.%20%3Cb%3E%3Ci%3EMethods%3A%3C%5C%2Fi%3E%3C%5C%2Fb%3E%20Retrospective%20analysis%20%282015%5Cu20132020%29%20of%20a%20comprehensive%20database%20was%20conducted%20including%20all%20results%20of%20cultures%20for%20mycobacteria%20in%20a%20University%20Hospital%20%28Geneva%2C%20Switzerland%29%2C%20covering%20a%20population%20of%20approximately%20500%2C000%20inhabitants.%20All%20NTM%20culture-positive%20patients%20were%20included%20in%20the%20analyses.%20Patients%5Cu2019%20characteristics%2C%20NTM%20strains%2C%20and%20time%20to%20culture%20positivity%20were%20reported.%20%3Cb%3E%3Ci%3EResults%3A%3C%5C%2Fi%3E%3C%5C%2Fb%3E%20Among%2038%2C065%20samples%20analyzed%20during%20the%20study%20period%2C%20411%20were%20culture-positive%20for%20NTM%2C%20representing%20236%20strains%2C%20and%20231%20episodes%20of%20care%20which%20occurred%20in%20222%20patients.%20Patients%20in%20whom%20NTM%20were%20identified%20were%20predominantly%20female%20%2855%25%29%2C%20with%20a%20median%20age%20of%2062%20years%2C%20and%20a%20low%20BMI%20%28median%3A%2022.6%20kg%5C%2Fm%3Csup%3E2%3C%5C%2Fsup%3E%29.%20The%20%3Ci%3EMycobacterium%20avium%3C%5C%2Fi%3E%20complex%20%28MAC%29%20was%20the%20most%20frequently%20identified%20group%20%2837%25%20of%20strains%29%20followed%20by%20%3Ci%3EMycobacterium%20gordonae%3C%5C%2Fi%3E%20%2825%25%29%20and%20%3Ci%3EMycobacterium%20xenopi%3C%5C%2Fi%3E%20%2812%25%29%20among%20the%20slowly%20growing%20mycobacteria%20%28SGM%29%2C%20while%20the%20%3Ci%3EMycobacterium%20chelonae%5C%2Fabscessus%3C%5C%2Fi%3E%20group%20%2811%25%29%20were%20the%20most%20frequently%20identified%20rapidly%20growing%20mycobacteria%20%28RGM%29.%20Only%2019%25%20of%20all%20patients%20were%20treated%2C%20mostly%20for%20pulmonary%20infections%3A%20the%20MAC%20was%20the%20most%20frequently%20treated%20NTM%20%28%3Ci%3En%3C%5C%2Fi%3E%20%3D%2019%2C%2043%25%20of%20cases%20in%20patients%20treated%29%20followed%20by%20RGM%20%28%3Ci%3En%3C%5C%2Fi%3E%20%3D%2015%2C%2034%25%29%20and%20%3Ci%3EM.%20xenopi%3C%5C%2Fi%3E%20%28%3Ci%3En%3C%5C%2Fi%3E%20%3D%206%2C%2014%25%29.%20Among%20those%20treated%2C%2023%25%20were%20immunosuppressed%2C%2012%25%20had%20pulmonary%20comorbidities%2C%20and%205%25%20systemic%20comorbidities.%20Cultures%20became%20positive%20after%20a%20median%20of%2041%20days%20%28IQR%3A%2023%3B%2068%29%20for%20SGM%20and%2028%20days%20%2814%3B%2035%29%20for%20RGM.%20%3Cb%3E%3Ci%3EConclusions%3A%3C%5C%2Fi%3E%3C%5C%2Fb%3E%20In%20Western%20Switzerland%2C%20%3Ci%3EM.%20avium%3C%5C%2Fi%3E%20and%20%3Ci%3EM.%20gordonae%3C%5C%2Fi%3E%20were%20the%20most%20prevalent%20NTM%20identified.%20Positive%20cultures%20for%20NTM%20led%20to%20a%20specific%20treatment%20in%2019%25%20of%20subjects.%20Patients%20with%20a%20positive%20culture%20for%20NTM%20were%20mostly%20female%2C%20with%20a%20median%20age%20of%2062%20years%2C%20a%20low%20BMI%2C%20and%20a%20low%20prevalence%20of%20immunosuppression%20or%20associated%20severe%20comorbidities.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22english%22%2C%22DOI%22%3A%2210.1159%5C%2F000520033%22%2C%22ISSN%22%3A%220025-7931%2C%201423-0356%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.karger.com%5C%2FArticle%5C%2FFullText%5C%2F520033%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T21%3A33%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22PWKQJRWD%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bemer%20et%20al.%22%2C%22parsedDate%22%3A%222021-12%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBemer%2C%20P.%2C%20Peuchant%2C%20O.%2C%20Guet-Revillet%2C%20H.%2C%20Bador%2C%20J.%2C%20Balavoine%2C%20C.%2C%20Basille%2C%20D.%2C%20Beltramo%2C%20G.%2C%20Blanc%2C%20F.-X.%2C%20Blanchard%2C%20E.%2C%20Boulanger%2C%20S.%2C%20Bourgoin%2C%20A.%2C%20Boutoille%2C%20D.%2C%20Cambau%2C%20E.%2C%20Canis%2C%20F.%2C%20Caparros%2C%20D.%2C%20Carricajo%2C%20A.%2C%20Carri%26%23xE8%3Bre%2C%20C.%2C%20Couetdic%2C%20G.%2C%20Couturaud%2C%20F.%2C%20Dalphin%2C%20J.-C.%2C%20Degot%2C%20T.%2C%20Desquiens%2C%20M.%2C%20Devouassoux%2C%20G.%2C%20Duez%2C%20J.-M.%2C%20Dumitrescu%2C%20O.%2C%20Dupuy-Grasset%2C%20M.%2C%20Gaudart%2C%20A.%2C%20Georges%2C%20M.%2C%20Godet%2C%20C.%2C%20Godreuil%2C%20S.%2C%20Guillouzouic%2C%20A.%2C%20Hamdad-Daoudi%2C%20F.%2C%20H%26%23xE9%3Bry-Arnaud%2C%20G.%2C%20Koebel%2C%20C.%2C%20Lagrange%2C%20A.%2C%20Lanotte%2C%20P.%2C%20Marchand-Adam%2C%20S.%2C%20Mougari%2C%20F.%2C%20Murris%2C%20M.%2C%20Patry%2C%20I.%2C%20P%26%23xE9%3Brouse%20de%20Montclos%2C%20M.%2C%20Raskine%2C%20L.%2C%20Risso%2C%20K.%2C%20Segonds%2C%20C.%2C%20Sicard%2C%20D.%2C%20Terru%2C%20D.%2C%20Vach%26%23xE9%3Be%2C%20A.%2C%20Vergnon%2C%20J.-M.%2C%20Martin%2C%20C.%2C%20Schramm%2C%20F.%20and%20Andrejak%2C%20C.%20%282021%29.%20%3Cb%3EManagement%20of%20patients%20with%20pulmonary%20mycobacteriosis%20in%20France%3A%20a%20multicenter%20retrospective%20cohort%20study%3C%5C%2Fb%3E.%20BMC%20Pulm%20Med%20%3Ci%3E21%3C%5C%2Fi%3E%2C%201%26%23x2013%3B9%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12890-021-01701-5%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12890-021-01701-5%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Management%20of%20patients%20with%20pulmonary%20mycobacteriosis%20in%20France%3A%20a%20multicenter%20retrospective%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascale%22%2C%22lastName%22%3A%22Bemer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivia%22%2C%22lastName%22%3A%22Peuchant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Guet-Revillet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Bador%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Balavoine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Basille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Beltramo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois-Xavier%22%2C%22lastName%22%3A%22Blanc%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Blanchard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Boulanger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Bourgoin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Boutoille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9rique%22%2C%22lastName%22%3A%22Canis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didier%22%2C%22lastName%22%3A%22Caparros%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Carricajo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Carri%5Cu00e8re%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Couetdic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francis%22%2C%22lastName%22%3A%22Couturaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Charles%22%2C%22lastName%22%3A%22Dalphin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tristan%22%2C%22lastName%22%3A%22Degot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marion%22%2C%22lastName%22%3A%22Desquiens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Devouassoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Marie%22%2C%22lastName%22%3A%22Duez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oana%22%2C%22lastName%22%3A%22Dumitrescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magali%22%2C%22lastName%22%3A%22Dupuy-Grasset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alice%22%2C%22lastName%22%3A%22Gaudart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marjolaine%22%2C%22lastName%22%3A%22Georges%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cendrine%22%2C%22lastName%22%3A%22Godet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Godreuil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Guillouzouic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farida%22%2C%22lastName%22%3A%22Hamdad-Daoudi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genevi%5Cu00e8ve%22%2C%22lastName%22%3A%22H%5Cu00e9ry-Arnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christelle%22%2C%22lastName%22%3A%22Koebel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurore%22%2C%22lastName%22%3A%22Lagrange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Lanotte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Marchand-Adam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fa%5Cu00efza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marl%5Cu00e8ne%22%2C%22lastName%22%3A%22Murris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Patry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mich%5Cu00e8le%22%2C%22lastName%22%3A%22P%5Cu00e9rouse%20de%20Montclos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karine%22%2C%22lastName%22%3A%22Risso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Segonds%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Sicard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Terru%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Vach%5Cu00e9e%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Vergnon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Schramm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%5D%2C%22abstractNote%22%3A%22Recent%20studies%20report%20very%20low%20adherence%20of%20practitioners%20to%20ATS%5C%2FIDSA%20recommendations%20for%20the%20treatment%20of%20nontuberculous%20mycobacteria%20pulmonary%20disease%20%28NTM-PD%29%2C%20as%20well%20as%20a%20great%20variability%20of%20practices.%20Type%20of%20management%20could%20impact%20prognosis.%20To%20evaluate%20management%20and%20prognosis%20of%20patients%20with%20NTM-PD%20cases%20with%20respect%20to%20ATS%20recommendations%2C%20we%20conducted%20a%20multicenter%20retrospective%20cohort%20study%20%2818%20sentinel%20sites%20distributed%20throughout%20France%29%2C%20over%20a%20period%20of%20six%20years.%20We%20collected%20clinical%2C%20radiological%2C%20microbiological%20characteristics%2C%20management%20and%20outcome%20of%20the%20patients%20%28especially%20death%20or%20not%29.%20477%20patients%20with%20NTM-PD%20were%20included.%20Respiratory%20comorbidities%20were%20found%20in%2068%25%20of%20cases%2C%20tuberculosis%20sequelae%20in%2031.4%25%20of%20patients%2C%20and%20immunosuppression%20in%2016.8%25%20of%20cases.%20The%20three%20most%20common%20NTM%20species%20were%20Mycobacterium%20avium%20complex%20%2860%25%29%2C%20M.%20xenopi%20%2820%25%29%20and%20M.%20kansasii%20%285.7%25%29.%20Smear-positive%20was%20found%20in%20one%20third%20of%20NTM-PD.%20Nodulobronchiectatic%20forms%20were%20observed%20in%2054.3%25%20of%20cases%2C%20and%20cavitary%20forms%20in%2019.1%25%20of%20patients.%20Sixty-three%20percent%20of%20patients%20were%20treated%2C%2072.4%25%20of%20patients%20with%20smear-positive%20samples%2C%20and%2057.5%25%20of%20patients%20with%20smear-negative%20samples.%20Treatment%20was%20in%20adequacy%20with%20ATS%20guidelines%20in%2073.5%25.%20The%202-year%20mortality%20was%2014.4%25.%20In%20the%20Cox%20regression%2C%20treatment%20%28HR%20%3D%200.51%29%2C%20age%20%28HR%20%3D%201.02%29%2C%20and%20M.%20abscessus%20%283.19%29%20appeared%20as%20the%203%20significant%20independent%20prognostic%20factors.%20These%20findings%20highlight%20the%20adequacy%20between%20French%20practices%20and%20the%20ATS%5C%2FIDSA%20guidelines.%20Treatment%20was%20associated%20with%20a%20better%20survival.%22%2C%22date%22%3A%222021%5C%2F12%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12890-021-01701-5%22%2C%22ISSN%22%3A%221471-2466%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcpulmmed.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12890-021-01701-5%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-21T14%3A01%3A12Z%22%7D%7D%2C%7B%22key%22%3A%228Q28BYZT%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Veziris%20et%20al.%22%2C%22parsedDate%22%3A%222021-12%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EVeziris%2C%20N.%2C%20Andr%26%23xE9%3Bjak%2C%20C.%2C%20Bou%26%23xE9%3Be%2C%20S.%2C%20Emery%2C%20C.%2C%20Obradovic%2C%20M.%20and%20Chiron%2C%20R.%20%282021%29.%20%3Cb%3ENon-tuberculous%20mycobacterial%20pulmonary%20diseases%20in%20France%3A%20an%208%20years%20nationwide%20study%3C%5C%2Fb%3E.%20BMC%20Infect%20Dis%20%3Ci%3E21%3C%5C%2Fi%3E%2C%201%26%23x2013%3B10%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-021-06825-x%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-021-06825-x%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Non-tuberculous%20mycobacterial%20pulmonary%20diseases%20in%20France%3A%20an%208%20years%20nationwide%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andr%5Cu00e9jak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phane%22%2C%22lastName%22%3A%22Bou%5Cu00e9e%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corinne%22%2C%22lastName%22%3A%22Emery%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marko%22%2C%22lastName%22%3A%22Obradovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rapha%5Cu00ebl%22%2C%22lastName%22%3A%22Chiron%22%7D%5D%2C%22abstractNote%22%3A%22The%20objective%20of%20the%20study%20was%20to%20describe%20the%20epidemiology%2C%20management%20and%20cost%20of%20non-tuberculous%20mycobacteria%20pulmonary%20disease%20%28NTM-PD%29%20in%20France.%20A%20retrospective%20analysis%20was%20performed%20using%20the%20SNDS%20%28%5Cu201cSyst%5Cu00e8me%20national%20des%20donn%5Cu00e9es%20de%20sant%5Cu00e9%5Cu201d%29%20database%20over%202010%5Cu20132017.%20Patients%20with%20NTM-PD%20were%20identified%20based%20on%20the%20ICD10%20codes%20during%20hospitalizations%20and%5C%2For%20specific%20antibiotics%20treatment%20regimens.%20The%20study%20population%20was%20matched%20%28age%2C%20sex%20and%20region%29%20to%20a%20control%20group%20%281%3A3%29%20without%20NTM-PD.%205628%20patients%20with%20NTM-PD%20%28men%3A%2052.9%25%2C%20mean%20age%20%3D%2060.9%20years%29%20were%20identified%20over%20the%20study%20period%20and%201433%20%2825.5%25%29%20were%20treated%20with%20antibiotics.%20The%20proportion%20of%20patients%20still%20receiving%20treatment%20at%206%20and%2012%20months%20was%2040%25%20and%2022%25%2C%20respectively.%20The%20prevalence%20of%20NTM-PD%20was%20estimated%20at%205.92%20per%20100%2C000%20inhabitants%20and%20the%20incidence%20rate%20of%20NTM-PD%20remained%20stable%20over%20time%20between%201.025%5C%2F100%2C000%20in%202010%20and%201.096%5C%2F100%2C000%20in%202017.%20Patients%20with%20NTM-PD%20had%20more%20co-morbidities%20compared%20to%20controls%3A%20corticoids%20%2857.3%25%20vs.%2033.8%25%29%2C%20chronic%20lower%20respiratory%20disease%20%2834.4%25%20vs.%202.7%25%29%2C%20other%20infectious%20pneumonia%20%2824.4%25%20vs.%201.4%25%29%2C%20malnutrition%20%28based%20on%20hospitalization%20with%20the%20ICD-10%20code%20reported%20during%20a%20hospital%20stay%20as%20a%20main%20or%20secondary%20diagnosis%29%20%2822.0%25%20vs.%202.0%25%29%2C%20history%20of%20tuberculosis%20%2814.1%25%20vs.%200.1%25%29%2C%20HIV%20%288.7%25%20vs.%200.2%25%29%2C%20lung%20cancer%20and%20lung%20graft%20%285.7%25%20vs.%200.4%25%29%2C%20cystic%20fibrosis%20%283.2%25%20vs.%200.0%25%29%2C%20gastro-esophageal%20reflux%20disease%20%282.9%25%20vs.%200.9%25%29%20and%20bone%20marrow%20transplant%20%281.3%25%20vs.%200.0%25%29%20%28p%20%3C%200.0001%29.%20The%20mean%20Charlson%20comorbidity%20index%20score%20was%201.6%20%28vs.%200.2%20for%20controls%3B%20p%20%3C%200.0001%29.%20NTM-PD%20was%20independently%20associated%20with%20an%20increased%20mortality%20rate%20with%20a%20hazard%20ratio%20of%202.8%20%2895%25%20CI%3A%202.53%3B%203.11%29.%20Mortality%20was%20lower%20for%20patients%20treated%20with%20antibiotics%20compared%20to%20untreated%20patients%20%28HR%20%3D%200.772%20%2895%25%20CI%20%5B0.628%3B%200.949%5D%29.%20Annual%20total%20expenses%20the%20year%20following%20the%20infection%20in%20a%20societal%20perspective%20were%20%5Cu20ac%2024%2C083%20%28SD%3A%2029%2C358%29%20in%20NTM-PD%20subjects%20vs.%20%5Cu20ac%203402%20%28SD%3A%208575%29%20in%20controls%20%28p%20%3C%200.0001%29.%20Main%20driver%20of%20the%20total%20expense%20for%20NTM-PD%20patients%20was%20hospital%20expense%20%28%3E%2050%25%20of%20the%20total%20expense%29.%20Patients%20with%20NTM-PD%20in%20France%20were%20shown%20to%20have%20many%20comorbidities%2C%20their%20mortality%20risk%20is%20high%20and%20mainly%20driven%20by%20NTM-PD%2C%20and%20their%20management%20costly.%20Only%20a%20minority%20of%20patients%20got%20treated%20with%20antibiotics%20and%20of%20those%20patients%20treated%2C%20many%20stopped%20their%20therapy%20prematurely.%20These%20results%20underline%20the%20high%20burden%20associated%20with%20NTM-PD%20and%20the%20need%20for%20improvement%20of%20NTM-PD%20management%20in%20France.%22%2C%22date%22%3A%222021%5C%2F12%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12879-021-06825-x%22%2C%22ISSN%22%3A%221471-2334%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcinfectdis.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12879-021-06825-x%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T21%3A33%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22XZIBFL9V%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lecorche%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELecorche%2C%20E.%2C%20Daniau%2C%20C.%2C%20La%2C%20K.%2C%20Mougari%2C%20F.%2C%20Benmansour%2C%20H.%2C%20Kumanski%2C%20S.%2C%20Robert%2C%20J.%2C%20Fournier%2C%20S.%2C%20Lebreton%2C%20G.%2C%20Carbonne%2C%20A.%2C%20Cambau%2C%20E.%20and%20CNR-MyRMA%20%282021%29.%20%3Cb%3EMycobacterium%20chimaera%20Genomics%20With%20Regard%20to%20Epidemiological%20and%20Clinical%20Investigations%20Conducted%20for%20an%20Open%20Chest%20Postsurgical%20Mycobacterium%20chimaera%20Infection%20Outbreak%3C%5C%2Fb%3E.%20Open%20Forum%20Infectious%20Diseases%20%3Ci%3E8%3C%5C%2Fi%3E%2C%20ofab192%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofab192%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofab192%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobacterium%20chimaera%20Genomics%20With%20Regard%20to%20Epidemiological%20and%20Clinical%20Investigations%20Conducted%20for%20an%20Open%20Chest%20Postsurgical%20Mycobacterium%20chimaera%20Infection%20Outbreak%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00f4me%22%2C%22lastName%22%3A%22Daniau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22La%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanaa%22%2C%22lastName%22%3A%22Benmansour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Kumanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Fournier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Lebreton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Carbonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22CNR-MyRMA%22%7D%5D%2C%22abstractNote%22%3A%22Postsurgical%20infections%20due%20to%20Mycobacterium%20chimaera%20appeared%20as%20a%20novel%20nosocomial%20threat%20in%202015%2C%20with%20a%20worldwide%20outbreak%20due%20to%20contaminated%20heater-cooler%20units%20used%20in%20open%20chest%20surgery.%20We%20report%20the%20results%20of%20investigations%20conducted%20in%20France%20including%20whole-genome%20sequencing%20comparison%20of%20patient%20and%20heater-cooler%20unit%20isolates.We%20sought%20M.%20chimaera%20infection%20cases%20from%202010%20onwards%20through%20national%20epidemiological%20investigations%20in%20health%20care%20facilities%20performing%20cardiopulmonary%20bypass%2C%20together%20with%20a%20survey%20on%20good%20practices%20and%20systematic%20heater-cooler%20unit%20microbial%20analyses.%20Clinical%20and%20heater-cooler%20unit%20isolates%20were%20subjected%20to%20whole-genome%20sequencing%20analyzed%20with%20regard%20to%20the%20reference%20outbreak%20strain%20Zuerich-1.Only%202%20clinical%20cases%20were%20shown%20to%20be%20related%20to%20the%20outbreak%2C%20although%2023%25%20%2841%5C%2F175%29%20of%20heater-cooler%20units%20were%20declared%20positive%20for%20M.%20avium%20complex.%20Specific%20measures%20to%20prevent%20infection%20were%20applied%20in%2089%25%20%2850%5C%2F56%29%20of%20health%20care%20facilities%2C%20although%20only%2014%25%20%288%5C%2F56%29%20of%20them%20followed%20the%20manufacturer%20maintenance%20recommendations.%20Whole-genome%20sequencing%20comparison%20showed%20that%20the%20clinical%20isolates%20and%2072%25%20%2826%5C%2F36%29%20of%20heater-cooler%20unit%20isolates%20belonged%20to%20the%20epidemic%20cluster.%20Within%20clinical%20isolates%2C%205%5Cu20139%20nonsynonymous%20single%20nucleotide%20polymorphisms%20were%20observed%2C%20among%20which%20an%20in%20vivo%20mutation%20in%20a%20putative%20efflux%20pump%20gene%20was%20observed%20in%20a%20clinical%20isolate%20obtained%20for%201%20patient%20on%20antimicrobial%20treatment.Cases%20of%20postsurgical%20M.%20chimaera%20infections%20have%20been%20declared%20to%20be%20rare%20in%20France%2C%20although%20heater-cooler%20units%20were%20contaminated%2C%20as%20in%20other%20countries.%20Genomic%20analyses%20confirmed%20the%20connection%20to%20the%20outbreak%20and%20identified%20specific%20single%20nucleotide%20polymorphisms%2C%20including%201%20suggesting%20fitness%20evolution%20in%20vivo.%22%2C%22date%22%3A%22juin%201%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fofid%5C%2Fofab192%22%2C%22ISSN%22%3A%222328-8957%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofab192%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-02-25T15%3A27%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22G45DGPGQ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Opota%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EOpota%2C%20O.%2C%20Mazza-Stalder%2C%20J.%2C%20Viveiros%2C%20M.%2C%20Cambau%2C%20E.%2C%20Santin%2C%20M.%20and%20Goletti%2C%20D.%20%282021%29.%20%3Cb%3EEditorial%3A%20Tuberculosis%20and%20Non-tuberculous%20Mycobacteria%20Infections%3A%20Control%2C%20Diagnosis%20and%20Treatment%3C%5C%2Fb%3E.%20Frontiers%20in%20Public%20Health%20%3Ci%3E9%3C%5C%2Fi%3E%2C%20URL%3A%20%3Ca%20class%3D%27zp-ItemURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffpubh.2021.666187%27%3Ehttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffpubh.2021.666187%3C%5C%2Fa%3E%20%5BAccessed%20March%202022%5D.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Editorial%3A%20Tuberculosis%20and%20Non-tuberculous%20Mycobacteria%20Infections%3A%20Control%2C%20Diagnosis%20and%20Treatment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Onya%22%2C%22lastName%22%3A%22Opota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jesica%22%2C%22lastName%22%3A%22Mazza-Stalder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Viveiros%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Santin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delia%22%2C%22lastName%22%3A%22Goletti%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%222296-2565%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffpubh.2021.666187%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-21T14%3A04%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22RDV6XIIK%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Daley%20et%20al.%22%2C%22parsedDate%22%3A%222020-08-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDaley%2C%20C.%20L.%2C%20Iaccarino%2C%20J.%20M.%2C%20Lange%2C%20C.%2C%20Cambau%2C%20E.%2C%20Wallace%2C%20R.%20J.%2C%20Jr%2C%20Andrejak%2C%20C.%2C%20B%26%23xF6%3Bttger%2C%20E.%20C.%2C%20Brozek%2C%20J.%2C%20Griffith%2C%20D.%20E.%2C%20Guglielmetti%2C%20L.%2C%20Huitt%2C%20G.%20A.%2C%20Knight%2C%20S.%20L.%2C%20Leitman%2C%20P.%2C%20Marras%2C%20T.%20K.%2C%20Olivier%2C%20K.%20N.%2C%20Santin%2C%20M.%2C%20Stout%2C%20J.%20E.%2C%20Tortoli%2C%20E.%2C%20van%20Ingen%2C%20J.%2C%20Wagner%2C%20D.%20and%20Winthrop%2C%20K.%20L.%20%282020%29.%20%3Cb%3ETreatment%20of%20Nontuberculous%20Mycobacterial%20Pulmonary%20Disease%3A%20An%20Official%20ATS%5C%2FERS%5C%2FESCMID%5C%2FIDSA%20Clinical%20Practice%20Guideline%3C%5C%2Fb%3E.%20Clinical%20Infectious%20Diseases%20%3Ci%3E71%3C%5C%2Fi%3E%2C%20e1%26%23x2013%3Be36%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciaa241%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciaa241%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Treatment%20of%20Nontuberculous%20Mycobacterial%20Pulmonary%20Disease%3A%20An%20Official%20ATS%5C%2FERS%5C%2FESCMID%5C%2FIDSA%20Clinical%20Practice%20Guideline%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20L%22%2C%22lastName%22%3A%22Daley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20M%22%2C%22lastName%22%3A%22Iaccarino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J%2C%20Jr%22%2C%22lastName%22%3A%22Wallace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%20C%22%2C%22lastName%22%3A%22B%5Cu00f6ttger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Brozek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20E%22%2C%22lastName%22%3A%22Griffith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gwen%20A%22%2C%22lastName%22%3A%22Huitt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shandra%20L%22%2C%22lastName%22%3A%22Knight%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Leitman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodore%20K%22%2C%22lastName%22%3A%22Marras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20N%22%2C%22lastName%22%3A%22Olivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Santin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%20E%22%2C%22lastName%22%3A%22Stout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrico%22%2C%22lastName%22%3A%22Tortoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%20L%22%2C%22lastName%22%3A%22Winthrop%22%7D%5D%2C%22abstractNote%22%3A%22Nontuberculous%20mycobacteria%20%28NTM%29%20represent%20over%20190%20species%20and%20subspecies%2C%20some%20of%20which%20can%20produce%20disease%20in%20humans%20of%20all%20ages%20and%20can%20affect%20both%20pulmonary%20and%20extrapulmonary%20sites.%20This%20guideline%20focuses%20on%20pulmonary%20disease%20in%20adults%20%28without%20cystic%20fibrosis%20or%20human%20immunodeficiency%20virus%20infection%29%20caused%20by%20the%20most%20common%20NTM%20pathogens%20such%20as%20Mycobacterium%20avium%20complex%2C%20Mycobacterium%20kansasii%2C%20and%20Mycobacterium%20xenopi%20among%20the%20slowly%20growing%20NTM%20and%20Mycobacterium%20abscessus%20among%20the%20rapidly%20growing%20NTM.%20A%20panel%20of%20experts%20was%20carefully%20selected%20by%20leading%20international%20respiratory%20medicine%20and%20infectious%20diseases%20societies%20%28ATS%2C%20ERS%2C%20ESCMID%2C%20IDSA%29%20and%20included%20specialists%20in%20pulmonary%20medicine%2C%20infectious%20diseases%20and%20clinical%20microbiology%2C%20laboratory%20medicine%2C%20and%20patient%20advocacy.%20Systematic%20reviews%20were%20conducted%20around%20each%20of%2022%20PICO%20%28Population%2C%20Intervention%2C%20Comparator%2C%20Outcome%29%20questions%20and%20the%20recommendations%20were%20formulated%2C%20written%2C%20and%20graded%20using%20the%20GRADE%20%28Grading%20of%20Recommendations%20Assessment%2C%20Development%2C%20and%20Evaluation%29%20approach.%20Thirty-one%20evidence-based%20recommendations%20about%20treatment%20of%20NTM%20pulmonary%20disease%20are%20provided.%20This%20guideline%20is%20intended%20for%20use%20by%20healthcare%20professionals%20who%20care%20for%20patients%20with%20NTM%20pulmonary%20disease%2C%20including%20specialists%20in%20infectious%20diseases%20and%20pulmonary%20diseases.%22%2C%22date%22%3A%222020-08-14%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciaa241%22%2C%22ISSN%22%3A%221058-4838%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciaa241%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T10%3A53%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22WJXYWJXE%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Marsollier%20et%20al.%22%2C%22parsedDate%22%3A%222020-03-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMarsollier%2C%20L.%2C%20Aubry%2C%20A.%2C%20Carbonnelle%2C%20E.%2C%20Canaan%2C%20S.%2C%20Laencina%2C%20L.%2C%20Cambau%2C%20E.%20and%20Herrmann%2C%20J.%20%282020%29.%20%3Cb%3EMycobact%26%23xE9%3Brioses%20cutan%26%23xE9%3Bes%20dues%20%26%23xE0%3B%20Mycobacterium%20ulcerans%2C%20Mycobacterium%20marinum%2C%20Mycobacterium%20abscessus%2C%20Mycobacterium%20chelonae%20et%20autres%20mycobact%26%23xE9%3Bries%20non%20tuberculeuses%3C%5C%2Fb%3E.%20EM-Consulte%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1166-8598%2819%2981974-9%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1166-8598%2819%2981974-9%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobact%5Cu00e9rioses%20cutan%5Cu00e9es%20dues%20%5Cu00e0%20Mycobacterium%20ulcerans%2C%20Mycobacterium%20marinum%2C%20Mycobacterium%20abscessus%2C%20Mycobacterium%20chelonae%20et%20autres%20mycobact%5Cu00e9ries%20non%20tuberculeuses%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%22%2C%22lastName%22%3A%22Marsollier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Carbonnelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Canaan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%22%2C%22lastName%22%3A%22Laencina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22JL%22%2C%22lastName%22%3A%22Herrmann%22%7D%5D%2C%22abstractNote%22%3A%22Mycobact%5Cu00e9rioses%20cutan%5Cu00e9es%20dues%20%5Cu00e0%20%3Ci%3EMycobacterium%20ulcerans%3C%5C%2Fi%3E%2C%20%3Ci%3EMycobacterium%20marinum%3C%5C%2Fi%3E%2C%20%3Ci%3EMycobacterium%20abscessus%3C%5C%2Fi%3E%2C%20%3Ci%3EMycobacterium%20chelonae%3C%5C%2Fi%3E%20et%20autres%20mycobact%5Cu00e9ries%20non%20tuberculeuses%22%2C%22date%22%3A%2203%5C%2F01%5C%2F2020%22%2C%22language%22%3A%22fr%22%2C%22DOI%22%3A%2210.1016%5C%2FS1166-8598%2819%2981974-9%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.em-consulte.com%5C%2Farticle%5C%2F1342652%5C%2Fmycobacterioses-cutanees-dues-a-mycobacterium-ulce%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-12T09%3A26%3A56Z%22%7D%7D%2C%7B%22key%22%3A%22A5YEI5ZD%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jaffr%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EJaffr%26%23xE9%3B%2C%20J.%2C%20Aubry%2C%20A.%2C%20Maitre%2C%20T.%2C%20Morel%2C%20F.%2C%20Brossier%2C%20F.%2C%20Robert%2C%20J.%2C%20Sougakoff%2C%20W.%2C%20Veziris%2C%20N.%20and%20the%20CNR-MyRMA%20%28Centre%20National%20de%20R%26%23xE9%3Bf%26%23xE9%3Brence%20des%20Mycobact%26%23xE9%3Bries%20et%20de%20la%20R%26%23xE9%3Bsistance%20des%20Mycobact%26%23xE9%3Bries%20aux%20Antituberculeux%29%20%282020%29.%20%3Cb%3ERational%20Choice%20of%20Antibiotics%20and%20Media%20for%20Mycobacterium%20avium%20Complex%20Drug%20Susceptibility%20Testing%3C%5C%2Fb%3E.%20Frontiers%20in%20Microbiology%20%3Ci%3E11%3C%5C%2Fi%3E%2C%20URL%3A%20%3Ca%20class%3D%27zp-ItemURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmicb.2020.00081%27%3Ehttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmicb.2020.00081%3C%5C%2Fa%3E%20%5BAccessed%20March%202022%5D.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rational%20Choice%20of%20Antibiotics%20and%20Media%20for%20Mycobacterium%20avium%20Complex%20Drug%20Susceptibility%20Testing%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00e9my%22%2C%22lastName%22%3A%22Jaffr%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Maitre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wladimir%22%2C%22lastName%22%3A%22Sougakoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22the%20CNR-MyRMA%20%28Centre%20National%20de%20R%5Cu00e9f%5Cu00e9rence%20des%20Mycobact%5Cu00e9ries%20et%20de%20la%20R%5Cu00e9sistance%20des%20Mycobact%5Cu00e9ries%20aux%20Antituberculeux%29%22%2C%22lastName%22%3A%22%22%7D%5D%2C%22abstractNote%22%3A%22The%20Clinical%20and%20Laboratory%20Standards%20Institute%20recommends%20the%20use%20of%20Mueller%20Hinton%20%28MH%29%20medium%20to%20perform%20drug%20susceptibility%20testing%20%28DST%29%20of%20Mycobacterium%20avium%20complex%20%28MAC%29%20using%20the%20microdilution%20method.%20For%20MAC%2C%20there%20has%20been%20no%20study%20on%20the%20impact%20of%20media%20on%20the%20determination%20of%20minimum%20inhibitory%20concentrations%20%28MICs%29%20of%20antibiotics%20other%20than%20clarithromycin.%20This%20study%20aimed%20at%20determining%20the%20impact%20of%20two%20media%20used%20for%20DST%20of%20MAC%20and%20at%20augmenting%20the%20number%20of%20pertinent%20MICs%20for%20MAC%20species%20encountered%20in%20clinical%20practice.%20MICs%20of%20antibiotics%20used%20for%20the%20treatment%20of%20MAC%20infections%20were%20determined%20for%20158%20clinical%20MAC%20isolates%20%2880%20M.%20avium%2C%2040%20M.%20intracellulare%2C%2035%20M.%20chimaera%2C%20two%20M.%20yongonense%20and%20one%20M.%20timonense%29%20in%20MH%20and%207H9%20broths%20using%20the%20SLOMYCO%20SensititreTM%20system%20%28TREK%20Diagnostic%20Systems%2C%20East%20Grinstead%2C%20United%20Kingdom%29.%20The%20modal%20MICs%20determined%20in%20both%20media%20were%20the%20same%20for%20linezolid%2C%20moxifloxacin%2C%20rifabutin%20and%20amikacin%20but%20not%20for%20clarithromycin%2C%20rifampin%20and%20ethambutol.%20The%20kappa%20test%20for%20MICs%20converted%20to%20susceptibility%20categories%20showed%20an%20excellent%20agreement%20for%20clarithromycin%2C%20a%20moderate%20agreement%20for%20linezolid%20and%20a%20weak%20agreement%20for%20moxifloxacin%20and%20amikacin.%20For%20amikacin%2C%207H9%20allowed%20a%20better%20distinction%20%28fewer%20intermediate%20strains%29%20of%20wild-type%20populations%20than%20MH.%20Existing%20breakpoints%20for%20linezolid%20and%20moxifloxacin%20are%20spread%20through%20the%20distribution%20of%20MICs%20for%20wild-type%20populations.%20The%20only%20breakpoints%20that%20can%20be%20used%20rationally%20are%20those%20for%20amikacin%20and%20clarithromycin.%20For%20amikacin%2C%207H9%20performs%20better%20than%20MH%2C%20whereas%20both%20media%20perform%20equally%20for%20clarithromycin.%20Given%20that%20testing%20in%207H9%2C%20as%20opposed%20to%20MH%2C%20allows%20easier%20MIC%20measurements%20and%20yields%20greater%20reproducibility%2C%20we%20propose%20the%20use%20of%207H9%20medium%20for%20DST%20of%20MAC.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221664-302X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmicb.2020.00081%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T10%3A50%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22PKC5HTPG%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lecorche%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELecorche%2C%20E.%2C%20Pean%20de%20Ponfilly%2C%20G.%2C%20Mougari%2C%20F.%2C%20Benmansour%2C%20H.%2C%20Poisnel%2C%20E.%2C%20Janvier%2C%20F.%20and%20Cambau%2C%20E.%20%282020%29.%20%3Cb%3EDisseminated%20Mycobacterium%20chimaera%20Following%20Open-Heart%20Surgery%2C%20the%20Heater%26%23x2013%3BCooler%20Unit%20Worldwide%20Outbreak%3A%20Case%20Report%20and%20Minireview%3C%5C%2Fb%3E.%20Frontiers%20in%20Medicine%20%3Ci%3E7%3C%5C%2Fi%3E%2C%20URL%3A%20%3Ca%20class%3D%27zp-ItemURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmed.2020.00243%27%3Ehttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmed.2020.00243%3C%5C%2Fa%3E%20%5BAccessed%20March%202022%5D.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Disseminated%20Mycobacterium%20chimaera%20Following%20Open-Heart%20Surgery%2C%20the%20Heater%5Cu2013Cooler%20Unit%20Worldwide%20Outbreak%3A%20Case%20Report%20and%20Minireview%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gauthier%22%2C%22lastName%22%3A%22Pean%20de%20Ponfilly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanaa%22%2C%22lastName%22%3A%22Benmansour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Poisnel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Janvier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Invasive%20cardiovascular%20infections%20by%20Mycobacterium%20chimaera%20associated%20with%20open-heart%20surgery%20have%20been%20reported%20worldwide%20since%202013.%20Here%2C%20we%20report%20a%20case%20of%20a%2061%20year%20old%20man%2C%20without%20any%20other%20particular%20medical%20background%2C%20who%20underwent%20cardiac%20surgery%20for%20replacing%20part%20of%20the%20ascending%20aorta%20by%20a%20bio-prosthetic%20graft.%20Eighteen%20months%20later%2C%20the%20patient%20was%20painful%20at%20the%20lower%20back%20with%20fever.%20A%20pyogenic%20vertebral%20osteomyelitis%20due%20to%20M.%20chimaera%20associated%20to%20graft%20infection%20was%20diagnosed%20after%206%20months%20of%20sub-acute%20infection.%20The%20patient%20presented%20a%20disseminated%20disease%20with%20cerebral%20lesions%2C%20chorioretinitis%2C%20and%20chronic%20renal%20failure.%20Despite%20adequate%20antimicrobial%20treatment%20and%20graft%20explantation%2C%20the%20patient%20died%20after%206%20years.%20We%20reviewed%20the%20literature%20on%20M.%20chimaera%20infections%20associated%20with%20open-heart%20surgery.%20The%20worldwide%20outbreak%20has%20been%20explained%20by%20airborne%20bioaerosol%20generated%20by%20the%203T%20heater%5Cu2013cooler%20unit%20%28HCU%29%20used%20during%20cardiac%20by-pass%20surgical%20procedures.%20These%20infections%20are%20difficult%20to%20diagnose%20because%20of%20a%20long%20latency%20period%20%28up%20to%20several%20years%29%2C%20with%20no%20specific%20symptoms%20and%20a%20highly%20specialized%20microbiological%20diagnosis.%20The%20treatment%20is%20based%20on%20antibiotics%20and%20surgery.%20These%20infections%20are%20also%20difficult%20to%20treat%2C%20since%20the%20mortality%20rate%20is%20high%20around%2050%25.%20Prevention%20is%20necessary%20by%20modifying%20the%20use%20of%20HCUs%20in%20operating%20rooms.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%222296-858X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmed.2020.00243%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T10%3A53%3A38Z%22%7D%7D%2C%7B%22key%22%3A%226A2DEBBX%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Daniau%20et%20al.%22%2C%22parsedDate%22%3A%222019-06-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDaniau%2C%20C.%2C%20Lecorch%26%23xE9%3B%2C%20E.%2C%20Mougari%2C%20F.%20and%20et%20al.%20%282019%29.%20%3Cb%3EInfections%20invasives%20%26%23xE0%3B%20Mycobacterium%20chimaera%20en%20chirurgie%20cardiaque%20et%20%26%23xE9%3Bvaluation%20des%20pratiques%20autour%20des%20mat%26%23xE9%3Briels%20de%20circulation%20extracorporelle%3C%5C%2Fb%3E.%20Hygienes%20%3Ci%3E27%3C%5C%2Fi%3E%2C%20351%26%23x2013%3B359%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.25329%5C%2Fhy_xxvii_6-1%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.25329%5C%2Fhy_xxvii_6-1%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Infections%20invasives%20%5Cu00e0%20Mycobacterium%20chimaera%20en%20chirurgie%20cardiaque%20et%20%5Cu00e9valuation%20des%20pratiques%20autour%20des%20mat%5Cu00e9riels%20de%20circulation%20extracorporelle%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Daniau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Lecorch%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%22%2C%22lastName%22%3A%22et%20al.%22%7D%5D%2C%22abstractNote%22%3A%22%3Cp%20class%3D%5C%22Resume_F%5C%22%3E%3Cstrong%20class%3D%5C%22F_Resume_bold%5C%22%3EObjectif.%5Cu00a0%3C%5C%2Fstrong%3ESuite%20aux%20deux%20cas%20confirm%5Cu00e9s%20d%5Cu2019infection%20%5Cu00e0%5Cu00a0%3Cem%3EMycobacterium%20chimaera%3C%5C%2Fem%3E%5Cu00a0identifi%5Cu00e9s%20en%202015%2C%20une%20recherche%20r%5Cu00e9trospective%20de%20cas%20apr%5Cu00e8s%20un%20acte%20de%20chirurgie%20cardiaque%20sous%20circulation%20extracorporelle%20%28CEC%29%20et%20une%20enqu%5Cu00eate%20sur%20les%20pratiques%20li%5Cu00e9es%20aux%20mat%5Cu00e9riels%20de%20CEC%20en%20France%20ont%20%5Cu00e9t%5Cu00e9%20mises%20en%20%5Cu0153uvre.%5Cu00a0%3Cstrong%20class%3D%5C%22F_Resume_bold%5C%22%3EM%5Cu00e9thode.%5Cu00a0%3C%5C%2Fstrong%3EL%5Cu2019enqu%5Cu00eate%20a%20cibl%5Cu00e9%20les%20%5Cu00e9tablissements%20de%20sant%5Cu00e9%20%28ES%29%20qui%20pratiquent%20des%20actes%20de%20chirurgie%20cardiaque%20sous%20CEC%20en%20France.%20Les%20informations%20recueillies%20par%20questionnaire%20portaient%20sur%20la%20p%5Cu00e9riode%20du%201%3Cspan%20class%3D%5C%22supp%20_idGenCharOverride-1%5C%22%3Eer%3C%5C%2Fspan%3E%5Cu00a0janvier%202015%20au%2031%5Cu00a0juin%202017.%5Cu00a0%3Cstrong%20class%3D%5C%22F_Resume_bold%5C%22%3ER%5Cu00e9sultats.%5Cu00a0%3C%5C%2Fstrong%3EParmi%20les%2061%20services%20de%20chirurgie%20cardiaque%20sollicit%5Cu00e9s%2C%2056%20%2892%25%29%20ont%20particip%5Cu00e9%20%5Cu00e0%20l%5Cu2019enqu%5Cu00eate.%20Aucun%20%5Cu00e9tablissement%20n%5Cu2019a%20d%5Cu00e9clar%5Cu00e9%20de%20cas%20d%5Cu2019infection%20invasive%20%5Cu00e0%5Cu00a0%3Cem%3EM.%5Cu00a0chimaera%3C%5C%2Fem%3E%5Cu00a0depuis%202015.%20L%5Cu2019utilisation%2C%20pour%20la%20CEC%2C%20de%20227%20g%5Cu00e9n%5Cu00e9rateurs%20thermiques%20%28GT%29%20a%20%5Cu00e9t%5Cu00e9%20d%5Cu00e9clar%5Cu00e9e%20par%20les%20ES%20participants%2C%20soit%205%2C8%20GT%20pour%201%20000%20interventions%20par%20an.%20Les%20recommandations%20des%20fabricants%20relatives%20%5Cu00e0%20l%5Cu2019entretien%20des%20GT%20%5Cu00e9taient%20appliqu%5Cu00e9es%20par%20une%20minorit%5Cu00e9%20d%5Cu2019%5Cu00e9tablissements%20%287%25%29.%20Les%20contr%5Cu00f4les%20microbiologiques%20de%20l%5Cu2019eau%20des%20GT%20ont%20montr%5Cu00e9%20que%2056%25%20d%5Cu2019entre%20eux%20%5Cu00e9taient%20contamin%5Cu00e9s%20par%20des%20bact%5Cu00e9ries%20usuelles%20et%2023%25%20par%20des%20mycobact%5Cu00e9ries%20du%20complexe%5Cu00a0%3Cem%3EMycobacterium%20avium.%3C%5C%2Fem%3E%5Cu00a0%3Cstrong%20class%3D%5C%22F_Resume_bold%5C%22%3EConclusion.%3C%5C%2Fstrong%3E%5Cu00a0Les%20ES%20n%5Cu2019ont%20pas%20identifi%5Cu00e9%20de%20nouveau%20cas%20d%5Cu2019infection%20%5Cu00e0%5Cu00a0%3Cem%3EM.%5Cu00a0chimaera%3C%5C%2Fem%3E%5Cu00a0mais%20la%20contamination%20des%20GT%20%5Cu00e9tait%20importante.%20Les%20difficult%5Cu00e9s%20rencontr%5Cu00e9es%20par%20les%20ES%20dans%20la%20mise%20en%20%5Cu0153uvre%20des%20recommandations%20des%20fabricants%20pour%20l%5Cu2019entretien%20et%20le%20contr%5Cu00f4le%20microbiologique%20des%20GT%20sugg%5Cu00e8rent%20la%20n%5Cu00e9cessit%5Cu00e9%20de%20recommandations%20nationales%20pour%20am%5Cu00e9liorer%20les%20pratiques%20d%5Cu2019entretien%20des%20mat%5Cu00e9riels%20de%20CEC.%3C%5C%2Fp%3E%22%2C%22date%22%3A%222019-06-01%22%2C%22language%22%3A%22fr-FR%22%2C%22DOI%22%3A%2210.25329%5C%2Fhy_xxvii_6-1%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.hygienes.net%5C%2Fboutique%5C%2Fhygienes-2%5C%2Finfections-invasives-a-mycobacterium-chimaera-en-chirurgie-cardiaque-et-evaluation-des-pratiques-autour-des-materiels-de-circulation-extracorporelle%5C%2F%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-12T08%3A24%3A20Z%22%7D%7D%2C%7B%22key%22%3A%225ARZ5CMY%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rollet-Cohen%20et%20al.%22%2C%22parsedDate%22%3A%222019-03-29%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERollet-Cohen%2C%20V.%2C%20Roux%2C%20A.-L.%2C%20Bourgeois%2C%20M.%20L.%2C%20Sapriel%2C%20G.%2C%20Bahri%2C%20M.%20E.%2C%20Jais%2C%20J.-P.%2C%20Heym%2C%20B.%2C%20Mougari%2C%20F.%2C%20Raskine%2C%20L.%2C%20V%26%23xE9%3Bziris%2C%20N.%2C%20Gaillard%2C%20J.-L.%20and%20Sermet-Gaudelus%2C%20I.%20%282019%29.%20%3Cb%3EMycobacterium%20bolletii%20lung%20disease%20in%20cystic%20fibrosis%3C%5C%2Fb%3E.%20CHEST%20%3Ci%3E0%3C%5C%2Fi%3E%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.chest.2019.03.019%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.chest.2019.03.019%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobacterium%20bolletii%20lung%20disease%20in%20cystic%20fibrosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginie%22%2C%22lastName%22%3A%22Rollet-Cohen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muriel%20Le%22%2C%22lastName%22%3A%22Bourgeois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Sapriel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manele%20El%22%2C%22lastName%22%3A%22Bahri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Jais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Heym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22V%5Cu00e9ziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Gaillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Sermet-Gaudelus%22%7D%5D%2C%22abstractNote%22%3A%22%3Ch2%3EAbstract%3C%5C%2Fh2%3E%3Ch3%3EBackground%3C%5C%2Fh3%3E%3Cp%3EThe%20cystic%20fibrosis%20%28CF%29%20pathogen%2C%20%3Ci%3EMycobacterium%20abscessus%3C%5C%2Fi%3E%20complex%2C%20covers%20three%20%5C%22subspecies%5C%22%3A%20%5C%22%3Ci%3EM.%20abscessus%5C%22%2C%20%5C%22M.%20massiliense%5C%22%2C%3C%5C%2Fi%3E%20and%20%5C%22%3Ci%3EM.%20bolletii%3C%5C%2Fi%3E%5C%22.%20There%20are%20no%20clinical%20outcome%20data%20concerning%20%3Ci%3EM.%20bolletii%3C%5C%2Fi%3E.%3C%5C%2Fp%3E%3Cp%3EOur%20aim%20was%20to%20characterize%20%3Ci%3EM.%20bolletii%3C%5C%2Fi%3E%20lung%20infections%20in%20CF%20patients.%3C%5C%2Fp%3E%3Ch3%3EMethods%3C%5C%2Fh3%3E%3Cp%3EWe%20included%20cases%20of%20%3Ci%3EM.%20bolletii%3C%5C%2Fi%3E%20lung%20infection%20recorded%20between%201994%20and%202012%20in%20France.%20Data%20were%20collected%20from%20the%20CF%20registry%2C%20medical%20records%2C%20and%20questionnaires%20submitted%20to%20the%20CF%20primary%20physician.%20Strains%20were%20typed%20by%20Multilocus%20Sequence%20Typing%20%28MLST%29%20analysis.%3C%5C%2Fp%3E%3Ch3%3EResults%3C%5C%2Fh3%3E%3Cp%3EFifteen%20cases%20were%20identified%20in%20nine%20CF%20centers.%20Nine%20patients%20%2860%25%29%20presented%20with%20nontuberculous%20mycobacteria%20pulmonary%20disease%20%28NTM-PD%29.%20Follow%20up%20of%2013%20patients%20showed%20a%20trend%20to%20a%20more%20rapid%20decline%20in%20FEV%3Csub%3E1%3C%5C%2Fsub%3E%20the%20first%20year%20of%20colonization%20%28-9.4%25%20%2819.3%29%29%20in%20comparison%20to%20non-infected%20controls%20%28-2.3%25%20%2812.1%29%3B%20%3Ci%3Ep%3C%5C%2Fi%3E%3D0.16%29.%20Twelve%20patients%20were%20treated%2C%20and%2011%20received%20oral%20macrolides.%20Treatment-induced%20eradication%20occured%20in%205%20patients%20%2841.7%25%29.%20Four%20patients%20died%20%2826.7%25%29%2C%20including%201%20case%20of%20fatal%20NTM-PD.%20Inducible%20macrolide%20resistance%20was%20demonstrated%20in%20all%20strains.%20Patients%20always%20harbored%20unique%20strains..%3C%5C%2Fp%3E%3Ch3%3EConclusion%3C%5C%2Fh3%3E%3Cp%3EOur%20study%20reports%20the%20largest%20study%20cohort%20of%20CF%20patients%20infected%20with%20%3Ci%3EM.%20bolletii.%20M%20bolletii%3C%5C%2Fi%3E%20infection%20affects%20both%20children%20and%20young%20adults%2C%20is%20most%20often%20symptomatic%20and%20may%20be%20fatal.%20Macrolide-based%20therapies%20have%20poor%20effectiveness.%20There%20is%20no%20evidence%20of%20patient-to-patient%20transmission.%3C%5C%2Fp%3E%22%2C%22date%22%3A%222019%5C%2F03%5C%2F29%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.chest.2019.03.019%22%2C%22ISSN%22%3A%220012-3692%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournal.chestnet.org%5C%2Farticle%5C%2FS0012-3692%2819%2930747-0%5C%2Fabstract%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-03T22%3A23%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22MTVU5FER%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dutertre%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDutertre%2C%20M.%2C%20Delobel%2C%20P.%2C%20Marchou%2C%20B.%2C%20Boyer%2C%20J.-F.%2C%20Mougari%2C%20F.%20and%20Martin-Blondel%2C%20G.%20%282019%29.%20%3Cb%3EOlecranon%20bursitis%20secondary%20to%20Mycobacterium%20europaeum%20infection%20in%20a%20patient%20receiving%20immunosuppressive%20drugs%20for%20rheumatoid%20arthritis%3C%5C%2Fb%3E.%20M%26%23xE9%3Bdecine%20et%20Maladies%20Infectieuses%20%3Ci%3E49%3C%5C%2Fi%3E%2C%20358%26%23x2013%3B359%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2019.03.002%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2019.03.002%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Olecranon%20bursitis%20secondary%20to%20Mycobacterium%20europaeum%20infection%20in%20a%20patient%20receiving%20immunosuppressive%20drugs%20for%20rheumatoid%20arthritis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Dutertre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Delobel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Marchou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Frederic%22%2C%22lastName%22%3A%22Boyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Martin-Blondel%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22ao%5Cu00fbt%201%2C%202019%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.medmal.2019.03.002%22%2C%22ISSN%22%3A%220399-077X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0399077X17308909%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-02-25T15%3A53%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22JINIH26W%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Decalonne%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDecalonne%2C%20M.%2C%20Lecorche%2C%20E.%2C%20Hau%2C%20E.%2C%20Petiteau%2C%20A.%2C%20Moreau%2C%20C.%2C%20Milan%2C%20O.%2C%20Lanotte%2C%20P.%2C%20Mereghetti%2C%20L.%2C%20Cambau%2C%20E.%20and%20van%20der%20Mee-Marquet%2C%20N.%20%282019%29.%20%3Cb%3ECause%20Analysis%20of%20an%20Infection%20in%20Facelift%20Surgery%20Due%20to%20Mycobacterium%20chelonae%3C%5C%2Fb%3E.%20Frontiers%20in%20Medicine%20%3Ci%3E6%3C%5C%2Fi%3E%2C%20URL%3A%20%3Ca%20class%3D%27zp-ItemURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmed.2019.00243%27%3Ehttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmed.2019.00243%3C%5C%2Fa%3E%20%5BAccessed%20February%202022%5D.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cause%20Analysis%20of%20an%20Infection%20in%20Facelift%20Surgery%20Due%20to%20Mycobacterium%20chelonae%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Decalonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Hau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agn%5Cu00e8s%22%2C%22lastName%22%3A%22Petiteau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9lia%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Odile%22%2C%22lastName%22%3A%22Milan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipe%22%2C%22lastName%22%3A%22Lanotte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Mereghetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22van%20der%20Mee-Marquet%22%7D%5D%2C%22abstractNote%22%3A%22We%20report%20a%20post-facelift%20infection%20due%20to%20Mycobacterium%20chelonae.%20An%20environmental%20strain%20recovered%20from%20the%20water%20supply%20network%20of%20the%20surgical%20clinic%20and%20the%20clinical%20strains%20were%20considered%20non-differentiable%20using%20whole%20genome%20sequencing.%20After%20the%20unhealed%20wound%27s%20exposure%20to%20M.%20chelonae%20while%20showering%20early%20at%20the%20clinic%20after%20surgery%2C%20a%20lasting%20exposure%20of%20the%20colonized%20wound%20to%20the%20warm%20and%20moist%20working%20conditions%20of%20a%20bakery%20may%20have%20been%20favorable%20to%20the%20infection%27s%20development.%22%2C%22date%22%3A%222019%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%222296-858X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmed.2019.00243%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-02-25T15%3A52%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22GJQMGE59%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Griffith%20et%20al.%22%2C%22parsedDate%22%3A%222018-12-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGriffith%2C%20D.%20E.%2C%20Eagle%2C%20G.%2C%20Thomson%2C%20R.%2C%20Aksamit%2C%20T.%20R.%2C%20Hasegawa%2C%20N.%2C%20Morimoto%2C%20K.%2C%20Addrizzo-Harris%2C%20D.%20J.%2C%20O%26%23x2019%3BDonnell%2C%20A.%20E.%2C%20Marras%2C%20T.%20K.%2C%20Flume%2C%20P.%20A.%2C%20Loebinger%2C%20M.%20R.%2C%20Morgan%2C%20L.%2C%20Codecasa%2C%20L.%20R.%2C%20Hill%2C%20A.%20T.%2C%20Ruoss%2C%20S.%20J.%2C%20Yim%2C%20J.-J.%2C%20Ringshausen%2C%20F.%20C.%2C%20Field%2C%20S.%20K.%2C%20Philley%2C%20J.%20V.%2C%20Wallace%2C%20R.%20J.%2C%20van%20Ingen%2C%20J.%2C%20Coulter%2C%20C.%2C%20Nezamis%2C%20J.%20and%20Winthrop%2C%20K.%20L.%20%282018%29.%20%3Cb%3EAmikacin%20Liposome%20Inhalation%20Suspension%20for%20Treatment-Refractory%20Lung%20Disease%20Caused%20by%20Mycobacterium%20avium%20Complex%20%28CONVERT%29.%20A%20Prospective%2C%20Open-Label%2C%20Randomized%20Study%3C%5C%2Fb%3E.%20Am%20J%20Respir%20Crit%20Care%20Med%20%3Ci%3E198%3C%5C%2Fi%3E%2C%201559%26%23x2013%3B1569%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1164%5C%2Frccm.201807-1318OC%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1164%5C%2Frccm.201807-1318OC%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Amikacin%20Liposome%20Inhalation%20Suspension%20for%20Treatment-Refractory%20Lung%20Disease%20Caused%20by%20Mycobacterium%20avium%20Complex%20%28CONVERT%29.%20A%20Prospective%2C%20Open-Label%2C%20Randomized%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20E.%22%2C%22lastName%22%3A%22Griffith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%22%2C%22lastName%22%3A%22Eagle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Thomson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20R.%22%2C%22lastName%22%3A%22Aksamit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naoki%22%2C%22lastName%22%3A%22Hasegawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kozo%22%2C%22lastName%22%3A%22Morimoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Doreen%20J.%22%2C%22lastName%22%3A%22Addrizzo-Harris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20E.%22%2C%22lastName%22%3A%22O%5Cu2019Donnell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodore%20K.%22%2C%22lastName%22%3A%22Marras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20A.%22%2C%22lastName%22%3A%22Flume%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20R.%22%2C%22lastName%22%3A%22Loebinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucy%22%2C%22lastName%22%3A%22Morgan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luigi%20R.%22%2C%22lastName%22%3A%22Codecasa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%20T.%22%2C%22lastName%22%3A%22Hill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20J.%22%2C%22lastName%22%3A%22Ruoss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jae-Joon%22%2C%22lastName%22%3A%22Yim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%20C.%22%2C%22lastName%22%3A%22Ringshausen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20K.%22%2C%22lastName%22%3A%22Field%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%20V.%22%2C%22lastName%22%3A%22Philley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Wallace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22Coulter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Nezamis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%20L.%22%2C%22lastName%22%3A%22Winthrop%22%7D%5D%2C%22abstractNote%22%3A%22Rationale%3A%20Improved%20therapeutic%20options%20are%20needed%20for%20patients%20with%20treatment-refractory%20nontuberculous%20mycobacterial%20lung%20disease%20caused%20by%20Mycobacterium%20avium%20complex%20%28MAC%29.%5Cn%5CnObjectives%3A%20To%20evaluate%20the%20efficacy%20and%20safety%20of%20daily%20amikacin%20liposome%20inhalation%20suspension%20%28ALIS%29%20added%20to%20standard%20guideline-based%20therapy%20%28GBT%29%20in%20patients%20with%20refractory%20MAC%20lung%20disease.%5Cn%5CnMethods%3A%20Adults%20with%20amikacin-susceptible%20MAC%20lung%20disease%20and%20MAC-positive%20sputum%20cultures%20despite%20at%20least%206%20months%20of%20stable%20GBT%20were%20randomly%20assigned%20%282%3A1%29%20to%20receive%20ALIS%20with%20GBT%20%28ALIS%5Cu2009%2B%5Cu2009GBT%29%20or%20GBT%20alone.%20Once-daily%20ALIS%20was%20supplied%20in%20single-use%20vials%20delivering%20590%20mg%20amikacin%20to%20the%20nebulizer.%20The%20primary%20endpoint%20was%20culture%20conversion%2C%20defined%20as%20three%20consecutive%20monthly%20MAC-negative%20sputum%20cultures%20by%20Month%206.%5Cn%5CnMeasurements%20and%20Main%20Results%3A%20Enrolled%20patients%20%28ALIS%5Cu2009%2B%5Cu2009GBT%2C%20n%5Cu2009%3D%5Cu2009224%3B%20GBT-alone%2C%20n%5Cu2009%3D%5Cu2009112%29%20were%20a%20mean%2064.7%20years%20old%20and%2069.3%25%20female.%20Most%20had%20underlying%20bronchiectasis%20%2862.5%25%29%2C%20chronic%20obstructive%20pulmonary%20disease%20%2814.3%25%29%2C%20or%20both%20%2811.9%25%29.%20Culture%20conversion%20was%20achieved%20by%2065%20of%20224%20patients%20%2829.0%25%29%20with%20ALIS%5Cu2009%2B%5Cu2009GBT%20and%2010%20of%20112%20%288.9%25%29%20with%20GBT%20alone%20%28odds%20ratio%2C%204.22%3B%2095%25%20confidence%20interval%2C%202.08%5Cu20138.57%3B%20P%5Cu2009%3C%5Cu20090.001%29.%20Patients%20in%20the%20ALIS%5Cu2009%2B%5Cu2009GBT%20arm%20versus%20GBT%20alone%20were%20more%20likely%20to%20achieve%20conversion%20%28hazard%20ratio%2C%203.90%3B%2095%25%20confidence%20interval%2C%202.00%5Cu20137.60%29.%20Respiratory%20adverse%20events%20%28primarily%20dysphonia%2C%20cough%2C%20and%20dyspnea%29%20were%20reported%20in%2087.4%25%20of%20patients%20receiving%20ALIS%5Cu2009%2B%5Cu2009GBT%20and%2050.0%25%20receiving%20GBT%20alone%3B%20serious%20treatment-emergent%20adverse%20events%20occurred%20in%2020.2%25%20and%2017.9%25%20of%20patients%2C%20respectively.%5Cn%5CnConclusions%3A%20Addition%20of%20ALIS%20to%20GBT%20for%20treatment-refractory%20MAC%20lung%20disease%20achieved%20significantly%20greater%20culture%20conversion%20by%20Month%206%20than%20GBT%20alone%2C%20with%20comparable%20rates%20of%20serious%20adverse%20events.%5Cn%5CnClinical%20trial%20registered%20with%20www.clinicaltrials.gov%20%28NCT02344004%29.%22%2C%22date%22%3A%222018-12-15%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1164%5C%2Frccm.201807-1318OC%22%2C%22ISSN%22%3A%221073-449X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.atsjournals.org%5C%2Fdoi%5C%2F10.1164%5C%2Frccm.201807-1318OC%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-04-19T20%3A42%3A05Z%22%7D%7D%2C%7B%22key%22%3A%222L3QBFXB%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Coolen-Allou%20et%20al.%22%2C%22parsedDate%22%3A%222018-07-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECoolen-Allou%2C%20N.%2C%20Touron%2C%20T.%2C%20Belmonte%2C%20O.%2C%20Gazaille%2C%20V.%2C%20Andre%2C%20M.%2C%20Allyn%2C%20J.%2C%20Picot%2C%20S.%2C%20Payet%2C%20A.%20and%20Veziris%2C%20N.%20%282018%29.%20%3Cb%3EClinical%2C%20Radiological%2C%20and%20Microbiological%20Characteristics%20of%20Mycobacterium%20simiae%20Infection%20in%2097%20Patients%3C%5C%2Fb%3E.%20Antimicrobial%20Agents%20and%20Chemotherapy%20%3Ci%3E62%3C%5C%2Fi%3E%2C%20e00395-18%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00395-18%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00395-18%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%2C%20Radiological%2C%20and%20Microbiological%20Characteristics%20of%20Mycobacterium%20simiae%20Infection%20in%2097%20Patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Coolen-Allou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Touron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Belmonte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virgile%22%2C%22lastName%22%3A%22Gazaille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michel%22%2C%22lastName%22%3A%22Andre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Allyn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Picot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annabelle%22%2C%22lastName%22%3A%22Payet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20simiae%20is%20a%20rare%20species%20of%20slow-growing%20nontuberculous%20mycobacteria%20%28NTM%29.%20From%202002%20to%202017%2C%20we%20conducted%20a%20retrospective%20study%20that%20included%20all%20patients%20with%20NTM-positive%20respiratory%20samples%20detected%20in%20two%20university%20hospitals%20of%20the%20French%20overseas%20department%20of%20Reunion%20Island.%20We%20recorded%20the%20prevalence%20of%20M.%20simiae%20in%20this%20cohort%2C%20as%20well%20as%20the%20clinical%2C%20radiological%2C%20and%20microbiological%20features%20of%20patients%20with%20at%20least%201%20sample%20positive%20for%20M.%20simiae.%20In%20our%20cohort%2C%2097%20patients%20%2815.1%25%29%20were%20positive%20for%20M.%20simiae.%20Twenty-one%20patients%20%2821.6%25%29%20met%20the%20American%20Thoracic%20Society%20%28ATS%29%20criteria%20for%20infection.%20M.%20simiae%20infection%20was%20associated%20with%20bronchiectasis%2C%20micronodular%20lesions%2C%20and%20weight%20loss.%20Antibiotic%20susceptibility%20testing%20was%20performed%20for%2060%20patients%2C%20and%20the%20isolates%20were%20found%20to%20have%20low%20susceptibility%20to%20antibiotics%2C%20except%20for%20amikacin%2C%20fluoroquinolones%2C%20and%20clarithromycin.%20Treatment%20failed%20for%204%20of%20the%208%20patients%20treated%20for%20M.%20simiae%20infection.%20Here%2C%20we%20describe%20a%20specific%20cluster%20corresponding%20to%20a%20large%20cohort%20of%20patients%20with%20M.%20simiae%2C%20a%20rare%20nontuberculous%20mycobacterium%20associated%20with%20low%20pathogenicity%20and%20poor%20susceptibility%20to%20antibiotics.%22%2C%22date%22%3A%222018%5C%2F07%5C%2F01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.00395-18%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F62%5C%2F7%5C%2Fe00395-18%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-03T22%3A39%3A55Z%22%7D%7D%2C%7B%22key%22%3A%226YZ9YSRS%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lecorche%20et%20al.%22%2C%22parsedDate%22%3A%222018-04-01%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELecorche%2C%20E.%2C%20Haenn%2C%20S.%2C%20Mougari%2C%20F.%2C%20Kumanski%2C%20S.%2C%20Veziris%2C%20N.%2C%20Benmansour%2C%20H.%2C%20Raskine%2C%20L.%2C%20Moulin%2C%20L.%2C%20Cambau%2C%20E.%2C%20Aubry%2C%20A.%2C%20Brossier%2C%20F.%2C%20Chauffour%2C%20A.%2C%20Jaffre%2C%20J.%2C%20Jarlier%2C%20V.%2C%20Robert%2C%20J.%20and%20Sougakoff%2C%20W.%20%282018%29.%20%3Cb%3EComparison%20of%20methods%20available%20for%20identification%20of%20Mycobacterium%20chimaera%3C%5C%2Fb%3E.%20Clinical%20Microbiology%20and%20Infection%20%3Ci%3E24%3C%5C%2Fi%3E%2C%20409%26%23x2013%3B413%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2017.07.031%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2017.07.031%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparison%20of%20methods%20available%20for%20identification%20of%20Mycobacterium%20chimaera%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Haenn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Kumanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Benmansour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Jaffre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22W.%22%2C%22lastName%22%3A%22Sougakoff%22%7D%5D%2C%22abstractNote%22%3A%22%3Ch2%3EAbstract%3C%5C%2Fh2%3E%3Ch3%3EObjectives%3C%5C%2Fh3%3E%3Cp%3E%3Ci%3EMycobacterium%20chimaera%3C%5C%2Fi%3E%20is%20a%20recently%20described%20nontuberculous%20mycobacterium%20belonging%20to%20the%20%3Ci%3EMycobacterium%20avium%3C%5C%2Fi%3E%20complex%20%28MAC%29.%20Because%20this%20species%20is%20implicated%20in%20a%20worldwide%20outbreak%20due%20to%20contaminated%20heater%5Cu2013cooler%20unit%20water%20tanks%20during%20open-heart%20surgery%2C%20it%20has%20become%20mandatory%20for%20clinical%20microbiology%20laboratories%20to%20be%20able%20to%20differentiate%20%3Ci%3EM.%20chimaera%3C%5C%2Fi%3E%20from%20the%20other%20MAC%20species%2C%20especially%20%3Ci%3EM.%20intracellulare%3C%5C%2Fi%3E.%20Such%20identification%20has%20so%20far%20been%20restricted%20to%20specialized%20laboratories%20because%20it%20required%20the%20analysis%20of%20several%20gene%20sequences.%20The%20aim%20of%20this%20study%20was%20to%20evaluate%20commercial%20methods%20for%20identifying%20%3Ci%3EM.%20chimaera%3C%5C%2Fi%3E%20with%20regard%20to%20the%20reference%20gene%20sequencing%20ITS%2C%20the%20internal%20transcribed%20spacer%2016%5Cu201323S.%3C%5C%2Fp%3E%3Ch3%3EMethods%3C%5C%2Fh3%3E%3Cp%3EForty-seven%20clinical%20and%20environmental%20isolates%20including%2041%20MAC%20were%20identified%20by%20%28a%29%20PCR%20sequencing%20of%20the%20ITS%20and%20%3Ci%3Ehsp65%3C%5C%2Fi%3E%20genes%2C%20%28b%29%20three%20molecular%20biology%20kits%20%28INNO-LiPA%20Mycobacteria%2C%20GenoType%20Mycobacterium%20CM%20and%20GenoType%20NTM-DR%29%20and%20%28c%29%20matrix-assisted%20desorption%20ionization%5Cu2013time%20of%20flight%20mass%20spectrometry%20%28MALDI-TOF%20MS%29%20using%20Microflex%20LT.%3C%5C%2Fp%3E%3Ch3%3EResults%3C%5C%2Fh3%3E%3Cp%3EThere%20was%20a%20high%20concordance%20for%20species%20determination%20between%20the%20reference%20ITS%20sequencing%20and%20the%20GenoType%20NTM-DR%20test%20%2839%5C%2F41%2C%2095%25%29%2C%20the%20INNO-LiPA%20Mycobacteria%20test%20%2838%5C%2F41%2C%2093%25%29%20and%20the%20%3Ci%3Ehsp65%3C%5C%2Fi%3E%20sequencing%20%2838%5C%2F41%2C%2093%25%29.%20The%20GenoType%20Mycobacterium%20CM%20test%20did%20not%20distinguish%20%3Ci%3EM.%20chimaera%3C%5C%2Fi%3E%20from%20%3Ci%3EM.%20intracellulare%3C%5C%2Fi%3E.%20MALDI-TOF%20MS%20distinguished%20two%20%3Ci%3EM.%20chimaera%3C%5C%2Fi%3E%5Cu2013%3Ci%3EM.%20intracellulare%3C%5C%2Fi%3E%20groups%20separated%20from%20%3Ci%3EM.%20avium%3C%5C%2Fi%3E%20and%20from%20the%20other%20mycobacterial%20species%20on%20a%20score-oriented%20dendrogram%2C%20but%20it%20also%20failed%20to%20differentiate%20the%20two%20species.%3C%5C%2Fp%3E%3Ch3%3EConclusions%3C%5C%2Fh3%3E%3Cp%3EINNO-LiPA%20Mycobacteria%20and%20GenoType%20NTM-DR%20are%20efficient%20assays%20for%20%3Ci%3EM.%20chimaera%3C%5C%2Fi%3E%20identification%20in%20clinical%20microbiology%20laboratories.%3C%5C%2Fp%3E%22%2C%22date%22%3A%222018%5C%2F04%5C%2F01%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2017.07.031%22%2C%22ISSN%22%3A%221198-743X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.clinicalmicrobiologyandinfection.com%5C%2Farticle%5C%2FS1198-743X%2817%2930417-2%5C%2Fabstract%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-05T15%3A09%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22W8ZZK3DJ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22van%20Ingen%20et%20al.%22%2C%22parsedDate%22%3A%222018-03-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3Evan%20Ingen%2C%20J.%2C%20Aksamit%2C%20T.%2C%20Andrejak%2C%20C.%2C%20B%26%23xF6%3Bttger%2C%20E.%20C.%2C%20Cambau%2C%20E.%2C%20Daley%2C%20C.%20L.%2C%20Griffith%2C%20D.%20E.%2C%20Guglielmetti%2C%20L.%2C%20Holland%2C%20S.%20M.%2C%20Huitt%2C%20G.%20A.%2C%20Koh%2C%20W.-J.%2C%20Lange%2C%20C.%2C%20Leitman%2C%20P.%2C%20Marras%2C%20T.%20K.%2C%20Morimoto%2C%20K.%2C%20Olivier%2C%20K.%20N.%2C%20Santin%2C%20M.%2C%20Stout%2C%20J.%20E.%2C%20Thomson%2C%20R.%2C%20Tortoli%2C%20E.%2C%20Wallace%2C%20R.%20J.%2C%20Winthrop%2C%20K.%20L.%20and%20Wagner%2C%20D.%20%282018%29.%20%3Cb%3ETreatment%20outcome%20definitions%20in%20nontuberculous%20mycobacterial%20pulmonary%20disease%3A%20an%20NTM-NET%20consensus%20statement%3C%5C%2Fb%3E.%20European%20Respiratory%20Journal%20%3Ci%3E51%3C%5C%2Fi%3E%2C%201800170%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.00170-2018%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.00170-2018%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Treatment%20outcome%20definitions%20in%20nontuberculous%20mycobacterial%20pulmonary%20disease%3A%20an%20NTM-NET%20consensus%20statement%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%22%2C%22lastName%22%3A%22Aksamit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%20C.%22%2C%22lastName%22%3A%22B%5Cu00f6ttger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20L.%22%2C%22lastName%22%3A%22Daley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20E.%22%2C%22lastName%22%3A%22Griffith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20M.%22%2C%22lastName%22%3A%22Holland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gwen%20A.%22%2C%22lastName%22%3A%22Huitt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Won-Jung%22%2C%22lastName%22%3A%22Koh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Leitman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodore%20K.%22%2C%22lastName%22%3A%22Marras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kozo%22%2C%22lastName%22%3A%22Morimoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20N.%22%2C%22lastName%22%3A%22Olivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Santin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%20E.%22%2C%22lastName%22%3A%22Stout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Thomson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrico%22%2C%22lastName%22%3A%22Tortoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Wallace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%20L.%22%2C%22lastName%22%3A%22Winthrop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Wagner%22%7D%5D%2C%22abstractNote%22%3A%22Tweetable%20abstract%20%40ERSpublications%5Cnclick%20to%20tweetImproving%20treatment%20outcome%20reporting%20in%20NTM%20disease%3A%20NTM-NET%20%28%40ntmnet%29%20consensus%20statement%20on%20treatment%20outcome%20definitions%20http%3A%5C%2F%5C%2Fow.ly%5C%2Fc6IC30iwLM4%22%2C%22date%22%3A%222018%5C%2F03%5C%2F01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1183%5C%2F13993003.00170-2018%22%2C%22ISSN%22%3A%220903-1936%2C%201399-3003%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Ferj.ersjournals.com%5C%2Fcontent%5C%2F51%5C%2F3%5C%2F1800170%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-05T14%3A58%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22TDU55DMW%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bouchet%20et%20al.%22%2C%22parsedDate%22%3A%222017-08-16%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBouchet%2C%20F.%2C%20Martin%2C%20B.%2C%20Aubry%2C%20A.%2C%20Veziris%2C%20N.%2C%20Lavigne%2C%20J.-P.%20and%20Sotto%2C%20A.%20%282017%29.%20%3Cb%3EShould%20single%20antibiotic%20therapy%20be%20avoided%20for%20nontuberculous%20mycobacteria%3F%3C%5C%2Fb%3E%20M%26%23xE9%3Bdecine%20et%20Maladies%20Infectieuses%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2017.07.004%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2017.07.004%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Should%20single%20antibiotic%20therapy%20be%20avoided%20for%20nontuberculous%20mycobacteria%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Bouchet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20-P.%22%2C%22lastName%22%3A%22Lavigne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Sotto%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22August%2016%2C%202017%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.medmal.2017.07.004%22%2C%22ISSN%22%3A%220399-077X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0399077X17301075%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222017-09-08T16%3A04%3A41Z%22%7D%7D%2C%7B%22key%22%3A%2283V4AFER%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Leyer%20et%20al.%22%2C%22parsedDate%22%3A%222017-07-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELeyer%2C%20C.%2C%20Gregorowicz%2C%20G.%2C%20Mougari%2C%20F.%2C%20Raskine%2C%20L.%2C%20Cambau%2C%20E.%20and%20Briel%2C%20D.%20de%20%282017%29.%20%3Cb%3EComparison%20of%20Saramis%204.12%20and%20IVD%203.0%20Vitek%20MS%20Matrix-Assisted%20Laser%20Desorption%20Ionization%26%23x2013%3BTime%20of%20Flight%20Mass%20Spectrometry%20for%20Identification%20of%20Mycobacteria%20from%20Solid%20and%20Liquid%20Culture%20Media%3C%5C%2Fb%3E.%20Journal%20of%20Clinical%20Microbiology%20%3Ci%3E55%3C%5C%2Fi%3E%2C%202045%26%23x2013%3B2054%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.00006-17%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.00006-17%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparison%20of%20Saramis%204.12%20and%20IVD%203.0%20Vitek%20MS%20Matrix-Assisted%20Laser%20Desorption%20Ionization%5Cu2013Time%20of%20Flight%20Mass%20Spectrometry%20for%20Identification%20of%20Mycobacteria%20from%20Solid%20and%20Liquid%20Culture%20Media%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Leyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Gregorowicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20de%22%2C%22lastName%22%3A%22Briel%22%7D%5D%2C%22abstractNote%22%3A%22During%20the%20last%20decade%2C%20many%20investigators%20have%20studied%20matrix-assisted%20laser%20desorption%20ionization%5Cu2013time%20of%20flight%20mass%20spectrometry%20%28MALDI-TOF%20MS%29%20for%20identification%20of%20mycobacteria.%20Diverse%20and%20contradictory%20results%20indicated%20that%20optimal%20level%20for%20routine%20testing%20has%20not%20been%20reached%20yet.%20This%20work%20aimed%20to%20assess%20Vitek%20MS%20through%20two%20distinct%20versions%2C%20Saramis%20v4.12%20RUO%20and%20the%20IVD%20v3.0%2C%20under%20conditions%20close%20to%20routine%20laboratory%20practice.%20Overall%2C%20111%20mycobacterial%20isolates%20were%20subjected%20to%20protein%20extraction%20and%20same%20spectra%20were%20matched%20against%20both%20databases.%20The%20IVD%20v3.0%20database%20proved%20to%20be%20superior%20to%20Saramis%20v4.12%20and%20its%20identification%20rates%20remarkably%20increased%2C%20from%2067%25%20to%2094%25%20for%20isolates%20grown%20on%20Middlebrook%207H10%20solid%20medium%20and%20from%2062%25%20to%2091%25%20for%20isolates%20grown%20on%20mycobacterial%20growth%20indicator%20tube%20%28MGIT%29%20liquid%20medium.%20With%20this%20new%20version%2C%20IVD%20v3.0%2C%20MALDI-TOF%20MS%20might%20be%20integrated%20into%20routine%20clinical%20diagnostics%2C%20although%20molecular%20techniques%20remain%20mandatory%20in%20some%20cases.%22%2C%22date%22%3A%222017%5C%2F07%5C%2F01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FJCM.00006-17%22%2C%22ISSN%22%3A%220095-1137%2C%201098-660X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjcm.asm.org%5C%2Fcontent%5C%2F55%5C%2F7%5C%2F2045%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-03T22%3A17%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22N2N9JDXB%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mougari%20et%20al.%22%2C%22parsedDate%22%3A%222017-06-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMougari%2C%20F.%2C%20Loiseau%2C%20J.%2C%20Veziris%2C%20N.%2C%20Bernard%2C%20C.%2C%20Bercot%2C%20B.%2C%20Sougakoff%2C%20W.%2C%20Jarlier%2C%20V.%2C%20Raskine%2C%20L.%20and%20Cambau%2C%20E.%20%282017%29.%20%3Cb%3EEvaluation%20of%20the%20new%20GenoType%20NTM-DR%20kit%20for%20the%20molecular%20detection%20of%20antimicrobial%20resistance%20in%20non-tuberculous%20mycobacteria%3C%5C%2Fb%3E.%20J%20Antimicrob%20Chemother%20%3Ci%3E72%3C%5C%2Fi%3E%2C%201669%26%23x2013%3B1677%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjac%5C%2Fdkx021%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjac%5C%2Fdkx021%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evaluation%20of%20the%20new%20GenoType%20NTM-DR%20kit%20for%20the%20molecular%20detection%20of%20antimicrobial%20resistance%20in%20non-tuberculous%20mycobacteria%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jade%22%2C%22lastName%22%3A%22Loiseau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00e9atrice%22%2C%22lastName%22%3A%22Bercot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wladimir%22%2C%22lastName%22%3A%22Sougakoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%3A%20Non-tuberculous%20mycobacteria%20%28NTM%29%20are%20emerging%20pathogens%20causing%20difficult-to-treat%20infections.%20We%20tested%20a%20new%20assay%20%28GenoType%20NTM-DR%29%20that%20detects%20natural%20and%20acquired%20resistance%20mechanisms%20to%20macrolides%20and%20aminoglycosides%20in%20frequently%20isolated%20NTM%20species.Methods%3A%20Performance%20was%20assessed%20on%20102%20isolates%20including%20reference%20strains%20%5B16%20Mycobacterium%20avium%2C%2010%20Mycobacterium%20intracellulare%2C%208%20Mycobacterium%20chimaera%2C%2015%20Mycobacterium%20chelonae%20and%2053%20Mycobacterium%20abscessus%20%28including%20subsp.%20abscessus%20isolates%2C%2018%20with%20a%20t28%20in%20erm%2841%29%20and%2010%20with%20a%20c28%2C%2013%20subsp.%20bolletii%20isolates%20and%2012%20subsp.%20massiliense%20isolates%29%5D.%20Genotypes%20were%20determined%20by%20PCR%20sequencing%20of%20erm%2841%29%20and%20rrl%20for%20clarithromycin%20resistance%20and%20of%20the%201400%5Cu20131480%20rrs%20region%20for%20aminoglycoside%20resistance.%20Phenotypes%20were%20determined%20by%20MIC%20microdilution.Results%3A%20GenoType%20NTM-DR%20yielded%20results%20concordant%20with%20Sanger%20sequencing%20for%20100%5C%2F102%20%2898%25%29%20isolates.%20The%20erm%2841%29%20genotypic%20pattern%20was%20accurately%20identified%20for%20M.%20abscessus%20isolates.%20Mutations%20in%20rrl%20were%20detected%20in%2015%20isolates%20%287%20M.%20avium%20complex%2C%205%20M.%20abscessus%20and%203%20M.%20chelonae%29%20with%20acquired%20clarithromycin%20resistance%20harbouring%20rrl%20mutations%20%28a2057c%2C%20a2058g%2C%20a2058t%20or%20a2059c%29.%20Mutations%20in%20rrs%20were%20detected%20in%20five%20isolates%20with%20amikacin%20resistance%20harbouring%20the%20rrs%20mutation%20a1408g.%20In%20two%20isolates%2C%20the%20NTM-DR%20test%20revealed%20an%20rrl%20mutation%20%28initial%20sequencing%20being%20WT%29%2C%20which%20was%20confirmed%20by%20re-sequencing.%20The%20test%20results%20were%20concordant%20with%20phenotypic%20susceptibility%20testing%20in%2096%5C%2F102%20%2894.1%25%29%20isolates%2C%20with%20four%20clarithromycin-resistant%20and%20two%20amikacin-resistant%20isolates%20not%20harbouring%20mutations.Conclusions%3A%20The%20GenoType%20NTM-DR%20test%20is%20efficient%20in%20detecting%20mutations%20predictive%20of%20antimicrobial%20resistance%20in%20M.%20avium%20complex%2C%20M.%20abscessus%20and%20M.%20chelonae.%22%2C%22date%22%3A%222017%5C%2F06%5C%2F01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fjac%5C%2Fdkx021%22%2C%22ISSN%22%3A%220305-7453%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Fjac%5C%2Farticle%5C%2F72%5C%2F6%5C%2F1669%5C%2F3058522%5C%2FEvaluation-of-the-new-GenoType-NTM-DR-kit-for-the%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222017-08-02T14%3A40%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22TDUI6NFB%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Delafont%20et%20al.%22%2C%22parsedDate%22%3A%222017-04-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDelafont%2C%20V.%2C%20Samba-Louaka%2C%20A.%2C%20Cambau%2C%20E.%2C%20Bouchon%2C%20D.%2C%20Moulin%2C%20L.%20and%20H%26%23xE9%3Bchard%2C%20Y.%20%282017%29.%20%3Cb%3EMycobacterium%20llatzerense%2C%20a%20waterborne%20Mycobacterium%2C%20that%20resists%20phagocytosis%20by%20Acanthamoeba%20castellanii%3C%5C%2Fb%3E.%20Scientific%20Reports%20%3Ci%3E7%3C%5C%2Fi%3E%2C%2046270%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fsrep46270%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fsrep46270%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobacterium%20llatzerense%2C%20a%20waterborne%20Mycobacterium%2C%20that%20resists%20phagocytosis%20by%20Acanthamoeba%20castellanii%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Delafont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ascel%22%2C%22lastName%22%3A%22Samba-Louaka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didier%22%2C%22lastName%22%3A%22Bouchon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22H%5Cu00e9chard%22%7D%5D%2C%22abstractNote%22%3A%22Nontuberculous%20mycobacteria%20%28NTM%29%20are%20environmental%20bacteria%20increasingly%20associated%20to%20public%20health%20problems.%20In%20water%20systems%2C%20free-living%20amoebae%20%28FLA%29%20feed%20on%20bacteria%20by%20phagocytosis%2C%20but%20several%20bacteria%2C%20including%20many%20NTM%2C%20are%20resistant%20to%20this%20predation.%20Thus%2C%20FLA%20can%20be%20seen%20as%20a%20training%20ground%20for%20pathogenic%20bacteria.%20Mycobacterium%20llatzerense%20was%20previously%20described%20as%20frequently%20associated%20with%20FLA%20in%20a%20drinking%20water%20network.%20The%20present%20study%20aimed%20to%20characterize%20the%20interactions%20between%20M.%20llatzerense%20and%20FLA.%20M.%20llatzerense%20was%20internalised%20by%20phagocytosis%20and%20featured%20lipid%20inclusions%2C%20suggesting%20a%20subversion%20of%20host%20resources.%20Moreover%2C%20M.%20llatzerense%20survived%20and%20even%20multiplied%20in%20presence%20of%20A.%20castellanii.%20Using%20a%20genomic-based%20comparative%20approach%2C%20twelve%20genes%20involved%20in%20phagocytosis%20interference%2C%20described%20in%20M.%20tuberculosis%2C%20were%20identified%20in%20the%20M.%20llatzerense%20genome%20sequenced%20in%20this%20study.%20Transcriptomic%20analyses%20showed%20that%20ten%20genes%20were%20significantly%20upregulated%20during%20the%20first%20hours%20of%20the%20infection%2C%20which%20could%20partly%20explain%20M.%20llatzerense%20resistance.%20Additionally%2C%20M.%20llatzerense%20was%20shown%20to%20actively%20inhibit%20phagosome%20acidification.%20In%20conclusion%2C%20M.%20llatzerense%20presents%20a%20high%20degree%20of%20resistance%20to%20phagocytosis%2C%20likely%20explaining%20its%20frequent%20occurrence%20within%20FLA%20in%20drinking%20water%20networks.%20It%20underscores%20that%20NTM%20should%20be%20carefully%20monitored%20in%20water%20networks%20to%20prevent%20human%20health%20concerns.%22%2C%22date%22%3A%222017-04-10%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fsrep46270%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fsrep46270%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-03T22%3A29%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22WURBXHFN%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Aubry%20et%20al.%22%2C%22parsedDate%22%3A%222017-04-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EAubry%2C%20A.%2C%20Mougari%2C%20F.%2C%20Reibel%2C%20F.%20and%20Cambau%2C%20E.%20%282017%29.%20%3Cb%3EMycobacterium%20marinum%3C%5C%2Fb%3E.%20Microbiology%20Spectrum%20%3Ci%3E5%3C%5C%2Fi%3E%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fmicrobiolspec.TNMI7-0038-2016%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fmicrobiolspec.TNMI7-0038-2016%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobacterium%20marinum%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Reibel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20marinum%20is%20a%20well-known%20pathogenic%20mycobacterium%20for%20skin%20and%20soft%20tissue%20infections%20and%20is%20associated%20with%20fishes%20and%20water.%20Among%20nontuberculous%20mycobacteria%20%28NTM%29%2C%20it%20is%20the%20leading%20cause%20of%20extrarespiratory%20human%20infections%20worldwide.%20In%20addition%2C%20there%20is%20a%20specific%20scientific%20interest%20in%20M.%20marinum%20because%20of%20its%20genetic%20relatedness%20to%20Mycobacterium%20tuberculosis%20and%20because%20experimental%20infection%20of%20M.%20marinum%20in%20fishes%20mimics%20tuberculosis%20pathogenesis.%20Microbiological%20characteristics%20include%20the%20fact%20that%20it%20grows%20in%207%20to%2014%20days%20with%20photochromogenic%20colonies%20and%20is%20difficult%20to%20differentiate%20from%20Mycobacterium%20ulcerans%20and%20other%20mycolactone-producing%20NTM%20on%20a%20molecular%20basis.%20The%20diagnosis%20is%20highly%20suspected%20by%20the%20mode%20of%20infection%2C%20which%20is%20related%20to%20the%20hobby%20of%20fishkeeping%2C%20professional%20handling%20of%20marine%20shells%2C%20or%20swimming%20in%20nonchlorinated%20pools.%20Clinics%20distinguished%20skin%20and%20soft%20tissue%20lesions%20%28typically%20sporotrichoid%20or%20subacute%20hand%20nodules%29%20and%20lesions%20disseminated%20to%20joint%20and%20bone%2C%20often%20related%20with%20the%20local%20use%20of%20corticosteroids.%20In%20clinical%20microbiology%2C%20microscopy%20and%20culture%20are%20often%20negative%20because%20growth%20requires%20low%20temperature%20%2830%5Cu00b0C%29%20and%20several%20weeks%20to%20succeed%20in%20primary%20cultivation.%20The%20treatment%20is%20not%20standardized%2C%20and%20no%20randomized%20control%20trials%20have%20been%20done.%20Therapy%20is%20a%20combination%20of%20surgery%20and%20antimicrobial%20agents%20such%20as%20cyclines%20and%20rifampin%2C%20with%20successful%20outcome%20in%20most%20of%20the%20skin%20diseases%20but%20less%20frequently%20in%20deep%20tissue%20infections.%20Prevention%20can%20be%20useful%20with%20hand%20protection%20recommendations%20for%20professionals%20and%20all%20persons%20manipulating%20fishes%20or%20fish%20tank%20water%20and%20use%20of%20alcohol%20disinfection%20after%20contact.%22%2C%22date%22%3A%222017-04-07%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2Fmicrobiolspec.TNMI7-0038-2016%22%2C%22ISSN%22%3A%222165-0497%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.asmscience.org%5C%2Fcontent%5C%2Fjournal%5C%2Fmicrobiolspec%5C%2F10.1128%5C%2Fmicrobiolspec.TNMI7-0038-2016%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-03T22%3A21%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22U8TQ72Y2%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mougari%20et%20al.%22%2C%22parsedDate%22%3A%222017-01-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMougari%2C%20F.%2C%20Bouziane%2C%20F.%2C%20Crockett%2C%20F.%2C%20Nessar%2C%20R.%2C%20Chau%2C%20F.%2C%20Veziris%2C%20N.%2C%20Sapriel%2C%20G.%2C%20Raskine%2C%20L.%20and%20Cambau%2C%20E.%20%282017%29.%20%3Cb%3ESelection%20of%20Resistance%20to%20Clarithromycin%20in%20Mycobacterium%20abscessus%20Subspecies%3C%5C%2Fb%3E.%20Antimicrob%20Agents%20Chemother%20%3Ci%3E61%3C%5C%2Fi%3E%2C%20e00943-16%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00943-16%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00943-16%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Selection%20of%20Resistance%20to%20Clarithromycin%20in%20Mycobacterium%20abscessus%20Subspecies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feriel%22%2C%22lastName%22%3A%22Bouziane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Flora%22%2C%22lastName%22%3A%22Crockett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachid%22%2C%22lastName%22%3A%22Nessar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%22%2C%22lastName%22%3A%22Chau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Sapriel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20abscessus%20is%20an%20emerging%20pathogen%20against%20which%20clarithromycin%20is%20the%20main%20drug%20used.%20Clinical%20failures%20are%20commonly%20observed%20and%20were%20first%20attributed%20to%20acquired%20mutations%20in%20rrl%20encoding%2023S%20rRNA%20but%20were%20then%20attributed%20to%20the%20intrinsic%20production%20of%20the%20erm%2841%29%2023S%20RNA%20methylase.%20Since%20strains%20of%20M.%20abscessus%20were%20recently%20distributed%20into%20subspecies%20and%20erm%2841%29%20sequevars%2C%20we%20investigated%20acquired%20clarithromycin%20resistance%20mechanisms%20in%20mutants%20selected%20in%20vitro%20from%20four%20representative%20strains.%20Mutants%20were%20sequenced%20for%20rrl%2C%20erm%2841%29%2C%20whiB%2C%20rpIV%2C%20and%20rplD%20and%20studied%20for%20seven%20antibiotic%20MICs.%20For%20mutants%20obtained%20from%20strain%20M.%20abscessus%20subsp.%20abscessus%20erm%2841%29%20T28%20sequevar%20and%20strain%20M.%20abscessus%20subsp.%20bolletii%2C%20which%20are%20both%20known%20to%20produce%20effective%20methylase%2C%20rrl%20was%20mutated%20in%20only%2019%25%20%284%5C%2F21%29%20and%2032.5%25%20%2813%5C%2F40%29%20of%20mutants%2C%20respectively%2C%20at%20position%202058%20%28A2058C%2C%20A2058G%29%20or%20position%202059%20%28A2059C%2C%20A2059G%29.%20No%20mutations%20were%20observed%20in%20any%20of%20the%20other%20genes%20studied%2C%20and%20resistance%20to%20other%20antibiotics%20%28amikacin%2C%20cefoxitin%2C%20imipenem%2C%20tigecycline%2C%20linezolid%2C%20and%20ciprofloxacin%29%20was%20mainly%20unchanged.%20For%20M.%20abscessus%20subsp.%20abscessus%20erm%2841%29%20C28%20sequevar%20and%20M.%20abscessus%20subsp.%20massiliense%2C%20not%20producing%20effective%20methylase%2C%20100%25%20%2826%5C%2F26%29%20and%2097.5%25%20%2839%5C%2F40%29%20of%20mutants%20had%20rrl%20mutations%20at%20position%202058%20%28A2058C%2C%20A2058G%2C%20A2058T%29%20or%20position%202059%20%28A2059C%2C%20A2059G%29.%20The%20remaining%20M.%20abscessus%20subsp.%20massiliense%20mutant%20showed%20an%2018-bp%20repeat%20insertion%20in%20rpIV%2C%20encoding%20the%20L22%20protein.%20Our%20results%20showed%20that%20acquisition%20of%20clarithromycin%20resistance%20is%20100%25%20mediated%20by%20structural%2050S%20ribosomal%20subunit%20mutations%20for%20M.%20abscessus%20subsp.%20abscessus%20erm%2841%29%20C28%20and%20M.%20abscessus%20subsp.%20massiliense%2C%20whereas%20it%20is%20less%20common%20for%20M.%20abscessus%20subsp.%20abscessus%20erm%2841%29%20T28%20sequevar%20and%20M.%20abscessus%20subsp.%20bolletii%2C%20where%20other%20mechanisms%20may%20be%20responsible%20for%20failure.%22%2C%22date%22%3A%2201%5C%2F01%5C%2F2017%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.00943-16%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F61%5C%2F1%5C%2Fe00943-16%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222017-08-02T14%3A40%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22RZ6CP2V6%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mougari%20et%20al.%22%2C%22parsedDate%22%3A%222016-12-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMougari%2C%20F.%2C%20Guglielmetti%2C%20L.%2C%20Raskine%2C%20L.%2C%20Sermet-Gaudelus%2C%20I.%2C%20Veziris%2C%20N.%20and%20Cambau%2C%20E.%20%282016%29.%20%3Cb%3EInfections%20caused%20by%20Mycobacterium%20abscessus%3A%20epidemiology%2C%20diagnostic%20tools%20and%20treatment%3C%5C%2Fb%3E.%20Expert%20Review%20of%20Anti-infective%20Therapy%20%3Ci%3E14%3C%5C%2Fi%3E%2C%201139%26%23x2013%3B1154%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F14787210.2016.1238304%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F14787210.2016.1238304%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Infections%20caused%20by%20Mycobacterium%20abscessus%3A%20epidemiology%2C%20diagnostic%20tools%20and%20treatment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Sermet-Gaudelus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%3A%20Mycobacterium%20abscessus%20is%20an%20emerging%20mycobacteria%20that%20is%20responsible%20for%20lung%20diseases%20and%20healthcare-associated%20extrapulmonary%20infections.%20Recent%20findings%20support%20its%20taxonomic%20status%20as%20a%20single%20species%20comprising%203%20subspecies%20designated%20abscessus%2C%20bolletii%20and%20massiliense.%20We%20performed%20a%20review%20of%20English-language%20publications%20investigating%20all%20three%20of%20these%20subspecies.Areas%20covered%3A%20Worldwide%2C%20human%20infections%20are%20often%20attributable%20to%20environmental%20contamination%2C%20although%20the%20isolation%20of%20M.%20abscessus%20in%20this%20reservoir%20is%20very%20rare.%20Basic%20research%20has%20demonstrated%20an%20association%20between%20virulence%20and%20cell%20wall%20components%20and%20cording%2C%20and%20genome%20analysis%20has%20identified%20gene%20transfer%20from%20other%20bacteria.%20The%20bacteriological%20diagnosis%20of%20M.%20abscessus%20is%20based%20on%20innovative%20tools%20combining%20molecular%20biology%20and%20mass%20spectrometry.%20Genotypic%20and%20phenotypic%20susceptibility%20testing%20are%20required%20to%20predict%20the%20success%20of%20macrolide%20%28clarithromycin%20or%20azithromycin%29-based%20therapeutic%20regimens.%20Genotyping%20methods%20are%20helpful%20to%20assess%20relapse%20and%20cross-transmission%20and%20to%20search%20for%20a%20common%20source.%20Treatment%20is%20not%20standardised%2C%20and%20outcomes%20are%20often%20unsatisfactory.Expert%20commentary%3A%20M.%20abscessus%20is%20still%20an%20open%20field%20in%20terms%20of%20clinical%20and%20bacteriological%20research.%20Further%20knowledge%20of%20its%20ecology%20and%20transmission%20routes%2C%20as%20well%20as%20host-pathogen%20interactions%2C%20is%20required.%20Because%20the%20number%20of%20human%20cases%20is%20increasing%2C%20it%20is%20also%20necessary%20to%20identify%20more%20active%20treatments%20and%20perform%20clinical%20trials%20to%20assess%20standard%20effective%20regimens.%22%2C%22date%22%3A%22December%201%2C%202016%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1080%5C%2F14787210.2016.1238304%22%2C%22ISSN%22%3A%221478-7210%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.doi.org%5C%2F10.1080%5C%2F14787210.2016.1238304%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222017-08-02T14%3A39%3A50Z%22%7D%7D%2C%7B%22key%22%3A%2277H4JAIT%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mougari%20et%20al.%22%2C%22parsedDate%22%3A%222016-08-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMougari%2C%20F.%2C%20Amarsy%2C%20R.%2C%20Veziris%2C%20N.%2C%20Bastian%2C%20S.%2C%20Brossier%2C%20F.%2C%20Ber%26%23xE7%3Bot%2C%20B.%2C%20Raskine%2C%20L.%20and%20Cambau%2C%20E.%20%282016%29.%20%3Cb%3EStandardized%20interpretation%20of%20antibiotic%20susceptibility%20testing%20and%20resistance%20genotyping%20for%20Mycobacterium%20abscessus%20with%20regard%20to%20subspecies%20and%20erm41%20sequevar%3C%5C%2Fb%3E.%20J%20Antimicrob%20Chemother%20%3Ci%3E71%3C%5C%2Fi%3E%2C%202208%26%23x2013%3B2212%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjac%5C%2Fdkw130%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjac%5C%2Fdkw130%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Standardized%20interpretation%20of%20antibiotic%20susceptibility%20testing%20and%20resistance%20genotyping%20for%20Mycobacterium%20abscessus%20with%20regard%20to%20subspecies%20and%20erm41%20sequevar%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rishma%22%2C%22lastName%22%3A%22Amarsy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvaine%22%2C%22lastName%22%3A%22Bastian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00e9atrice%22%2C%22lastName%22%3A%22Ber%5Cu00e7ot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%20The%20objective%20of%20this%20study%20was%20to%20provide%20standardized%20antibiotic%20susceptibility%20testing%20%28AST%29%20for%20Mycobacterium%20abscessus%20with%20regard%20to%20subspecies.%5CnMethods%20One%20hundred%20and%20sixty-five%20clinical%20isolates%20were%20tested%20for%20susceptibility%20to%2015%20antibiotics%20using%20a%20commercial%20microdilution%20method%2C%20at%20two%20reading%20times%3A%20%28i%29%20early%20reading%20time%20%28ERT%29%2C%20when%20the%20growth%20control%20was%20first%20positive%3B%20and%20%28ii%29%20late%20reading%20time%20%28LRT%29%2C%20of%2014%20days%2C%20for%20detecting%20inducible%20resistance.%20In%20addition%2C%20genes%20or%20mutations%20involved%20in%20resistance%20were%20studied%20%5Berm%2841%29%2C%20rrl%20and%20rrs%5D.%5CnResults%20Three%20patterns%20were%20observed%20for%20clarithromycin%3A%20%28i%29%20MIC%20%3E16%20mg%5C%2FL%20at%20ERT%20%28median%205%20days%29%20for%2015%20isolates%20%5B10%20subsp.%20abscessus%20erm%2841%29%20sequevar%20T28%2C%203%20subsp.%20bolletii%20and%202%20subsp.%20massiliense%5D%20among%20which%209%20harboured%20an%20a2058g%5C%2Fc%20rrl%20mutation%3B%20%28ii%29%20MIC%20%5Cu226416%20mg%5C%2FL%20at%20ERT%2C%20but%20%3E16%20mg%5C%2FL%20at%20LRT%2C%20for%20106%20isolates%20%5B84%20abscessus%20erm%2841%29%20T28%20and%2022%20bolletii%5D%20showing%20intrinsic%20inducible%20resistance%3B%20and%20%28iii%29%20MIC%20%5Cu22644%20mg%5C%2FL%20at%20ERT%20and%20LRT%20for%2044%20isolates%20%5B18%20abscessus%20erm%2841%29%20C28%20and%2026%20massiliense%5D.%20Amikacin%20MIC%20was%20%3E64%20mg%5C%2FL%20for%20eight%20isolates%20%5Bfive%20abscessus%20erm%2841%29%20T28%2C%20two%20massiliense%20and%20one%20bolletii%5D%20among%20which%20seven%20harboured%20the%20a1408g%20rrs%20mutation%2C%20but%20%5Cu226464%20mg%5C%2FL%20for%20the%20remaining%20isolates%20without%20mutation.%20For%20the%20other%20antibiotics%2C%20only%20one%20WT%20pattern%20was%20observed%2C%20with%20cefoxitin%2C%20tigecycline%20and%20linezolid%20showing%20MIC%20values%20compatible%20with%20susceptibility.%5CnConclusions%20Standard%20AST%20can%20predict%20clarithromycin%20and%20amikacin%20resistance%20using%20interpretation%20rules%20with%20regard%20to%20subspecies.%20For%20other%20antibiotics%2C%20since%20only%20one%20pattern%20is%20observed%2C%20there%20is%20no%20need%20for%20systematic%20phenotypic%20or%20genotypic%20testing.%22%2C%22date%22%3A%2208%5C%2F01%5C%2F2016%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1093%5C%2Fjac%5C%2Fdkw130%22%2C%22ISSN%22%3A%220305-7453%2C%201460-2091%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjac.oxfordjournals.org%5C%2Fcontent%5C%2F71%5C%2F8%5C%2F2208%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-09-18T14%3A30%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22A9ZUD9JN%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Parize%20et%20al.%22%2C%22parsedDate%22%3A%222016%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EParize%2C%20P.%2C%20Hamelin%2C%20A.%2C%20Veziris%2C%20N.%2C%20Morand%2C%20P.%20C.%2C%20Guillemain%2C%20R.%2C%20Lortholary%2C%20O.%20and%20Dupin%2C%20N.%20%282016%29.%20%3Cb%3EInduction%20therapy%20with%20linezolid%5C%2Fclarithromycin%20combination%20for%20Mycobacterium%20chelonae%20skin%20infections%20in%20immunocompromised%20hosts%3C%5C%2Fb%3E.%20Journal%20of%20the%20European%20Academy%20of%20Dermatology%20and%20Venereology%20%3Ci%3E30%3C%5C%2Fi%3E%2C%20101%26%23x2013%3B105%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjdv.12965%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjdv.12965%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Induction%20therapy%20with%20linezolid%5C%2Fclarithromycin%20combination%20for%20Mycobacterium%20chelonae%20skin%20infections%20in%20immunocompromised%20hosts%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Parize%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Hamelin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.C.%22%2C%22lastName%22%3A%22Morand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Guillemain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%22%2C%22lastName%22%3A%22Lortholary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Dupin%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2201%5C%2F2016%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1111%5C%2Fjdv.12965%22%2C%22ISSN%22%3A%2209269959%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdoi.wiley.com%5C%2F10.1111%5C%2Fjdv.12965%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-12T09%3A23%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22W88HJZMM%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chazel%20et%20al.%22%2C%22parsedDate%22%3A%222016%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EChazel%2C%20M.%2C%20Marchandin%2C%20H.%2C%20Keck%2C%20N.%2C%20Terru%2C%20D.%2C%20Carri%26%23xE8%3Bre%2C%20C.%2C%20Ponsoda%2C%20M.%2C%20Jacomo%2C%20V.%2C%20Panteix%2C%20G.%2C%20Bouzinbi%2C%20N.%2C%20Ba%26%23xF1%3Buls%2C%20A.-L.%2C%20Choisy%2C%20M.%2C%20Solassol%2C%20J.%2C%20Aubry%2C%20A.%20and%20Godreuil%2C%20S.%20%282016%29.%20%3Cb%3EEvaluation%20of%20the%20SLOMYCO%20Sensititre%26%23xAE%3B%20panel%20for%20testing%20the%20antimicrobial%20susceptibility%20of%20Mycobacterium%20marinum%20isolates%3C%5C%2Fb%3E.%20Annals%20of%20Clinical%20Microbiology%20and%20Antimicrobials%20%3Ci%3E15%3C%5C%2Fi%3E%2C%2030%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12941-016-0145-1%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12941-016-0145-1%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evaluation%20of%20the%20SLOMYCO%20Sensititre%5Cu00ae%20panel%20for%20testing%20the%20antimicrobial%20susceptibility%20of%20Mycobacterium%20marinum%20isolates%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marion%22%2C%22lastName%22%3A%22Chazel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Marchandin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Keck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Terru%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Carri%5Cu00e8re%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Ponsoda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%5Cu00e9ronique%22%2C%22lastName%22%3A%22Jacomo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Panteix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Bouzinbi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Ba%5Cu00f1uls%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Choisy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Solassol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Godreuil%22%7D%5D%2C%22abstractNote%22%3A%22The%20agar%20dilution%20method%20is%20currently%20considered%20as%20the%20reference%20method%20for%20Mycobacterium%20marinum%20drug%20susceptibility%20testing%20%28DST%29.%20As%20it%20is%20time-consuming%2C%20alternative%20methods%2C%20such%20as%20the%20E-test%2C%20were%20evaluated%20for%20M.%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20marinum%20DST%2C%20but%20without%20success.%20The%20SLOMYCO%20Sensititre%5Cu00ae%20panel%2C%20recently%20commercialized%20by%20TREK%20Diagnostic%20Systems%20%28Cleveland%2C%20OH%29%2C%20can%20be%20used%20for%20DST%20in%20slow-growing%20mycobacteria%20and%20for%20antimicrobial%20agents%20recommended%20by%20the%20Clinical%20and%20Laboratory%20Standards%20Institute%20%28CLSI%29%20for%20M.%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20marinum%20DST.%20The%20main%20goal%20of%20this%20work%20was%20to%20evaluate%20the%20SLOMYCO%20Sensititre%5Cu00ae%20panel%20method%20for%20DST%20in%20M.%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20marinum%20isolates%20from%20human%20patients%20and%20fish%20relative%20to%20the%20reference%20agar%20dilution%20method.%22%2C%22date%22%3A%222016%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12941-016-0145-1%22%2C%22ISSN%22%3A%221476-0711%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.doi.org%5C%2F10.1186%5C%2Fs12941-016-0145-1%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-09-18T14%3A29%3A50Z%22%7D%7D%2C%7B%22key%22%3A%229W9IFB5M%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Renvois%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERenvois%26%23xE9%3B%2C%20A.%2C%20Brossier%2C%20F.%2C%20Galati%2C%20E.%2C%20Veziris%2C%20N.%2C%20Sougakoff%2C%20W.%2C%20Aubry%2C%20A.%2C%20Robert%2C%20J.%2C%20Cambau%2C%20E.%2C%20Jarlier%2C%20V.%20and%20Bernard%2C%20C.%20%282015%29.%20%3Cb%3EAssessing%20Primary%20and%20Secondary%20Resistance%20to%20Clarithromycin%20and%20Amikacin%20in%20Infections%20Due%20to%20Mycobacterium%20avium%20Complex%3C%5C%2Fb%3E.%20Antimicrobial%20Agents%20and%20Chemotherapy%20%3Ci%3E59%3C%5C%2Fi%3E%2C%207153%26%23x2013%3B7155%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.01027-15%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.01027-15%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Assessing%20Primary%20and%20Secondary%20Resistance%20to%20Clarithromycin%20and%20Amikacin%20in%20Infections%20Due%20to%20Mycobacterium%20avium%20Complex%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Renvois%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Galati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wladimir%22%2C%22lastName%22%3A%22Sougakoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Bernard%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2211%5C%2F2015%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.01027-15%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Flookup%5C%2Fdoi%5C%2F10.1128%5C%2FAAC.01027-15%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-03-26T17%3A47%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22D5NBDMRS%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guglielmetti%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGuglielmetti%2C%20L.%2C%20Mougari%2C%20F.%2C%20Lopes%2C%20A.%2C%20Raskine%2C%20L.%20and%20Cambau%2C%20E.%20%282015%29.%20%3Cb%3EHuman%20infections%20due%20to%20nontuberculous%20mycobacteria%3A%20the%20infectious%20diseases%20and%20clinical%20microbiology%20specialists%26%23x2019%3B%20point%20of%20view%3C%5C%2Fb%3E.%20Future%20Microbiology%20%3Ci%3E10%3C%5C%2Fi%3E%2C%201467%26%23x2013%3B1483%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2217%5C%2Ffmb.15.64%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2217%5C%2Ffmb.15.64%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Human%20infections%20due%20to%20nontuberculous%20mycobacteria%3A%20the%20infectious%20diseases%20and%20clinical%20microbiology%20specialists%5Cu2019%20point%20of%20view%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%22%2C%22lastName%22%3A%22Lopes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2209%5C%2F2015%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.2217%5C%2Ffmb.15.64%22%2C%22ISSN%22%3A%221746-0913%2C%201746-0921%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.futuremedicine.com%5C%2Fdoi%5C%2F10.2217%5C%2Ffmb.15.64%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-03-26T17%3A49%3A02Z%22%7D%7D%2C%7B%22key%22%3A%227FHR7W58%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Coolen%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECoolen%2C%20N.%2C%20Morand%2C%20P.%2C%20Martin%2C%20C.%2C%20Hubert%2C%20D.%2C%20Kanaan%2C%20R.%2C%20Chapron%2C%20J.%2C%20Honor%26%23xE9%3B%2C%20I.%2C%20Dusser%2C%20D.%2C%20Audureau%2C%20E.%2C%20Veziris%2C%20N.%20and%20Burgel%2C%20P.-R.%20%282015%29.%20%3Cb%3EReduced%20risk%20of%20nontuberculous%20mycobacteria%20in%20cystic%20fibrosis%20adults%20receiving%20long-term%20azithromycin%3C%5C%2Fb%3E.%20Journal%20of%20Cystic%20Fibrosis%20%3Ci%3E14%3C%5C%2Fi%3E%2C%20594%26%23x2013%3B599%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jcf.2015.02.006%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jcf.2015.02.006%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reduced%20risk%20of%20nontuberculous%20mycobacteria%20in%20cystic%20fibrosis%20adults%20receiving%20long-term%20azithromycin%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Coolen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Morand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9mence%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Hubert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reem%22%2C%22lastName%22%3A%22Kanaan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanne%22%2C%22lastName%22%3A%22Chapron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Honor%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Dusser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Etienne%22%2C%22lastName%22%3A%22Audureau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre-R%5Cu00e9gis%22%2C%22lastName%22%3A%22Burgel%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2209%5C%2F2015%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jcf.2015.02.006%22%2C%22ISSN%22%3A%2215691993%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1569199315000466%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-03-26T17%3A56%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22SCP4EEUH%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Roux%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERoux%2C%20A.-L.%2C%20Catherinot%2C%20E.%2C%20Soismier%2C%20N.%2C%20Heym%2C%20B.%2C%20Bellis%2C%20G.%2C%20Lemonnier%2C%20L.%2C%20Chiron%2C%20R.%2C%20Fauroux%2C%20B.%2C%20Le%20Bourgeois%2C%20M.%2C%20Munck%2C%20A.%2C%20Pin%2C%20I.%2C%20Sermet%2C%20I.%2C%20Gutierrez%2C%20C.%2C%20Veziris%2C%20N.%2C%20Jarlier%2C%20V.%2C%20Cambau%2C%20E.%2C%20Herrmann%2C%20J.-L.%2C%20Guillemot%2C%20D.%20and%20Gaillard%2C%20J.-L.%20%282015%29.%20%3Cb%3EComparing%20Mycobacterium%20massiliense%20and%20Mycobacterium%20abscessus%20lung%20infections%20in%20cystic%20fibrosis%20patients%3C%5C%2Fb%3E.%20Journal%20of%20Cystic%20Fibrosis%20%3Ci%3E14%3C%5C%2Fi%3E%2C%2063%26%23x2013%3B69%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jcf.2014.07.004%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jcf.2014.07.004%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparing%20Mycobacterium%20massiliense%20and%20Mycobacterium%20abscessus%20lung%20infections%20in%20cystic%20fibrosis%20patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Catherinot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Soismier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Heym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gil%22%2C%22lastName%22%3A%22Bellis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lydie%22%2C%22lastName%22%3A%22Lemonnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rapha%5Cu00ebl%22%2C%22lastName%22%3A%22Chiron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brigitte%22%2C%22lastName%22%3A%22Fauroux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muriel%22%2C%22lastName%22%3A%22Le%20Bourgeois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Munck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Pin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Sermet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Gutierrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Herrmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didier%22%2C%22lastName%22%3A%22Guillemot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Gaillard%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnMycobacterium%20massiliense%20is%20closely%20related%20to%20Mycobacterium%20abscessus%20and%20is%20also%20a%20frequent%20cause%20of%20mycobacterial%20lung%20disease%20in%20patients%20with%20cystic%20fibrosis%20%28CF%29.%20There%20has%20been%20no%20previous%20investigation%20of%20possible%20differences%20between%20M.%20massiliense%20and%20M.%20abscessus%20infections%20in%20the%20setting%20of%20CF.%5CnMethods%5CnWe%20studied%20a%20prospective%20cohort%20of%2016%20M.%20massiliense%20and%2027%20M.%20abscessus%20lung%20infection%20cases%20with%20CF%2C%20with%20a%20mean%20follow-up%20of%206%5Cu2005years.%5CnResults%5CnM.%20massiliense%20cases%20were%20younger%20than%20M.%20abscessus%20cases%20%28mean%20age%3A%2012.8%20vs%2017.1%5Cu2005years%3B%20p%5Cu2005%3D%5Cu20050.02%29%20at%20the%20time%20of%20the%20first%20mycobacterial%20isolation%20and%20also%20had%20lower%20body%20mass%20index%20values%20%28mean%3A%2016.4%20vs%2019.3%5Cu2005kg%5C%2Fm2%2C%20p%5Cu2005%3D%5Cu20050.002%29.%20All%20M.%20massiliense%20cases%2C%20except%20one%2C%20had%20negative%20BMI%20Z-score%20values%20at%20the%20time%20of%20the%20first%20mycobacterial%20isolation%20%2811%5C%2F12%20vs%2016%5C%2F23%20M.%20abscessus%20cases%2C%20p%5Cu2005%3D%5Cu20050.04%29.%20Clarithromycin-based%20combination%20therapies%20led%20to%20mycobacterial%20eradication%20in%20100%25%20of%20M.%20massiliense%20cases%20but%20only%20in%2027%25%20of%20M.%20abscessus%20cases%20%28p%5Cu2005%3D%5Cu20050.009%29.%5CnConclusion%5CnOur%20data%20show%20a%20particular%20link%20between%20M.%20massiliense%20and%20malnutrition%20specifically%20in%20CF%20patients.%20Unlike%20M.%20abscessus%2C%20the%20bacteriological%20response%20of%20M.%20massiliense%20to%20combination%20antibiotic%20therapies%20containing%20clarithromycin%20was%20excellent.%20Distinguishing%20between%20M.%20massiliense%20and%20M.%20abscessus%20has%20major%20clinical%20implications%20for%20CF%20patients.%22%2C%22date%22%3A%222015%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jcf.2014.07.004%22%2C%22ISSN%22%3A%221569-1993%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.cysticfibrosisjournal.com%5C%2Farticle%5C%2FS1569199314001659%5C%2Fabstract%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222017-09-08T15%3A58%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22W9TXPI32%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Renvoise%20et%20al.%22%2C%22parsedDate%22%3A%222014-12-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERenvoise%2C%20A.%2C%20Bernard%2C%20C.%2C%20Veziris%2C%20N.%2C%20Galati%2C%20E.%2C%20Jarlier%2C%20V.%20and%20Robert%2C%20J.%20%282014%29.%20%3Cb%3ESignificant%20Difference%20in%20Drug%20Susceptibility%20Distribution%20between%20Mycobacterium%20avium%20and%20Mycobacterium%20intracellulare%3C%5C%2Fb%3E.%20Journal%20of%20Clinical%20Microbiology%20%3Ci%3E52%3C%5C%2Fi%3E%2C%204439%26%23x2013%3B4440%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.02127-14%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.02127-14%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Significant%20Difference%20in%20Drug%20Susceptibility%20Distribution%20between%20Mycobacterium%20avium%20and%20Mycobacterium%20intracellulare%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Renvoise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Galati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Robert%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222014-12-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FJCM.02127-14%22%2C%22ISSN%22%3A%220095-1137%2C%201098-660X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjcm.asm.org%5C%2Fcgi%5C%2Fdoi%5C%2F10.1128%5C%2FJCM.02127-14%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-03-26T17%3A50%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22RFR9SHRP%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Renvoise%20and%20Bernard%22%2C%22parsedDate%22%3A%222014-11-24%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERenvoise%2C%20A.%20and%20Bernard%2C%20C.%20%282014%29.%20%3Cb%3ETraitement%20des%20infections%20a%26%23x300%3B%20Mycobacterium%20avium%20complex%3C%5C%2Fb%3E.%20J%20Antiinf%20%3Ci%3E16%3C%5C%2Fi%3E%2C%20199%26%23x2013%3B206%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.antinf.2014.10.003%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.antinf.2014.10.003%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Traitement%20des%20infections%20a%5Cu0300%20Mycobacterium%20avium%20complex%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Renvoise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Bernard%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2224%5C%2F11%5C%2F2014%22%2C%22language%22%3A%22fr%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.antinf.2014.10.003%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.em-consulte.com%5C%2Farticle%5C%2F939859%5C%2Farticle%5C%2Ftraitement-des-infections-a-complex%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-04-27T17%3A12%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22NHCWA8HP%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Delafont%20et%20al.%22%2C%22parsedDate%22%3A%222014-09-23%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDelafont%2C%20V.%2C%20Mougaris%2C%20F.%2C%20Cambau%2C%20E.%2C%20Joyeux%2C%20%20michel%2C%20Bouchon%2C%20D.%2C%20Hechard%2C%20Y.%20and%20Moulin%2C%20L.%20%282014%29.%20%3Cb%3EFirst%20evidence%20of%20amoebae%20%26%23x2013%3B%20mycobacteria%20association%20in%20drinking%20water%20network%3C%5C%2Fb%3E.%20Environ%20Sci%20Technol%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Fes5036255%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Fes5036255%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22First%20evidence%20of%20amoebae%20%5Cu2013%20mycobacteria%20association%20in%20drinking%20water%20network%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Delafont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougaris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22michel%22%2C%22lastName%22%3A%22Joyeux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dider%22%2C%22lastName%22%3A%22Bouchon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Hechard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Moulin%22%7D%5D%2C%22abstractNote%22%3A%22Free-living%20amoebae%20are%20protozoa%20ubiquitously%20found%20in%20water%20systems.%20They%20mainly%20feed%20on%20bacteria%20by%20phagocytosis%2C%20but%20some%20bacterial%20species%20are%20able%20to%20resist%20or%20even%20escape%20this%20lethal%20process.%20Among%20these%20amoeba%20resistant%20bacteria%20are%20numerous%20members%20of%20the%20genus%20Mycobacterium.%20Nontuberculous%20Mycobacteria%20%28NTM%29%20are%20opportunistic%20pathogens%20that%20share%20the%20same%20ecological%20niches%20as%20amoebae.%20While%20several%20studies%20have%20demonstrated%20the%20ability%20of%20these%20bacteria%20to%20colonise%20and%20persist%20within%20drinking%20water%20networks%2C%20there%20is%20also%20strong%20suspicion%20that%20mycobacteria%20could%20use%20amoebae%20as%20a%20vehicle%20for%20protection%20and%20even%20replication.%20We%20investigated%20here%20the%20presence%20of%20NTM%20and%20FLA%20on%20a%20drinking%20water%20network%20during%20an%20all%20year%20round%20sampling%20campaign.%20We%20observed%20that%2087.6%25%20of%20recovered%20amoebal%20cultures%20carried%20high%20numbers%20of%20NTM.%20Identification%20of%20these%20amoeba%20and%20mycobacteria%20strains%20indicated%20that%20the%20main%20genera%20found%20in%20drinking%20water%20networks%2C%20i.e.%20Acanthamoeba%2C%20Vermamoeba%2C%20Echinamoeba%20and%20Protacanthamoeba%20are%20able%20to%20carry%20and%20likely%20to%20allow%20replication%20of%20several%20environmental%20and%20potentially%20pathogenic%20mycobacteria%20including%20M.%20llatzerense%20and%20M.%20chelonae.%20Direct%20Sanger%20sequencing%20as%20well%20as%20pyrosequencing%20of%20environmental%20isolates%20demonstrated%20the%20frequent%20association%20of%20mycobacteria%20and%20FLA%2C%20as%20they%20are%20part%20of%20the%20most%20represented%20genera%20composing%20amoebae%27s%20microbiome.%20This%20is%20the%20first%20time%20that%20an%20association%20between%20FLA%20and%20NTM%20is%20observed%20in%20water%20networks%2C%20highlighting%20the%20importance%20of%20FLA%20in%20the%20ecology%20of%20NTM.%22%2C%22date%22%3A%22September%2023%2C%202014%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1021%5C%2Fes5036255%22%2C%22ISSN%22%3A%220013-936X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.doi.org%5C%2F10.1021%5C%2Fes5036255%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-03-26T17%3A51%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22VHRV75TG%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fangous%20et%20al.%22%2C%22parsedDate%22%3A%222014-09-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EFangous%2C%20M.-S.%2C%20Mougari%2C%20F.%2C%20Gouriou%2C%20S.%2C%20Calvez%2C%20E.%2C%20Raskine%2C%20L.%2C%20Cambau%2C%20E.%2C%20Payan%2C%20C.%20and%20H%26%23xE9%3Bry-Arnaud%2C%20G.%20%282014%29.%20%3Cb%3EClassification%20Algorithm%20for%20Subspecies%20Identification%20within%20the%20Mycobacterium%20abscessus%20Species%2C%20Based%20on%20Matrix-Assisted%20Laser%20Desorption%20Ionization%26%23x2013%3BTime%20of%20Flight%20Mass%20Spectrometry%3C%5C%2Fb%3E.%20J%20Clin%20Microbiol%20%3Ci%3E52%3C%5C%2Fi%3E%2C%203362%26%23x2013%3B3369%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.00788-14%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.00788-14%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Classification%20Algorithm%20for%20Subspecies%20Identification%20within%20the%20Mycobacterium%20abscessus%20Species%2C%20Based%20on%20Matrix-Assisted%20Laser%20Desorption%20Ionization%5Cu2013Time%20of%20Flight%20Mass%20Spectrometry%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Sarah%22%2C%22lastName%22%3A%22Fangous%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Gouriou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Calvez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Payan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genevi%5Cu00e8ve%22%2C%22lastName%22%3A%22H%5Cu00e9ry-Arnaud%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20abscessus%2C%20as%20a%20species%2C%20has%20been%20increasingly%20implicated%20in%20respiratory%20infections%2C%20notably%20in%20cystic%20fibrosis%20patients.%20The%20species%20comprises%203%20subspecies%2C%20which%20can%20be%20difficult%20to%20identify.%20Since%20they%20differ%20in%20antibiotic%20susceptibility%20and%20clinical%20relevance%2C%20developing%20a%20routine%20diagnostic%20tool%20discriminating%20Mycobacterium%20abscessus%20at%20the%20subspecies%20level%20is%20a%20real%20challenge.%20Forty-three%20Mycobacterium%20abscessus%20species%20isolates%2C%20previously%20identified%20by%20multilocus%20sequence%20typing%2C%20were%20analyzed%20by%20matrix-assisted%20laser%20desorption%20ionization%5Cu2013time%20of%20flight%20mass%20spectrometry%20%28MALDI-TOF%20MS%29.%20A%20subspecies%20identification%20algorithm%2C%20based%20on%20five%20discriminating%20peaks%2C%20was%20drawn%20up%20and%20validated%20by%20blind%20identification%20of%20a%20further%2049%20strains%2C%2094%25%20of%20which%20%28n%20%3D%2046%29%20were%20correctly%20identified.%20Two%20M.%20abscessus%20subsp.%20massiliense%20strains%20were%20misidentified%20as%20M.%20abscessus%20subsp.%20abscessus%2C%20and%20for%201%20other%20strain%20identification%20failed.%20Inter-%20and%20intralaboratory%20reproducibility%20tests%20were%20conclusive.%20This%20study%20presents%2C%20for%20the%20first%20time%2C%20a%20classification%20algorithm%20for%20MALDI-TOF%20MS%20identification%20of%20the%203%20M.%20abscessus%20subspecies.%20MALDI-TOF%20MS%20proved%20effective%20in%20discriminating%20within%20the%20M.%20abscessus%20species%20and%20might%20be%20easily%20integrated%20into%20the%20workflow%20of%20microbiology%20labs.%22%2C%22date%22%3A%2209%5C%2F01%5C%2F2014%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FJCM.00788-14%22%2C%22ISSN%22%3A%220095-1137%2C%201098-660X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjcm.asm.org%5C%2Fcontent%5C%2F52%5C%2F9%5C%2F3362%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-04-27T17%3A05%3A36Z%22%7D%7D%2C%7B%22key%22%3A%228XGU67HN%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mougari%20et%20al.%22%2C%22parsedDate%22%3A%222014-06-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMougari%2C%20F.%2C%20Raskine%2C%20L.%2C%20Ferroni%2C%20A.%2C%20Marcon%2C%20E.%2C%20Sermet-Gaudelus%2C%20I.%2C%20Veziris%2C%20N.%2C%20Heym%2C%20B.%2C%20Gaillard%2C%20J.-L.%2C%20Nassif%2C%20X.%20and%20Cambau%2C%20E.%20%282014%29.%20%3Cb%3EClonal%20Relationship%20and%20Differentiation%20among%20Mycobacterium%20abscessus%20Isolates%20as%20Determined%20Using%20the%20Semiautomated%20Repetitive%20Extragenic%20Palindromic%20Sequence%20PCR-Based%20DiversiLab%20System%3C%5C%2Fb%3E.%20J%20Clin%20Microbiol%20%3Ci%3E52%3C%5C%2Fi%3E%2C%201969%26%23x2013%3B1977%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.03600-13%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.03600-13%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clonal%20Relationship%20and%20Differentiation%20among%20Mycobacterium%20abscessus%20Isolates%20as%20Determined%20Using%20the%20Semiautomated%20Repetitive%20Extragenic%20Palindromic%20Sequence%20PCR-Based%20DiversiLab%20System%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agn%5Cu00e8s%22%2C%22lastName%22%3A%22Ferroni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Marcon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Sermet-Gaudelus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Heym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Gaillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%22%2C%22lastName%22%3A%22Nassif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20abscessus%20is%20a%20rapidly%20growing%20mycobacterium%20that%20causes%20respiratory%20tract%20infections%20in%20predisposed%20patients%2C%20such%20as%20those%20with%20cystic%20fibrosis%20and%20nosocomial%20skin%20and%20soft%20tissue%20infections.%20In%20order%20to%20investigate%20the%20clonal%20relationships%20between%20the%20strains%20causing%20epidemic%20episodes%2C%20we%20evaluated%20the%20discriminatory%20power%20of%20the%20semiautomated%20DiversiLab%20%28DL%29%20repetitive%20extragenic%20palindromic%20sequence%20PCR%20%28REP-PCR%29%20test%20for%20M.%20abscessus%20genotyping.%20Since%20M.%20abscessus%20was%20shown%20to%20be%20composed%20of%20subspecies%20%28M.%20abscessus%20subsp.%20massiliense%2C%20M.%20abscessus%20subsp.%20bolletii%2C%20and%20M.%20abscessus%20subsp.%20abscessus%29%2C%20we%20also%20evaluated%20the%20ability%20of%20this%20technique%20to%20differentiate%20subspecies.%20The%20technique%20was%20applied%20to%20two%20collections%20of%20clinical%20isolates%2C%20%28i%29%2083%20M.%20abscessus%20original%20isolates%20%2843%20M.%20abscessus%20subsp.%20abscessus%2C%2012%20M.%20abscessus%20subsp.%20bolletii%2C%20and%2028%20M.%20abscessus%20subsp.%20massiliense%29%20from%20infected%20patients%20and%20%28ii%29%2035%20repeated%20isolates%20obtained%20over%201%20year%20from%20four%20cystic%20fibrosis%20patients.%20The%20DL%20REP-PCR%20test%20was%20standardized%20for%20DNA%20extraction%2C%20DNA%20amplification%2C%20and%20electrophoresis%20pattern%20comparisons.%20Among%20the%20isolates%20from%20distinct%20patients%2C%2053%5C%2F83%20%2862%25%29%20isolates%20showed%20a%20specific%20pattern%2C%20and%2030%20were%20distributed%20in%2011%20clusters%20and%206%20patterns%2C%20with%202%20to%204%20isolates%20per%20pattern.%20The%20clusters%20and%20patterns%20did%20not%20fully%20correlate%20with%20multilocus%20sequence%20typing%20%28MLST%29%20analysis%20results.%20This%20revealed%20a%20high%20genomic%20diversity%20between%20patients%2C%20with%20a%20discriminatory%20power%20of%2098%25%20%28Simpson%27s%20diversity%20index%29.%20However%2C%20since%20some%20isolates%20shared%20identical%20patterns%2C%20this%20raises%20the%20question%20of%20whether%20it%20is%20due%20to%20transmission%20between%20patients%20or%20a%20common%20reservoir.%20Multiple%20isolates%20from%20the%20same%20patient%20showed%20identical%20patterns%2C%20except%20for%20one%20patient%20infected%20by%20two%20strains.%20Between%20the%20M.%20abscessus%20subspecies%2C%20the%20indexes%20were%20%3C70%25%2C%20indicating%20that%20the%20DL%20REP-PCR%20test%20is%20not%20an%20accurate%20tool%20for%20identifying%20organisms%20to%20the%20subspecies%20level.%20REP-PCR%20appears%20to%20be%20a%20rapid%20genotyping%20method%20that%20is%20useful%20for%20investigating%20epidemics%20of%20M.%20abscessus%20infections.%22%2C%22date%22%3A%2206%5C%2F01%5C%2F2014%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FJCM.03600-13%22%2C%22ISSN%22%3A%220095-1137%2C%201098-660X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjcm.asm.org%5C%2Fcontent%5C%2F52%5C%2F6%5C%2F1969%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-26T17%3A56%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22E38XJ99U%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lerat%20et%20al.%22%2C%22parsedDate%22%3A%222014-03-15%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELerat%2C%20I.%2C%20Cambau%2C%20E.%2C%20Bettoni%2C%20R.%20R.%20dit%2C%20Gaillard%2C%20J.-L.%2C%20Jarlier%2C%20V.%2C%20Truffot%2C%20C.%20and%20Veziris%2C%20N.%20%282014%29.%20%3Cb%3EIn%20Vivo%20Evaluation%20of%20Antibiotic%20Activity%20Against%20Mycobacterium%20abscessus%3C%5C%2Fb%3E.%20J%20Infect%20Dis%20%3Ci%3E209%3C%5C%2Fi%3E%2C%20905%26%23x2013%3B912%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjit614%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjit614%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22In%20Vivo%20Evaluation%20of%20Antibiotic%20Activity%20Against%20Mycobacterium%20abscessus%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Lerat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%20Roth%20dit%22%2C%22lastName%22%3A%22Bettoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Gaillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Truffot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%5D%2C%22abstractNote%22%3A%22Background.%20The%20prognosis%20of%20Mycobacterium%20abscessus%20infections%20is%20poor%20due%20to%20the%20lack%20of%20effective%20drug%20treatment.%20The%20objective%20of%20this%20study%20was%20to%20set%20up%20an%20animal%20model%20suitable%20to%20test%20antibiotic%20activity%20against%20M.%20abscessus.%5CnMethods.%20The%20following%20mouse%20strains%20were%20evaluated%3A%20Swiss%2C%20BALB%5C%2Fc%2C%20C57BL%5C%2F6%2C%20nude%2C%20beige%2C%20A%5C%2FJ%2C%20and%20GKO.%20Antibiotic%20activity%20was%20tested%20for%20clarithromycin%2C%20amikacin%2C%20cefoxitin%2C%20tigecycline%2C%20and%20bedaquiline%20%28TMC207%29.%20Finally%2C%20we%20evaluated%20the%203-drug%20combination%20clarithromycin%2C%20cefoxitin%2C%20and%20amikacin.%5CnResults.%20Nude%20and%20GKO%20mice%20fulfilled%20criteria%20for%20the%20model%20but%20only%20nude%20mice%20offered%20sufficient%20availability%20for%20large%20therapeutic%20experiments.%20Among%20the%203%20drugs%20usually%20combined%20for%20treatment%20of%20M.%20abscessus%20infection%2C%20cefoxitin%20was%20the%20most%20active%20because%20it%20improved%20survival%20and%20reduced%20bacillary%20loads%20in%20spleen%20whereas%20clarithromycin%20and%20amikacin%20prevented%20death%20but%20had%20little%20impact%20on%20bacillary%20loads.%20The%20triple-drug%20combination%20was%20not%20more%20active%20than%20cefoxitin%20alone.%20Tigecycline%20displayed%20bactericidal%20activity%20whereas%20bedaquiline%20was%20almost%20inactive.%5CnConclusions.%20Nude%20mice%20are%20an%20adequate%20model%20for%20in%20vivo%20chemotherapy%20studies.%20Among%20tested%20drugs%2C%20cefoxitin%20and%20tigecycline%20showed%20promising%20in%20vivo%20activity%20against%20M.%20abscessus.%20The%20best%20drug%20combination%20remains%20to%20be%20determined.%22%2C%22date%22%3A%2203%5C%2F15%5C%2F2014%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1093%5C%2Finfdis%5C%2Fjit614%22%2C%22ISSN%22%3A%220022-1899%2C%201537-6613%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjid.oxfordjournals.org%5C%2Fcontent%5C%2F209%5C%2F6%5C%2F905%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-04-27T17%3A07%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22NXSXGW9A%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Macheras%20et%20al.%22%2C%22parsedDate%22%3A%222014%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMacheras%2C%20E.%2C%20Konjek%2C%20J.%2C%20Roux%2C%20A.-L.%2C%20Thiberge%2C%20J.-M.%2C%20Bastian%2C%20S.%2C%20Le%26%23xE3%3Bo%2C%20S.%20C.%2C%20Palaci%2C%20M.%2C%20Sivadon-Tardy%2C%20V.%2C%20Gutierrez%2C%20C.%2C%20Richter%2C%20E.%2C%20R%26%23xFC%3Bsch-Gerdes%2C%20S.%2C%20Pfyffer%2C%20G.%20E.%2C%20Bodmer%2C%20T.%2C%20Jarlier%2C%20V.%2C%20Cambau%2C%20E.%2C%20Brisse%2C%20S.%2C%20Caro%2C%20V.%2C%20Rastogi%2C%20N.%2C%20Gaillard%2C%20J.-L.%20and%20Heym%2C%20B.%20%282014%29.%20%3Cb%3EMultilocus%20sequence%20typing%20scheme%20for%20the%20Mycobacterium%20abscessus%20complex%3C%5C%2Fb%3E.%20Research%20in%20Microbiology%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.resmic.2013.12.003%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.resmic.2013.12.003%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multilocus%20sequence%20typing%20scheme%20for%20the%20Mycobacterium%20abscessus%20complex%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edouard%22%2C%22lastName%22%3A%22Macheras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Konjek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Thiberge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvaine%22%2C%22lastName%22%3A%22Bastian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%20Cardoso%22%2C%22lastName%22%3A%22Le%5Cu00e3o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moises%22%2C%22lastName%22%3A%22Palaci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Sivadon-Tardy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Gutierrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elvira%22%2C%22lastName%22%3A%22Richter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22R%5Cu00fcsch-Gerdes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaby%20E.%22%2C%22lastName%22%3A%22Pfyffer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Bodmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Brisse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Caro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nalin%22%2C%22lastName%22%3A%22Rastogi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Gaillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Heym%22%7D%5D%2C%22abstractNote%22%3A%22We%20developed%20a%20multilocus%20sequence%20typing%20%28MLST%29%20scheme%20for%20Mycobacterium%20abscessus%20sensu%20lato%2C%20based%20on%20the%20partial%20sequencing%20of%20seven%20housekeeping%20genes%3A%20argH%2C%20cya%2C%20glpK%2C%20gnd%2C%20murC%2C%20pta%20and%20purH.%20This%20scheme%20was%20used%20to%20characterize%20a%20collection%20of%20227%20isolates%20recovered%20between%201994%20and%202010%20in%20France%2C%20Germany%2C%20Switzerland%20and%20Brazil.%20We%20identified%20100%20different%20sequence%20types%20%28STs%29%2C%20which%20were%20distributed%20into%20three%20groups%20on%20the%20tree%20obtained%20by%20concatenating%20the%20sequences%20of%20the%20seven%20housekeeping%20gene%20fragments%20%283576%20bp%29%3A%20the%20M.%20abscessus%20sensu%20stricto%20group%20%2844%20STs%29%2C%20the%20%5Cu201cM.%20massiliense%5Cu201d%20group%20%2831%20STs%29%20and%20the%20%5Cu201cM.%20bolletii%5Cu201d%20group%20%2825%20STs%29.%20SplitTree%20analysis%20showed%20a%20degree%20of%20intergroup%20lateral%20transfers.%20There%20was%20also%20evidence%20of%20lateral%20transfer%20events%20involving%20rpoB.%20The%20most%20prevalent%20STs%20in%20our%20collection%20were%20ST1%20%28CC5%3B%2020%20isolates%29%20and%20ST23%20%28CC3%3B%2031%20isolates%29.%20Both%20STs%20were%20found%20in%20Europe%20and%20Brazil%2C%20and%20the%20latter%20was%20implicated%20in%20a%20large%20post-surgical%20procedure%20outbreak%20in%20Brazil.%20Respiratory%20isolates%20from%20patients%20with%20cystic%20fibrosis%20belonged%20to%20a%20large%20variety%20of%20STs%3B%20however%2C%20ST2%20was%20predominant%20in%20this%20group%20of%20patients.%5CnOur%20MLST%20scheme%2C%20publicly%20available%20at%20www.pasteur.fr%5C%2Fmlst%2C%20offers%20investigators%20a%20valuable%20typing%20tool%20for%20M.%20abscessus%20sensu%20lato%20in%20future%20epidemiological%20studies%20throughout%20the%20world.%22%2C%22date%22%3A%222014%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.resmic.2013.12.003%22%2C%22ISSN%22%3A%220923-2508%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0923250813002234%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222015-07-20T16%3A26%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22WBTAVC3N%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Radomski%20et%20al.%22%2C%22parsedDate%22%3A%222013-12-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERadomski%2C%20N.%2C%20Roguet%2C%20A.%2C%20Lucas%2C%20F.%20S.%2C%20Veyrier%2C%20F.%20J.%2C%20Cambau%2C%20E.%2C%20Accrombessi%2C%20H.%2C%20Moilleron%2C%20R.%2C%20Behr%2C%20M.%20A.%20and%20Moulin%2C%20L.%20%282013%29.%20%3Cb%3EatpE%20gene%20as%20a%20new%20useful%20specific%20molecular%20target%20to%20quantify%20Mycobacterium%20in%20environmental%20samples%3C%5C%2Fb%3E.%20BMC%20Microbiology%20%3Ci%3E13%3C%5C%2Fi%3E%2C%20277%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2F1471-2180-13-277%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2F1471-2180-13-277%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22atpE%20gene%20as%20a%20new%20useful%20specific%20molecular%20target%20to%20quantify%20Mycobacterium%20in%20environmental%20samples%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Radomski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ad%5Cu00e9la%5Cu00efde%22%2C%22lastName%22%3A%22Roguet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%20S.%22%2C%22lastName%22%3A%22Lucas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%20J.%22%2C%22lastName%22%3A%22Veyrier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9berte%22%2C%22lastName%22%3A%22Accrombessi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%5Cu00e9gis%22%2C%22lastName%22%3A%22Moilleron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%20A.%22%2C%22lastName%22%3A%22Behr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Moulin%22%7D%5D%2C%22abstractNote%22%3A%22The%20environment%20is%20the%20likely%20source%20of%20many%20pathogenic%20mycobacterial%20species%20but%20detection%20of%20mycobacteria%20by%20bacteriological%20tools%20is%20generally%20difficult%20and%20time-consuming.%20Consequently%2C%20several%20molecular%20targets%20based%20on%20the%20sequences%20of%20housekeeping%20genes%2C%20non-functional%20RNA%20and%20structural%20ribosomal%20RNAs%20have%20been%20proposed%20for%20the%20detection%20and%20identification%20of%20mycobacteria%20in%20clinical%20or%20environmental%20samples.%20While%20certain%20of%20these%20targets%20were%20proposed%20as%20specific%20for%20this%20genus%2C%20most%20are%20prone%20to%20false%20positive%20results%20in%20complex%20environmental%20samples%20that%20include%20related%2C%20but%20distinct%2C%20bacterial%20genera.%20Nowadays%20the%20increased%20number%20of%20sequenced%20genomes%20and%20the%20availability%20of%20software%20for%20genomic%20comparison%20provide%20tools%20to%20develop%20novel%2C%20mycobacteria-specific%20targets%2C%20and%20the%20associated%20molecular%20probes%20and%20primers.%20Consequently%2C%20we%20conducted%20an%20in%20silico%20search%20for%20proteins%20exclusive%20to%20Mycobacterium%20spp.%20genomes%20in%20order%20to%20design%20sensitive%20and%20specific%20molecular%20targets.%5CnPMID%3A%2024299240%22%2C%22date%22%3A%222013-12-03%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2F1471-2180-13-277%22%2C%22ISSN%22%3A%221471-2180%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.biomedcentral.com%5C%2F1471-2180%5C%2F13%5C%2F277%5C%2Fabstract%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222015-07-20T16%3A42%3A12Z%22%7D%7D%2C%7B%22key%22%3A%22HRKPMGKG%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Veziris%20et%20al.%22%2C%22parsedDate%22%3A%222013-11-14%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EVeziris%2C%20N.%2C%20Chauffour%2C%20A.%2C%20Escolano%2C%20S.%2C%20Henquet%2C%20S.%2C%20Matsuoka%2C%20M.%2C%20Jarlier%2C%20V.%20and%20Aubry%2C%20A.%20%282013%29.%20%3Cb%3EResistance%20of%20M.%20leprae%20to%20Quinolones%3A%20A%20Question%20of%20Relativity%3F%3C%5C%2Fb%3E%20PLoS%20Negl%20Trop%20Dis%20%3Ci%3E7%3C%5C%2Fi%3E%2C%20e2559%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0002559%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0002559%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Resistance%20of%20M.%20leprae%20to%20Quinolones%3A%20A%20Question%20of%20Relativity%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvie%22%2C%22lastName%22%3A%22Escolano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Henquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masanori%22%2C%22lastName%22%3A%22Matsuoka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22Author%20SummaryAlthough%20there%20is%20efficient%20multidrug%20therapy%20to%20cure%20leprosy%2C%20the%20transmission%20of%20M.%20leprae%20is%20still%20active%2C%20leading%20to%20219%2C000%20new%20cases%20in%202011.%20Drug%20resistant%20leprosy%20has%20been%20described%20and%20may%20prevent%20eradication%20of%20the%20disease%2C%20notably%20multidrug%20resistant%20defined%20as%20resistance%20to%20rifampin%2C%20dapsone%20and%20fluoroquinolones%20%28FQ%29.%20Resistance%20to%20FQ%20is%20due%20to%20mutations%20in%20DNA%20gyrase.%20We%20used%20a%20mouse%20model%20to%20measure%20the%20impact%20of%20DNA%20gyrase%20mutations%20on%20in%20vivo%20FQ%20activity.%20All%20the%20FQ%20tested%20showed%20in%20vivo%20activity%20against%20the%20mutant%20tested%20%28A91V%20mutant%20in%20subunit%20A%20of%20DNA%20gyrase%29.%20However%2C%20whereas%20ofloxacin%20was%20less%20active%20than%20the%20control%20treatment%20clarithromycin%2C%20it%20appeared%20that%20latter%20generation%20fluoroquinolones%20moxifloxacin%20and%20garenoxacin%20were%20as%20active%20as%20clarithromycin.%20Our%20results%20demonstrate%20that%20DNA%20gyrase%20mutation%20is%20not%20synonymous%20of%20total%20lack%20of%20in%20vivo%20FQ%20activity%20against%20M.%20leprae.%20Therefore%2C%20as%20for%20M.%20tuberculosis%2C%20in%20vivo%20studies%20are%20mandatory%20in%20order%20to%20measure%20the%20impact%20of%20DNA%20gyrase%20mutations%20on%20treatment%20efficacy%20against%20M.%20leprae.%22%2C%22date%22%3A%22November%2014%2C%202013%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0002559%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.doi.org%5C%2F10.1371%5C%2Fjournal.pntd.0002559%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222015-07-20T16%3A28%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22R29VZXBH%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pang%20et%20al.%22%2C%22parsedDate%22%3A%222013-10-31%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPang%2C%20S.%2C%20Renvois%26%23xE9%3B%2C%20A.%2C%20Perret%2C%20C.%2C%20Guinier%2C%20M.%2C%20Chelghoum%2C%20N.%2C%20Brossier%2C%20F.%2C%20Capton%2C%20E.%2C%20Jarlier%2C%20V.%20and%20Sougakoff%2C%20W.%20%282013%29.%20%3Cb%3EWhole-Genome%20Sequence%20of%20Mycobacterium%20abscessus%20Clinical%20Strain%20V06705%3C%5C%2Fb%3E.%20Genome%20Announc%20%3Ci%3E1%3C%5C%2Fi%3E%2C%20e00690-13%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FgenomeA.00690-13%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FgenomeA.00690-13%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Whole-Genome%20Sequence%20of%20Mycobacterium%20abscessus%20Clinical%20Strain%20V06705%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stanley%22%2C%22lastName%22%3A%22Pang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Renvois%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Perret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Guinier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadjim%22%2C%22lastName%22%3A%22Chelghoum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Capton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wladimir%22%2C%22lastName%22%3A%22Sougakoff%22%7D%5D%2C%22abstractNote%22%3A%22Infection%20caused%20by%20Mycobacterium%20abscessus%20strains%20is%20a%20growing%20cause%20of%20concern%20in%20both%20community-acquired%20and%20health%20care-associated%20diseases%2C%20as%20these%20organisms%20naturally%20display%20multiple%20drug%20resistances.%20We%20report%20an%20annotated%20draft%20genome%20sequence%20of%20M.%20abscessus%20strain%20V06705%20obtained%20from%20a%20patient%20in%20France.%22%2C%22date%22%3A%2210%5C%2F31%5C%2F2013%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FgenomeA.00690-13%22%2C%22ISSN%22%3A%22%2C%202169-8287%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fgenomea.asm.org%5C%2Fcontent%5C%2F1%5C%2F5%5C%2Fe00690-13%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222015-07-20T16%3A42%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22SI3UU2U6%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gomez%20et%20al.%22%2C%22parsedDate%22%3A%222013-02-15%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGomez%2C%20C.%2C%20Ponien%2C%20P.%2C%20Serradji%2C%20N.%2C%20Lamouri%2C%20A.%2C%20Pantel%2C%20A.%2C%20Capton%2C%20E.%2C%20Jarlier%2C%20V.%2C%20Anquetin%2C%20G.%20and%20Aubry%2C%20A.%20%282013%29.%20%3Cb%3ESynthesis%20of%20gatifloxacin%20derivatives%20and%20their%20biological%20activities%20against%20Mycobacterium%20leprae%20and%20Mycobacterium%20tuberculosis%3C%5C%2Fb%3E.%20Bioorganic%20%26amp%3B%20Medicinal%20Chemistry%20%3Ci%3E21%3C%5C%2Fi%3E%2C%20948%26%23x2013%3B956%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.bmc.2012.12.011%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.bmc.2012.12.011%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Synthesis%20of%20gatifloxacin%20derivatives%20and%20their%20biological%20activities%20against%20Mycobacterium%20leprae%20and%20Mycobacterium%20tuberculosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Gomez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prishila%22%2C%22lastName%22%3A%22Ponien%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nawal%22%2C%22lastName%22%3A%22Serradji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aazdine%22%2C%22lastName%22%3A%22Lamouri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alix%22%2C%22lastName%22%3A%22Pantel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Capton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Anquetin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22Novel%203%5Cu2032-piperazinyl%20derivatives%20of%20the%208-hydrogeno%20and%208-methoxy-6-fluoro-1-cyclopropyl-4-quinolone-3-carboxylic%20acid%20scaffolds%20were%20designed%2C%20synthesized%20and%20characterized%20by%201H%2C%2013C%20and%2019F%20NMR%2C%20and%20HRMS.%20The%20activity%20of%20these%20derivatives%20against%20pathogenic%20mycobacteria%20%28M.%20leprae%20and%20M.%20tuberculosis%29%2C%20wild-type%20%28WT%29%20strains%20or%20strains%20harboring%20mutations%20implicated%20in%20quinolone%20resistance%2C%20were%20determined%20by%20measuring%20drug%20concentrations%20inhibiting%20cell%20growth%20%28MIC%29%20and%5C%2For%20DNA%20supercoiling%20by%20DNA%20gyrase%20%28IC50%29%2C%20or%20inducing%2025%25%20DNA%20cleavage%20by%20DNA%20gyrase%20%28CC25%29.%20Compound%204%20%28with%20a%20methoxy%20in%20R8%20and%20a%20secondary%20carbamate%20in%20R3%5Cu2032%29%20and%20compound%205%20%28with%20a%20hydrogen%20in%20R8%20and%20an%20ethyl%20ester%20in%20R3%5Cu2032%29%20displayed%20biological%20activities%20close%20to%20those%20of%20ofloxacin%20but%20inferior%20to%20those%20of%20gatifloxacin%20and%20moxifloxacin%20against%20M.%20tuberculosis%20and%20M.%20leprae%20WT%20DNA%20gyrases%2C%20whereas%20all%20of%20the%20compounds%20were%20less%20active%20in%20inhibiting%20M.%20tuberculosis%20growth%20and%20M.%20leprae%20mutant%20DNA%20gyrases.%20Since%20R3%5Cu2032%20substitutions%20have%20been%20poorly%20investigated%20previously%2C%20our%20results%20may%20help%20to%20design%20new%20quinolone%20derivatives%20in%20the%20future.%22%2C%22date%22%3A%22February%2015%2C%202013%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.bmc.2012.12.011%22%2C%22ISSN%22%3A%220968-0896%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0968089612009728%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-26T18%3A04%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22EGSG6U4Z%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Grammatico-Guillon%20et%20al.%22%2C%22parsedDate%22%3A%222013-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGrammatico-Guillon%2C%20L.%2C%20Lanotte%2C%20P.%2C%20Bastides%2C%20F.%2C%20Veziris%2C%20N.%2C%20Bernard%2C%20L.%20and%20Rosset%2C%20P.%20%282013%29.%20%3Cb%3EVoluminous%20pseudotumor%20due%20to%20Mycobacterium%20malmoense%3C%5C%2Fb%3E.%20Presse%20Med%20%3Ci%3E42%3C%5C%2Fi%3E%2C%20227%26%23x2013%3B230%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.lpm.2012.02.042%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.lpm.2012.02.042%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Voluminous%20pseudotumor%20due%20to%20Mycobacterium%20malmoense%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%22%2C%22lastName%22%3A%22Grammatico-Guillon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Lanotte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Bastides%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Rosset%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Feb%202013%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.lpm.2012.02.042%22%2C%22ISSN%22%3A%220755-4982%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-04-12T13%3A10%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22W3F54SCP%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mecha%5Cu00ef%20et%20al.%22%2C%22parsedDate%22%3A%222013-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMecha%26%23xEF%3B%2C%20F.%2C%20Veziris%2C%20N.%2C%20Aoun%2C%20O.%2C%20Bille%2C%20E.%2C%20Lecuit%2C%20M.%2C%20Brossier%2C%20F.%2C%20Viard%2C%20J.%20P.%20and%20Lortholary%2C%20O.%20%282013%29.%20%3Cb%3EIn%20vivo%20selection%20of%20a%20multidrug-resistant%20Mycobacterium%20avium%20isolate%20in%20a%20patient%20with%20AIDS%3C%5C%2Fb%3E.%20Int%20J%20Tuberc%20Lung%20Dis%20%3Ci%3E17%3C%5C%2Fi%3E%2C%20141%26%23x2013%3B142%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.12.0778%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.12.0778%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22In%20vivo%20selection%20of%20a%20multidrug-resistant%20Mycobacterium%20avium%20isolate%20in%20a%20patient%20with%20AIDS%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%22%2C%22lastName%22%3A%22Mecha%5Cu00ef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O%22%2C%22lastName%22%3A%22Aoun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Bille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%22%2C%22lastName%22%3A%22Lecuit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20P%22%2C%22lastName%22%3A%22Viard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O%22%2C%22lastName%22%3A%22Lortholary%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Jan%202013%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtld.12.0778%22%2C%22ISSN%22%3A%221815-7920%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-04-12T13%3A10%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22B92FWP7Z%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mougari%20et%20al.%22%2C%22parsedDate%22%3A%222013%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMougari%2C%20F.%2C%20Guglielmetti%2C%20L.%2C%20Lopes%2C%20A.%2C%20Raskine%2C%20L.%20and%20Cambau%2C%20E.%20%282013%29.%20%3Cb%3EMycobact%26%23xE9%3Brioses%20non%20tuberculeuses%20hors%20mycobact%26%23xE9%3Brioses%20cutan%26%23xE9%3Bes%3C%5C%2Fb%3E.%20In%3A%20%3Cb%3ERevue%20Encyclop%26%23xE9%3Bdie%20M%26%23xE9%3Bdico%20Chirurgicale%3C%5C%2Fb%3E%2C.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Mycobact%5Cu00e9rioses%20non%20tuberculeuses%20hors%20mycobact%5Cu00e9rioses%20cutan%5Cu00e9es%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Lopes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22bookTitle%22%3A%22Revue%20Encyclop%5Cu00e9die%20M%5Cu00e9dico%20Chirurgicale%22%2C%22date%22%3A%222013%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-04-25T16%3A29%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22ZCC5MGPH%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lhuillier%20et%20al.%22%2C%22parsedDate%22%3A%222012-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELhuillier%2C%20E.%2C%20Brugi%26%23xE8%3Bre%2C%20O.%2C%20Veziris%2C%20N.%2C%20Danel%2C%20C.%2C%20Mourvilliers%2C%20B.%2C%20Mal%2C%20H.%2C%20Dauriat%2C%20G.%20and%20Ruimy%2C%20R.%20%282012%29.%20%3Cb%3ERelapsing%20Mycobacterium%20genavense%20infection%20as%20a%20cause%20of%20late%20death%20in%20a%20lung%20transplant%20recipient%3A%20case%20report%20and%20review%20of%20the%20literature%3C%5C%2Fb%3E.%20Exp%20Clin%20Transplant%20%3Ci%3E10%3C%5C%2Fi%3E%2C%20618%26%23x2013%3B620%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.6002%5C%2Fect.2012.0052%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.6002%5C%2Fect.2012.0052%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Relapsing%20Mycobacterium%20genavense%20infection%20as%20a%20cause%20of%20late%20death%20in%20a%20lung%20transplant%20recipient%3A%20case%20report%20and%20review%20of%20the%20literature%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Lhuillier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Brugi%5Cu00e8re%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Danel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Mourvilliers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herv%5Cu00e9%22%2C%22lastName%22%3A%22Mal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ga%5Cu00eblle%22%2C%22lastName%22%3A%22Dauriat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%22%2C%22lastName%22%3A%22Ruimy%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20genavense%20is%20recognized%20as%20a%20life-threatening%20pathogen%20in%20severely%20immunocompromised%20patients%2C%20mostly%20in%20those%20with%20advanced%20human%20immunodeficiency%20virus%20infection.%20We%20report%20a%20case%20of%20M.%20genavense%20infection%20in%20a%20lung-transplant%20recipient%20with%20late-onset%20death%20occurring%20from%20disseminated%20infection.%20In%20human%20immunodeficiency%20virus-negative%20patients%2C%20there%20exist%20only%20about%2010%20reports%20of%20disseminated%20M.%20genavense%20infection%20in%20immunocompromised%20hosts%3B%20and%20to%20our%20knowledge%2C%20this%20is%20a%20first%20reported%20case%20of%20M.%20genavense%20infection%20after%20a%20lung%20transplant.%20Diagnosis%20of%20M.%20genavense%20was%20obtained%20only%20with%20nucleic%20acid-based%20identification%20technique%2C%20as%20frequently%20observed%20in%20a%20few%20cases%20of%20human%20immunodeficiency%20virus-negative%20patients.%20A%20striking%20feature%20was%20the%20recurrence%20of%20this%20infection%20in%20our%20patient%20after%20a%20seemingly%20infection-free%20period%20of%203%20years.%20Because%20M.%20genavense%20infection%20can%20be%20life-threatening%2C%20clinicians%20must%20be%20aware%20of%20the%20frequent%20requirement%20for%20nucleic-acid-based%20identification%20for%20its%20diagnosis.%22%2C%22date%22%3A%22Dec%202012%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.6002%5C%2Fect.2012.0052%22%2C%22ISSN%22%3A%222146-8427%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.ectrx.org%5C%2Fforms%5C%2Fectrxcontentshow.php%3Fyear%3D2012%26volume%3D10%26issue%3D6%26supplement%3D0%26makale_no%3D0%26spage_number%3D618%26content_type%3DFULL%2520TEXT%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-04-02T21%3A28%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22M9C7WMI9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dutilh%20et%20al.%22%2C%22parsedDate%22%3A%222012-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDutilh%2C%20J.%2C%20Caron%2C%20F.%2C%20Bourgoin%2C%20A.%2C%20Veziris%2C%20N.%20and%20Meurice%2C%20J.-C.%20%282012%29.%20%3Cb%3EUn%20cas%20atypique%20de%20mycobact%26%23xE9%3Brie%3C%5C%2Fb%3E.%20Revue%20des%20Maladies%20Respiratoires%20%3Ci%3E29%3C%5C%2Fi%3E%2C%201182%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.rmr.2012.10.014%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.rmr.2012.10.014%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Un%20cas%20atypique%20de%20mycobact%5Cu00e9rie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Dutilh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Caron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Bourgoin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.-C.%22%2C%22lastName%22%3A%22Meurice%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22November%202012%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.rmr.2012.10.014%22%2C%22ISSN%22%3A%220761-8425%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0761842512003397%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222015-07-20T16%3A50%3A17Z%22%7D%7D%2C%7B%22key%22%3A%225585VGWC%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cosson%20et%20al.%22%2C%22parsedDate%22%3A%222012-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECosson%2C%20M.-A.%2C%20Bertrand%2C%20J.-B.%2C%20Martin%2C%20C.%2C%20Veziris%2C%20N.%2C%20Picard%2C%20C.%2C%20Goulvestre%2C%20C.%2C%20Coignard%2C%20S.%2C%20Benoit%2C%20J.-P.%2C%20Silvera%2C%20S.%2C%20Moro%2C%20M.-R.%2C%20Poyart%2C%20C.%20and%20Morand%2C%20P.%20C.%20%282012%29.%20%3Cb%3ETemporal%20interferon-gamma%20release%20response%20to%20Mycobacterium%20kansasii%20infection%20in%20an%20anorexia%20nervosa%20patient%3C%5C%2Fb%3E.%20J%20Med%20Microbiol%20%3Ci%3E61%3C%5C%2Fi%3E%2C%201617%26%23x2013%3B1620%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1099%5C%2Fjmm.0.042739-0%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1099%5C%2Fjmm.0.042739-0%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Temporal%20interferon-gamma%20release%20response%20to%20Mycobacterium%20kansasii%20infection%20in%20an%20anorexia%20nervosa%20patient%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Anne%22%2C%22lastName%22%3A%22Cosson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Baptiste%22%2C%22lastName%22%3A%22Bertrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9mence%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Capucine%22%2C%22lastName%22%3A%22Picard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Goulvestre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Coignard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Benoit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phane%22%2C%22lastName%22%3A%22Silvera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Rose%22%2C%22lastName%22%3A%22Moro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Poyart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%20C%22%2C%22lastName%22%3A%22Morand%22%7D%5D%2C%22abstractNote%22%3A%22Due%20to%20the%20differences%20in%20the%20management%20of%20Mycobacterium%20kansasii%20disease%20and%20tuberculosis%2C%20an%20accurate%20diagnosis%20is%20required.%20This%20report%2C%20which%20describes%20what%20we%20believe%20to%20be%20the%20first%20documented%20case%20of%20M.%20kansasii%20infection%20in%20a%20patient%20suffering%20from%20anorexia%20nervosa%2C%20sheds%20light%20on%20the%20possible%20occurrence%20of%20a%20non-tuberculous%20mycobacterial%20infection%20that%20can%20mimic%20tuberculosis%2C%20on%20the%20risk%20of%20a%20misleading%20interpretation%20of%20interferon-gamma%20release%20assays%2C%20and%20on%20the%20temporal%20response%20to%20these%20tests.%22%2C%22date%22%3A%22Nov%202012%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1099%5C%2Fjmm.0.042739-0%22%2C%22ISSN%22%3A%221473-5644%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.microbiologyresearch.org%5C%2Fcontent%5C%2Fjournal%5C%2Fjmm%5C%2F10.1099%5C%2Fjmm.0.042739-0%23tab2%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-04-02T21%3A26%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22KKA6U77X%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Legout%20et%20al.%22%2C%22parsedDate%22%3A%222012-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELegout%2C%20L.%2C%20Ettahar%2C%20N.%2C%20Massongo%2C%20M.%2C%20Veziris%2C%20N.%2C%20Ajana%2C%20F.%2C%20Beltrand%2C%20E.%20and%20Senneville%2C%20E.%20%282012%29.%20%3Cb%3EOsteomyelitis%20of%20the%20wrist%20caused%20by%20Mycobacterium%20arupense%20in%20an%20immunocompetent%20patient%3A%20a%20unique%20case%3C%5C%2Fb%3E.%20Int%20J%20Infect%20Dis%20%3Ci%3E16%3C%5C%2Fi%3E%2C%20e761-762%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2012.05.007%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2012.05.007%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Osteomyelitis%20of%20the%20wrist%20caused%20by%20Mycobacterium%20arupense%20in%20an%20immunocompetent%20patient%3A%20a%20unique%20case%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%22%2C%22lastName%22%3A%22Legout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Ettahar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%22%2C%22lastName%22%3A%22Massongo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%22%2C%22lastName%22%3A%22Ajana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Beltrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Senneville%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Oct%202012%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ijid.2012.05.007%22%2C%22ISSN%22%3A%221878-3511%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ijidonline.com%5C%2Farticle%5C%2FS1201-9712%2812%2900159-2%5C%2Ffulltext%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-04-02T21%3A27%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22U272CXV3%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cambau%20et%20al.%22%2C%22parsedDate%22%3A%222012-07-31%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECambau%2C%20E.%2C%20Chauffour-Nevejans%2C%20A.%2C%20Tejmar-Kolar%2C%20L.%2C%20Matsuoka%2C%20M.%20and%20Jarlier%2C%20V.%20%282012%29.%20%3Cb%3EDetection%20of%20Antibiotic%20Resistance%20in%20Leprosy%20Using%20GenoType%20LepraeDR%2C%20a%20Novel%20Ready-To-Use%20Molecular%20Test%3C%5C%2Fb%3E.%20PLoS%20Negl%20Trop%20Dis%20%3Ci%3E6%3C%5C%2Fi%3E%2C%20e1739%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0001739%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0001739%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Detection%20of%20Antibiotic%20Resistance%20in%20Leprosy%20Using%20GenoType%20LepraeDR%2C%20a%20Novel%20Ready-To-Use%20Molecular%20Test%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour-Nevejans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liana%22%2C%22lastName%22%3A%22Tejmar-Kolar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masanori%22%2C%22lastName%22%3A%22Matsuoka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22Author%20SummaryAlthough%20leprosy%20is%20a%20curable%20disease%20using%20a%20combination%20of%20antibiotics%20for%20one%20year%2C%20the%20transmission%20is%20still%20active%20with%20230%2C000%20new%20cases%20in%202010.%20Drug%20resistance%20has%20been%20described%20and%20may%20prevent%20eradication%20of%20the%20disease.%20The%20infectious%20agent%20causing%20leprosy%2C%20Mycobacterium%20leprae%2C%20is%20not%20growing%20in%20vitro%20and%20antibiotic%20susceptibility%20testing%20is%20possible%20only%20in%20the%20mouse%20footpad%20model%20that%20requires%20a%20one%20year%20experiment.%20Consequently%20this%20testing%20is%20rarely%20done%20and%20antibiotic%20resistance%20rates%20in%20leprosy%20are%20unknown.%20This%20is%20the%20reason%20why%20we%20endeavored%20to%20set%20a%20new%20diagnosis%20test%20that%20detects%20for%20antibiotic%20resistance%20in%20M.%20leprae.%20The%20test%20is%20based%20on%20the%20method%20of%20a%20DNA%20strip%20test%20with%20a%20multiplex%20PCR%20followed%20by%20reverse%20hybridization.%20It%20was%20developed%20as%20an%20easy-to-use%20test%20and%20it%20will%20be%20available%20in%20endemic%20countries%2C%20where%20these%20kinds%20of%20strip%20tests%20are%20already%20used%20for%20detection%20of%20drug%20resistance%20in%20tuberculosis.%20The%20results%20of%20the%20new%20test%2C%20Genotype%20LepraeDR%2C%20performed%20on%20120%20M.%20leprae%20strains%20were%20concordant%20with%20those%20of%20the%20standard%20PCR%20sequencing%20and%20mouse%20footpad%20susceptibility%20testing.%22%2C%22date%22%3A%22July%2031%2C%202012%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0001739%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.doi.org%5C%2F10.1371%5C%2Fjournal.pntd.0001739%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-26T18%3A04%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22QFCEGFUJ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nessar%20et%20al.%22%2C%22parsedDate%22%3A%222012-04-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ENessar%2C%20R.%2C%20Cambau%2C%20E.%2C%20Reyrat%2C%20J.%20M.%2C%20Murray%2C%20A.%20and%20Gicquel%2C%20B.%20%282012%29.%20%3Cb%3EMycobacterium%20abscessus%3A%20a%20new%20antibiotic%20nightmare%3C%5C%2Fb%3E.%20J%20Antimicrob%20Chemother%20%3Ci%3E67%3C%5C%2Fi%3E%2C%20810%26%23x2013%3B818%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjac%5C%2Fdkr578%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjac%5C%2Fdkr578%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobacterium%20abscessus%3A%20a%20new%20antibiotic%20nightmare%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachid%22%2C%22lastName%22%3A%22Nessar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Marc%22%2C%22lastName%22%3A%22Reyrat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alan%22%2C%22lastName%22%3A%22Murray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brigitte%22%2C%22lastName%22%3A%22Gicquel%22%7D%5D%2C%22abstractNote%22%3A%22The%20intrinsic%20and%20acquired%20resistance%20of%20Mycobacterium%20abscessus%20to%20commonly%20used%20antibiotics%20limits%20the%20chemotherapeutic%20options%20for%20infections%20caused%20by%20these%20mycobacteria.%20Intrinsic%20resistance%20is%20attributed%20to%20a%20combination%20of%20the%20permeability%20barrier%20of%20the%20complex%20multilayer%20cell%20envelope%2C%20drug%20export%20systems%2C%20antibiotic%20targets%20with%20low%20affinity%20and%20enzymes%20that%20neutralize%20antibiotics%20in%20the%20cytoplasm.%20To%20date%2C%20acquired%20resistance%20has%20only%20been%20observed%20for%20aminoglycosides%20and%20macrolides%2C%20which%20is%20conferred%20by%20mutations%20affecting%20the%20genes%20encoding%20the%20antibiotic%20targets%20%28rrs%20and%20rrl%2C%20respectively%29.%20Here%20we%20summarize%20previous%20and%20recent%20findings%20on%20the%20resistance%20of%20M.%20abscessus%20to%20antibiotics%20in%20light%20of%20what%20has%20been%20discovered%20for%20other%20mycobacteria.%20Since%20we%20can%20now%20distinguish%20three%20groups%20of%20strains%20belonging%20to%20M.%20abscessus%20%28M.%20abscessus%20sensu%20stricto%2C%20Mycobacterium%20massiliense%20and%20Mycobacterium%20bolletii%29%2C%20studies%20on%20antibiotic%20susceptibility%20and%20resistance%20should%20be%20considered%20according%20to%20this%20new%20classification.%20This%20review%20raises%20the%20profile%20of%20this%20important%20pathogen%20and%20highlights%20the%20work%20needed%20to%20decipher%20the%20molecular%20events%20responsible%20for%20its%20extensive%20chemotherapeutic%20resistance.%22%2C%22date%22%3A%2204%5C%2F01%5C%2F2012%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1093%5C%2Fjac%5C%2Fdkr578%22%2C%22ISSN%22%3A%220305-7453%2C%201460-2091%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjac.oxfordjournals.org%5C%2Fcontent%5C%2F67%5C%2F4%5C%2F810%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222015-07-20T16%3A52%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22FPRF73U3%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Andr%5Cu00e9jak%20et%20al.%22%2C%22parsedDate%22%3A%222012-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EAndr%26%23xE9%3Bjak%2C%20C.%2C%20Veziris%2C%20N.%2C%20Lescure%2C%20X.%2C%20Cadranel%2C%20J.%20and%20Jounieaux%2C%20V.%20%282012%29.%20%3Cb%3EEssai%20CaMoMy%26%23xA0%3B%3A%20%26%23xE9%3Bvaluation%20de%20la%20capacit%26%23xE9%3B%20de%20deux%20sch%26%23xE9%3Bmas%20th%26%23xE9%3Brapeutiques%20%28Clarithromycine%20ou%20Moxifloxacine%29%20%26%23xE0%3B%20n%26%23xE9%3Bgativer%20les%20cultures%20%26%23xE0%3B%20six%20mois%20de%20malades%20porteurs%20d%26%23x2019%3Bune%20infection%20pulmonaire%20%26%23xE0%3B%20Mycobacterium%20xenopi.%20PHRC%20national%202010%3C%5C%2Fb%3E.%20Revue%20des%20Maladies%20Respiratoires%20%3Ci%3E29%2C%20Supplement%201%3C%5C%2Fi%3E%2C%20A25%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.rmr.2011.10.030%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.rmr.2011.10.030%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Essai%20CaMoMy%5Cu00a0%3A%20%5Cu00e9valuation%20de%20la%20capacit%5Cu00e9%20de%20deux%20sch%5Cu00e9mas%20th%5Cu00e9rapeutiques%20%28Clarithromycine%20ou%20Moxifloxacine%29%20%5Cu00e0%20n%5Cu00e9gativer%20les%20cultures%20%5Cu00e0%20six%20mois%20de%20malades%20porteurs%20d%5Cu2019une%20infection%20pulmonaire%20%5Cu00e0%20Mycobacterium%20xenopi.%20PHRC%20national%202010%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Andr%5Cu00e9jak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22X.%22%2C%22lastName%22%3A%22Lescure%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Cadranel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Jounieaux%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22January%202012%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.rmr.2011.10.030%22%2C%22ISSN%22%3A%220761-8425%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0761842511004372%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222015-07-20T16%3A55%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22GIFVPNTH%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bussone%20et%20al.%22%2C%22parsedDate%22%3A%222012%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBussone%2C%20G.%2C%20Brossier%2C%20F.%2C%20Roudiere%2C%20L.%2C%20Bille%2C%20E.%2C%20Sekkal%2C%20N.%2C%20Charlier%2C%20C.%2C%20Gilquin%2C%20J.%2C%20Lanternier%2C%20F.%2C%20Lecuit%2C%20M.%2C%20Lortholary%2C%20O.%20and%20Catherinot%2C%20E.%20%282012%29.%20%3Cb%3ERecurrent%20Mycobacterium%20avium%20infection%20after%20seven%20years%20of%20latency%20in%20a%20HIV-infected%20patient%20receiving%20efficient%20antiretroviral%20therapy%3C%5C%2Fb%3E.%20Journal%20of%20Infection%20%3Ci%3E64%3C%5C%2Fi%3E%2C%20613%26%23x2013%3B617%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jinf.2011.12.020%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jinf.2011.12.020%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Recurrent%20Mycobacterium%20avium%20infection%20after%20seven%20years%20of%20latency%20in%20a%20HIV-infected%20patient%20receiving%20efficient%20antiretroviral%20therapy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Bussone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Roudiere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Bille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nawal%22%2C%22lastName%22%3A%22Sekkal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Charlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Gilquin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fanny%22%2C%22lastName%22%3A%22Lanternier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Lecuit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Lortholary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Catherinot%22%7D%5D%2C%22abstractNote%22%3A%22Summary%5CnWe%20report%20the%20first%20case%20of%20Mycobacterium%20avium%20reactivation%2C%20after%20prolonged%20latency%2C%20in%20a%20HIV-infected%20patient%20receiving%20highly%20active%20antiretroviral%20therapy%20with%20undetectable%20viral%20replication%20and%20normal%20CD4%20cell%20count.%20The%20patient%20presented%20with%20a%20painful%20swollen%20shoulder%20seven%20years%20after%20initial%20M.%20avium%20bacteriaemia.%20Articular%20puncture%20grew%20M.%20avium.%20The%20isolates%20of%20the%20first%20and%20second%20infection%20were%20identical%20using%20repetitive-sequence-based%20Polymerase%20Chain%20Reaction%20analyses.%22%2C%22date%22%3A%22juin%202012%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jinf.2011.12.020%22%2C%22ISSN%22%3A%220163-4453%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0163445311006244%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-04-25T16%3A05%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22VTXFK3VD%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Prevotat%20et%20al.%22%2C%22parsedDate%22%3A%222011-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPrevotat%2C%20A.%2C%20Bonne%2C%20S.%2C%20Veziris%2C%20N.%2C%20Senneville%2C%20E.%2C%20Yazdanpanah%2C%20Y.%20and%20Legout%2C%20L.%20%282011%29.%20%3Cb%3E%5BMycobacterium%20abscessus%20pulmonary%20infection%20treated%20with%20tigecyclin-amikacin%20and%20cefoxitin%20in%20a%20diabetic%20patient%5D%3C%5C%2Fb%3E.%20Med%20Mal%20Infect%20%3Ci%3E41%3C%5C%2Fi%3E%2C%20446%26%23x2013%3B448%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2011.02.011%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2011.02.011%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22%5BMycobacterium%20abscessus%20pulmonary%20infection%20treated%20with%20tigecyclin-amikacin%20and%20cefoxitin%20in%20a%20diabetic%20patient%5D%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Prevotat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Bonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Senneville%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y%22%2C%22lastName%22%3A%22Yazdanpanah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%22%2C%22lastName%22%3A%22Legout%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Aug%202011%22%2C%22language%22%3A%22fre%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.medmal.2011.02.011%22%2C%22ISSN%22%3A%221769-6690%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T09%3A49%3A56Z%22%7D%7D%2C%7B%22key%22%3A%222T94ZQUC%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Radomski%20et%20al.%22%2C%22parsedDate%22%3A%222011-06-15%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERadomski%2C%20N.%2C%20Betelli%2C%20L.%2C%20Moilleron%2C%20R.%2C%20Haenn%2C%20S.%2C%20Moulin%2C%20L.%2C%20Cambau%2C%20E.%2C%20Rocher%2C%20V.%2C%20Gon%26%23xE7%3Balves%2C%20A.%20and%20Lucas%2C%20F.%20S.%20%282011%29.%20%3Cb%3EMycobacterium%20Behavior%20in%20Wastewater%20Treatment%20Plant%2C%20A%20Bacterial%20Model%20Distinct%20From%20Escherichia%20coli%20and%20Enterococci%3C%5C%2Fb%3E.%20Environ%20Sci%20Technol%20%3Ci%3E45%3C%5C%2Fi%3E%2C%205380%26%23x2013%3B5386%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Fes104084c%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Fes104084c%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobacterium%20Behavior%20in%20Wastewater%20Treatment%20Plant%2C%20A%20Bacterial%20Model%20Distinct%20From%20Escherichia%20coli%20and%20Enterococci%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Radomski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laetitia%22%2C%22lastName%22%3A%22Betelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%5Cu00e9gis%22%2C%22lastName%22%3A%22Moilleron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Haenn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Rocher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Gon%5Cu00e7alves%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%20S.%22%2C%22lastName%22%3A%22Lucas%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacteria%20are%20waterborne%20emerging%20pathogens%20causing%20infections%20in%20human.%20Mycobacteria%20have%20been%20previously%20isolated%20from%20wastewater%20and%20sludge%2C%20but%20their%20densities%20were%20not%20estimated%20due%20to%20cultural%20biases.%20In%20order%20to%20evaluate%20the%20impact%20of%20wastewater%20treatment%20processes%20on%20mycobacteria%20removal%2C%20we%20used%20a%20real%20time%20PCR%20method.%20First%20we%20compared%20six%20DNA%20extraction%20methods%20and%20second%20we%20used%20the%20more%20efficient%20DNA%20extraction%20procedure%20%28i.e.%2C%20enzymatic%20lysis%20combined%20with%20hexadecyltrimethylammonium%20bromide-NaCl%20procedure%29%20in%20order%20to%20quantify%20Mycobacterium.%20With%20the%20aim%20to%20identify%20parameters%20that%20could%20serve%20as%20indicator%20of%20mycobacterial%20behavior%2C%20mycobacterial%20densities%20were%20measured%20in%20parallel%20to%20those%20of%20Escherichia%20coli%20and%20enterococci%2C%20and%20to%20concentrations%20of%20chemical%20parameters%20usually%20monitored%20in%20wastewater.%20Mycobacterium%20reached%205.5%20%3F%20105%20%5Cu00b1%203.9%20%3F%20105%20copies%5C%2FL%20in%20the%20influent%2C%20but%20was%20not%20detected%20in%20the%20effluent%20after%20decantation%20and%20biofiltration.%20Most%20mycobacteria%20%2898.6%20%5Cu00b1%202.7%25%2C%20i.e.%202.4%20%5Cu00b1%200.7%20log10%29%20were%20removed%20by%20the%20physical%3Fchemical%20decantation%2C%20and%20the%20remaining%20mycobacteria%20were%20removed%20by%20biofiltration.%20In%20contrast%2C%20enterococci%20and%20E.%20coli%20were%20lightly%20removed%20by%20decantation%20step%20and%20mainly%20removed%20by%20biofiltration.%20Our%20results%20showed%20that%20Mycobacterium%20corresponds%20to%20a%20hydrophobic%20behavior%20linked%20to%20insoluble%20compound%20removal%2C%20whereas%20enterococci%20and%20E.%20coli%20refer%20to%20hydrophilic%20behaviors%20linked%20to%20soluble%20compound%20removals.%22%2C%22date%22%3A%22June%2015%2C%202011%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1021%5C%2Fes104084c%22%2C%22ISSN%22%3A%220013-936X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.doi.org%5C%2F10.1021%5C%2Fes104084c%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222014-07-23T15%3A17%3A02Z%22%7D%7D%2C%7B%22key%22%3A%226PX9I7RU%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Macheras%20et%20al.%22%2C%22parsedDate%22%3A%222011-02-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMacheras%2C%20E.%2C%20Roux%2C%20A.-L.%2C%20Bastian%2C%20S.%2C%20Le%26%23xE3%3Bo%2C%20S.%20C.%2C%20Palaci%2C%20M.%2C%20Sivadon-Tardy%2C%20V.%2C%20Gutierrez%2C%20C.%2C%20Richter%2C%20E.%2C%20R%26%23xFC%3Bsch-Gerdes%2C%20S.%2C%20Pfyffer%2C%20G.%2C%20Bodmer%2C%20T.%2C%20Cambau%2C%20E.%2C%20Gaillard%2C%20J.-L.%20and%20Heym%2C%20B.%20%282011%29.%20%3Cb%3EMultilocus%20Sequence%20Analysis%20and%20rpoB%20Sequencing%20of%20Mycobacterium%20abscessus%20%28Sensu%20Lato%29%20Strains%3C%5C%2Fb%3E.%20J%20Clin%20Microbiol%20%3Ci%3E49%3C%5C%2Fi%3E%2C%20491%26%23x2013%3B499%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.01274-10%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.01274-10%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multilocus%20Sequence%20Analysis%20and%20rpoB%20Sequencing%20of%20Mycobacterium%20abscessus%20%28Sensu%20Lato%29%20Strains%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edouard%22%2C%22lastName%22%3A%22Macheras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvaine%22%2C%22lastName%22%3A%22Bastian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%20Cardoso%22%2C%22lastName%22%3A%22Le%5Cu00e3o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moises%22%2C%22lastName%22%3A%22Palaci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Sivadon-Tardy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Gutierrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elvira%22%2C%22lastName%22%3A%22Richter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22R%5Cu00fcsch-Gerdes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaby%22%2C%22lastName%22%3A%22Pfyffer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Bodmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Gaillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Heym%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20abscessus%2C%20Mycobacterium%20bolletii%2C%20and%20Mycobacterium%20massiliense%20%28Mycobacterium%20abscessus%20sensu%20lato%29%20are%20closely%20related%20species%20that%20currently%20are%20identified%20by%20the%20sequencing%20of%20the%20rpoB%20gene.%20However%2C%20recent%20studies%20show%20that%20rpoB%20sequencing%20alone%20is%20insufficient%20to%20discriminate%20between%20these%20species%2C%20and%20some%20authors%20have%20questioned%20their%20current%20taxonomic%20classification.%20We%20studied%20here%20a%20large%20collection%20of%20M.%20abscessus%20%28sensu%20lato%29%20strains%20by%20partial%20rpoB%20sequencing%20%28752%20bp%29%20and%20multilocus%20sequence%20analysis%20%28MLSA%29.%20The%20final%20MLSA%20scheme%20developed%20was%20based%20on%20the%20partial%20sequences%20of%20eight%20housekeeping%20genes%3A%20argH%2C%20cya%2C%20glpK%2C%20gnd%2C%20murC%2C%20pgm%2C%20pta%2C%20and%20purH.%20The%20strains%20studied%20included%20the%20three%20type%20strains%20%28M.%20abscessus%20CIP%20104536T%2C%20M.%20massiliense%20CIP%20108297T%2C%20and%20M.%20bolletii%20CIP%20108541T%29%20and%20120%20isolates%20recovered%20between%201997%20and%202007%20in%20France%2C%20Germany%2C%20Switzerland%2C%20and%20Brazil.%20The%20rpoB%20phylogenetic%20tree%20confirmed%20the%20existence%20of%20three%20main%20clusters%2C%20each%20comprising%20the%20type%20strain%20of%20one%20species.%20However%2C%20divergence%20values%20between%20the%20M.%20massiliense%20and%20M.%20bolletii%20clusters%20all%20were%20below%203%25%20and%20between%20the%20M.%20abscessus%20and%20M.%20massiliense%20clusters%20were%20from%202.66%20to%203.59%25.%20The%20tree%20produced%20using%20the%20concatenated%20MLSA%20gene%20sequences%20%284%2C071%20bp%29%20also%20showed%20three%20main%20clusters%2C%20each%20comprising%20the%20type%20strain%20of%20one%20species.%20The%20M.%20abscessus%20cluster%20had%20a%20bootstrap%20value%20of%20100%25%20and%20was%20mostly%20compact.%20Bootstrap%20values%20for%20the%20M.%20massiliense%20and%20M.%20bolletii%20branches%20were%20much%20lower%20%2871%20and%2061%25%2C%20respectively%29%2C%20with%20the%20M.%20massiliense%20cluster%20having%20a%20fuzzy%20aspect.%20Mean%20%28range%29%20divergence%20values%20were%202.17%25%20%281.13%20to%202.58%25%29%20between%20the%20M.%20abscessus%20and%20M.%20massiliense%20clusters%2C%202.37%25%20%281.5%20to%202.85%25%29%20between%20the%20M.%20abscessus%20and%20M.%20bolletii%20clusters%2C%20and%202.28%25%20%280.86%20to%202.68%25%29%20between%20the%20M.%20massiliense%20and%20M.%20bolletii%20clusters.%20Adding%20the%20rpoB%20sequence%20to%20the%20MLSA-concatenated%20sequence%20%28total%20sequence%2C%204%2C823%20bp%29%20had%20little%20effect%20on%20the%20clustering%20of%20strains.%20We%20found%2010%5C%2F120%20%288.3%25%29%20isolates%20for%20which%20the%20concatenated%20MLSA%20gene%20sequence%20and%20rpoB%20sequence%20were%20discordant%20%28e.g.%2C%20M.%20massiliense%20MLSA%20sequence%20and%20M.%20abscessus%20rpoB%20sequence%29%2C%20suggesting%20the%20intergroup%20lateral%20transfers%20of%20rpoB.%20In%20conclusion%2C%20our%20study%20strongly%20supports%20the%20recent%20proposal%20that%20M.%20abscessus%2C%20M.%20massiliense%2C%20and%20M.%20bolletii%20should%20constitute%20a%20single%20species.%20Our%20findings%20also%20indicate%20that%20there%20has%20been%20a%20horizontal%20transfer%20of%20rpoB%20sequences%20between%20these%20subgroups%2C%20precluding%20the%20use%20of%20rpoB%20sequencing%20alone%20for%20the%20accurate%20identification%20of%20the%20two%20proposed%20M.%20abscessus%20subspecies.%22%2C%22date%22%3A%2202%5C%2F01%5C%2F2011%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FJCM.01274-10%22%2C%22ISSN%22%3A%220095-1137%2C%201098-660X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjcm.asm.org%5C%2Fcontent%5C%2F49%5C%2F2%5C%2F491%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T09%3A49%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22SZDG7VRE%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bastian%20et%20al.%22%2C%22parsedDate%22%3A%222011-02-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBastian%2C%20S.%2C%20Veziris%2C%20N.%2C%20Roux%2C%20A.-L.%2C%20Brossier%2C%20F.%2C%20Gaillard%2C%20J.-L.%2C%20Jarlier%2C%20V.%20and%20Cambau%2C%20E.%20%282011%29.%20%3Cb%3EAssessment%20of%20Clarithromycin%20Susceptibility%20in%20Strains%20Belonging%20to%20the%20Mycobacterium%20abscessus%20Group%20by%20erm%2841%29%20and%20rrl%20Sequencing%3C%5C%2Fb%3E.%20Antimicrob%20Agents%20Chemother%20%3Ci%3E55%3C%5C%2Fi%3E%2C%20775%26%23x2013%3B781%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00861-10%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00861-10%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Assessment%20of%20Clarithromycin%20Susceptibility%20in%20Strains%20Belonging%20to%20the%20Mycobacterium%20abscessus%20Group%20by%20erm%2841%29%20and%20rrl%20Sequencing%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvaine%22%2C%22lastName%22%3A%22Bastian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Laure%22%2C%22lastName%22%3A%22Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Gaillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22Clarithromycin%20was%20the%20drug%20of%20choice%20for%20Mycobacterium%20abscessus%20infections%20until%20inducible%20resistance%20due%20to%20erm%2841%29%20was%20described.%20Because%20M.%20abscessus%20was%20split%20into%20M.%20abscessus%20sensu%20stricto%2C%20Mycobacterium%20massiliense%2C%20and%20Mycobacterium%20bolletii%2C%20we%20looked%20for%20erm%2841%29%20in%20the%20three%20species%20and%20determined%20their%20clarithromycin%20susceptibility%20levels.%20Ninety%20strains%20were%20included%3A%2087%20clinical%20strains%20from%20cystic%20fibrosis%20patients%20%2861%25%29%20and%20others%20%2839%25%29%2C%20representing%2043%20M.%20abscessus%2C%2030%20M.%20massiliense%2C%20and%2014%20M.%20bolletii%20strains%20identified%20on%20a%20molecular%20basis%2C%20and%203%20reference%20strains.%20Clarithromycin%20and%20azithromycin%20MICs%20were%20determined%20by%20broth%20microdilution%20and%20Etest%20with%20a%2014-day%20incubation%20period.%20Mutations%20in%20rrl%20%2823S%20rRNA%20gene%29%20known%20to%20confer%20acquired%20clarithromycin%20resistance%20were%20also%20sought.%20erm%2841%29%20was%20detected%20in%20all%20strains%20but%20with%20two%20deletions%20in%20all%20M.%20massiliense%20strains.%20These%20strains%20were%20indeed%20susceptible%20to%20clarithromycin%20%28MIC90%20of%201%20%5Cu03bcg%5C%2Fml%29%20except%20for%20four%20strains%20with%20rrl%20mutations.%20M.%20abscessus%20strains%20harbored%20an%20intact%20erm%2841%29%20but%20had%20a%20T%5C%2FC%20polymorphism%20at%20the%2028th%20nucleotide%3A%20T28%20strains%20%28Trp10%20codon%29%20demonstrated%20inducible%20clarithromycin%20resistance%20%28MIC90%20of%20%3E16%20%5Cu03bcg%5C%2Fml%29%2C%20while%20C28%20strains%20%28Arg10%29%20were%20susceptible%20%28MIC90%20of%202%20%5Cu03bcg%5C%2Fml%29%20except%20for%20two%20strains%20with%20rrl%20mutations.%20M.%20bolletii%20strains%20had%20erm%2841%29%20sequences%20similar%20to%20the%20sequence%20of%20the%20T28%20M.%20abscessus%20group%2C%20associated%20with%20inducible%20clarithromycin%20resistance%20%28MIC90%20of%20%3E16%20%5Cu03bcg%5C%2Fml%29.%20erm%2841%29%20sequences%20appeared%20species%20specific%20within%20the%20M.%20abscessus%20group%20and%20were%20fully%20concordant%20with%20clarithromycin%20susceptibility%20when%20erm%2841%29%20sequencing%20was%20associated%20with%20detection%20of%20rrl%20mutations.%20Clarithromycin-resistant%20strains%2C%20including%20the%20six%20rrl%20mutants%2C%20were%20more%20often%20isolated%20in%20cystic%20fibrosis%20patients%2C%20but%20this%20was%20not%20significantly%20associated%20with%20a%20previous%20treatment.%22%2C%22date%22%3A%2202%5C%2F01%5C%2F2011%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.00861-10%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F55%5C%2F2%5C%2F775%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-04-25T16%3A09%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22PNDATX4F%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cribier%20et%20al.%22%2C%22parsedDate%22%3A%222011-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECribier%2C%20B.%2C%20Aubry%2C%20A.%2C%20Caumes%2C%20E.%2C%20Cambau%2C%20E.%2C%20Jarlier%2C%20V.%20and%20Chosidow%2C%20O.%20%282011%29.%20%3Cb%3E%5BHistopathological%20study%20of%20Mycobacterium%20marinum%20infection%5D%3C%5C%2Fb%3E.%20Ann%20Dermatol%20Venereol%20%3Ci%3E138%3C%5C%2Fi%3E%2C%2017%26%23x2013%3B22%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annder.2010.10.025%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annder.2010.10.025%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22%5BHistopathological%20study%20of%20Mycobacterium%20marinum%20infection%5D%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%22%2C%22lastName%22%3A%22Cribier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Caumes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O%22%2C%22lastName%22%3A%22Chosidow%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Skin%20infection%20by%20Mycobacterium%20marinum%20induces%20the%20classic%20granuloma%20of%20aquariums%20and%20swimming%20pools.%20The%20histopathological%20signs%20have%20been%20described%20primarily%20in%20small%20series%20of%20typical%20cases%2C%20generally%20with%20no%20bacteriological%20evidence.%20In%20a%20national%20survey%20of%20proven%20infection%20with%20M.%20marinum%20detailed%20data%20was%20collected%20for%2063%20patients.%20The%20aim%20of%20this%20new%20study%20was%20to%20describe%20microscopic%20signs%20of%20the%20infection%20based%20upon%20biopsies%20taken%20from%20these%20patients.%5CnPATIENTS%20AND%20METHODS%3A%20Unstained%20slides%20from%2032%20biopsies%20of%20the%20skin%20%28n%3D24%29%20or%20synovial%20biopsies%20%28n%3D8%29%20were%20prepared%3B%20they%20originated%20from%2027%20patients.%20They%20were%20examined%20after%20standard%20staining%20and%20after%20Ziehl-Neelsen%20staining%2C%20without%20knowledge%20of%20the%20clinical%20data.%5CnRESULTS%3A%20All%20biopsies%20were%20taken%20from%20the%20upper%20limb%20of%2018%20men%20and%20nine%20women%20of%20mean%20age%2048%20years.%20Tubercular%20granulomas%20were%20observed%20in%20only%2060%25%20of%20cases.%20The%20largest%20and%20most%20numerous%20were%20seen%20in%20the%20synovial%20samples.%20Due%20to%20their%20palisade%20appearance%2C%20they%20were%20occasionally%20impossible%20to%20distinguish%20from%20rheumatoid%20nodules.%20In%2020%25%20of%20cases%2C%20neutrophil%20collections%20were%20seen%20without%20granulomas%20and%20in%20remaining%2020%25%20of%20cases%2C%20relatively%20non-specific%20infiltrate%20was%20observed.%20Epidermal%20changes%20consisted%20in%20psoriasiform%20or%20pseudocarcinomatous%20hyperplasia%2C%20particularly%20at%20the%20edges%20of%20ulcerated%20areas%3B%20invasion%20of%20the%20dermo-epidermal%20junction%20was%20seen%20in%20five%20cases.%20Follicular%20necrosis%20was%20observed%20in%20four%20cases%20with%20lymphoplasmacytic%20infiltrates%20remote%20from%20the%20granulomas%20being%20seen%20in%2022%20biopsies.%20Ziehl-Neelsen%20staining%20revealed%20no%20bacilli.%5CnDISCUSSION%3A%20The%20originality%20of%20this%20series%20consists%20of%20bacteriological%20proof%20of%20M.%20marinum%20infection%20and%20the%20absence%20of%20biopsy%20selection%20based%20on%20clinical%20criteria.%20It%20shows%20that%20the%20typical%20granulomas%20are%20in%20fact%20present%20in%20less%20than%20two%20third%20of%20cases%2C%20and%20that%20these%20may%20be%20confused%20with%20rheumatoid%20nodules.%20The%20chief%20characteristic%20of%20these%20lesions%20is%20the%20very%20low%20concentration%20of%20microorganisms%20present%2C%20in%20contrast%20with%20other%20forms%20of%20mycobacterium%2C%20making%20them%20difficult%20to%20see%3B%20routine%20confirmation%20cannot%20thus%20be%20expected%20from%20specific%20staining%20procedures.%20In%20one%20case%20out%20of%20five%2C%20the%20infiltrate%20suggested%20no%20infectious%20origin%2C%20although%20deep%20skin%20biopsies%20and%20synovial%20biopsies%20provided%20more%20information.%20For%20all%20forms%20of%20necrotic%20granuloma%2C%20whether%20or%20not%20accompanied%20by%20collections%20of%20neutrophils%2C%20a%20culture%20should%20be%20carried%20out%20in%20a%20specific%20medium%2C%20even%20in%20the%20absence%20of%20microscopic%20evidence%20of%20bacilli.%22%2C%22date%22%3A%22Jan%202011%22%2C%22language%22%3A%22fre%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.annder.2010.10.025%22%2C%22ISSN%22%3A%220151-9638%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T09%3A49%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22FKIAEBCV%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ali%20et%20al.%22%2C%22parsedDate%22%3A%222011%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EAli%2C%20M.%20A.%2C%20Bastian%2C%20S.%2C%20Ismail%2C%20R.%2C%20Choon%2C%20T.%20S.%2C%20Ali%2C%20S.%2C%20Aubry%2C%20A.%2C%20Pandian%2C%20S.%2C%20Saraswat%2C%20P.%2C%20Singh%2C%20A.%20and%20Gaur%2C%20R.%20%282011%29.%20%3Cb%3EDiscovery%20of%20novel%20methanone%20derivatives%20acting%20as%20antimycobacterial%20agents%3C%5C%2Fb%3E.%20Journal%20of%20Enzyme%20Inhibition%20and%20Medicinal%20Chemistry%20%3Ci%3E26%3C%5C%2Fi%3E%2C%20890%26%23x2013%3B894%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3109%5C%2F14756366.2011.559945%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3109%5C%2F14756366.2011.559945%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Discovery%20of%20novel%20methanone%20derivatives%20acting%20as%20antimycobacterial%20agents%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%20Ashraf%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvaine%22%2C%22lastName%22%3A%22Bastian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rusli%22%2C%22lastName%22%3A%22Ismail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tan%20Soo%22%2C%22lastName%22%3A%22Choon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sadath%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suresh%22%2C%22lastName%22%3A%22Pandian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pankaj%22%2C%22lastName%22%3A%22Saraswat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abhimanyu%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramakant%22%2C%22lastName%22%3A%22Gaur%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2212%5C%2F2011%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3109%5C%2F14756366.2011.559945%22%2C%22ISSN%22%3A%221475-6366%2C%201475-6374%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Finformahealthcare.com%5C%2Fdoi%5C%2Fabs%5C%2F10.3109%5C%2F14756366.2011.559945%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T09%3A49%3A49Z%22%7D%7D%2C%7B%22key%22%3A%223NDD3VC3%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Couderc%20et%20al.%22%2C%22parsedDate%22%3A%222011%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECouderc%2C%20C.%2C%20Carbonne%2C%20A.%2C%20Thiolet%2C%20J.%20M.%2C%20Brossier%2C%20F.%2C%20Savey%2C%20A.%2C%20Bernet%2C%20C.%2C%20Ortmans%2C%20C.%2C%20Lecadet-Morin%2C%20C.%2C%20Coudi%26%23xE8%3Bre%2C%20I.%2C%20Aggoune%2C%20M.%2C%20Astagneau%2C%20P.%2C%20Coignard%2C%20B.%20and%20Cambau%2C%20E.%20%282011%29.%20%3Cb%3EInfections%20%26%23xE0%3B%20mycobact%26%23xE9%3Bries%20atypiques%20li%26%23xE9%3Bes%20%26%23xE0%3B%20des%20soins%20esth%26%23xE9%3Btiques%20en%20France%2C%202001%26%23x2013%3B2010%3C%5C%2Fb%3E.%20M%26%23xE9%3Bdecine%20et%20Maladies%20Infectieuses%20%3Ci%3E41%3C%5C%2Fi%3E%2C%20379%26%23x2013%3B383%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2011.02.007%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2011.02.007%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Infections%20%5Cu00e0%20mycobact%5Cu00e9ries%20atypiques%20li%5Cu00e9es%20%5Cu00e0%20des%20soins%20esth%5Cu00e9tiques%20en%20France%2C%202001%5Cu20132010%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Couderc%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Carbonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.M.%22%2C%22lastName%22%3A%22Thiolet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Savey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Bernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Ortmans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lecadet-Morin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Coudi%5Cu00e8re%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Aggoune%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Astagneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Coignard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%227%5C%2F2011%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.medmal.2011.02.007%22%2C%22ISSN%22%3A%220399077X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.em-consulte.com%5C%2Farticle%5C%2F284859%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-26T17%3A46%3A34Z%22%7D%7D%2C%7B%22key%22%3A%222739786Z%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lerat%20et%20al.%22%2C%22parsedDate%22%3A%222011%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELerat%2C%20I.%2C%20Truffot%2C%20C.%20and%20Veziris%2C%20N.%20%282011%29.%20%3Cb%3EInfections%20%26%23xE0%3B%20Mycobacterium%20abscessus%26%23x202F%3B%3A%20%26%23xE9%3Bpid%26%23xE9%3Bmiologie%2C%20aspects%20cliniques%20et%20traitement%3C%5C%2Fb%3E.%20Journal%20des%20Anti-infectieux%20%3Ci%3E13%3C%5C%2Fi%3E%2C%2049%26%23x2013%3B55.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Infections%20%5Cu00e0%20Mycobacterium%20abscessus%20%3A%20%5Cu00e9pid%5Cu00e9miologie%2C%20aspects%20cliniques%20et%20traitement%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I%22%2C%22lastName%22%3A%22Lerat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Truffot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222011%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T09%3A59%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22FRPW9NJK%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Radomski%20et%20al.%22%2C%22parsedDate%22%3A%222010-06-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERadomski%2C%20N.%2C%20Cambau%2C%20E.%2C%20Moulin%2C%20L.%2C%20Haenn%2C%20S.%2C%20Moilleron%2C%20R.%20and%20Lucas%2C%20F.%20S.%20%282010%29.%20%3Cb%3EComparison%20of%20Culture%20Methods%20for%20Isolation%20of%20Nontuberculous%20Mycobacteria%20from%20Surface%20Waters%3C%5C%2Fb%3E.%20Appl%20Environ%20Microbiol%20%3Ci%3E76%3C%5C%2Fi%3E%2C%203514%26%23x2013%3B3520%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAEM.02659-09%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAEM.02659-09%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparison%20of%20Culture%20Methods%20for%20Isolation%20of%20Nontuberculous%20Mycobacteria%20from%20Surface%20Waters%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Radomski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Moulin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Haenn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%5Cu00e9gis%22%2C%22lastName%22%3A%22Moilleron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%20S.%22%2C%22lastName%22%3A%22Lucas%22%7D%5D%2C%22abstractNote%22%3A%22The%20environment%20is%20the%20likely%20source%20of%20most%20nontuberculous%20mycobacteria%20%28NTM%29%20involved%20in%20human%20infections%2C%20especially%20pulmonary%2C%20skin%2C%20and%20soft%20tissue%20infections.%20In%20order%20to%20measure%20the%20prevalence%20of%20NTM%20in%20different%20aquatic%20ecosystems%2C%20we%20tried%20to%20standardize%20the%20culture%20methods%20used%20for%20surface%20water%20testing%20since%20many%20procedures%20have%20been%20described%20previously.%20Cultivation%20of%20mycobacteria%20requires%20long-term%20incubation%20in%20rich%20media%20and%20inactivation%20of%20rapidly%20growing%20microorganisms%20whose%20growth%20impedes%20observation%20of%20mycobacterial%20colonies.%20Consequently%2C%20the%20two%20criteria%20used%20for%20evaluation%20of%20the%20methods%20examined%20were%20%28i%29%20the%20rate%20of%20inhibition%20of%20nontarget%20microorganisms%20and%20%28ii%29%20the%20efficiency%20of%20recovery%20of%20mycobacteria.%20We%20compared%20the%20competitive%20growth%20of%20Mycobacterium%20chelonae%20and%20M.%20avium%20with%20nontarget%20microorganisms%20on%20rich%20Middlebrook%207H11-mycobactin%20medium%20after%20treatment%20by%20several%20chemical%20decontamination%20methods%20that%20included%20acids%2C%20bases%2C%20detergent%2C%20or%20cetylpyridinium%20chloride%20%28CPC%29%20with%20and%20without%20an%20antibiotic%20cocktail%2C%20either%20PANTA%20%2840%20U%5C%2Fml%20polymyxin%2C%204%20%5Cu03bcg%5C%2Fml%20amphotericin%20B%2C%2016%20%5Cu03bcg%5C%2Fml%20nalidixic%20acid%2C%204%20%5Cu03bcg%5C%2Fml%20trimethoprim%2C%20and%204%20%5Cu03bcg%5C%2Fml%20azlocillin%29%20or%20PANTAV%20%28PANTA%20plus%2010%20%5Cu03bcg%5C%2Fml%20vancomycin%29.%20Our%20results%20showed%20that%20treatment%20for%2030%20min%20with%20CPC%20%28final%20concentration%2C%200.05%25%29%20of%20water%20concentrated%20by%20centrifugation%2C%20followed%20by%20culture%20on%20a%20rich%20medium%20supplemented%20with%20PANTA%2C%20significantly%20decreased%20the%20growth%20of%20nontarget%20microorganisms%20%28the%20concentrations%20were%206.2%20%5Cu00b1%200.4%20log10%20CFU%5C%2Fliter%20on%20Middlebrook%207H11j%20medium%20and%204.2%20%5Cu00b1%200.2%20log10%20CFU%5C%2Fliter%20on%20Middlebrook%207H11j%20medium%20containing%20PANTA%20%5BP%20%3C%200.001%5D%29%2C%20while%20the%20effect%20of%20this%20procedure%20on%20NTM%20was%20not%20as%20great%20%28the%20concentrations%20of%20M.%20chelonae%20on%20the%20two%20media%20were%207.0%20%5Cu00b1%200.0%20log10%20CFU%5C%2Fliter%20and%206.9%20%5Cu00b1%200.0%20log10%20CFU%5C%2Fliter%2C%20respectively%2C%20and%20the%20concentrations%20of%20M.%20avium%20were%209.1%20%5Cu00b1%200.0%20log10%20CFU%5C%2Fliter%20and%208.9%20%5Cu00b1%200.0%20log10%20CFU%5C%2Fliter%2C%20respectively%29.%20We%20propose%20that%20this%20standardized%20culture%20procedure%20could%20be%20used%20for%20detection%20of%20NTM%20in%20aquatic%20samples.%22%2C%22date%22%3A%2206%5C%2F01%5C%2F2010%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FAEM.02659-09%22%2C%22ISSN%22%3A%220099-2240%2C%201098-5336%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faem.asm.org%5C%2Fcontent%5C%2F76%5C%2F11%5C%2F3514%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T12%3A23%3A34Z%22%7D%7D%2C%7B%22key%22%3A%226SZE3RAM%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bastian%20et%20al.%22%2C%22parsedDate%22%3A%222010-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBastian%2C%20S.%2C%20Brossier%2C%20F.%2C%20Wichlacz%2C%20C.%2C%20Jarlier%2C%20V.%20and%20Veziris%2C%20N.%20%282010%29.%20%3Cb%3EDaptomycin%20is%20not%20active%20against%20rapidly%20growing%20mycobacteria%3C%5C%2Fb%3E.%20J%20Med%20Microbiol%20%3Ci%3E59%3C%5C%2Fi%3E%2C%20135%26%23x2013%3B136%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1099%5C%2Fjmm.0.014274-0%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1099%5C%2Fjmm.0.014274-0%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Daptomycin%20is%20not%20active%20against%20rapidly%20growing%20mycobacteria%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvaine%22%2C%22lastName%22%3A%22Bastian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudine%22%2C%22lastName%22%3A%22Wichlacz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Jan%202010%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1099%5C%2Fjmm.0.014274-0%22%2C%22ISSN%22%3A%221473-5644%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.microbiologyresearch.org%5C%2Fcontent%5C%2Fjournal%5C%2Fjmm%5C%2F10.1099%5C%2Fjmm.0.014274-0%23tab2%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-04-02T21%3A15%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22GX85AMQ9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Marsollier%20et%20al.%22%2C%22parsedDate%22%3A%222010%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMarsollier%2C%20L.%2C%20Aubry%2C%20A.%2C%20Carbonnelle%2C%20E.%2C%20Canaan%2C%20S.%2C%20Cambau%2C%20E.%20and%20Herrmann%2C%20J.-L.%20%282010%29.%20%3Cb%3ELes%20Mycobact%26%23xE9%3Brioses%20cutan%26%23xE9%3Bes%20dues%20%26%23xE0%3B%20Mycobacterium%20ulcerans%2C%20Mycobacterium%20marinum%2C%20Mycobacterium%20abscessus%2C%20Mycobacterium%20chelonae%20et%20autres%20mycobact%26%23xE9%3Bries%20non%20tuberculeuses%3C%5C%2Fb%3E%2C%20%3Ci%3EL%26%23x2019%3BEncyclop%26%23xE9%3Bdie%20M%26%23xE9%3Bdico-chirurgicale%3C%5C%2Fi%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22encyclopediaArticle%22%2C%22title%22%3A%22Les%20Mycobact%5Cu00e9rioses%20cutan%5Cu00e9es%20dues%20%5Cu00e0%20Mycobacterium%20ulcerans%2C%20Mycobacterium%20marinum%2C%20Mycobacterium%20abscessus%2C%20Mycobacterium%20chelonae%20et%20autres%20mycobact%5Cu00e9ries%20non%20tuberculeuses%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%22%2C%22lastName%22%3A%22Marsollier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Carbonnelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Canaan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J-L%22%2C%22lastName%22%3A%22Herrmann%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22encyclopediaTitle%22%3A%22L%27Encyclop%5Cu00e9die%20M%5Cu00e9dico-chirurgicale%22%2C%22date%22%3A%222010%22%2C%22ISBN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-26T17%3A46%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22C7V7I3K4%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cambau%20and%20Aubry%22%2C%22parsedDate%22%3A%222010%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECambau%2C%20E.%20and%20Aubry%2C%20A.%20%282010%29.%20%3Cb%3EMycobacterium%20marinum%3C%5C%2Fb%3E.%20In%3A%20%3Cb%3ETuberculosis%3C%5C%2Fb%3E%2C%20McGraw-Hill%20Professional%20Medical%20Publishing%20Division.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Mycobacterium%20marinum%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22bookTitle%22%3A%22Tuberculosis%22%2C%22date%22%3A%222010%22%2C%22language%22%3A%22English%22%2C%22ISBN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T09%3A54%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22CPWDGKWS%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Carbonne%20et%20al.%22%2C%22parsedDate%22%3A%222009-06-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECarbonne%2C%20A.%2C%20Brossier%2C%20F.%2C%20Arnaud%2C%20I.%2C%20Bougmiza%2C%20I.%2C%20Caumes%2C%20E.%2C%20Meningaud%2C%20J.-P.%2C%20Dubrou%2C%20S.%2C%20Jarlier%2C%20V.%2C%20Cambau%2C%20E.%20and%20Astagneau%2C%20P.%20%282009%29.%20%3Cb%3EOutbreak%20of%20Nontuberculous%20Mycobacterial%20Subcutaneous%20Infections%20Related%20to%20Multiple%20Mesotherapy%20Injections%3C%5C%2Fb%3E.%20J%20Clin%20Microbiol%20%3Ci%3E47%3C%5C%2Fi%3E%2C%201961%26%23x2013%3B1964%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.00196-09%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FJCM.00196-09%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Outbreak%20of%20Nontuberculous%20Mycobacterial%20Subcutaneous%20Infections%20Related%20to%20Multiple%20Mesotherapy%20Injections%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Carbonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Arnaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iheb%22%2C%22lastName%22%3A%22Bougmiza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Caumes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Paul%22%2C%22lastName%22%3A%22Meningaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvie%22%2C%22lastName%22%3A%22Dubrou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Astagneau%22%7D%5D%2C%22abstractNote%22%3A%22We%20describe%20an%20outbreak%20of%20severe%20subcutaneous%20infections%20due%20to%20nontuberculous%20mycobacteria%20following%20mesotherapy.%20Epidemiological%20studies%20and%20molecular%20comparisons%20of%20Mycobacterium%20chelonae%20strains%20from%20different%20patients%20and%20the%20environment%20suggested%20that%20contamination%20may%20be%20associated%20with%20inappropriate%20cleaning%20of%20the%20multiple-injection%20device%20with%20tap%20water.%22%2C%22date%22%3A%2206%5C%2F01%5C%2F2009%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1128%5C%2FJCM.00196-09%22%2C%22ISSN%22%3A%220095-1137%2C%201098-660X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjcm.asm.org%5C%2Fcontent%5C%2F47%5C%2F6%5C%2F1961%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T21%3A41%3A32Z%22%7D%7D%2C%7B%22key%22%3A%223BXJXDJ2%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Veziris%20et%20al.%22%2C%22parsedDate%22%3A%222009%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EVeziris%2C%20N.%2C%20Aubry%2C%20A.%2C%20Robert%2C%20J.%2C%20Cambau%2C%20E.%2C%20Jarlier%2C%20V.%20and%20Truffot-Pernot%2C%20C.%20%282009%29.%20%3Cb%3EMycobacteria%3C%5C%2Fb%3E.%20In%3A%20%3Cb%3EAntibiogram%3C%5C%2Fb%3E%2C%20Eska%20and%20ASM%20editors.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Mycobacteria%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Truffot-Pernot%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22bookTitle%22%3A%22Antibiogram%22%2C%22date%22%3A%222009%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T21%3A37%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22M9AJ6CQK%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22R%5Cu00e9gnier%20et%20al.%22%2C%22parsedDate%22%3A%222008-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ER%26%23xE9%3Bgnier%2C%20S.%2C%20Martinez%2C%20V.%2C%20Veziris%2C%20N.%2C%20Bonvallot%2C%20T.%2C%20Meningaud%2C%20J.-P.%20and%20Caumes%2C%20E.%20%282008%29.%20%3Cb%3E%5BTreatment%20of%20cutaneous%20infections%20due%20to%20Mycobacterium%20fortuitum%3A%20two%20cases%5D%3C%5C%2Fb%3E.%20Ann%20Dermatol%20Venereol%20%3Ci%3E135%3C%5C%2Fi%3E%2C%20591%26%23x2013%3B595%2C%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annder.2008.03.029%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annder.2008.03.029%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22%5BTreatment%20of%20cutaneous%20infections%20due%20to%20Mycobacterium%20fortuitum%3A%20two%20cases%5D%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22R%5Cu00e9gnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T%22%2C%22lastName%22%3A%22Bonvallot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J-P%22%2C%22lastName%22%3A%22Meningaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Caumes%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Cutaneous%20infections%20due%20to%20Mycobacterium%20fortuitum%2C%20a%20rapidly%20growing%20environmental%20mycobacteria%2C%20are%20often%20iatrogenic%2C%20resulting%20from%20surgery%20or%20injection.%20We%20report%20two%20cases%20following%20plastic%20surgery%20and%20describe%20the%20outcome%20after%20surgery%20and%20antibiotics.%5CnCASE%20REPORTS%3A%20Two%20immunocompetent%20women%20underwent%20abdominal%20plastic%20surgery%20and%20liposuction%2C%20which%20were%20complicated%20with%20recurrent%20abscesses%20one%20and%2013%20months%20later%20respectively.%20Cultures%20of%20bacteriologic%20samples%20isolated%20M.%20fortuitum%20in%20the%20two%20patients.%20The%20two%20strains%20exhibited%20different%20antibiotic%20sensibility%20profiles.%20The%20initial%20antibiotic%20therapy%20consisted%20of%20combined%20amikacin%20and%20moxifloxacin%20in%20both%20patients%20plus%20imipenem%20in%20one%2C%20followed%20by%20oral%20doxycycline%20and%20clarithromycin%20in%20one%20and%20moxifloxacin%20in%20the%20other%20for%20a%20total%20duration%20of%20nine%20and%20five%20months%2C%20respectively.%20In%20both%20cases%2C%20surgical%20treatment%20was%20also%20given%20before%2C%20during%20and%20after%20antibiotic%20therapy.%20No%20new%20lesions%20had%20appeared%20six%20months%20after%20the%20end%20of%20antibiotic%20therapy.%5CnDISCUSSION%3A%20Cutaneous%20infections%20due%20to%20M.%20fortuitum%20are%20rare%20and%20secondary%20to%20iatrogenic%20skin%20wounds.%20The%20clinical%20appearance%20is%20not%20specific%2C%20accounting%20for%20delayed%20diagnosis.%20Treatment%20is%20difficult%20and%20there%20is%20no%20consensus.%20According%20to%20our%20experience%2C%20surgical%20treatment%20is%20essential%20whereas%20the%20efficacy%20of%20antibiotics%2C%20even%20involving%20multiple%20agents%2C%20seems%20more%20doubtful.%22%2C%22date%22%3A%222008%20Aug-Sep%22%2C%22language%22%3A%22fre%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.annder.2008.03.029%22%2C%22ISSN%22%3A%220151-9638%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T15%3A49%3A08Z%22%7D%7D%5D%7D
Bémer, P., Aubry, A., Schramm, F., Koebel, C., Revillet, H., Baltes, V., Brun, C. L., Chazerain, P., Zeller, V., Hamdad, F., Morand, P. C., Guillouzouic, A., Piau, C., Roux, A.-L., Soueges, S., Martin, C., Gaudart, A., Hüssler, S., Fihman, V., Carricajo, A., Caruba, C. G., Bador, J., Dauchy, F.-A., Dutronc, H., Vignals, C. and Peuchant, O. (2024). Clinical features and treatment outcomes of bone and joint nontuberculous mycobacterial infections according to immune status: a 9-year retrospective observational cohort. International Journal of Infectious Diseases 146, 107122, http://doi.org/10.1016/j.ijid.2024.107122.
Loebinger, M. R., Aliberti, S., Haworth, C., Jankovic Makek, M., Lange, C., Lorent, N., Papavasileiou, A., Polverino, E., Rohde, G., Veziris, N., Wagner, D. and Van Ingen, J. (2024). Patients at risk of nontuberculous mycobacterial pulmonary disease who need testing evaluated using a modified Delphi process by European experts. ERJ Open Res 10, 00791–02023, http://doi.org/10.1183/23120541.00791-2023.
Tagliani, E., Kohl, T. A., Ghodousi, A., Groenheit, R., Holicka, Y., Niemann, S., Maurer, F. P., Cirillo, D. M. and Cambau, E. (2024). Appeal from the European tuberculosis reference laboratory network (ERLTB-Net) for improving the diagnosis of infections due to nontuberculous mycobacteria. Clinical Microbiology and Infection 30, 4–6, http://doi.org/10.1016/j.cmi.2023.06.005.
Heid-Picard, B., Awad, Z., Mougari, F. and Cambau, E. (2023). Mycobactérioses non tuberculeuses hors mycobactérioses cutanées. EM-Consulte, http://doi.org/10.1016/S1166-8598(23)44823-5.
Chiron, R., Hoefsloot, W., Van Ingen, J., Marchandin, H., Kremer, L., Morisse-Pradier, H., Charriot, J., Mallet, J.-P., Herrmann, J.-L., Caimmi, D., Moreau, J., Dumont, Y., Godreuil, S., Bergeron, A., Drevait, M., Bouzat-Rossigneux, E., Terrail, N., Andrejak, C., Veziris, N., Grenet, D., Coudrat, A. and Catherinot, E. (2022). Amikacin Liposomal Inhalation Suspension in the Treatment of Mycobacterium abscessus Lung Infection: A French Observational Experience. Open Forum Infect Dis 9, ofac465, http://doi.org/10.1093/ofid/ofac465.
Chaptal, M., Andrejak, C., Bonifay, T., Beillard, E., Guillot, G., Guyomard-Rabenirina, S., Demar, M., Trombert-Paolantoni, S., Jacomo, V., Mosnier, E., Veziris, N., Djossou, F., Epelboin, L. and Group, F. G. P. working (2022). Epidemiology of infection by pulmonary non-tuberculous mycobacteria in French Guiana 2008–2018. PLOS Neglected Tropical Diseases 16, e0010693, http://doi.org/10.1371/journal.pntd.0010693.
Kilinç, G., Walburg, K. V., Franken, K. L. M. C., Valkenburg, M. L., Aubry, A., Haks, M. C., Saris, A. and Ottenhoff, T. H. M. (2022). Development of Human Cell-Based In Vitro Infection Models to Determine the Intracellular Survival of Mycobacterium avium. Front Cell Infect Microbiol 12, 872361, http://doi.org/10.3389/fcimb.2022.872361.
Daniau, C., Lecorche, E., Mougari, F., Benmansour, H., Bernet, C., Blanchard, H., Robert, J., Berger-Carbonne, A. and Cambau, E. (2022). Association of Healthcare and Aesthetic Procedures with Infections Caused by Nontuberculous Mycobacteria, France, 2012‒2020. Emerg Infect Dis 28, 518–526, http://doi.org/10.3201/eid2803.211791.
Lange, C., Böttger, E. C., Cambau, E., Griffith, D. E., Guglielmetti, L., van Ingen, J., Knight, S. L., Marras, T. K., Olivier, K. N., Santin, M., Stout, J. E., Tortoli, E., Wagner, D., Winthrop, K., Daley, C. L., Lange, C., Andrejak, C., Böttger, E., Cambau, E., Griffith, D., Guglielmetti, L., van Ingen, J., Knight, S., Leitman, P., Marras, T. K., Olivier, K. N., Santin, M., Stout, J. E., Tortoli, E., Wagner, D., Wallace, R. J., Winthrop, K. and Daley, C. (2022). Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases. The Lancet Infectious Diseases, http://doi.org/10.1016/S1473-3099(21)00586-7.
Vongthilath-Moeung, R., Plojoux, J., Poncet, A., Renzi, G., Veziris, N., Schrenzel, J. and Janssens, J.-P. (2022). Nontuberculous Mycobacteria under Scrutiny in the Geneva Area (2015–2020). RES 101, 367–375, http://doi.org/10.1159/000520033.
Bemer, P., Peuchant, O., Guet-Revillet, H., Bador, J., Balavoine, C., Basille, D., Beltramo, G., Blanc, F.-X., Blanchard, E., Boulanger, S., Bourgoin, A., Boutoille, D., Cambau, E., Canis, F., Caparros, D., Carricajo, A., Carrière, C., Couetdic, G., Couturaud, F., Dalphin, J.-C., Degot, T., Desquiens, M., Devouassoux, G., Duez, J.-M., Dumitrescu, O., Dupuy-Grasset, M., Gaudart, A., Georges, M., Godet, C., Godreuil, S., Guillouzouic, A., Hamdad-Daoudi, F., Héry-Arnaud, G., Koebel, C., Lagrange, A., Lanotte, P., Marchand-Adam, S., Mougari, F., Murris, M., Patry, I., Pérouse de Montclos, M., Raskine, L., Risso, K., Segonds, C., Sicard, D., Terru, D., Vachée, A., Vergnon, J.-M., Martin, C., Schramm, F. and Andrejak, C. (2021). Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study. BMC Pulm Med 21, 1–9, http://doi.org/10.1186/s12890-021-01701-5.
Veziris, N., Andréjak, C., Bouée, S., Emery, C., Obradovic, M. and Chiron, R. (2021). Non-tuberculous mycobacterial pulmonary diseases in France: an 8 years nationwide study. BMC Infect Dis 21, 1–10, http://doi.org/10.1186/s12879-021-06825-x.
Lecorche, E., Daniau, C., La, K., Mougari, F., Benmansour, H., Kumanski, S., Robert, J., Fournier, S., Lebreton, G., Carbonne, A., Cambau, E. and CNR-MyRMA (2021). Mycobacterium chimaera Genomics With Regard to Epidemiological and Clinical Investigations Conducted for an Open Chest Postsurgical Mycobacterium chimaera Infection Outbreak. Open Forum Infectious Diseases 8, ofab192, http://doi.org/10.1093/ofid/ofab192.
Opota, O., Mazza-Stalder, J., Viveiros, M., Cambau, E., Santin, M. and Goletti, D. (2021). Editorial: Tuberculosis and Non-tuberculous Mycobacteria Infections: Control, Diagnosis and Treatment. Frontiers in Public Health 9, URL: https://www.frontiersin.org/article/10.3389/fpubh.2021.666187 [Accessed March 2022].
Daley, C. L., Iaccarino, J. M., Lange, C., Cambau, E., Wallace, R. J., Jr, Andrejak, C., Böttger, E. C., Brozek, J., Griffith, D. E., Guglielmetti, L., Huitt, G. A., Knight, S. L., Leitman, P., Marras, T. K., Olivier, K. N., Santin, M., Stout, J. E., Tortoli, E., van Ingen, J., Wagner, D. and Winthrop, K. L. (2020). Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline. Clinical Infectious Diseases 71, e1–e36, http://doi.org/10.1093/cid/ciaa241.
Marsollier, L., Aubry, A., Carbonnelle, E., Canaan, S., Laencina, L., Cambau, E. and Herrmann, J. (2020). Mycobactérioses cutanées dues à Mycobacterium ulcerans, Mycobacterium marinum, Mycobacterium abscessus, Mycobacterium chelonae et autres mycobactéries non tuberculeuses. EM-Consulte, http://doi.org/10.1016/S1166-8598(19)81974-9.
Jaffré, J., Aubry, A., Maitre, T., Morel, F., Brossier, F., Robert, J., Sougakoff, W., Veziris, N. and the CNR-MyRMA (Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux) (2020). Rational Choice of Antibiotics and Media for Mycobacterium avium Complex Drug Susceptibility Testing. Frontiers in Microbiology 11, URL: https://www.frontiersin.org/article/10.3389/fmicb.2020.00081 [Accessed March 2022].
Lecorche, E., Pean de Ponfilly, G., Mougari, F., Benmansour, H., Poisnel, E., Janvier, F. and Cambau, E. (2020). Disseminated Mycobacterium chimaera Following Open-Heart Surgery, the Heater–Cooler Unit Worldwide Outbreak: Case Report and Minireview. Frontiers in Medicine 7, URL: https://www.frontiersin.org/article/10.3389/fmed.2020.00243 [Accessed March 2022].
Daniau, C., Lecorché, E., Mougari, F. and et al. (2019). Infections invasives à Mycobacterium chimaera en chirurgie cardiaque et évaluation des pratiques autour des matériels de circulation extracorporelle. Hygienes 27, 351–359, http://doi.org/10.25329/hy_xxvii_6-1.
Rollet-Cohen, V., Roux, A.-L., Bourgeois, M. L., Sapriel, G., Bahri, M. E., Jais, J.-P., Heym, B., Mougari, F., Raskine, L., Véziris, N., Gaillard, J.-L. and Sermet-Gaudelus, I. (2019). Mycobacterium bolletii lung disease in cystic fibrosis. CHEST 0, http://doi.org/10.1016/j.chest.2019.03.019.
Dutertre, M., Delobel, P., Marchou, B., Boyer, J.-F., Mougari, F. and Martin-Blondel, G. (2019). Olecranon bursitis secondary to Mycobacterium europaeum infection in a patient receiving immunosuppressive drugs for rheumatoid arthritis. Médecine et Maladies Infectieuses 49, 358–359, http://doi.org/10.1016/j.medmal.2019.03.002.
Decalonne, M., Lecorche, E., Hau, E., Petiteau, A., Moreau, C., Milan, O., Lanotte, P., Mereghetti, L., Cambau, E. and van der Mee-Marquet, N. (2019). Cause Analysis of an Infection in Facelift Surgery Due to Mycobacterium chelonae. Frontiers in Medicine 6, URL: https://www.frontiersin.org/article/10.3389/fmed.2019.00243 [Accessed February 2022].
Griffith, D. E., Eagle, G., Thomson, R., Aksamit, T. R., Hasegawa, N., Morimoto, K., Addrizzo-Harris, D. J., O’Donnell, A. E., Marras, T. K., Flume, P. A., Loebinger, M. R., Morgan, L., Codecasa, L. R., Hill, A. T., Ruoss, S. J., Yim, J.-J., Ringshausen, F. C., Field, S. K., Philley, J. V., Wallace, R. J., van Ingen, J., Coulter, C., Nezamis, J. and Winthrop, K. L. (2018). Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT). A Prospective, Open-Label, Randomized Study. Am J Respir Crit Care Med 198, 1559–1569, http://doi.org/10.1164/rccm.201807-1318OC.
Coolen-Allou, N., Touron, T., Belmonte, O., Gazaille, V., Andre, M., Allyn, J., Picot, S., Payet, A. and Veziris, N. (2018). Clinical, Radiological, and Microbiological Characteristics of Mycobacterium simiae Infection in 97 Patients. Antimicrobial Agents and Chemotherapy 62, e00395-18, http://doi.org/10.1128/AAC.00395-18.
Lecorche, E., Haenn, S., Mougari, F., Kumanski, S., Veziris, N., Benmansour, H., Raskine, L., Moulin, L., Cambau, E., Aubry, A., Brossier, F., Chauffour, A., Jaffre, J., Jarlier, V., Robert, J. and Sougakoff, W. (2018). Comparison of methods available for identification of Mycobacterium chimaera. Clinical Microbiology and Infection 24, 409–413, http://doi.org/10.1016/j.cmi.2017.07.031.
van Ingen, J., Aksamit, T., Andrejak, C., Böttger, E. C., Cambau, E., Daley, C. L., Griffith, D. E., Guglielmetti, L., Holland, S. M., Huitt, G. A., Koh, W.-J., Lange, C., Leitman, P., Marras, T. K., Morimoto, K., Olivier, K. N., Santin, M., Stout, J. E., Thomson, R., Tortoli, E., Wallace, R. J., Winthrop, K. L. and Wagner, D. (2018). Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement. European Respiratory Journal 51, 1800170, http://doi.org/10.1183/13993003.00170-2018.
Bouchet, F., Martin, B., Aubry, A., Veziris, N., Lavigne, J.-P. and Sotto, A. (2017). Should single antibiotic therapy be avoided for nontuberculous mycobacteria? Médecine et Maladies Infectieuses, http://doi.org/10.1016/j.medmal.2017.07.004.
Leyer, C., Gregorowicz, G., Mougari, F., Raskine, L., Cambau, E. and Briel, D. de (2017). Comparison of Saramis 4.12 and IVD 3.0 Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Identification of Mycobacteria from Solid and Liquid Culture Media. Journal of Clinical Microbiology 55, 2045–2054, http://doi.org/10.1128/JCM.00006-17.
Mougari, F., Loiseau, J., Veziris, N., Bernard, C., Bercot, B., Sougakoff, W., Jarlier, V., Raskine, L. and Cambau, E. (2017). Evaluation of the new GenoType NTM-DR kit for the molecular detection of antimicrobial resistance in non-tuberculous mycobacteria. J Antimicrob Chemother 72, 1669–1677, http://doi.org/10.1093/jac/dkx021.
Delafont, V., Samba-Louaka, A., Cambau, E., Bouchon, D., Moulin, L. and Héchard, Y. (2017). Mycobacterium llatzerense, a waterborne Mycobacterium, that resists phagocytosis by Acanthamoeba castellanii. Scientific Reports 7, 46270, http://doi.org/10.1038/srep46270.
Aubry, A., Mougari, F., Reibel, F. and Cambau, E. (2017). Mycobacterium marinum. Microbiology Spectrum 5, http://doi.org/10.1128/microbiolspec.TNMI7-0038-2016.
Mougari, F., Bouziane, F., Crockett, F., Nessar, R., Chau, F., Veziris, N., Sapriel, G., Raskine, L. and Cambau, E. (2017). Selection of Resistance to Clarithromycin in Mycobacterium abscessus Subspecies. Antimicrob Agents Chemother 61, e00943-16, http://doi.org/10.1128/AAC.00943-16.
Mougari, F., Guglielmetti, L., Raskine, L., Sermet-Gaudelus, I., Veziris, N. and Cambau, E. (2016). Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. Expert Review of Anti-infective Therapy 14, 1139–1154, http://doi.org/10.1080/14787210.2016.1238304.
Mougari, F., Amarsy, R., Veziris, N., Bastian, S., Brossier, F., Berçot, B., Raskine, L. and Cambau, E. (2016). Standardized interpretation of antibiotic susceptibility testing and resistance genotyping for Mycobacterium abscessus with regard to subspecies and erm41 sequevar. J Antimicrob Chemother 71, 2208–2212, http://doi.org/10.1093/jac/dkw130.
Parize, P., Hamelin, A., Veziris, N., Morand, P. C., Guillemain, R., Lortholary, O. and Dupin, N. (2016). Induction therapy with linezolid/clarithromycin combination for Mycobacterium chelonae skin infections in immunocompromised hosts. Journal of the European Academy of Dermatology and Venereology 30, 101–105, http://doi.org/10.1111/jdv.12965.
Chazel, M., Marchandin, H., Keck, N., Terru, D., Carrière, C., Ponsoda, M., Jacomo, V., Panteix, G., Bouzinbi, N., Bañuls, A.-L., Choisy, M., Solassol, J., Aubry, A. and Godreuil, S. (2016). Evaluation of the SLOMYCO Sensititre® panel for testing the antimicrobial susceptibility of Mycobacterium marinum isolates. Annals of Clinical Microbiology and Antimicrobials 15, 30, http://doi.org/10.1186/s12941-016-0145-1.
Renvoisé, A., Brossier, F., Galati, E., Veziris, N., Sougakoff, W., Aubry, A., Robert, J., Cambau, E., Jarlier, V. and Bernard, C. (2015). Assessing Primary and Secondary Resistance to Clarithromycin and Amikacin in Infections Due to Mycobacterium avium Complex. Antimicrobial Agents and Chemotherapy 59, 7153–7155, http://doi.org/10.1128/AAC.01027-15.
Guglielmetti, L., Mougari, F., Lopes, A., Raskine, L. and Cambau, E. (2015). Human infections due to nontuberculous mycobacteria: the infectious diseases and clinical microbiology specialists’ point of view. Future Microbiology 10, 1467–1483, http://doi.org/10.2217/fmb.15.64.
Coolen, N., Morand, P., Martin, C., Hubert, D., Kanaan, R., Chapron, J., Honoré, I., Dusser, D., Audureau, E., Veziris, N. and Burgel, P.-R. (2015). Reduced risk of nontuberculous mycobacteria in cystic fibrosis adults receiving long-term azithromycin. Journal of Cystic Fibrosis 14, 594–599, http://doi.org/10.1016/j.jcf.2015.02.006.
Roux, A.-L., Catherinot, E., Soismier, N., Heym, B., Bellis, G., Lemonnier, L., Chiron, R., Fauroux, B., Le Bourgeois, M., Munck, A., Pin, I., Sermet, I., Gutierrez, C., Veziris, N., Jarlier, V., Cambau, E., Herrmann, J.-L., Guillemot, D. and Gaillard, J.-L. (2015). Comparing Mycobacterium massiliense and Mycobacterium abscessus lung infections in cystic fibrosis patients. Journal of Cystic Fibrosis 14, 63–69, http://doi.org/10.1016/j.jcf.2014.07.004.
Renvoise, A., Bernard, C., Veziris, N., Galati, E., Jarlier, V. and Robert, J. (2014). Significant Difference in Drug Susceptibility Distribution between Mycobacterium avium and Mycobacterium intracellulare. Journal of Clinical Microbiology 52, 4439–4440, http://doi.org/10.1128/JCM.02127-14.
Renvoise, A. and Bernard, C. (2014). Traitement des infections à Mycobacterium avium complex. J Antiinf 16, 199–206, http://doi.org/10.1016/j.antinf.2014.10.003.
Delafont, V., Mougaris, F., Cambau, E., Joyeux, michel, Bouchon, D., Hechard, Y. and Moulin, L. (2014). First evidence of amoebae – mycobacteria association in drinking water network. Environ Sci Technol, http://doi.org/10.1021/es5036255.
Fangous, M.-S., Mougari, F., Gouriou, S., Calvez, E., Raskine, L., Cambau, E., Payan, C. and Héry-Arnaud, G. (2014). Classification Algorithm for Subspecies Identification within the Mycobacterium abscessus Species, Based on Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry. J Clin Microbiol 52, 3362–3369, http://doi.org/10.1128/JCM.00788-14.
Mougari, F., Raskine, L., Ferroni, A., Marcon, E., Sermet-Gaudelus, I., Veziris, N., Heym, B., Gaillard, J.-L., Nassif, X. and Cambau, E. (2014). Clonal Relationship and Differentiation among Mycobacterium abscessus Isolates as Determined Using the Semiautomated Repetitive Extragenic Palindromic Sequence PCR-Based DiversiLab System. J Clin Microbiol 52, 1969–1977, http://doi.org/10.1128/JCM.03600-13.
Lerat, I., Cambau, E., Bettoni, R. R. dit, Gaillard, J.-L., Jarlier, V., Truffot, C. and Veziris, N. (2014). In Vivo Evaluation of Antibiotic Activity Against Mycobacterium abscessus. J Infect Dis 209, 905–912, http://doi.org/10.1093/infdis/jit614.
Macheras, E., Konjek, J., Roux, A.-L., Thiberge, J.-M., Bastian, S., Leão, S. C., Palaci, M., Sivadon-Tardy, V., Gutierrez, C., Richter, E., Rüsch-Gerdes, S., Pfyffer, G. E., Bodmer, T., Jarlier, V., Cambau, E., Brisse, S., Caro, V., Rastogi, N., Gaillard, J.-L. and Heym, B. (2014). Multilocus sequence typing scheme for the Mycobacterium abscessus complex. Research in Microbiology, http://doi.org/10.1016/j.resmic.2013.12.003.
Radomski, N., Roguet, A., Lucas, F. S., Veyrier, F. J., Cambau, E., Accrombessi, H., Moilleron, R., Behr, M. A. and Moulin, L. (2013). atpE gene as a new useful specific molecular target to quantify Mycobacterium in environmental samples. BMC Microbiology 13, 277, http://doi.org/10.1186/1471-2180-13-277.
Veziris, N., Chauffour, A., Escolano, S., Henquet, S., Matsuoka, M., Jarlier, V. and Aubry, A. (2013). Resistance of M. leprae to Quinolones: A Question of Relativity? PLoS Negl Trop Dis 7, e2559, http://doi.org/10.1371/journal.pntd.0002559.
Pang, S., Renvoisé, A., Perret, C., Guinier, M., Chelghoum, N., Brossier, F., Capton, E., Jarlier, V. and Sougakoff, W. (2013). Whole-Genome Sequence of Mycobacterium abscessus Clinical Strain V06705. Genome Announc 1, e00690-13, http://doi.org/10.1128/genomeA.00690-13.
Gomez, C., Ponien, P., Serradji, N., Lamouri, A., Pantel, A., Capton, E., Jarlier, V., Anquetin, G. and Aubry, A. (2013). Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry 21, 948–956, http://doi.org/10.1016/j.bmc.2012.12.011.
Grammatico-Guillon, L., Lanotte, P., Bastides, F., Veziris, N., Bernard, L. and Rosset, P. (2013). Voluminous pseudotumor due to Mycobacterium malmoense. Presse Med 42, 227–230, http://doi.org/10.1016/j.lpm.2012.02.042.
Mechaï, F., Veziris, N., Aoun, O., Bille, E., Lecuit, M., Brossier, F., Viard, J. P. and Lortholary, O. (2013). In vivo selection of a multidrug-resistant Mycobacterium avium isolate in a patient with AIDS. Int J Tuberc Lung Dis 17, 141–142, http://doi.org/10.5588/ijtld.12.0778.
Mougari, F., Guglielmetti, L., Lopes, A., Raskine, L. and Cambau, E. (2013). Mycobactérioses non tuberculeuses hors mycobactérioses cutanées. In: Revue Encyclopédie Médico Chirurgicale,.
Lhuillier, E., Brugière, O., Veziris, N., Danel, C., Mourvilliers, B., Mal, H., Dauriat, G. and Ruimy, R. (2012). Relapsing Mycobacterium genavense infection as a cause of late death in a lung transplant recipient: case report and review of the literature. Exp Clin Transplant 10, 618–620, http://doi.org/10.6002/ect.2012.0052.
Dutilh, J., Caron, F., Bourgoin, A., Veziris, N. and Meurice, J.-C. (2012). Un cas atypique de mycobactérie. Revue des Maladies Respiratoires 29, 1182, http://doi.org/10.1016/j.rmr.2012.10.014.
Cosson, M.-A., Bertrand, J.-B., Martin, C., Veziris, N., Picard, C., Goulvestre, C., Coignard, S., Benoit, J.-P., Silvera, S., Moro, M.-R., Poyart, C. and Morand, P. C. (2012). Temporal interferon-gamma release response to Mycobacterium kansasii infection in an anorexia nervosa patient. J Med Microbiol 61, 1617–1620, http://doi.org/10.1099/jmm.0.042739-0.
Legout, L., Ettahar, N., Massongo, M., Veziris, N., Ajana, F., Beltrand, E. and Senneville, E. (2012). Osteomyelitis of the wrist caused by Mycobacterium arupense in an immunocompetent patient: a unique case. Int J Infect Dis 16, e761-762, http://doi.org/10.1016/j.ijid.2012.05.007.
Cambau, E., Chauffour-Nevejans, A., Tejmar-Kolar, L., Matsuoka, M. and Jarlier, V. (2012). Detection of Antibiotic Resistance in Leprosy Using GenoType LepraeDR, a Novel Ready-To-Use Molecular Test. PLoS Negl Trop Dis 6, e1739, http://doi.org/10.1371/journal.pntd.0001739.
Nessar, R., Cambau, E., Reyrat, J. M., Murray, A. and Gicquel, B. (2012). Mycobacterium abscessus: a new antibiotic nightmare. J Antimicrob Chemother 67, 810–818, http://doi.org/10.1093/jac/dkr578.
Andréjak, C., Veziris, N., Lescure, X., Cadranel, J. and Jounieaux, V. (2012). Essai CaMoMy : évaluation de la capacité de deux schémas thérapeutiques (Clarithromycine ou Moxifloxacine) à négativer les cultures à six mois de malades porteurs d’une infection pulmonaire à Mycobacterium xenopi. PHRC national 2010. Revue des Maladies Respiratoires 29, Supplement 1, A25, http://doi.org/10.1016/j.rmr.2011.10.030.
Bussone, G., Brossier, F., Roudiere, L., Bille, E., Sekkal, N., Charlier, C., Gilquin, J., Lanternier, F., Lecuit, M., Lortholary, O. and Catherinot, E. (2012). Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapy. Journal of Infection 64, 613–617, http://doi.org/10.1016/j.jinf.2011.12.020.
Prevotat, A., Bonne, S., Veziris, N., Senneville, E., Yazdanpanah, Y. and Legout, L. (2011). [Mycobacterium abscessus pulmonary infection treated with tigecyclin-amikacin and cefoxitin in a diabetic patient]. Med Mal Infect 41, 446–448, http://doi.org/10.1016/j.medmal.2011.02.011.
Radomski, N., Betelli, L., Moilleron, R., Haenn, S., Moulin, L., Cambau, E., Rocher, V., Gonçalves, A. and Lucas, F. S. (2011). Mycobacterium Behavior in Wastewater Treatment Plant, A Bacterial Model Distinct From Escherichia coli and Enterococci. Environ Sci Technol 45, 5380–5386, http://doi.org/10.1021/es104084c.
Macheras, E., Roux, A.-L., Bastian, S., Leão, S. C., Palaci, M., Sivadon-Tardy, V., Gutierrez, C., Richter, E., Rüsch-Gerdes, S., Pfyffer, G., Bodmer, T., Cambau, E., Gaillard, J.-L. and Heym, B. (2011). Multilocus Sequence Analysis and rpoB Sequencing of Mycobacterium abscessus (Sensu Lato) Strains. J Clin Microbiol 49, 491–499, http://doi.org/10.1128/JCM.01274-10.
Bastian, S., Veziris, N., Roux, A.-L., Brossier, F., Gaillard, J.-L., Jarlier, V. and Cambau, E. (2011). Assessment of Clarithromycin Susceptibility in Strains Belonging to the Mycobacterium abscessus Group by erm(41) and rrl Sequencing. Antimicrob Agents Chemother 55, 775–781, http://doi.org/10.1128/AAC.00861-10.
Cribier, B., Aubry, A., Caumes, E., Cambau, E., Jarlier, V. and Chosidow, O. (2011). [Histopathological study of Mycobacterium marinum infection]. Ann Dermatol Venereol 138, 17–22, http://doi.org/10.1016/j.annder.2010.10.025.
Ali, M. A., Bastian, S., Ismail, R., Choon, T. S., Ali, S., Aubry, A., Pandian, S., Saraswat, P., Singh, A. and Gaur, R. (2011). Discovery of novel methanone derivatives acting as antimycobacterial agents. Journal of Enzyme Inhibition and Medicinal Chemistry 26, 890–894, http://doi.org/10.3109/14756366.2011.559945.
Couderc, C., Carbonne, A., Thiolet, J. M., Brossier, F., Savey, A., Bernet, C., Ortmans, C., Lecadet-Morin, C., Coudière, I., Aggoune, M., Astagneau, P., Coignard, B. and Cambau, E. (2011). Infections à mycobactéries atypiques liées à des soins esthétiques en France, 2001–2010. Médecine et Maladies Infectieuses 41, 379–383, http://doi.org/10.1016/j.medmal.2011.02.007.
Lerat, I., Truffot, C. and Veziris, N. (2011). Infections à Mycobacterium abscessus : épidémiologie, aspects cliniques et traitement. Journal des Anti-infectieux 13, 49–55.
Radomski, N., Cambau, E., Moulin, L., Haenn, S., Moilleron, R. and Lucas, F. S. (2010). Comparison of Culture Methods for Isolation of Nontuberculous Mycobacteria from Surface Waters. Appl Environ Microbiol 76, 3514–3520, http://doi.org/10.1128/AEM.02659-09.
Bastian, S., Brossier, F., Wichlacz, C., Jarlier, V. and Veziris, N. (2010). Daptomycin is not active against rapidly growing mycobacteria. J Med Microbiol 59, 135–136, http://doi.org/10.1099/jmm.0.014274-0.
Marsollier, L., Aubry, A., Carbonnelle, E., Canaan, S., Cambau, E. and Herrmann, J.-L. (2010). Les Mycobactérioses cutanées dues à Mycobacterium ulcerans, Mycobacterium marinum, Mycobacterium abscessus, Mycobacterium chelonae et autres mycobactéries non tuberculeuses, L’Encyclopédie Médico-chirurgicale.
Cambau, E. and Aubry, A. (2010). Mycobacterium marinum. In: Tuberculosis, McGraw-Hill Professional Medical Publishing Division.
Carbonne, A., Brossier, F., Arnaud, I., Bougmiza, I., Caumes, E., Meningaud, J.-P., Dubrou, S., Jarlier, V., Cambau, E. and Astagneau, P. (2009). Outbreak of Nontuberculous Mycobacterial Subcutaneous Infections Related to Multiple Mesotherapy Injections. J Clin Microbiol 47, 1961–1964, http://doi.org/10.1128/JCM.00196-09.
Veziris, N., Aubry, A., Robert, J., Cambau, E., Jarlier, V. and Truffot-Pernot, C. (2009). Mycobacteria. In: Antibiogram, Eska and ASM editors.
Régnier, S., Martinez, V., Veziris, N., Bonvallot, T., Meningaud, J.-P. and Caumes, E. (2008). [Treatment of cutaneous infections due to Mycobacterium fortuitum: two cases]. Ann Dermatol Venereol 135, 591–595, http://doi.org/10.1016/j.annder.2008.03.029.