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Publications du CNR en 2025

1368488 2025 1 heidelberg-university-faculty-of-medicine 50 creator asc year 1 1723 https://cnrmyrma.fr/wp-content/plugins/zotpress/
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Bonnet, I., Orgeur, M., Brossier, F., Sayes, F., Frigui, W., Madacki, J., Varet, H., Chauffour, A., Aubry, A., Veziris, N., Sougakoff, W., Brosch, R. and Tournebize, R. (2025). Evaluation of the role of whiB6 and kdpDE in the dominant multidrug-resistant clone Mycobacterium tuberculosis B0/W148 Ed. Doucet-Populaire, F. C. Microbiol Spectr e03224-24, http://doi.org/10.1128/spectrum.03224-24.
Chauffour, A., Cambau, E., Pethe, K., Veziris, N. and Aubry, A. (2025). Unprecedented in vivo activity of telacebec against Mycobacterium leprae Ed. Steinmann, P. PLoS Negl Trop Dis 19, e0013076, http://doi.org/10.1371/journal.pntd.0013076.
Fomba, A., Haidara, F. C., Kodio, M., Arama, C., Cambau, E., Chauffour, A., Veziris, N., Broeckling, B. E., Warren, A. K., Cauchoix, B., Alcaïs, A., Marsollier, L., Assé, H., Jackson, M., Sow, S. O., Faye, O., Jarlier, V., Cole, S. T., Avanzi, C., Aubry, A. and Johnson, R. C. (2025). Bedaquiline Activity against Leprosy. New England Journal of Medicine 392, 2174–2176, http://doi.org/10.1056/NEJMc2412487.
Fouchet, T., Nait Chabane, M., Allam, C., Awad, Z., Mougari, F., Hartmann, A., Rochelet, M. and Cambau, E. (2025). Clinical evaluation of the diagnostic performances and treatment monitoring of the new PATHFAST TB LAM Ag assay in sputum specimens of patients with tuberculosis or with nontuberculous mycobacteria pulmonary disease Ed. Miller, M. B. J Clin Microbiol 63, e01269-25, http://doi.org/10.1128/jcm.01269-25.
Gerussi, V., Petersen, T., Bonnet, I., Aubry, A., Bachir, M., Gyde, E., Morel, F., Poignon, C., Rached, B., Pourcher, V., Rioux, C., Vallois, D., Veziris, N., Robert, J. and Guglielmetti, L. (2025). Evaluation of High-Dose Isoniazid in Multidrug-Resistant Tuberculosis Treatment. Emerg Infect Dis 31, http://doi.org/10.3201/eid3103.241473.
Goletti, D., Banaei, N., Batra, R., Berger, A. E., Blazevic, A., Botelho-Nevers, E., Breen, R., Bruiners, N., Cambau, E., Carbonnelle, E., Daley, C. L., Descotes-Genon, C., Gennaro, F. D., Doucet-Populaire, F., Esmail, A., Guzman, J. D. E., Fontana, L., Gennaro, M. L., Handler, D., Torres, R. M. H., Hoft, D., Ismail, N., Isnard, M., Kenny, J., Lardizabal, A., Lesage, F. X., Lopes, A., Vidal, W. L. L., Contreras, R. M., Manivet, P., Marotte, H., Méchaï, F., Medjahed-Artebasse, A., Meldau, R., Mérieux, Y., Morel, J., Mougari, F., Oelofse, S., Palmieri, F., Perrot, J. L., Petruccioli, E., Pride, D. T., Tuaillon, E., Upton, C., Vanker, N. and Dheda, K. (2025). Accuracy of VIDAS® TB-IGRA in TB patients and individuals with different thresholds of exposure. International Journal of Infectious Diseases 108318, http://doi.org/10.1016/j.ijid.2025.108318.
Guglielmetti, L., Khan, U., Velásquez, G. E., Gouillou, M., Abubakirov, A., Baudin, E., Berikova, E., Berry, C., Bonnet, M., Cellamare, M., Chavan, V., Cox, V., Dakenova, Z., De Jong, B. C., Ferlazzo, G., Karabayev, A., Kirakosyan, O., Kiria, N., Kunda, M., Lachenal, N., Lecca, L., McIlleron, H., Motta, I., Toscano, S. M., Mushtaque, H., Nahid, P., Oyewusi, L., Panda, S., Patil, S., Phillips, P. P. J., Ruiz, J., Salahuddin, N., Garavito, E. S., Seung, K. J., Ticona, E., Trippa, L., Vasquez, D. E. V., Wasserman, S., Rich, M. L., Varaine, F. and Mitnick, C. D. (2025). Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis. N Engl J Med 392, 468–482, http://doi.org/10.1056/NEJMoa2400327.
Guglielmetti, L., Panda, S., Abubakirov, A., Salahuddin, N., Perrin, C. and Mitnick, C. D. (2025). Equitable, personalised medicine for tuberculosis: treating patients, not diseases. The Lancet Respiratory Medicine 13, 382–385, http://doi.org/10.1016/S2213-2600(25)00080-3.
Guglielmetti, L., Khan, U., Velásquez, G. E., Gouillou, M., Ali, M. H., Amjad, S., Kamal, F., Abubakirov, A., Ardizzoni, E., Baudin, E., Bektassov, S., Berry, C., Bonnet, M., Chavan, V., Coutisson, S., Dakenova, Z., de Jong, B. C., Dinh, L. V., Ferlazzo, G., Kirakosyan, O., Lachenal, N., Lecca, L., McIlleron, H., Mikanda, K. K., Mucching-Toscano, S., Mulders, W., Mushtaque, H., Nahid, P., Nguyen, D. V., Nguyen, N. V., Oyewusi, L., Motta, I., Panda, S., Patil, Sandip, Pham, T. H., Phan, D. T., Phan, H. T. T., Phillips, P. P. J., Ruiz, J., Rupasinghe, Praharshinie, Salahuddin, N., Sanchez-Garavito, E., Seung, K. J., Asfaw, M. T., Vargas Vasquez, D., Rich, M. L., Varaine, F., Mitnick, C. D., Arora, G., Ashara, V., Bhattacharjee, S., Borkar, R., Chincholikar, N., Choudhary, N., Davuluri, P., Desai, N., Dipika, Dhongade, S., Dulani, D., Ghule, S., Hirani, N., Hurali, P., Irani, R., Jadhav, K., Jadhav, P., Jadhav, R., Joseph, N., Joshi, A., Joshi, P., K, A., K, S., Kamble, M., Kate, R., Keer, T., S Kenche, M., Khandare, H., Koli, P., Kulkarni, A., Patra, S. K., Kuwar, A., Lande, P., Mane, N., Masalge, P., Mishra, P., Mitkari, R., More, A., Munot, P., Murgesh, R., Muthe, S., Nakashe, N., Natarajan, D., Paril, S., Patil, Supriya, Patil, V., Patwardhan, V., Posture, V., Pradeshi, A., Prasad, V., Pundir, B., Rajendran, S., Randhit, Y., Rekart, M., Samant, P., Shaikh, H., Sharma, A., Sharma, N., Sharma, S., Shinde, N., Shinde, S., Shingare, G., Shulka, A., Shriwas, A., Sonawane, L., Sudhindra, U., Suryavanshi, D., Thakare, A., Udare, D., Vaidya, G., Wagh, R., Isenova, L., Konigratbayeva, G., Nurtayeva, G., Zekeshov, N., Chenu, R., Garba, S., Tozzi, D., Yuya-Septoh, F.-J., Thi Tuyet Mai, B., Thi Hai, D., Thi Thuy, D., Thi Oanh, L., Do, B. T., Nguyen, D. T., Nguyen, P. H., Nguyen, T. M. A., Nguyen, Thi Thuy Hanh, Nguyen, T. K. N., Nguyen, T. N., Nguyen, V. K., Nog, N., Pham, T. N., Pham, T. L., Pham, T. A., Phung, T. B., Tran, B. T., Trinh, M. T., Chang, E., Coit, J., Do, J.-M., LaHood, A., O’Brien, K., Okunbor, E., Osso, E., Chávez, V., Larco, P., Mendoza, D., Robles, C., Rojas, A., Salazar, J., Santos, G., Sosa, J., Ticona, C., Carranza, S., Delgado, D., Galarza, C., Murga, G., Ramos, E., Cantaro, K., Huerta, A., Maldonado, J., Nuñez, R., Panduro, K., Rafael, R., Abdul, A., Abedin, S., Afreen, E., Ahmed, Sohail, Ahmed, U., Ali Shah, J., Ashraf, A., Aslam, F., Bashir, Z., Fayyaz, S., Hafeez, K., Hamid, M., Hassan, B., Hussain, M., Irfan, M., Omar, M., Parveen, S., Sunail, S., Farooq, M., Mazhar, B., Munir, S., Sonia, N., Yaseen, M., Zubair, M., Zehra, F., Zulfiqar, I., Abbasi, T., Akbar Abro, G., Ahmed, M., Ahmed, N., Hammad Ali, M., Ali, N., Danish, R., Farhat, A., Gill, S., Hafeez, M., Hussain, G., Inayat, H., Johnson, S., Kamal, F., Kamran, A., Kumar, Sanjeet, Maheshwari, M., Mamsa, S., Massey, S., Mehmood, A., Memon, A., Ali Mirani, A., Naz, S., Rafique Qureshi, T., Roop Moazzam Sheikh, Y., Rafi Siddiqui, M., Singh, B., Soomro, M., Ardizzoni, E., Rigouts, L., Rupasinghe, Praha, Aftab, A., Ahmed, Saman, Adnan Alamgir, M., Ali, Ayaz, Ali, Azhar, Ahmed Ali, S., Ali, S., Altaf, S., Amjad, S., Sahiba Arshad, M., Ausim, S., Basit, A., Ezik, H., Hussain, H., Hyder, S., Inayat, S., Janmohammed, A., Jaseem, K., Jawed, A., Maniar, L., Kumar, P., Kumar, Susheel, Latif, R., Liaqat, S., Ammar Nasser, M., Shakeel, M., Shaikh, S., Siddiqui, A., Singh, J., Sivan, K., Taimoor, M., Zia, N., Li, I., Otepbergenova, M., Dinh, T. H., Do, Thi Thu, Do, Thu Thuong, Le, T. N., Nguyen, K. C., Nguyen, T. T., Nguyen, V. H., Abildayeva, G., Maryash, O., Telegina, E., Tursynbekova, L., Amanzholova, Z., Bektassova, P., Belgozhanova, A., Birimkulova, N., Dyusebayeva, N., Erkut, N., Gusmanov, A., Kassenova, B., Kassym, A., Khazhidinov, K., Lee, T., Magzumova, A., Mussabayeva, M., Omarova, G., Ryapolova, N., Sagyndykova, L., Serekbay, A., Stambekova, A., Tanatarova, G., Uaisov, Z., Zhantuarova, Z., Zhumakairova, G., Arlyapova, N., Bogus, J., Cain, M., Carmona, M., Flanagan, C., McAnaw, S., Scharff, A., Soni, S., Striplin, M., Abebe, S., Alakaye, J., Bulane, A., Custodio, M., Hajison, P., Hetsa, M., Holtzman, D., Khesa, M., Lethola, M., Lebitsa, T., Mahamo, M., Makaka, J., Matoko, M., Mpinda, S., Mohoang, P., Monyaesa, D., Nkundayirazo, P., Ntsane Sesomo Mohale, M., Ntsibane, S., Phate, S., Radebe (Retsepile Tlali), M., Rakhetsi, M., Ranoosi, T., Tamirat, M., Thokoana, M., Alegre, E., Aguilar, C., Armuto, L., Barreda, N., Barreto, M., Cabrera, S., Calderon, R., Castro, M., Chavez, J., Chavez, L., Cheje, H., Cori, L., Dávalos, D., de la Gala, S., Delgadillo, K., Diaz, H., Flores, X., Galarza, J., García, D., Garcia, F., Gaspar, M., Godos, R., Gomez, P., Gonzales, L., Guerrero, L., Inga, S., Jasaycucho, J., Martel, B., Pro Martinez, A., Molina, R., Mugruza, R., Mundaca, H., Nuahan, M., Ore, K., Panduro, L., Peña, O., Perea, S., Pinedo, C., Ponce, Y., Quinte, C., Quiñones, M., Ramos, A., Ramirez, E., Reynoso, R., Reyes, C., Reyes, J., Riccio, V., Robles, B., Rojas, K., Sanabria, O., Saravia, M., Saravia, S., Senador, L., Soberon, J., Soncco, E., Soto, M., Suarez, C., Suarez, M., Suarez, V., Torpoco, E., Torres, O., Torrez, C., Tunque, G., Ugarte, A., Vaderrama, G., Valdivia, W., Valdivia, Y., Valverde, I., Vargas, C., Vargas, J., Vasquez, E., Veliz, J., Villa, D., Villafuerte, S., Villar, G., Villegas, S., Wong, M., Yataco, R., Pham, H., Truong, H., Nguyen, H., Huy, V., Nguyen, V. S., Nguyen, T. M. K., Minh, T., Bui, D. T. T., Truong, V. V., Nguyen, Thi Thu Ha, Coutisson, S., Atger, M., Nadia Baya, S., Bekhiet, M., Boissière, V., Caboclo, R., Chaudhry, M., Cloez, S., Collin, S., Delifer, C., Demaisons, S., Ducher, V., Hewison, C., Ibrahim, M., Lebeau, K., Mazmanian, M., Mirzayeva, R., Moreau, M., Moschioni, M., Pâquet, A., Perrin, C., Pichon, L., Roussel, J., Scotton, M., Austin, A. and Sun, P. (2025). Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial. The Lancet Respiratory Medicine, http://doi.org/10.1016/S2213-2600(25)00194-8.
Guthmann, J.-P., Robert, J., Viriot, D. and Parent Du Chatelet, I. (2025). Incidence, severity and treatment outcome of tuberculosis in the era of the COVID-19 pandemic, France, 2018–2023. Journal of Epidemiology and Population Health 73, 202795, http://doi.org/10.1016/j.jeph.2024.202795.
Hillemann, D., Cambau, E., Polsfuß, S. and Friesen, I. (2025). Comparison of a modified broth microdilution SensititreTM SLOMYCOI assay with the CLSI-recommended agar disk elution method for antimicrobial susceptibility testing of Mycobacterium haemophilum. Journal of Antimicrobial Chemotherapy 80, 1993–1996, http://doi.org/10.1093/jac/dkaf162.
Kherabi, Y., Skouvig Pedersen, O., Lange, C., Bénézit, F., Chesov, D., Codecasa, L. R., Dudnyk, A., Kiria, N., Konstantynovska, O., Marigot-Outtandy, D., Panciu, T.-C., Poignon, C., Sasi, S., Schaub, D., Solodovnikova, V., Vasiliauskaitè, L., Yeghiazaryan, L., Günther, G., Guglielmetti, L. and TBnet/ESGMYC XDR-TB Study Group (2025). Treatment outcomes of extensively drug-resistant tuberculosis in Europe: a retrospective cohort study. Lancet Reg Health Eur 56, 101380, http://doi.org/10.1016/j.lanepe.2025.101380.
Kuksa, L., Andrejak, C., Haecker, B., Bothamley, G., Calcagno, A., Cirillo, D. M., Duarte, R., Fatima, R., Ferlazzo, G., Guglielmetti, L., Günther, G., Hewison, C., Horsburgh, C. R., Jäger, T., Kalancha, Y., Otto-Knapp, R., Kranzer, K., Lillebaek, T., Marks, G., Middelkoop, K., Motta, I., Rabinova, V., Sommerfeld, P., Tattevin, P. and Lange, C. (2025). Urgent request for pretomanid label expansion to align with WHO guidelines and improve treatment accessibility and efficacy. IJTLD OPEN 2, 117–119, http://doi.org/10.5588/ijtldopen.25.0152.
Lange, C., Bothamley, G., Günther, G., Guglielmetti, L., Kontsevaya, I., Kuksa, L., Lange, B., Lorent, N., Saluzzo, F., Sester, M., Tebruegge, M., Tunesi, S. and Tweed, C. (2025). A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2025 Update for Clinicians and Scientists. PAI 10, 1–45, http://doi.org/10.20411/pai.v10i2.791.
Méchaï, F., Beugre, E., Billard-Pomares, T., Mougari, F., Wyplosz, B., Cambau, E. and Vignier, N. (2025). Usefulness of the GeneXpert MTB/RIF Ct for predicting tuberculosis infectiousness. Infectious Diseases Now 55, 105061, http://doi.org/10.1016/j.idnow.2025.105061.
Sadowski, E., Pietrancosta, N., Veyron-Churlet, R., Boucher, J.-L., Pionneau, C., Clodic, G., Matheron, L., Poch, O., Mayer, C., Sachon, E. and Aubry, A. (2025). Characterization of the Orphan Cytochrome P450 CYP135B1 from Mycobacterium tuberculosis : Involvement in Metabolism but Not in the Antibacterial Activity of the Antitubercular Drug SQ109. ACS Infect Dis 11, 869–881, http://doi.org/10.1021/acsinfecdis.4c00893.
Seddon, J. A., Achar, J., Malik, A. A., Hughes, J., Burzynski, J., Chen, C., Denholm, J. T., Dravniece, G., Fox, G. J., Furin, J., Geliukh, E., Goncharova, O., Guglielmetti, L., Harries, A. D., Hesseling, A. C., Nguyen, B. H., Kavenga, F., Khan, U., Kherabi, Y., Kiria, N., Kock, Y., Liu, Q., Mesic, A., Moore, D. A. J., Mubanga, A., Naidoo, L., Nilsen, D., Piubello, A., Reuter, A., Rich, M. L., Satyanarayana, S., Schaaf, H. S., Schoeman, I., Skrahina, A., Udwadia, Z., Khan, P. Y., Esmail, H. and Martinez, L. (2025). Management of individuals exposed to multidrug-resistant or rifampicin-resistant tuberculosis. The Lancet Infectious Diseases, http://doi.org/10.1016/S1473-3099(25)00157-4.
Serge Diagbouga, P., Djibougou, A. D., Pease, C., Alcaide, A., Berthoux, A., Bruiners, N., Cirillo, D. M., Combary, A., Falchero, N., Handler, D., Kaboré, A., Lardizabal, A., Lopes, A., Loubet, M., Manivet, P., Margain, C., Meunier, V., Mougari, F., Onyuka, A., Rivoiron, S., Sagna, T., Sanvert, M., Sawadogo, L., Simporé, J., Cambau, E. and Gennaro, M. L. (2025). Preliminary performance of the VIDAS TB-IGRA as an aid in the diagnosis of individuals infected with Mycobacterium tuberculosis Ed. Miller, M. B. J Clin Microbiol 63, e01641-24, http://doi.org/10.1128/jcm.01641-24.
Soutou, M. A., Allam, C., Abi Fadel, M., Najjar, J., Guyeux, C., Cambau, E. and Sola, C. (2025). An insight into the characterization of L2 Beijing multi-drug resistant tuberculosis: Description of resistance-associated-variants and discovery of Modern 7 L2 sublineage. Infection, Genetics and Evolution 134, 105797, http://doi.org/10.1016/j.meegid.2025.105797.
Verma, A. K., Kim, R. Q., Lamprecht, D. A., Aguilar-Pérez, C., Wong, S., Veziris, N., Aubry, A., Bartolomé-Nebreda, J. M., Carbajo, R. J., Wetzel, J. and Lamers, M. H. (2025). Structural and mechanistic study of a novel inhibitor analogue of M. tuberculosis cytochrome bc1:aa3. npj Drug Discov 2, 6, http://doi.org/10.1038/s44386-025-00008-3.

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    1368488 2024 1 heidelberg-university-faculty-of-medicine 50 creator asc year 1 1541 https://cnrmyrma.fr/wp-content/plugins/zotpress/
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    Kikhney, J., Friesen, I., Wiesener, S., Kursawe, L., Loddenkemper, C., Zündorf, J., Häuser, B., Cónsul Tejero, E. P., Schöning, D. V., Sarbandi, K., Hillemann, D., Kuhns, M., Stegemann, M. S., Pfäfflin, F., Klefisch, F.-R., Düsterhöft, V., Haller, S., Laer, A. V., Eckmanns, T., Cambau, E., Tschudin-Sutter, S., Hasse, B., Friedrichs, A., Panholzer, B., Eichinger, W., Gastmeier, P., Falk, V. and Moter, A. (2024). Endocarditis associated with contamination of cardiovascular bioprostheses with Mycobacterium chelonae: a collaborative microbiological study. The Lancet Microbe 5, 100934, http://doi.org/10.1016/j.lanmic.2024.06.001.
    Kunst, H., Lange, B., Hovardovska, O., Bockey, A., Zenner, D., Andersen, A. B., Hargreaves, S., Pareek, M., Friedland, J. S., Wejse, C., Bothamley, G., Guglielmetti, L., Chesov, D., Tiberi, S., Matteelli, A., Mandalakas, A. M., Heyckendorf, J., Eimer, J., Malhotra, A., Zamora, J., Vasiliu, A., Lange, C. and for the TBnet (2024). Tuberculosis in adult migrants in Europe: a TBnet consensus statement. Eur Respir J 2401612, http://doi.org/10.1183/13993003.01612-2024.
    Lange, C., Kherabi, Y., Guglielmetti, L., Duarte, R. and Günther, G. (2024). Availability of drugs and resistance testing for bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL(M)) regimen for rifampicin-resistant tuberculosis in Europe: author’s response. Clinical Microbiology and Infection 30, 1207–1208, http://doi.org/10.1016/j.cmi.2024.06.009.
    Leymarie, A., Thibon, P., Bernigaud, C., Daurel, C., Ouedraogo, E., Lheure, C., Lemaitre, N., Cribier, B., Calugareanu, A., Ducroux, E., Baron, S., Vanhaecke, C., Lehericey, M., Goujon, E., Allard, T., Fouéré, S., Dompmartin, A., Chosidow, O., Robert, J., Cambau, E., Dupin, N., Verdon, R., Kottler, D. and for Gr/IDIST (Groupe Infectiologie Dermatologique et Infections Sexuellement Transmissibles) (2024). Mycobacterium chelonae cutaneous infections unrelated to invasive procedures: A multicentre retrospective case series. Acad Dermatol Venereol jdv.20521, http://doi.org/10.1111/jdv.20521.
    Loebinger, M. R., Aliberti, S., Haworth, C., Jankovic Makek, M., Lange, C., Lorent, N., Papavasileiou, A., Polverino, E., Rohde, G., Veziris, N., Wagner, D. and Van Ingen, J. (2024). Patients at risk of nontuberculous mycobacterial pulmonary disease who need testing evaluated using a modified Delphi process by European experts. ERJ Open Res 10, 00791–02023, http://doi.org/10.1183/23120541.00791-2023.
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