Catégories
Documents Tout le CNR-MyRMA

Publications – Lèpre

1368488 leprae 1 heidelberg-university-faculty-of-medicine 50 date desc 1 264 https://cnrmyrma.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A50%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22K52S8828%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fomba%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFomba%2C%20A.%2C%20Haidara%2C%20F.%20C.%2C%20Kodio%2C%20M.%2C%20Arama%2C%20C.%2C%20Cambau%2C%20E.%2C%20Chauffour%2C%20A.%2C%20Veziris%2C%20N.%2C%20Broeckling%2C%20B.%20E.%2C%20Warren%2C%20A.%20K.%2C%20Cauchoix%2C%20B.%2C%20Alca%26%23xEF%3Bs%2C%20A.%2C%20Marsollier%2C%20L.%2C%20Ass%26%23xE9%3B%2C%20H.%2C%20Jackson%2C%20M.%2C%20Sow%2C%20S.%20O.%2C%20Faye%2C%20O.%2C%20Jarlier%2C%20V.%2C%20Cole%2C%20S.%20T.%2C%20Avanzi%2C%20C.%2C%20Aubry%2C%20A.%20and%20Johnson%2C%20R.%20C.%20%282025%29.%20%26lt%3Bb%26gt%3BBedaquiline%20Activity%20against%20Leprosy%26lt%3B%5C%2Fb%26gt%3B.%20New%20England%20Journal%20of%20Medicine%20%26lt%3Bi%26gt%3B392%26lt%3B%5C%2Fi%26gt%3B%2C%202174%26%23x2013%3B2176%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1056%5C%2FNEJMc2412487%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1056%5C%2FNEJMc2412487%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bedaquiline%20Activity%20against%20Leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdoulaye%22%2C%22lastName%22%3A%22Fomba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fadima%20C.%22%2C%22lastName%22%3A%22Haidara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamoudou%22%2C%22lastName%22%3A%22Kodio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Arama%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bettina%20E.%22%2C%22lastName%22%3A%22Broeckling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alaine%20K.%22%2C%22lastName%22%3A%22Warren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Cauchoix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Alca%5Cu00efs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Marsollier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henri%22%2C%22lastName%22%3A%22Ass%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary%22%2C%22lastName%22%3A%22Jackson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samba%20Ousmane%22%2C%22lastName%22%3A%22Sow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ousmane%22%2C%22lastName%22%3A%22Faye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stewart%20T.%22%2C%22lastName%22%3A%22Cole%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Avanzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roch%20C.%22%2C%22lastName%22%3A%22Johnson%22%7D%5D%2C%22abstractNote%22%3A%22In%20this%20report%2C%2030%20patients%20in%20Mali%20with%20untreated%20multibacillary%20leprosy%20were%20treated%20with%20bedaquiline%20for%208%20weeks%2C%20followed%20by%20standard%20multidrug%20therapy.%20Cultures%20were%20cleared%20in%20all%20the%20patients%20with%20bedaquiline%20therapy.%22%2C%22date%22%3A%222025-06-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1056%5C%2FNEJMc2412487%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nejm.org%5C%2Fdoi%5C%2Ffull%5C%2F10.1056%5C%2FNEJMc2412487%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220028-4793%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-06-07T08%3A23%3A39Z%22%7D%7D%2C%7B%22key%22%3A%223GKCD4HL%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chauffour%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-08%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChauffour%2C%20A.%2C%20Cambau%2C%20E.%2C%20Pethe%2C%20K.%2C%20Veziris%2C%20N.%20and%20Aubry%2C%20A.%20%282025%29.%20%26lt%3Bb%26gt%3BUnprecedented%20in%20vivo%20activity%20of%20telacebec%20against%20Mycobacterium%20leprae%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Steinmann%2C%20P.%20PLoS%20Negl%20Trop%20Dis%20%26lt%3Bi%26gt%3B19%26lt%3B%5C%2Fi%26gt%3B%2C%20e0013076%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0013076%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0013076%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Unprecedented%20in%20vivo%20activity%20of%20telacebec%20against%20Mycobacterium%20leprae%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Pethe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Steinmann%22%7D%5D%2C%22abstractNote%22%3A%22Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20New%20drugs%20targeting%20the%20electron%20transport%20chain%20%28ETC%29%20seem%20to%20be%20a%20promising%20advance%20in%20leprosy%20treatment.%20In%20this%20study%2C%20we%20evaluated%20the%20bactericidal%20activity%20of%20telacebec%20%28TCB%29%2C%20a%20phase%202%20drug%20candidate%20for%20tuberculosis%2C%20alongside%20known%20ETC-targeting%20antibiotics%2C%20bedaquiline%20%28BDQ%29%20and%20clofazimine%20%28CFZ%29%2C%20as%20monotherapy%20or%20in%20combination.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methodology%5C%2F%20Principal%20Findings%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20used%20the%20reference%20leprosy%20proportional%20bactericidal%20mouse%20footpad%20model.%20Four%20hundred%20and%20ten%20mice%20were%20inoculated%20in%20the%20footpads%20with%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%204%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20to%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20bacilli%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20strain%20THAI53%20for%20the%20untreated%20control%20group%20and%20groups%20treated%20with%20drug-monotherapies%2C%20and%20with%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%204%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20to%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20for%20groups%20treated%20with%20drug-combinations.%20Mice%20were%20randomly%20allocated%20into%20the%20following%20groups%3A%202%20control%20groups%20%28untreated%20or%20standard%20multi%20drug%20therapy%20%28MDT%29%2C%20rifampin%2C%20dapsone%20and%20clofazimine%20with%20dosing%20equipotent%20to%20human%20dosing%29%20and%207%20test%20groups%20%28TCB%2010mg%5C%2Fkg%2C%20bedaquiline%2025mg%5C%2Fkg%20%28BDQ%29%2C%20clofazimine%2020mg%5C%2Fkg%20%28CFZ%29%2C%20CFZ%5Cu2009%2B%5Cu2009BDQ%2C%20TCB%5Cu2009%2B%5Cu2009BDQ%2C%20TCB%5Cu2009%2B%5Cu2009CFZ%2C%20TCB%5Cu2009%2B%5Cu2009CFZ%5Cu2009%2B%5Cu2009BDQ%29.%20Mice%20in%20the%20test%20groups%20received%20either%20one%20month%20treatment%20%28MDT%29%20or%20a%20single%20dose%20of%20the%20drugs%20%28TCB%2C%20RIF%2C%20BDQ%2C%20CFZ%29.%20Twelve%20months%20later%2C%20mice%20were%20sacrificed%20to%20enumerate%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20bacilli%20in%20the%20footpad.%20All%20the%20footpads%20became%20negative%20in%20the%20MDT%2C%20TCB%20and%20combination%20groups%20except%20in%20the%20TCB%5Cu2009%2B%5Cu2009CFZ%20group%20where%202%20mice%20remained%20positive%20in%20the%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%204%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20inoculum.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20demonstrated%20that%20monotherapy%20of%20TCB%20exhibited%20bactericidal%20activity%20against%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20comparable%20to%20that%20of%20MDT%20and%20that%20all%20combination%20therapies%20were%20as%20effective%20as%20MDT%2C%20except%20the%20combination%20TCB%5Cu2009%2B%5Cu2009CFZ%2C%20possibly%20due%20to%20an%20antagonism%20between%20these%20two%20drugs.%22%2C%22date%22%3A%222025-5-8%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0013076%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pntd.0013076%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221935-2735%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-05-09T12%3A31%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22RHQIETLY%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hasker%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHasker%2C%20E.%2C%20Assoumani%2C%20Y.%2C%20Randrianantoandro%2C%20A.%2C%20Ramboarina%2C%20S.%2C%20Braet%2C%20S.%20M.%2C%20Cauchoix%2C%20B.%2C%20Baco%2C%20A.%2C%20Mzembaba%2C%20A.%2C%20Salim%2C%20Z.%2C%20Amidy%2C%20M.%2C%20Grillone%2C%20S.%2C%20Attoumani%2C%20N.%2C%20Grillone%2C%20S.%20H.%2C%20Ronse%2C%20M.%2C%20Peeters%20Grietens%2C%20K.%2C%20Rakoto-Andrianarivelo%2C%20M.%2C%20Harinjatovo%2C%20H.%2C%20Supply%2C%20P.%2C%20Snijders%2C%20R.%2C%20Hoof%2C%20C.%2C%20Tsoumanis%2C%20A.%2C%20Suffys%2C%20P.%2C%20Rasamoelina%2C%20T.%2C%20Corstjens%2C%20P.%2C%20Ortuno-Gutierrez%2C%20N.%2C%20Geluk%2C%20A.%2C%20Cambau%2C%20E.%20and%20De%20Jong%2C%20B.%20C.%20%282024%29.%20%26lt%3Bb%26gt%3BPost-exposure%20prophylaxis%20in%20leprosy%20%28PEOPLE%29%3A%20a%20cluster%20randomised%20trial%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Global%20Health%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%2C%20e1017%26%23x2013%3Be1026%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2214-109X%2824%2900062-7%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2214-109X%2824%2900062-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Post-exposure%20prophylaxis%20in%20leprosy%20%28PEOPLE%29%3A%20a%20cluster%20randomised%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Epco%22%2C%22lastName%22%3A%22Hasker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Younoussa%22%2C%22lastName%22%3A%22Assoumani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andriamira%22%2C%22lastName%22%3A%22Randrianantoandro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Ramboarina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sofie%20Marijke%22%2C%22lastName%22%3A%22Braet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Cauchoix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdallah%22%2C%22lastName%22%3A%22Baco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aboubacar%22%2C%22lastName%22%3A%22Mzembaba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zahara%22%2C%22lastName%22%3A%22Salim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohammed%22%2C%22lastName%22%3A%22Amidy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saverio%22%2C%22lastName%22%3A%22Grillone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nissad%22%2C%22lastName%22%3A%22Attoumani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sillahi%20Halifa%22%2C%22lastName%22%3A%22Grillone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maya%22%2C%22lastName%22%3A%22Ronse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Koen%22%2C%22lastName%22%3A%22Peeters%20Grietens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mala%22%2C%22lastName%22%3A%22Rakoto-Andrianarivelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanitra%22%2C%22lastName%22%3A%22Harinjatovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Supply%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rian%22%2C%22lastName%22%3A%22Snijders%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolien%22%2C%22lastName%22%3A%22Hoof%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Achilleas%22%2C%22lastName%22%3A%22Tsoumanis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Suffys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tahinamandranto%22%2C%22lastName%22%3A%22Rasamoelina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Corstjens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nimer%22%2C%22lastName%22%3A%22Ortuno-Gutierrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annemieke%22%2C%22lastName%22%3A%22Geluk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%20Catharina%22%2C%22lastName%22%3A%22De%20Jong%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2206%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2214-109X%2824%2900062-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2214109X24000627%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222214109X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-07-17T14%3A31%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22FEICKLB8%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mengeot%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMengeot%2C%20L.%2C%20Jachiet%2C%20M.%2C%20Bourrat%2C%20E.%2C%20Mah%26%23xE9%3B%2C%20A.%2C%20Cambau%2C%20E.%2C%20Bernard%2C%20E.%2C%20Pasqualini%2C%20C.%2C%20Chamouine%2C%20A.%2C%20Truong%2C%20J.%2C%20Dumaine%2C%20C.%2C%20Bertolotti%2C%20A.%20and%20Franco%2C%20J.%20%282024%29.%20%26lt%3Bb%26gt%3BEffective%20management%20of%20severe%20chronic%20erythema%20nodosum%20leprosum%20in%20adolescent%20patient%20using%20ustekinumab%20and%20apremilast%3A%20A%20case%20report%26lt%3B%5C%2Fb%26gt%3B.%20Acad%20Dermatol%20Venereol%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjdv.19552%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fjdv.19552%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effective%20management%20of%20severe%20chronic%20erythema%20nodosum%20leprosum%20in%20adolescent%20patient%20using%20ustekinumab%20and%20apremilast%3A%20A%20case%20report%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Mengeot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Jachiet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Bourrat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Mah%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elise%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cassandre%22%2C%22lastName%22%3A%22Pasqualini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdourahim%22%2C%22lastName%22%3A%22Chamouine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanne%22%2C%22lastName%22%3A%22Truong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9cile%22%2C%22lastName%22%3A%22Dumaine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Bertolotti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justine%22%2C%22lastName%22%3A%22Franco%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2203%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fjdv.19552%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1111%5C%2Fjdv.19552%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220926-9959%2C%201468-3083%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-10-22T15%3A12%3A31Z%22%7D%7D%2C%7B%22key%22%3A%22XYNZ7MRL%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chauffour%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-27%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChauffour%2C%20A.%2C%20Lounis%2C%20N.%2C%20Andries%2C%20K.%2C%20Jarlier%2C%20V.%2C%20Veziris%2C%20N.%20and%20Aubry%2C%20A.%20%282023%29.%20%26lt%3Bb%26gt%3BMinimal%20effective%20dose%20of%20bedaquiline%20administered%20orally%20and%20activity%20of%20a%20long%20acting%20formulation%20of%20bedaquiline%20in%20the%20murine%20model%20of%20leprosy%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Converse%2C%20P.%20J.%20PLoS%20Negl%20Trop%20Dis%20%26lt%3Bi%26gt%3B17%26lt%3B%5C%2Fi%26gt%3B%2C%20e0011379%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0011379%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0011379%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Minimal%20effective%20dose%20of%20bedaquiline%20administered%20orally%20and%20activity%20of%20a%20long%20acting%20formulation%20of%20bedaquiline%20in%20the%20murine%20model%20of%20leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nacer%22%2C%22lastName%22%3A%22Lounis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Koen%22%2C%22lastName%22%3A%22Andries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Paul%20J.%22%2C%22lastName%22%3A%22Converse%22%7D%5D%2C%22abstractNote%22%3A%22Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Bedaquiline%20%28BDQ%29%2C%20by%20targeting%20the%20electron%20transport%20chain%20and%20having%20a%20long%20half-life%2C%20is%20a%20good%20candidate%20to%20simplify%20leprosy%20treatment.%20Our%20objectives%20were%20to%20%28i%29%20determine%20the%20minimal%20effective%20dose%20%28MED%29%20of%20BDQ%20administered%20orally%2C%20%28ii%29%20evaluate%20the%20benefit%20of%20combining%20two%20inhibitors%20of%20the%20respiratory%20chain%2C%20BDQ%20administered%20orally%20and%20clofazimine%20%28CFZ%29%29%20and%20%28iii%29%20evaluate%20the%20benefit%20of%20an%20intramuscular%20injectable%20long-acting%20formulation%20of%20BDQ%20%28intramuscular%20BDQ%2C%20BDQ-LA%20IM%29%2C%20in%20a%20murine%20model%20of%20leprosy.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methodology%5C%2FPrincipal%20findings%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20To%20determine%20the%20MED%20of%20BDQ%20administered%20orally%20and%20the%20benefit%20of%20adding%20CFZ%2C%20100%20four-week-old%20female%20nude%20mice%20were%20inoculated%20in%20the%20footpads%20with%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%203%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20bacilli%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20strain%20THAI53.%20Mice%20were%20randomly%20allocated%20into%3A%201%20untreated%20group%2C%205%20groups%20treated%20with%20BDQ%20administered%20orally%20%280.10%20to%2025%20mg%5C%2Fkg%29%2C%203%20groups%20treated%20with%20CFZ%2020%20mg%5C%2Fkg%20alone%20or%20combined%20with%20BDQ%20administered%20orally%200.10%20or%200.33%20mg%5C%2Fkg%2C%20and%201%20group%20treated%20with%20rifampicin%20%28RIF%29%2010%20mg%5C%2Fkg.%20Mice%20were%20treated%205%20days%20a%20week%20during%2024%20weeks.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20To%20evaluate%20the%20benefit%20of%20the%20BDQ-LA%20IM%2C%20340%20four-week-old%20female%20swiss%20mice%20were%20inoculated%20in%20the%20footpads%20with%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%203%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20to%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20bacilli%20%28or%205x10%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20for%20the%20untreated%20control%20group%29%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20strain%20THAI53.%20Mice%20were%20randomly%20allocated%20into%20the%20following%2011%20groups%20treated%20with%20a%20single%20dose%20%28SD%29%20or%203%20doses%20%283D%29%2024h%20after%20the%20inoculation%3A%201%20untreated%20group%2C%202%20treated%20with%20RIF%2010%20mg%5C%2Fkg%20SD%20or%203D%2C%208%20treated%20with%20BDQ%20administered%20orally%20or%20BDQ-LA%20IM%202%20or%2020%20mg%5C%2Fkg%2C%20SD%20or%203D.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Twelve%20months%20later%2C%20mice%20were%20sacrificed%20and%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20bacilli%20enumerated%20in%20the%20footpad.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20All%20the%20footpads%20became%20negative%20with%20BDQ%20at%203.3%20mg%5C%2Fkg.%20The%20MED%20of%20BDQ%20administered%20orally%20against%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20this%20model%20is%20therefore%203.3%20mg%5C%2Fkg.%20The%20combination%20of%20CFZ%20and%20BDQ%2010-fold%20lower%20than%20this%20MED%20did%20not%20significantly%20increase%20the%20bactericidal%20activity%20of%20CFZ.%20The%20BDQ-LA%20IM%20displayed%20similar%20or%20lower%20bactericidal%20activity%20than%20the%20BDQ%20administered%20orally.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20demonstrated%20that%20the%20MED%20of%20BDQ%20administered%20orally%20against%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20was%203.3%20mg%5C%2Fkg%20in%20mice%20and%20BDQ%20did%20not%20add%20significantly%20to%20the%20efficacy%20of%20CFZ%20at%20the%20doses%20tested.%20BDQ-LA%20IM%20was%20similar%20or%20less%20active%20than%20BDQ%20administered%20orally%20at%20equivalent%20dosing%20and%20frequency%20but%20should%20be%20tested%20at%20higher%20dosing%20in%20order%20to%20reach%20equivalent%20exposure%20in%20further%20experiments.%22%2C%22date%22%3A%222023-11-27%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0011379%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pntd.0011379%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221935-2735%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-12-31T16%3A07%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22MAVM5UFU%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jaume%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-20%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJaume%2C%20L.%2C%20Hau%2C%20E.%2C%20Monsel%2C%20G.%2C%20Mah%26%23xE9%3B%2C%20A.%2C%20Bertolotti%2C%20A.%2C%20Petit%2C%20A.%2C%20Le%2C%20B.%2C%20Chauveau%2C%20M.%2C%20Duhamel%2C%20E.%2C%20Maisonobe%2C%20T.%2C%20Bagot%2C%20M.%2C%20Bouaziz%2C%20J.-D.%2C%20Mougari%2C%20F.%2C%20Cambau%2C%20E.%2C%20Jachiet%2C%20M.%20and%20Groupe%20d%26%23x2019%3Binfectiologie%20en%20dermatologie%20et%20des%20infections%20sexuellement%20transmissibles%20%28GrIDIST%29%20%282023%29.%20%26lt%3Bb%26gt%3BMethotrexate%20as%20a%20corticosteroid-sparing%20agent%20in%20leprosy%20reactions%3A%20A%20French%20multicenter%20retrospective%20study%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Poonawala%2C%20H.%20PLoS%20Negl%20Trop%20Dis%20%26lt%3Bi%26gt%3B17%26lt%3B%5C%2Fi%26gt%3B%2C%20e0011238%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0011238%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0011238%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Methotrexate%20as%20a%20corticosteroid-sparing%20agent%20in%20leprosy%20reactions%3A%20A%20French%20multicenter%20retrospective%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9a%22%2C%22lastName%22%3A%22Jaume%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Hau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gentiane%22%2C%22lastName%22%3A%22Monsel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Mah%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Bertolotti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Petit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Britney%22%2C%22lastName%22%3A%22Le%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Chauveau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Duhamel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Maisonobe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martine%22%2C%22lastName%22%3A%22Bagot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-David%22%2C%22lastName%22%3A%22Bouaziz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fa%5Cu00efza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Jachiet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Groupe%20d%5Cu2019infectiologie%20en%20dermatologie%20et%20des%20infections%20sexuellement%20transmissibles%20%28GrIDIST%29%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Husain%22%2C%22lastName%22%3A%22Poonawala%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Leprosy%20reactions%20%28LRs%29%20are%20inflammatory%20responses%20observed%20in%2030%25-50%25%20of%20people%20with%20leprosy.%20First-line%20treatment%20is%20glucocorticoids%20%28GCs%29%2C%20often%20administered%20at%20high%20doses%20with%20prolonged%20courses%2C%20resulting%20in%20high%20morbi-mortality.%20Methotrexate%20%28MTX%29%20is%20an%20immunomodulating%20agent%20used%20to%20treat%20inflammatory%20diseases%20and%20has%20an%20excellent%20safety%20profile%20and%20worldwide%20availability.%20In%20this%20study%2C%20we%20describe%20the%20efficacy%2C%20GCs-sparing%20effect%20and%20safety%20of%20MTX%20in%20LRs.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20conducted%20a%20retrospective%20multicentric%20study%20in%20France%20consisting%20of%20leprosy%20patients%20receiving%20MTX%20for%20a%20reversal%20reaction%20%28RR%29%20and%5C%2For%20erythema%20nodosum%20leprosum%20%28ENL%29%20since%202016.%20The%20primary%20endpoint%20was%20the%20rate%20of%20good%20response%20%28GR%29%20defined%20as%20the%20complete%20disappearance%20of%20inflammatory%20cutaneous%20or%20neurological%20symptoms%20without%20recurrence%20during%20MTX%20treatment.%20The%20secondary%20endpoint%20was%20the%20GCs-sparing%20effect%2C%20safety%20and%20clinical%20relapse%20after%20MTX%20discontinuation.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Our%20study%20included%2013%20patients%20with%20LRs%20%288%20men%2C%205%20women%29%3A%206%20had%20ENL%20and%207%20had%20RR.%20All%20patients%20had%20had%20at%20least%20one%20previous%20course%20of%20GCs%20and%202%20previous%20treatment%20lines%20before%20starting%20MTX.%20Overall%2C%208%5C%2F13%20%2861.5%25%29%20patients%20had%20GR%2C%20allowing%20for%20GCs-sparing%20and%20even%20GCs%20withdrawal%20in%206%5C%2F11%20%2854.5%25%29.%20No%20severe%20adverse%20effects%20were%20observed.%20Relapse%20after%20MTX%20discontinuation%20was%20substantial%20%2842%25%29%3A%20the%20median%20relapse%20time%20was%205.5%20months%20%28range%203%5Cu201314%29%20after%20stopping%20treatment.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20MTX%20seems%20to%20be%20an%20effective%20alternative%20treatment%20in%20LRs%2C%20allowing%20for%20GCs-sparing%20with%20a%20good%20safety%20profile.%20Furthermore%2C%20early%20introduction%20during%20LRs%20may%20lead%20to%20a%20better%20therapeutic%20response.%20However%2C%20its%20efficacy%20seems%20to%20suggest%20prolonged%20therapy%20to%20prevent%20recurrence.%22%2C%22date%22%3A%222023-4-20%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0011238%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pntd.0011238%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221935-2735%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-11-13T15%3A44%3A46Z%22%7D%7D%2C%7B%22key%22%3A%22KIL3J8HA%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kirga%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-15%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKirga%2C%20K.%20A.%2C%20Nadlaou%2C%20B.%2C%20Mahamat%2C%20A.%2C%20Cambau%2C%20E.%2C%20Penlap%2C%20V.%20and%20Godreuil%2C%20S.%20%282023%29.%20%26lt%3Bb%26gt%3BGenotypic%20characterization%20of%20Mycobacterium%20leprae%20strains%20resistant%20to%20rifampicin%20and%20ofloxacin%20in%20three%20health%20districts%20in%20Chad%26lt%3B%5C%2Fb%26gt%3B.%20J%20Drug%20Delivery%20Ther%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%2C%207%26%23x2013%3B11%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.22270%5C%2Fjddt.v13i3.5748%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.22270%5C%2Fjddt.v13i3.5748%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Genotypic%20characterization%20of%20Mycobacterium%20leprae%20strains%20resistant%20to%20rifampicin%20and%20ofloxacin%20in%20three%20health%20districts%20in%20Chad%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kabo%20Abakar%22%2C%22lastName%22%3A%22Kirga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bessimbaye%22%2C%22lastName%22%3A%22Nadlaou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abakar%22%2C%22lastName%22%3A%22Mahamat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%5Cu00e9ronique%22%2C%22lastName%22%3A%22Penlap%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Godreuil%22%7D%5D%2C%22abstractNote%22%3A%22Antimicrobial%20surveillance%20and%20identification%20of%20the%20genetic%20basis%20of%20antimicrobial%20resistance%20provides%20important%20information%20to%20optimize%20patient%20care.%20The%20present%20study%20was%20an%20analytical%20cross-sectional%20study%20aimed%20at%20determining%20the%20prevalence%20of%20rifampicin%20and%20ofloxacin%20resistance%20genes%20among%20Mycobacterium%20leprae%20strains%20in%20three%20health%20districts%20in%20Chad.%20%20%5CnThe%20determination%20of%20the%20folP1%2C%20rpoB%20and%20gyrA%20resistance%20genes%20was%20carried%20out%20by%20PCR-RLEP%20and%20confirmed%20by%20sequencing%20from%2080%20biopsy%20samples%20taken%20from%20patients%20with%20multibacillary%20leprosy%2C%20including%2012%20relapsed%20patients%20and%2068%20new%20cases.%20In%20the%20whole%20cohort%2C%201%5C%2F80%20%281.2%25%29%20showed%20resistance%20to%20rifampicin%20and%201%5C%2F80%20%281.2%25%29%20to%20ofloxacin.%20No%20mutations%20were%20detected%20for%20dapsone.%20The%20presence%20of%20M.%20leprae%20mutation%20associated%20with%20rifampicin%20resistance%20was%20observed%20in%20a%20relapsed%20patient%20and%20the%20mutation%20associated%20with%20ofloxacin%20resistance%20was%20observed%20in%20a%20patient%20with%20multibacillary%20leprosy%20who%20had%20not%20been%20sensitized%20by%20ofloxacin%20but%20should%20have%20used%20other%20quinolones.%20Both%20mutant%20strains%20revealed%20the%20emergence%20of%20secondary%20resistance.%20%20%5CnThis%20study%2C%20the%20first%20to%20highlight%20the%20emergence%20of%20resistance%20to%20rifampicin%20and%20ofloxacin%20in%20Chad.%20It%20raises%20the%20need%20to%20implement%20a%20robust%20surveillance%20system%20to%20detect%20resistance%20of%20Mycobacterium%20leprae%20in%20Chad%20and%20even%20in%20Central%20Africa.%20%20%5CnKeywords%3A%20Mycobacterium%20leprae%2C%20resistance%2C%20Chad%22%2C%22date%22%3A%222023-03-15%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.22270%5C%2Fjddt.v13i3.5748%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjddtonline.info%5C%2Findex.php%5C%2Fjddt%5C%2Farticle%5C%2Fview%5C%2F5748%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222250-1177%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-01-04T16%3A45%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22N5B9XVNP%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cambau%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCambau%2C%20E.%20%282023%29.%20%26lt%3Bb%26gt%3BLa%20l%26%23xE8%3Bpre%20aujourd%26%23x2019%3Bhui%26%23x202F%3B%3A%20de%20gros%20progr%26%23xE8%3Bs%20mais%20des%20r%26%23xE9%3Bsistances%26lt%3B%5C%2Fb%26gt%3B.%20Bulletin%20de%20l%26%23x2019%3BAcad%26%23xE9%3Bmie%20Nationale%20de%20M%26%23xE9%3Bdecine%20%26lt%3Bi%26gt%3B207%26lt%3B%5C%2Fi%26gt%3B%2C%201053%26%23x2013%3B1063%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.banm.2023.04.017%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.banm.2023.04.017%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22La%20l%5Cu00e8pre%20aujourd%5Cu2019hui%20%3A%20de%20gros%20progr%5Cu00e8s%20mais%20des%20r%5Cu00e9sistances%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2210%5C%2F2023%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.banm.2023.04.017%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0001407923002042%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2200014079%22%2C%22language%22%3A%22fr%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-01-04T16%3A43%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22D6WISGK7%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jouet%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJouet%2C%20A.%2C%20Braet%2C%20S.%20M.%2C%20Gaudin%2C%20C.%2C%20Bisch%2C%20G.%2C%20Vasconcellos%2C%20S.%2C%20Epaminondas%20Nicacio%20De%20Oliveira%20Do%20Livramento%2C%20R.%20E.%2C%20Prado%20Palacios%2C%20Y.%20Y.%2C%20Fontes%2C%20A.%20B.%2C%20Lucena%2C%20N.%2C%20Rosa%2C%20P.%2C%20Moraes%2C%20M.%2C%20La%2C%20K.%2C%20Badalato%2C%20N.%2C%20Lenoir%2C%20E.%2C%20Ferr%26%23xE9%3B%2C%20A.%2C%20Cl%26%23xE9%3Bment%2C%20M.%2C%20Hasker%2C%20E.%2C%20Grillone%2C%20S.%20H.%2C%20Abdou%2C%20W.%2C%20Said%2C%20A.%2C%20Assoumani%2C%20Y.%2C%20Attoumani%2C%20N.%2C%20Laurent%2C%20Y.%2C%20Cambau%2C%20E.%2C%20De%20Jong%2C%20B.%20C.%2C%20Suffys%2C%20P.%20N.%20and%20Supply%2C%20P.%20%282023%29.%20%26lt%3Bb%26gt%3BHi-plex%20deep%20amplicon%20sequencing%20for%20identification%2C%20high-resolution%20genotyping%20and%20multidrug%20resistance%20prediction%20of%20Mycobacterium%20leprae%20directly%20from%20patient%20biopsies%20by%20using%20Deeplex%20Myc-Lep%26lt%3B%5C%2Fb%26gt%3B.%20eBioMedicine%20%26lt%3Bi%26gt%3B93%26lt%3B%5C%2Fi%26gt%3B%2C%20104649%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ebiom.2023.104649%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ebiom.2023.104649%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hi-plex%20deep%20amplicon%20sequencing%20for%20identification%2C%20high-resolution%20genotyping%20and%20multidrug%20resistance%20prediction%20of%20Mycobacterium%20leprae%20directly%20from%20patient%20biopsies%20by%20using%20Deeplex%20Myc-Lep%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agathe%22%2C%22lastName%22%3A%22Jouet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sofie%20Marijke%22%2C%22lastName%22%3A%22Braet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cyril%22%2C%22lastName%22%3A%22Gaudin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ga%5Cu00eblle%22%2C%22lastName%22%3A%22Bisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sidra%22%2C%22lastName%22%3A%22Vasconcellos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rebecca%20Emmanuela%22%2C%22lastName%22%3A%22Epaminondas%20Nicacio%20De%20Oliveira%20Do%20Livramento%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yrneh%20Yadamis%22%2C%22lastName%22%3A%22Prado%20Palacios%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%20Brum%22%2C%22lastName%22%3A%22Fontes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norma%22%2C%22lastName%22%3A%22Lucena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Rosa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milton%22%2C%22lastName%22%3A%22Moraes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22La%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nelly%22%2C%22lastName%22%3A%22Badalato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esteban%22%2C%22lastName%22%3A%22Lenoir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alice%22%2C%22lastName%22%3A%22Ferr%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Cl%5Cu00e9ment%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Epco%22%2C%22lastName%22%3A%22Hasker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silahi%20Halifa%22%2C%22lastName%22%3A%22Grillone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wirdane%22%2C%22lastName%22%3A%22Abdou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aouladi%22%2C%22lastName%22%3A%22Said%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Younoussa%22%2C%22lastName%22%3A%22Assoumani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nissad%22%2C%22lastName%22%3A%22Attoumani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Laurent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%20Catherine%22%2C%22lastName%22%3A%22De%20Jong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20No%5Cu00ebl%22%2C%22lastName%22%3A%22Suffys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Supply%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2207%5C%2F2023%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ebiom.2023.104649%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2352396423002141%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2223523964%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-11-13T15%3A47%3A15Z%22%7D%7D%2C%7B%22key%22%3A%222V395TDR%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Marijke%20Braet%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMarijke%20Braet%2C%20S.%2C%20Jouet%2C%20A.%2C%20Aubry%2C%20A.%2C%20Van%20Dyck-Lippens%2C%20M.%2C%20Lenoir%2C%20E.%2C%20Assoumani%2C%20Y.%2C%20Baco%2C%20A.%2C%20Mzembaba%2C%20A.%2C%20Cambau%2C%20E.%2C%20Vasconcellos%2C%20S.%20E.%20G.%2C%20Rigouts%2C%20L.%2C%20Suffys%2C%20P.%20N.%2C%20Hasker%2C%20E.%2C%20Supply%2C%20P.%20and%20de%20Jong%2C%20B.%20C.%20%282022%29.%20%26lt%3Bb%26gt%3BInvestigating%20drug%20resistance%20of%20Mycobacterium%20leprae%20in%20the%20Comoros%3A%20an%20observational%20deep-sequencing%20study%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Microbe%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%2C%20e693%26%23x2013%3Be700%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2666-5247%2822%2900117-3%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2666-5247%2822%2900117-3%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Investigating%20drug%20resistance%20of%20Mycobacterium%20leprae%20in%20the%20Comoros%3A%20an%20observational%20deep-sequencing%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sofie%22%2C%22lastName%22%3A%22Marijke%20Braet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agathe%22%2C%22lastName%22%3A%22Jouet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magalie%22%2C%22lastName%22%3A%22Van%20Dyck-Lippens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esteban%22%2C%22lastName%22%3A%22Lenoir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Younoussa%22%2C%22lastName%22%3A%22Assoumani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdallah%22%2C%22lastName%22%3A%22Baco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aboubacar%22%2C%22lastName%22%3A%22Mzembaba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sidra%20Ezidio%20Gon%5Cu00e7alves%22%2C%22lastName%22%3A%22Vasconcellos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leen%22%2C%22lastName%22%3A%22Rigouts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20Noel%22%2C%22lastName%22%3A%22Suffys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Epco%22%2C%22lastName%22%3A%22Hasker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Supply%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%20Catherine%22%2C%22lastName%22%3A%22de%20Jong%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnDespite%20strong%20leprosy%20control%20measures%2C%20including%20effective%20treatment%2C%20leprosy%20persists%20in%20the%20Comoros.%20As%20of%20May%2C%202022%2C%20no%20resistance%20to%20anti-leprosy%20drugs%20had%20been%20reported%2C%20but%20there%20are%20no%20nationally%20representative%20data.%20Post-exposure%20prophylaxis%20%28PEP%29%20with%20rifampicin%20is%20offered%20to%20contacts%20of%20patients%20with%20leprosy.%20We%20aimed%20to%20conduct%20a%20countrywide%20drug%20resistance%20survey%20and%20investigate%20whether%20PEP%20led%20to%20the%20emergence%20of%20drug%20resistance%20in%20patients%20with%20leprosy.%5CnMethods%5CnIn%20this%20observational%2C%20deep-sequencing%20analysis%20we%20assessed%20Mycobacterium%20leprae%20genomes%20from%20skin%20biopsies%20of%20patients%20in%20Anjouan%20and%20Moh%5Cu00e9li%2C%20Comoros%2C%20collected%20as%20part%20of%20the%20ComLep%20%28NCT03526718%29%20and%20PEOPLE%20%28NCT03662022%29%20studies.%20Skin%20biopsies%20that%20had%20sufficient%20M%20leprae%20DNA%20%28%26gt%3B2000%20bacilli%20in%202%20%5Cu03bcl%20of%20DNA%20extract%29%20were%20assessed%20for%20the%20presence%20of%20seven%20drug%20resistance-associated%20genes%20%28ie%2C%20rpoB%2C%20ctpC%2C%20ctpI%2C%20folP1%2C%20gyrA%2C%20gyrB%2C%20and%20nth%29%20using%20Deeplex%20Myc-Lep%20%28targeted%20next%20generation%20deep%20sequencing%29%2C%20with%20a%20limit%20of%20detection%20of%2010%25%20for%20minority%20M%20leprae%20bacterial%20populations%20bearing%20a%20polymorphism%20in%20these%20genes.%20All%20newly%20registered%20patients%20with%20leprosy%20for%20whom%20written%20informed%20consent%20was%20obtained%20were%20eligible%20for%20inclusion%20in%20the%20survey.%20Patients%20younger%20than%202%20years%20or%20with%20a%20single%20lesion%20on%20the%20face%20did%20not%20have%20biopsies%20taken.%20The%20primary%20outcome%20of%20our%20study%20was%20the%20proportion%20of%20patients%20with%20leprosy%20%28ie%2C%20new%20cases%2C%20patients%20with%20relapses%20or%20reinfections%2C%20patients%20who%20received%20single%20%28double%29%20dose%20rifampicin-PEP%2C%20or%20patients%20who%20lived%20in%20villages%20where%20PEP%20was%20distributed%29%20who%20were%20infected%20with%20M%20leprae%20with%20a%20drug-resistant%20mutation%20for%20rifampicin%2C%20fluoroquinolone%2C%20or%20dapsone%20in%20the%20Comoros.%5CnFindings%5CnBetween%20July%201%2C%202017%2C%20and%20Dec%2031%2C%202020%2C%201199%20patients%20with%20leprosy%20were%20identified%20on%20the%20basis%20of%20clinical%20criteria%2C%20of%20whom%201030%20provided%20a%20skin%20biopsy.%20Of%20these%201030%20patients%2C%20755%20%2873%5Cu00b73%25%29%20tested%20positive%20for%20the%20M%20leprae-specific%20repetitive%20element-quantitative%20PCR%20%28qPCR%29%20assay.%20Of%20these%20755%20patients%2C%20260%20%2834%5Cu00b74%25%29%20were%20eligible%20to%20be%20analysed%20using%20Deeplex%20Myc-Lep.%20251%20%2896%5Cu00b75%25%29%20were%20newly%20diagnosed%20with%20leprosy%2C%20whereas%20nine%20%283%5Cu00b74%25%29%20patients%20had%20previously%20received%20multidrug%20therapy.%2045%20%2817%5Cu00b73%25%29%20patients%20resided%20in%20villages%20where%20PEP%20had%20been%20administered%20in%202015%20or%202019%2C%20two%20%284%5Cu00b74%25%29%20of%20whom%20received%20PEP.%20All%20seven%20drug%20resistance-associated%20targets%20were%20successfully%20sequenced%20in%20216%20samples%2C%2039%20samples%20had%20incomplete%20results%2C%20and%20five%20had%20no%20results.%20No%20mutations%20were%20detected%20in%20any%20of%20the%20seven%20drug%20resistance-related%20genes%20for%20any%20patient%20with%20successfully%20sequenced%20results.%5CnInterpretation%5CnThis%20drug%20resistance%20survey%20provides%20evidence%20to%20show%20that%20M%20leprae%20is%20fully%20susceptible%20to%20rifampicin%2C%20fluoroquinolones%2C%20and%20dapsone%20in%20the%20Comoros.%20Our%20results%20also%20show%2C%20for%20the%20first%20time%2C%20the%20applicability%20of%20targeted%20sequencing%20directly%20on%20skin%20biopsies%20from%20patients%20with%20either%20paucibacillary%20or%20multibacillary%20leprosy.%20These%20data%20suggest%20that%20PEP%20had%20not%20selected%20rifampicin-resistant%20strains%2C%20although%20further%20support%20for%20this%20finding%20should%20be%20confirmed%20with%20a%20larger%20sample%20size.%5CnFunding%5CnEffect%3AHope%2C%20The%20Mission%20To%20End%20Leprosy%2C%20the%20Fonds%20Wetenschappelijk%20Onderzoek%2C%20the%20EU.%22%2C%22date%22%3A%222022-09-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2666-5247%2822%2900117-3%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS2666524722001173%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222666-5247%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A29%3A27Z%22%7D%7D%2C%7B%22key%22%3A%223996TQSC%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Aubry%20et%20al.%22%2C%22parsedDate%22%3A%222022-08-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAubry%2C%20A.%2C%20Sammarco%20Rosa%2C%20P.%2C%20Chauffour%2C%20A.%2C%20Fletcher%2C%20M.%20L.%2C%20Cambau%2C%20E.%20and%20Avanzi%2C%20C.%20%282022%29.%20%26lt%3Bb%26gt%3BDrug%20resistance%20in%20leprosy%3A%20An%20update%20following%2070years%20of%20chemotherapy%26lt%3B%5C%2Fb%26gt%3B.%20Infectious%20Diseases%20Now%20%26lt%3Bi%26gt%3B52%26lt%3B%5C%2Fi%26gt%3B%2C%20243%26%23x2013%3B251%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.idnow.2022.04.001%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.idnow.2022.04.001%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Drug%20resistance%20in%20leprosy%3A%20An%20update%20following%2070years%20of%20chemotherapy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Sammarco%20Rosa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20L.%22%2C%22lastName%22%3A%22Fletcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Avanzi%22%7D%5D%2C%22abstractNote%22%3A%22Leprosy%20is%20one%20of%20the%20oldest%20infectious%20diseases%2C%20reported%20for%20more%20than%202000years.%20Leprosy%20elimination%20goal%20as%20a%20public%20health%20problem%20set%20by%20the%20World%20Health%20Organization%2C%20aiming%20for%20a%20global%20prevalence%20rate%26lt%3B1%20patient%20in%20a%20population%20of%2010%2C000%2C%20was%20achieved%20in%202000%20mainly%20thanks%20to%20the%20worldwide%20use%20of%20leprosy%20drugs%20starting%20in%20the%201980s%20and%20their%20access%20at%20no%20cost%20for%20patients%20since%201995.%20However%2C%20around%20200%2C000%20new%20cases%20are%20still%20reported%20each%20year%2C%20particularly%20in%20India%2C%20Brazil%2C%20and%20Indonesia.%20As%20with%20other%20bacteria%20of%20medical%20interest%2C%20antimicrobial%20resistance%20is%20observed%20in%20Mycobacterium%20leprae%20strains%20in%20several%20parts%20of%20the%20world%2C%20despite%20multidrug%20therapy%20being%20the%20recommended%20standard%20leprosy%20treatment%20to%20avoid%20resistance%20selection%20since%201982.%20Therefore%2C%20identifying%20and%20monitoring%20resistance%20is%20necessary.%20We%20provide%20an%20overview%20of%20the%20historical%20facts%20that%20led%20to%20the%20current%20drug%20resistance%20situation%2C%20the%20antibiotics%20effective%20against%20M.%5Cu00a0leprae%2C%20their%20mechanisms%20of%20action%20and%20resistance%2C%20and%20resistance%20detection%20methods.%20We%20also%20discuss%20therapeutic%20management%20of%20the%20resistant%20cases%2C%20new%20genes%20with%20potential%20roles%20in%20drug%20resistance%20and%20bacterial%20adaptation%2C%20new%20drugs%20under%20investigation%2C%20and%20the%20risk%20for%20resistance%20selection%20with%20the%20chemoprophylaxis%20measures.%22%2C%22date%22%3A%222022-08-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.idnow.2022.04.001%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS2666991922000665%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222666-9919%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A26%3A59Z%22%7D%7D%2C%7B%22key%22%3A%226ZBLUWE8%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chauffour%20et%20al.%22%2C%22parsedDate%22%3A%222021-11-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChauffour%2C%20A.%2C%20Morel%2C%20F.%2C%20Reibel%2C%20F.%2C%20Petrella%2C%20S.%2C%20Mayer%2C%20C.%2C%20Cambau%2C%20E.%20and%20Aubry%2C%20A.%20%282021%29.%20%26lt%3Bb%26gt%3BA%20systematic%20review%20of%20Mycobacterium%20leprae%20DNA%20gyrase%20mutations%20and%20their%20impact%20on%20fluoroquinolone%20resistance%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Microbiology%20and%20Infection%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%2C%201601%26%23x2013%3B1612%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2021.07.007%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2021.07.007%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20systematic%20review%20of%20Mycobacterium%20leprae%20DNA%20gyrase%20mutations%20and%20their%20impact%20on%20fluoroquinolone%20resistance%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Reibel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Petrella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudine%22%2C%22lastName%22%3A%22Mayer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnThe%20fact%20that%20Mycobacterium%20leprae%20does%20not%20grow%20in%5Cu00a0vitro%20remains%20a%20challenge%20in%20the%20survey%20of%20its%20antimicrobial%20resistance%20%28AMR%29.%20Mainly%20molecular%20methods%20are%20used%20to%20diagnose%20AMR%20in%20M.%5Cu00a0leprae%20to%20provide%20reliable%20data%20concerning%20mutations%20and%20their%20impact.%20Fluoroquinolones%20%28FQs%29%20are%20efficient%20for%20the%20treatment%20of%20leprosy%20and%20the%20main%20second-line%20drugs%20in%20case%20of%20multidrug%20resistance.%5CnObjectives%5CnThis%20study%20aimed%20at%20performing%20a%20systematic%20review%20%28a%29%20to%20characterize%20all%20DNA%20gyrase%20gene%20mutations%20described%20in%20clinical%20isolates%20of%20M.%5Cu00a0leprae%2C%20%28b%29%20to%20distinguish%20between%20those%20associated%20with%20FQ%20resistance%20or%20susceptibility%20and%20%28c%29%20to%20delineate%20a%20consensus%20numbering%20system%20for%20M.%5Cu00a0leprae%20GyrA%20and%20GyrB.%5CnData%20sources%5CnData%20source%20was%20PubMed.%5CnStudy%20eligibility%20criteria%5CnPublications%20reporting%20genotypic%20susceptibility-testing%20methods%20and%20gyrase%20gene%20mutations%20in%20M.%5Cu00a0leprae%20clinical%20strains.%5CnResults%5CnIn%2025%20studies%20meeting%20our%20inclusion%20criteria%2C%202884%20M.%5Cu00a0leprae%20isolates%20were%20analysed%20%282236%20for%20gyrA%20only%20%2877%25%29%20and%20755%20for%20both%20gyrA%20and%20gyrB%20%2826%25%29%29%3A%203.8%25%20of%20isolates%20had%20gyrA%20mutations%20%28n%5Cu00a0%3D%5Cu00a0110%29%2C%20mostly%20at%20position%2091%20%28n%5Cu00a0%3D%5Cu00a075%2C%2068%25%29%20and%200.8%25%20gyrB%20mutations%20%28n%5Cu00a0%3D%5Cu00a06%29.%20Since%20we%20found%20discrepancies%20regarding%20the%20location%20of%20substitutions%20associated%20with%20FQ%20resistance%2C%20we%20established%20a%20consensus%20numbering%20system%20to%20properly%20number%20the%20mutations.%20We%20also%20designed%20a%203D%20model%20of%20the%20M.%5Cu00a0leprae%20DNA%20gyrase%20to%20predict%20the%20impact%20of%20mutations%20whose%20role%20in%20FQ-susceptibility%20has%20not%20been%20demonstrated%20previously.%5CnConclusions%5CnMutations%20in%20DNA%20gyrase%20are%20observed%20in%204%25%20of%20the%20M.%5Cu00a0leprae%20clinical%20isolates.%20To%20solve%20discrepancies%20among%20publications%20and%20to%20distinguish%20between%20mutations%20associated%20with%20FQ%20resistance%20or%20susceptibility%2C%20the%20consensus%20numbering%20system%20we%20proposed%20as%20well%20as%20the%203D%20model%20of%20the%20M.%5Cu00a0leprae%20gyrase%20for%20the%20evaluation%20of%20the%20impact%20of%20unknown%20mutations%20in%20FQ%20resistance%2C%20will%20provide%20help%20for%20resistance%20surveillance.%22%2C%22date%22%3A%22novembre%201%2C%202021%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2021.07.007%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1198743X21003815%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198-743X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-02-25T15%3A26%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22W4PB7XMU%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ortu%5Cu00f1o-Guti%5Cu00e9rrez%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BOrtu%26%23xF1%3Bo-Guti%26%23xE9%3Brrez%2C%20N.%2C%20Mzembaba%2C%20A.%2C%20Ramboarina%2C%20S.%2C%20Andriamira%2C%20R.%2C%20Baco%2C%20A.%2C%20Braet%2C%20S.%2C%20Younoussa%2C%20A.%2C%20Cauchoix%2C%20B.%2C%20Salim%2C%20Z.%2C%20Amidy%2C%20M.%2C%20Grillone%2C%20S.%2C%20Rasamoelina%2C%20T.%2C%20Cambau%2C%20E.%2C%20Geluk%2C%20A.%2C%20de%20Jong%2C%20B.%20C.%2C%20Richardus%2C%20J.%20H.%20and%20Hasker%2C%20E.%20%282021%29.%20%26lt%3Bb%26gt%3BExploring%20clustering%20of%20leprosy%20in%20the%20Comoros%20and%20Madagascar%3A%20A%20geospatial%20analysis%26lt%3B%5C%2Fb%26gt%3B.%20International%20Journal%20of%20Infectious%20Diseases%20%26lt%3Bi%26gt%3B108%26lt%3B%5C%2Fi%26gt%3B%2C%2096%26%23x2013%3B101%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2021.05.014%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2021.05.014%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Exploring%20clustering%20of%20leprosy%20in%20the%20Comoros%20and%20Madagascar%3A%20A%20geospatial%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nimer%22%2C%22lastName%22%3A%22Ortu%5Cu00f1o-Guti%5Cu00e9rrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aboubacar%22%2C%22lastName%22%3A%22Mzembaba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Ramboarina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Randrianantoandro%22%2C%22lastName%22%3A%22Andriamira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdallah%22%2C%22lastName%22%3A%22Baco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sofie%22%2C%22lastName%22%3A%22Braet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Assoumani%22%2C%22lastName%22%3A%22Younoussa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Cauchoix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zahara%22%2C%22lastName%22%3A%22Salim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%22%2C%22lastName%22%3A%22Amidy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saverio%22%2C%22lastName%22%3A%22Grillone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tahinamandranto%22%2C%22lastName%22%3A%22Rasamoelina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annemieke%22%2C%22lastName%22%3A%22Geluk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%20C.%22%2C%22lastName%22%3A%22de%20Jong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20Hendrik%22%2C%22lastName%22%3A%22Richardus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Epco%22%2C%22lastName%22%3A%22Hasker%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2207%5C%2F2021%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ijid.2021.05.014%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS120197122100415X%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2212019712%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-21T14%3A00%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22F3L9SGJN%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rousset%20et%20al.%22%2C%22parsedDate%22%3A%222020-12-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRousset%2C%20L.%2C%20Sokal%2C%20A.%2C%20Vignon-Pennamen%2C%20M.-D.%2C%20Pagis%2C%20V.%2C%20Rybojad%2C%20M.%2C%20Lecorche%2C%20E.%2C%20Mougari%2C%20F.%2C%20Bagot%2C%20M.%2C%20Bouaziz%2C%20J.-D.%20and%20Jachiet%2C%20M.%20%282020%29.%20%26lt%3Bb%26gt%3BAssociation%20d%26%23x2019%3Bune%20l%26%23xE8%3Bpre%20borderline%20tuberculo%26%23xEF%3Bde%20et%20d%26%23x2019%3Bune%20tuberculose%26%23xA0%3B%3A%20un%20cas%20et%20revue%20de%20la%20litt%26%23xE9%3Brature%26lt%3B%5C%2Fb%26gt%3B.%20Annales%20de%20Dermatologie%20et%20de%20V%26%23xE9%3Bn%26%23xE9%3Br%26%23xE9%3Bologie%20%26lt%3Bi%26gt%3B147%26lt%3B%5C%2Fi%26gt%3B%2C%20886%26%23x2013%3B891%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annder.2020.09.571%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annder.2020.09.571%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20d%5Cu2019une%20l%5Cu00e8pre%20borderline%20tuberculo%5Cu00efde%20et%20d%5Cu2019une%20tuberculose%5Cu00a0%3A%20un%20cas%20et%20revue%20de%20la%20litt%5Cu00e9rature%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Rousset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Sokal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20-D.%22%2C%22lastName%22%3A%22Vignon-Pennamen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Pagis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Rybojad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Bagot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20-D.%22%2C%22lastName%22%3A%22Bouaziz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Jachiet%22%7D%5D%2C%22abstractNote%22%3A%22R%5Cu00e9sum%5Cu00e9%5CnIntroduction%5CnEn%20m%5Cu00e9tropole%2C%20pr%5Cu00e8s%20de%2020%5Cu00a0nouveaux%20cas%20de%20l%5Cu00e8pre%20sont%20diagnostiqu%5Cu00e9s%20chaque%20ann%5Cu00e9e.%20L%5Cu2019incidence%20de%20la%20tuberculose%20en%20France%20est%20de%208%5C%2F100%20000%5Cu00a0habitants%20et%20l%5Cu2019association%20des%202%5Cu00a0mycobact%5Cu00e9ries%20a%20%5Cu00e9t%5Cu00e9%20exceptionnellement%20rapport%5Cu00e9e.%20Nous%20rapportons%20un%20cas%20de%20co-infection%20l%5Cu00e8pre%20Borderline%20Tuberculo%5Cu00efde%20%28BT%29%20et%20tuberculose%20diss%5Cu00e9min%5Cu00e9e%2C%20diagnostiqu%5Cu00e9%20en%20m%5Cu00e9tropole.%5CnObservation%5CnUn%20homme%20pr%5Cu00e9sentait%20des%20plaques%20%5Cu00e9ryth%5Cu00e9mateuses%20infiltr%5Cu00e9es%20hypoesth%5Cu00e9siques%20diffuses.%20La%20biopsie%20montrait%20un%20granulome%20%5Cu00e9pith%5Cu00e9lio%5Cu00efde%20lympho-histiocytaire%20p%5Cu00e9ri-sudoral%20et%20p%5Cu00e9ri-nerveux%2C%20avec%20des%20bacilles%20acido-alcoolo-r%5Cu00e9sistants%20sur%20la%20coloration%20de%20Ziehl.%20La%20PCR%20Mycobacterium%20Leprae%20%5Cu00e9tait%20positive%2C%20confirmant%20le%20diagnostic%20de%20l%5Cu00e8pre%2C%20dans%20une%20forme%20BT.%20Le%20bilan%20d%5Cu2019extension%20r%5Cu00e9v%5Cu00e9lait%20un%20%5Cu00e9panchement%20pleural%20gauche%20%5Cu00e0%20pr%5Cu00e9dominance%20lymphocytaire%2C%20une%20ad%5Cu00e9nopathie%20hilaire%20droite%20%5Cu00e0%20centre%20n%5Cu00e9crotique%20sans%20granulome%20histologique%2C%20une%20recherche%20de%20BK%20n%5Cu00e9gative%2C%20un%20test%20quantiFERON-TB%5Cu2122%20et%20une%20intra-dermo%20r%5Cu00e9action%20%5Cu00e0%20la%20tuberculine%20positifs.%20Le%20tableau%20clinique%20et%20radiologique%20%5Cu00e9tait%20en%20faveur%20d%5Cu2019une%20tuberculose%20diss%5Cu00e9min%5Cu00e9e.%20La%20quadrith%5Cu00e9rapie%20anti-tuberculeuse%20%28rifampicine%2C%20isoniazide%2C%20ethambutol%20et%20pyrazinamide%29%20et%20la%20clofazimine%20permettaient%20une%20r%5Cu00e9gression%20des%20l%5Cu00e9sions%20cutan%5Cu00e9es%20et%20extra-cutan%5Cu00e9es.%5CnDiscussion%5CnCette%20rare%20co-infection%20associe%20une%20l%5Cu00e8pre%20souvent%20l%5Cu00e9promateuse%20%5Cu00e9volutive%20depuis%20plusieurs%20ann%5Cu00e9es%20et%20une%20tuberculose%20souvent%20pulmonaire%20d%5Cu2019apparition%20ult%5Cu00e9rieure.%20L%5Cu2019%20hypoth%5Cu00e8se%20physiopathologique%20est%20celle%20de%20l%5Cu2019immunit%5Cu00e9%20crois%5Cu00e9e%20%28l%5Cu2019immunit%5Cu00e9%20anti-tuberculeuse%20prot%5Cu00e9geant%20contre%20une%20l%5Cu00e8pre%20ult%5Cu00e9rieure%20et%20inversement%29%2C%20%5Cu00e9tay%5Cu00e9e%20par%20la%20corr%5Cu00e9lation%20inverse%20des%20deux%20pr%5Cu00e9valences%20et%20par%20la%20protection%20induite%20par%20la%20vaccination%20antituberculeuse.%20Dans%20la%20plupart%20des%20cas%2C%20le%20traitement%20antituberculeux%20et%20antil%5Cu00e9preux%20permettent%20une%20am%5Cu00e9lioration%20des%20deux%20maladies.%20Un%20cas%20de%20l%5Cu00e8pre%20doit%20faire%20rechercher%20une%20tuberculose%20latente%20afin%20d%5Cu2019%5Cu00e9viter%20une%20r%5Cu00e9activation%2C%20%5Cu00e0%20fortiori%20si%20une%20corticoth%5Cu00e9rapie%20est%20associ%5Cu00e9e.%5CnSummary%5CnIntroduction%5CnIn%20metropolitan%20France%2C%20nearly%2020%5Cu00a0new%20cases%20of%20leprosy%20are%20diagnosed%20each%20year.%20The%20incidence%20of%20tuberculosis%20in%20France%20is%208%5C%2F100%2C000%5Cu00a0inhabitants%20and%20there%20are%20very%20few%20accounts%20of%20association%20of%20these%20two%20mycobacteria.%20Herein%20we%20report%20a%20case%20of%20co-infection%20with%20borderline%20tuberculoid%20%28BT%29%20leprosy%20and%20disseminated%20tuberculosis%20diagnosed%20in%20metropolitan%20France.%5CnPatients%20and%20methods%5CnA%20male%20subject%20presented%20with%20diffuse%20painless%20infiltrated%20erythematous%20plaques.%20The%20biopsy%20revealed%20perisudoral%20and%20perineural%20lymphohistiocytic%20epithelioid%20cell%20granuloma%20as%20well%20as%20acid-alcohol-fast%20bacilli%20on%20Ziehl%20staining.%20PCR%20was%20positive%20for%20Mycobacterium%20leprae%2C%20confirming%20the%20diagnosis%20of%20leprosy%20in%20the%20BT%20form.%20The%20staging%20examination%20revealed%20predominantly%20lymphocytic%20left%20pleural%20effusion%2C%20right-central%20necrotic%20adenopathy%20without%20histological%20granuloma%2C%20negative%20screening%20for%20BK%2C%20a%20positive%20QuantiFERON-TB%5Cu2122%20test%2C%20and%20a%20positive%20intradermal%20tuberculin%20reaction.%20The%20clinical%20and%20radiological%20results%20militated%20in%20favour%20of%20disseminated%20tuberculosis.%20Combined%20therapy%20%28rifampicin%2C%20isoniazid%2C%20ethambutol%20and%20pyrazinamide%29%20together%20with%20clofazimine%20resulted%20in%20regression%20of%20both%20cutaneous%20and%20extra-cutaneous%20lesions.%20This%20rare%20co-infection%20combines%20leprosy%2C%20often%20present%20for%20several%20years%2C%20and%20tuberculosis%20%28usually%20pulmonary%29%20of%20subsequent%20onset.%20The%20pathophysiological%20hypothesis%20is%20that%20of%20cross-immunity%20%28with%20anti-TB%20immunity%20protecting%20against%20subsequent%20leprosy%20and%20vice%20versa%29%2C%20supported%20by%20the%20inverse%20correlation%20of%20the%20two%20levels%20of%20prevalence%20and%20by%20the%20protection%20afforded%20by%20tuberculosis%20vaccination.%20In%20most%20cases%2C%20treatment%20for%20TB%20and%20leprosy%20improves%20both%20diseases.%20Patients%20presenting%20leprosy%20should%20be%20screened%20for%20latent%20tuberculosis%20in%20order%20to%20avoid%20reactivation%2C%20particularly%20in%20cases%20where%20corticosteroid%20treatment%20is%20being%20given.%22%2C%22date%22%3A%222020-12-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.annder.2020.09.571%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0151963820310188%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220151-9638%22%2C%22language%22%3A%22fr%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T10%3A59%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22AYDHEMCY%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Avanzi%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAvanzi%2C%20C.%2C%20L%26%23xE9%3Bcorch%26%23xE9%3B%2C%20E.%2C%20Rakotomalala%2C%20F.%20A.%2C%20Benjak%2C%20A.%2C%20Rapelanoro%20Rabenja%2C%20F.%2C%20Ramarozatovo%2C%20L.%20S.%2C%20Cauchoix%2C%20B.%2C%20Rakoto-Andrianarivelo%2C%20M.%2C%20Ti%26%23xF3%3B-Coma%2C%20M.%2C%20Leal-Calvo%2C%20T.%2C%20Busso%2C%20P.%2C%20Boy-R%26%23xF6%3Bttger%2C%20S.%2C%20Chauffour%2C%20A.%2C%20Rasamoelina%2C%20T.%2C%20Andrianarison%2C%20A.%2C%20Sendrasoa%2C%20F.%2C%20Spencer%2C%20J.%20S.%2C%20Singh%2C%20P.%2C%20Dashatwar%2C%20D.%20R.%2C%20Narang%2C%20R.%2C%20Berland%2C%20J.-L.%2C%20Jarlier%2C%20V.%2C%20Salgado%2C%20C.%20G.%2C%20Moraes%2C%20M.%20O.%2C%20Geluk%2C%20A.%2C%20Randrianantoandro%2C%20A.%2C%20Cambau%2C%20E.%20and%20Cole%2C%20S.%20T.%20%282020%29.%20%26lt%3Bb%26gt%3BPopulation%20Genomics%20of%20Mycobacterium%20leprae%20Reveals%20a%20New%20Genotype%20in%20Madagascar%20and%20the%20Comoros%26lt%3B%5C%2Fb%26gt%3B.%20Frontiers%20in%20Microbiology%20%26lt%3Bi%26gt%3B11%26lt%3B%5C%2Fi%26gt%3B%2C%20URL%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmicb.2020.00711%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmicb.2020.00711%26lt%3B%5C%2Fa%26gt%3B%20%5BAccessed%20March%202022%5D.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Population%20Genomics%20of%20Mycobacterium%20leprae%20Reveals%20a%20New%20Genotype%20in%20Madagascar%20and%20the%20Comoros%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Avanzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22L%5Cu00e9corch%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fetra%20Angelot%22%2C%22lastName%22%3A%22Rakotomalala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrej%22%2C%22lastName%22%3A%22Benjak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fahafahantsoa%22%2C%22lastName%22%3A%22Rapelanoro%20Rabenja%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lala%20S.%22%2C%22lastName%22%3A%22Ramarozatovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bertrand%22%2C%22lastName%22%3A%22Cauchoix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mala%22%2C%22lastName%22%3A%22Rakoto-Andrianarivelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Ti%5Cu00f3-Coma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thyago%22%2C%22lastName%22%3A%22Leal-Calvo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Busso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Boy-R%5Cu00f6ttger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tahinamandrato%22%2C%22lastName%22%3A%22Rasamoelina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aina%22%2C%22lastName%22%3A%22Andrianarison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fandresena%22%2C%22lastName%22%3A%22Sendrasoa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20S.%22%2C%22lastName%22%3A%22Spencer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pushpendra%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Digambar%20Ramchandra%22%2C%22lastName%22%3A%22Dashatwar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rahul%22%2C%22lastName%22%3A%22Narang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Luc%22%2C%22lastName%22%3A%22Berland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudio%20G.%22%2C%22lastName%22%3A%22Salgado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milton%20O.%22%2C%22lastName%22%3A%22Moraes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annemieke%22%2C%22lastName%22%3A%22Geluk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andriamira%22%2C%22lastName%22%3A%22Randrianantoandro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stewart%20T.%22%2C%22lastName%22%3A%22Cole%22%7D%5D%2C%22abstractNote%22%3A%22Human%20settlement%20of%20Madagascar%20traces%20back%20to%20the%20beginning%20of%20the%20first%20millennium%20with%20the%20arrival%20of%20Austronesians%20from%20Southeast%20Asia%2C%20followed%20by%20migrations%20from%20Africa%20and%20the%20Middle%20East.%20Remains%20of%20these%20different%20cultural%2C%20genetic%2C%20and%20linguistic%20legacies%20are%20still%20present%20in%20Madagascar%20and%20other%20islands%20of%20the%20Indian%20Ocean.%20The%20close%20relationship%20between%20human%20migration%20and%20the%20introduction%20and%20spread%20of%20infectious%20diseases%2C%20a%20well-documented%20phenomenon%2C%20is%20particularly%20evident%20for%20the%20causative%20agent%20of%20leprosy%2C%20Mycobacterium%20leprae.%20In%20this%20study%2C%20we%20used%20whole-genome%20sequencing%20%28WGS%29%20and%20molecular%20dating%20to%20characterize%20the%20genetic%20background%20and%20retrace%20the%20origin%20of%20the%20M.%20leprae%20strains%20circulating%20in%20Madagascar%20%28n%20%3D%2030%29%20and%20the%20Comoros%20%28n%20%3D%203%29%2C%20two%20islands%20where%20leprosy%20is%20still%20considered%20a%20public%20health%20problem%20and%20monitored%20as%20part%20of%20a%20drug%20resistance%20surveillance%20program.%20Most%20M.%20leprae%20strains%20%2897%25%29%20from%20Madagascar%20and%20Comoros%20belonged%20to%20a%20new%20genotype%20as%20part%20of%20branch%201%2C%20closely%20related%20to%20single%20nucleotide%20polymorphism%20%28SNP%29%20type%201D%2C%20named%201D-Malagasy.%20Other%20strains%20belonged%20to%20the%20genotype%201A%20%283%25%29.%20We%20sequenced%2039%20strains%20from%20nine%20other%20countries%2C%20which%2C%20together%20with%20previously%20published%20genomes%2C%20amounted%20to%20242%20genomes%20that%20were%20used%20for%20molecular%20dating.%20Specific%20SNP%20markers%20for%20the%20new%201D-Malagasy%20genotype%20were%20used%20to%20screen%20samples%20from%2011%20countries%20and%20revealed%20this%20genotype%20to%20be%20restricted%20to%20Madagascar%2C%20with%20the%20sole%20exception%20being%20a%20strain%20from%20Malawi.%20The%20overall%20analysis%20thus%20ruled%20out%20a%20possible%20introduction%20of%20leprosy%20by%20the%20Austronesian%20settlers%20and%20suggests%20a%20later%20origin%20from%20East%20Africa%2C%20the%20Middle%20East%2C%20or%20South%20Asia.%22%2C%22date%22%3A%222020%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffmicb.2020.00711%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221664-302X%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T10%3A54%3A24Z%22%7D%7D%2C%7B%22key%22%3A%2223X4SDIJ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Baron%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBaron%2C%20V.%2C%20Forfait%2C%20C.%2C%20Colot%2C%20J.%2C%20Carzola%2C%20C.%2C%20Descloux%2C%20E.%2C%20Cauchoix%2C%20B.%2C%20Cambau%2C%20E.%2C%20Gaumery%2C%20J.%2C%20Grangeon%2C%20J.%20and%20Klement%2C%20E.%20%282019%29.%20%26lt%3Bb%26gt%3B%26%23xC9%3Bpid%26%23xE9%3Bmiologie%20de%20la%20l%26%23xE8%3Bpre%20en%20Nouvelle-Cal%26%23xE9%3Bdonie%20de%201983%20%26%23xE0%3B%202017%26lt%3B%5C%2Fb%26gt%3B.%20BEH%20400%26%23x2013%3B405%2C%20URL%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.santepubliquefrance.fr%5C%2Fimport%5C%2Fepidemiologie-de-la-lepre-en-nouvelle-caledonie-de-1983-a-2017%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fwww.santepubliquefrance.fr%5C%2Fimport%5C%2Fepidemiologie-de-la-lepre-en-nouvelle-caledonie-de-1983-a-2017%26lt%3B%5C%2Fa%26gt%3B%20%5BAccessed%20February%202022%5D.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22%5Cu00c9pid%5Cu00e9miologie%20de%20la%20l%5Cu00e8pre%20en%20Nouvelle-Cal%5Cu00e9donie%20de%201983%20%5Cu00e0%202017%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Violaine%22%2C%22lastName%22%3A%22Baron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Forfait%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%22%2C%22lastName%22%3A%22Colot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Carzola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Descloux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%22%2C%22lastName%22%3A%22Cauchoix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22JB%22%2C%22lastName%22%3A%22Gaumery%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22JP%22%2C%22lastName%22%3A%22Grangeon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Klement%22%7D%5D%2C%22abstractNote%22%3A%22%5Cu00c9pid%5Cu00e9miologie%20de%20la%20l%5Cu00e8pre%20en%20Nouvelle-Cal%5Cu00e9donie%5Cnde%201983%20%5Cu00e0%202017%22%2C%22date%22%3A%222019%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.santepubliquefrance.fr%5C%2Fimport%5C%2Fepidemiologie-de-la-lepre-en-nouvelle-caledonie-de-1983-a-2017%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22fr%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-06-03T06%3A54%3A59Z%22%7D%7D%2C%7B%22key%22%3A%225DABHW8P%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cambau%20et%20al.%22%2C%22parsedDate%22%3A%222018-12-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCambau%2C%20E.%2C%20Saunderson%2C%20P.%2C%20Matsuoka%2C%20M.%2C%20Cole%2C%20S.%20T.%2C%20Kai%2C%20M.%2C%20Suffys%2C%20P.%2C%20Rosa%2C%20P.%20S.%2C%20Williams%2C%20D.%2C%20Gupta%2C%20U.%20D.%2C%20Lavania%2C%20M.%2C%20Cardona-Castro%2C%20N.%2C%20Miyamoto%2C%20Y.%2C%20Hagge%2C%20D.%2C%20Srikantam%2C%20A.%2C%20Hongseng%2C%20W.%2C%20Indropo%2C%20A.%2C%20Vissa%2C%20V.%2C%20Johnson%2C%20R.%20C.%2C%20Cauchoix%2C%20B.%2C%20Pannikar%2C%20V.%20K.%2C%20Cooreman%2C%20E.%20a.%20W.%20D.%2C%20Pemmaraju%2C%20V.%20R.%20R.%2C%20Gillini%2C%20L.%2C%20Kriswamati%2C%20A.%2C%20Al-Samie%2C%20A.%20R.%2C%20Issoufou%2C%20A.%2C%20Tiendrebeogo%2C%20A.%2C%20Kingalu%2C%20A.%2C%20Randrianantoandro%2C%20A.%2C%20Kumar%2C%20A.%2C%20Chauffour%2C%20A.%2C%20Win%2C%20A.%20A.%2C%20Pandey%2C%20B.%2C%20Agrawal%2C%20C.%20M.%2C%20Widaningrum%2C%20C.%2C%20Schmotzer%2C%20C.%2C%20Kafando%2C%20C.%2C%20Bhandari%2C%20C.%20M.%2C%20Sema%2C%20C.%2C%20Vidanagama%2C%20D.%20S.%2C%20Scollard%2C%20D.%20M.%2C%20Beyene%2C%20D.%2C%20Morelo%2C%20E.%20F.%2C%20Kassa%2C%20E.%20D.%2C%20Ramarolahy%2C%20E.%20B.%2C%20Claco%2C%20E.%2C%20Villalon%2C%20E.%20E.%2C%20Sidibe%2C%20F.%2C%20Sakho%2C%20F.%2C%20Abdoulaye%2C%20F.%2C%20Guilengue%2C%20F.%20F.%2C%20Gajete%2C%20F.%2C%20Babu%2C%20G.%20R.%2C%20Moussa%2C%20G.%2C%20Thakur%2C%20G.%20D.%2C%20Cabanos%2C%20G.%2C%20Sock%2C%20G.%2C%20Clugston%2C%20G.%2C%20Zaidy%2C%20H.%2C%20Watanabe%2C%20H.%2C%20Kawuma%2C%20H.%20J.%2C%20Mallari%2C%20I.%20B.%2C%20Goulart%2C%20I.%20M.%20B.%2C%20Ahamed%2C%20I.%2C%20Subbanna%2C%20J.%2C%20Houzeo%2C%20J.%20G.%2C%20Luengu%2C%20J.%20N.%20M.%2C%20Bertolli%2C%20J.%2C%20Lloyd-Owen%2C%20J.%2C%20Matheu%2C%20J.%2C%20Brunelli%2C%20J.%20P.%2C%20Alzate%2C%20J.%20C.%20B.%2C%20Neupane%2C%20Kapil%20Dev%2C%20Osuga%2C%20K.%2C%20Yamaguchi%2C%20K.%2C%20Azam%2C%20K.%2C%20Lin%2C%20K.%20M.%2C%20Momoudu%2C%20K.%2C%20Kyaw%2C%20K.%2C%20Bide%2C%20L.%2C%20Doanh%2C%20L.%20H.%2C%20My%2C%20L.%20H.%2C%20Shah%2C%20M.%2C%20Kodio%2C%20M.%2C%20Sidibe%2C%20M.%2C%20Ebenezer%2C%20M.%2C%20Grossi%2C%20M.%20A.%20de%20F.%2C%20Balagon%2C%20M.%20F.%2C%20Canlonon%2C%20M.%2C%20Makino%2C%20M.%2C%20Htoo%2C%20M.%20M.%2C%20Ahmed%2C%20M.%20J.%2C%20Nadine%2C%20M.-M.%2C%20Roferos%2C%20F.%20O.%2C%20Krismawati%2C%20H.%2C%20Thida%2C%20M.%2C%20Htoon%2C%20M.%20T.%2C%20Neupane%2C%20K.%20D.%2C%20Phuc%2C%20N.%20H.%20N.%2C%20Van%2C%20N.%20H.%2C%20Hai%2C%20N.%20P.%20N.%2C%20Ishii%2C%20N.%2C%20Soe%2C%20O.%2C%20Amiel%2C%20O.%2C%20Tossou%2C%20O.%2C%20Konare%2C%20O.%2C%20Joshi%2C%20P.%20L.%2C%20Rao%2C%20P.%20V.%20R.%2C%20Krishnamurthy%2C%20P.%2C%20Brennan%2C%20P.%20J.%2C%20Busso%2C%20P.%2C%20Bhatia%2C%20R.%2C%20Andrianarivelo%2C%20M.%20R.%2C%20Ramdas%2C%20D.%20R.%2C%20Chabi%2C%20R.%2C%20Gusmao%2C%20R.%2C%20DjupuriIzwardy%2C%20R.%2C%20Soares%2C%20R.%20C.%20F.%20R.%2C%20Jhadav%2C%20R.%2C%20Buhrer%2C%20S.%2C%20Cho%2C%20S.-N.%20R.%2C%20Jianping%2C%20S.%2C%20Lzumi%2C%20S.%2C%20Barua%2C%20S.%2C%20Chaitanya%2C%20S.%2C%20Tiendrebeogo%2C%20S.%20M.%20R.%2C%20Khang%2C%20T.%20H.%2C%20Gillis%2C%20T.%20P.%2C%20Mori%2C%20T.%2C%20Vijayalakshmi%2C%20V.%2C%20Kamara%2C%20V.%20D.%2C%20Wei%2C%20W.%2C%20Smith%2C%20W.%20C.%20S.%2C%20Li%2C%20W.%2C%20Lew%2C%20W.%2C%20Al-Qubati%2C%20Y.%2C%20Suzuki%2C%20Y.%20and%20Nanba%2C%20Y.%20%282018%29.%20%26lt%3Bb%26gt%3BAntimicrobial%20resistance%20in%20leprosy%3A%20results%20of%20the%20first%20prospective%20open%20survey%20conducted%20by%20a%20WHO%20surveillance%20network%20for%20the%20period%202009%26%23x2013%3B15%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Microbiology%20and%20Infection%20%26lt%3Bi%26gt%3B24%26lt%3B%5C%2Fi%26gt%3B%2C%201305%26%23x2013%3B1310%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2018.02.022%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2018.02.022%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Antimicrobial%20resistance%20in%20leprosy%3A%20results%20of%20the%20first%20prospective%20open%20survey%20conducted%20by%20a%20WHO%20surveillance%20network%20for%20the%20period%202009%5Cu201315%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Saunderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Matsuoka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20T.%22%2C%22lastName%22%3A%22Cole%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Kai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Suffys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%20S.%22%2C%22lastName%22%3A%22Rosa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22U.%20D.%22%2C%22lastName%22%3A%22Gupta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Lavania%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Cardona-Castro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Miyamoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Hagge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Srikantam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22W.%22%2C%22lastName%22%3A%22Hongseng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Indropo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Vissa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20C.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Cauchoix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%20K.%22%2C%22lastName%22%3A%22Pannikar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20a.%20W.%20D.%22%2C%22lastName%22%3A%22Cooreman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%20R.%20R.%22%2C%22lastName%22%3A%22Pemmaraju%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Gillini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Kriswamati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdul%20Rahim%22%2C%22lastName%22%3A%22Al-Samie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahamed%22%2C%22lastName%22%3A%22Issoufou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Tiendrebeogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22AmriMiraju%22%2C%22lastName%22%3A%22Kingalu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andriamira%22%2C%22lastName%22%3A%22Randrianantoandro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anil%22%2C%22lastName%22%3A%22Kumar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aye%20Aye%22%2C%22lastName%22%3A%22Win%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Basudev%22%2C%22lastName%22%3A%22Pandey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20M.%22%2C%22lastName%22%3A%22Agrawal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiana%22%2C%22lastName%22%3A%22Widaningrum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Schmotzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Kafando%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chuda%20Mani%22%2C%22lastName%22%3A%22Bhandari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cynthia%22%2C%22lastName%22%3A%22Sema%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%20S.%22%2C%22lastName%22%3A%22Vidanagama%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20M.%22%2C%22lastName%22%3A%22Scollard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Demmissew%22%2C%22lastName%22%3A%22Beyene%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%20Faria%22%2C%22lastName%22%3A%22Morelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20Dizaneh%22%2C%22lastName%22%3A%22Kassa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enerantien%20Benoit%22%2C%22lastName%22%3A%22Ramarolahy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Claco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ernesto%20ES%22%2C%22lastName%22%3A%22Villalon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Famoussa%22%2C%22lastName%22%3A%22Sidibe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fatoumata%22%2C%22lastName%22%3A%22Sakho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fomba%22%2C%22lastName%22%3A%22Abdoulaye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francisco%20F.%22%2C%22lastName%22%3A%22Guilengue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fransesca%22%2C%22lastName%22%3A%22Gajete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gadde%20Rajan%22%2C%22lastName%22%3A%22Babu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gado%22%2C%22lastName%22%3A%22Moussa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Garib%20Das%22%2C%22lastName%22%3A%22Thakur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gemma%22%2C%22lastName%22%3A%22Cabanos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gouressi%22%2C%22lastName%22%3A%22Sock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Greame%22%2C%22lastName%22%3A%22Clugston%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hany%22%2C%22lastName%22%3A%22Zaidy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haruo%22%2C%22lastName%22%3A%22Watanabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herman%20Joseph%22%2C%22lastName%22%3A%22Kawuma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%20Balenton%22%2C%22lastName%22%3A%22Mallari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabella%20Maria%20Bernandes%22%2C%22lastName%22%3A%22Goulart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Issoufou%22%2C%22lastName%22%3A%22Ahamed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Subbanna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Gabin%22%2C%22lastName%22%3A%22Houzeo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Norbert%20Mputu%22%2C%22lastName%22%3A%22Luengu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanne%22%2C%22lastName%22%3A%22Bertolli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Lloyd-Owen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Matheu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%20Pereira%22%2C%22lastName%22%3A%22Brunelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20Camilo%20Beltran%22%2C%22lastName%22%3A%22Alzate%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kapil%20Dev%22%2C%22lastName%22%3A%22Neupane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katsunori%22%2C%22lastName%22%3A%22Osuga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kazuko%22%2C%22lastName%22%3A%22Yamaguchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khalid%22%2C%22lastName%22%3A%22Azam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khin%20Maung%22%2C%22lastName%22%3A%22Lin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kodia%22%2C%22lastName%22%3A%22Momoudu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyaw%22%2C%22lastName%22%3A%22Kyaw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Landry%22%2C%22lastName%22%3A%22Bide%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Le%20Huu%22%2C%22lastName%22%3A%22Doanh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ley%20Huyen%22%2C%22lastName%22%3A%22My%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mahesh%22%2C%22lastName%22%3A%22Shah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamadou%22%2C%22lastName%22%3A%22Kodio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamadou%22%2C%22lastName%22%3A%22Sidibe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mannam%22%2C%22lastName%22%3A%22Ebenezer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Aparecida%20de%20Faria%22%2C%22lastName%22%3A%22Grossi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marivic%20F.%22%2C%22lastName%22%3A%22Balagon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marlience%22%2C%22lastName%22%3A%22Canlonon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masahiko%22%2C%22lastName%22%3A%22Makino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maung%20Maung%22%2C%22lastName%22%3A%22Htoo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Md%20Jamsheed%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mintsey-mi-Makuth%22%2C%22lastName%22%3A%22Nadine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florenda%20Orcullo%22%2C%22lastName%22%3A%22Roferos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hana%22%2C%22lastName%22%3A%22Krismawati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mya%22%2C%22lastName%22%3A%22Thida%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Myo%20Thet%22%2C%22lastName%22%3A%22Htoon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20D.%22%2C%22lastName%22%3A%22Neupane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nhu%20Ha%20Nguyen%22%2C%22lastName%22%3A%22Phuc%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22NguyenThi%20Hai%22%2C%22lastName%22%3A%22Van%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ngyuen%20Phuc%20Nhu%22%2C%22lastName%22%3A%22Hai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norisha%22%2C%22lastName%22%3A%22Ishii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oke%22%2C%22lastName%22%3A%22Soe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Amiel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Omar%22%2C%22lastName%22%3A%22Tossou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ousmane%22%2C%22lastName%22%3A%22Konare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%20L.%22%2C%22lastName%22%3A%22Joshi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%20V.%20Ranganadha%22%2C%22lastName%22%3A%22Rao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Padebettu%22%2C%22lastName%22%3A%22Krishnamurthy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20J.%22%2C%22lastName%22%3A%22Brennan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Phillipe%22%2C%22lastName%22%3A%22Busso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rajesh%22%2C%22lastName%22%3A%22Bhatia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mala%20Rakoto%22%2C%22lastName%22%3A%22Andrianarivelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%20R.%22%2C%22lastName%22%3A%22Ramdas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raoul%22%2C%22lastName%22%3A%22Chabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Renato%22%2C%22lastName%22%3A%22Gusmao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22DjupuriIzwardy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rosa%20Castalia%20Franca%20Riberio%22%2C%22lastName%22%3A%22Soares%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rupendra%22%2C%22lastName%22%3A%22Jhadav%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samira%22%2C%22lastName%22%3A%22Buhrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sang-Nae%20Ray%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shen%22%2C%22lastName%22%3A%22Jianping%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shinzo%22%2C%22lastName%22%3A%22Lzumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sumana%22%2C%22lastName%22%3A%22Barua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sundeep%22%2C%22lastName%22%3A%22Chaitanya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvestre%20Marie%20Roget%22%2C%22lastName%22%3A%22Tiendrebeogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tan%20Hau%22%2C%22lastName%22%3A%22Khang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20P.%22%2C%22lastName%22%3A%22Gillis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Toru%22%2C%22lastName%22%3A%22Mori%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Vijayalakshmi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vedastus%20Deusdedit%22%2C%22lastName%22%3A%22Kamara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wang%22%2C%22lastName%22%3A%22Wei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22W.%20Cairn%20S.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Woojin%22%2C%22lastName%22%3A%22Lew%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasin%22%2C%22lastName%22%3A%22Al-Qubati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasuhiko%22%2C%22lastName%22%3A%22Suzuki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoshio%22%2C%22lastName%22%3A%22Nanba%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bh2%26gt%3BAbstract%26lt%3B%5C%2Fh2%26gt%3B%26lt%3Bh3%26gt%3BObjectives%26lt%3B%5C%2Fh3%26gt%3B%26lt%3Bp%26gt%3BAntimicrobial%20resistance%20%28AMR%29%20is%20a%20priority%20for%20surveillance%20in%20bacterial%20infections.%20For%20leprosy%2C%20AMR%20has%20not%20been%20assessed%20because%20%26lt%3Bi%26gt%3BMycobacterium%20leprae%26lt%3B%5C%2Fi%26gt%3B%20does%20not%20grow%20%26lt%3Bi%26gt%3Bin%20vitro%26lt%3B%5C%2Fi%26gt%3B.%20We%20aim%20to%20obtain%20AMR%20data%20using%20molecular%20detection%20of%20resistance%20genes%20and%20to%20conduct%20a%20prospective%20open%20survey%20of%20resistance%20to%20antileprosy%20drugs%20in%20countries%20where%20leprosy%20is%20endemic%20through%20a%20WHO%20surveillance%20network.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bh3%26gt%3BMethods%26lt%3B%5C%2Fh3%26gt%3B%26lt%3Bp%26gt%3BFrom%202009%20to%202015%2C%20multi-bacillary%20leprosy%20cases%20at%20sentinel%20sites%20of%2019%20countries%20were%20studied%20for%20resistance%20to%20rifampicin%2C%20dapsone%20and%20ofloxacin%20by%20PCR%20sequencing%20of%20the%20drug-resistance-determining%20regions%20of%20the%20genes%20%26lt%3Bi%26gt%3BrpoB%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3BfolP1%26lt%3B%5C%2Fi%26gt%3B%20and%20%26lt%3Bi%26gt%3BgyrA%26lt%3B%5C%2Fi%26gt%3B.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bh3%26gt%3BResults%26lt%3B%5C%2Fh3%26gt%3B%26lt%3Bp%26gt%3BAmong%201932%20%281143%20relapse%20and%20789%20new%29%20cases%20studied%2C%20154%20%288.0%25%29%20%26lt%3Bi%26gt%3BM.%20leprae%26lt%3B%5C%2Fi%26gt%3B%20strains%20were%20found%20with%20mutations%20conferring%20resistance%20showing%20182%20resistance%20traits%20%2874%20for%20rifampicin%2C%2087%20for%20dapsone%20and%2021%20for%20ofloxacin%29.%20Twenty%20cases%20showed%20rifampicin%20and%20dapsone%20resistance%2C%20four%20showed%20ofloxacin%20and%20dapsone%20resistance%2C%20but%20no%20cases%20were%20resistant%20to%20rifampicin%20and%20ofloxacin.%20Rifampicin%20resistance%20was%20observed%20among%20relapse%20%2858%5C%2F1143%2C%205.1%25%29%20and%20new%20%2816%5C%2F789%2C%202.0%25%29%20cases%20in%2012%20countries.%20India%2C%20Brazil%20and%20Colombia%20reported%20more%20than%20five%20rifampicin-resistant%20cases.%26lt%3B%5C%2Fp%26gt%3B%26lt%3Bh3%26gt%3BConclusions%26lt%3B%5C%2Fh3%26gt%3B%26lt%3Bp%26gt%3BThis%20is%20the%20first%20study%20reporting%20global%20data%20on%20AMR%20in%20leprosy.%20Rifampicin%20resistance%20emerged%2C%20stressing%20the%20need%20for%20expansion%20of%20surveillance.%20This%20is%20also%20a%20call%20for%20vigilance%20on%20the%20global%20use%20of%20antimicrobial%20agents%2C%20because%20ofloxacin%20resistance%20probably%20developed%20in%20relation%20to%20the%20general%20intake%20of%20antibiotics%20for%20other%20infections%20as%20it%20is%20not%20part%20of%20the%20multidrug%20combination%20used%20to%20treat%20leprosy.%26lt%3B%5C%2Fp%26gt%3B%22%2C%22date%22%3A%222018%5C%2F12%5C%2F01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2018.02.022%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.clinicalmicrobiologyandinfection.com%5C%2Farticle%5C%2FS1198-743X%2818%2930197-6%5C%2Fabstract%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198-743X%22%2C%22language%22%3A%22English%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-03T22%3A28%3A25Z%22%7D%7D%2C%7B%22key%22%3A%22XJTY4VYG%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chauffour%20et%20al.%22%2C%22parsedDate%22%3A%222018-11-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChauffour%2C%20A.%2C%20Lecorche%2C%20E.%2C%20Reibel%2C%20F.%2C%20Mougari%2C%20F.%2C%20Raskine%2C%20L.%2C%20Aubry%2C%20A.%2C%20Jarlier%2C%20V.%20and%20Cambau%2C%20E.%20%282018%29.%20%26lt%3Bb%26gt%3BProspective%20study%20on%20antimicrobial%20resistance%20in%20leprosy%20cases%20diagnosed%20in%20France%20from%202001%20to%202015%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Microbiology%20and%20Infection%20%26lt%3Bi%26gt%3B24%26lt%3B%5C%2Fi%26gt%3B%2C%201213.e5-1213.e8%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2018.06.004%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2018.06.004%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prospective%20study%20on%20antimicrobial%20resistance%20in%20leprosy%20cases%20diagnosed%20in%20France%20from%202001%20to%202015%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Reibel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Raskine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222018-11-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2018.06.004%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.clinicalmicrobiologyandinfection.com%5C%2Farticle%5C%2FS1198-743X%2818%2930463-4%5C%2Ffulltext%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198-743X%22%2C%22language%22%3A%22English%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-12T08%3A27%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22AILCSCWE%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mieras%20et%20al.%22%2C%22parsedDate%22%3A%222018-10-05%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMieras%2C%20L.%20F.%2C%20Taal%2C%20A.%20T.%2C%20van%20Brakel%2C%20W.%20H.%2C%20Cambau%2C%20E.%2C%20Saunderson%2C%20P.%20R.%2C%20Smith%2C%20W.%20C.%20S.%2C%20Prakoeswa%2C%20C.%20R.%20S.%2C%20Astari%2C%20L.%2C%20Scollard%2C%20D.%20M.%2C%20do%20Nascimento%2C%20D.%20C.%2C%20Grosset%2C%20J.%2C%20Kar%2C%20H.%20K.%2C%20Izumi%2C%20S.%2C%20Gillini%2C%20L.%2C%20Virmond%2C%20M.%20C.%20L.%20and%20Sturkenboom%2C%20M.%20G.%20G.%20%282018%29.%20%26lt%3Bb%26gt%3BAn%20enhanced%20regimen%20as%20post-exposure%20chemoprophylaxis%20for%20leprosy%3A%20PEP%2B%2B%26lt%3B%5C%2Fb%26gt%3B.%20BMC%20Infectious%20Diseases%20%26lt%3Bi%26gt%3B18%26lt%3B%5C%2Fi%26gt%3B%2C%20506%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-018-3402-4%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-018-3402-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22An%20enhanced%20regimen%20as%20post-exposure%20chemoprophylaxis%20for%20leprosy%3A%20PEP%2B%2B%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liesbeth%20F.%22%2C%22lastName%22%3A%22Mieras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20T.%22%2C%22lastName%22%3A%22Taal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wim%20H.%22%2C%22lastName%22%3A%22van%20Brakel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20R.%22%2C%22lastName%22%3A%22Saunderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22W.%20Cairns%20S.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cita%20Rosita%20S.%22%2C%22lastName%22%3A%22Prakoeswa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Astari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20M.%22%2C%22lastName%22%3A%22Scollard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dejair%20Caitano%22%2C%22lastName%22%3A%22do%20Nascimento%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Grosset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hemanta%20K.%22%2C%22lastName%22%3A%22Kar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shinzo%22%2C%22lastName%22%3A%22Izumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Gillini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcos%20C.%20L.%22%2C%22lastName%22%3A%22Virmond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marieke%20G.%20G.%22%2C%22lastName%22%3A%22Sturkenboom%22%7D%5D%2C%22abstractNote%22%3A%22The%20ongoing%20transmission%20of%20Mycobacterium%20%28M.%29%20leprae%20reflected%20in%20a%20very%20slow%20decline%20in%20leprosy%20incidence%2C%20forces%20us%20to%20be%20innovative%20and%20conduct%20cutting-edge%20research.%20Single%20dose%20rifampicin%20%28SDR%29%20as%20post-exposure%20prophylaxis%20%28PEP%29%20for%20contacts%20of%20leprosy%20patients%2C%20reduces%20their%20risk%20to%20develop%20leprosy%20by%2060%25.%20This%20is%20a%20promising%20new%20preventive%20measure%20that%20can%20be%20integrated%20into%20routine%20leprosy%20control%20programmes%2C%20as%20is%20being%20demonstrated%20in%20the%20Leprosy%20Post-Exposure%20Programme%20that%20is%20currently%20ongoing%20in%20eight%20countries.%22%2C%22date%22%3A%22October%205%2C%202018%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12879-018-3402-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-018-3402-4%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2334%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-03T22%3A26%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22Q5DCBVM4%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cambau%22%2C%22parsedDate%22%3A%222018%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCambau%2C%20E.%20%282018%29.%20%26lt%3Bb%26gt%3BAntileprosy%20drugs%3A%20mode%20of%20action%20and%20mechanisms%26lt%3B%5C%2Fb%26gt%3B.%20In%3A%20%26lt%3Bb%26gt%3BInternational%20textbook%20of%20leprosy%26lt%3B%5C%2Fb%26gt%3B%2C%20URL%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Finternationaltextbookofleprosy.org%5C%2Fchapter%5C%2Fanti-leprosy-drugs-modes-action-and-mechanisms-resistance-mycobacterium-leprae%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Finternationaltextbookofleprosy.org%5C%2Fchapter%5C%2Fanti-leprosy-drugs-modes-action-and-mechanisms-resistance-mycobacterium-leprae%26lt%3B%5C%2Fa%26gt%3B%20%5BAccessed%20May%202022%5D.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Antileprosy%20drugs%3A%20mode%20of%20action%20and%20mechanisms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22bookTitle%22%3A%22International%20textbook%20of%20leprosy%22%2C%22date%22%3A%222018%22%2C%22originalDate%22%3A%22%22%2C%22originalPublisher%22%3A%22%22%2C%22originalPlace%22%3A%22%22%2C%22format%22%3A%22%22%2C%22ISBN%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Finternationaltextbookofleprosy.org%5C%2Fchapter%5C%2Fanti-leprosy-drugs-modes-action-and-mechanisms-resistance-mycobacterium-leprae%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22English%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-05-16T15%3A24%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22Q4ZJ4XZI%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Machado%20et%20al.%22%2C%22parsedDate%22%3A%222018%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMachado%2C%20D.%2C%20Lecorche%2C%20E.%2C%20Mougari%2C%20F.%2C%20Cambau%2C%20E.%20and%20Viveiros%2C%20M.%20%282018%29.%20%26lt%3Bb%26gt%3BInsights%20on%20Mycobacterium%20leprae%20Efflux%20Pumps%20and%20Their%20Implications%20in%20Drug%20Resistance%20and%20Virulence%26lt%3B%5C%2Fb%26gt%3B.%20Front%20Microbiol%20%26lt%3Bi%26gt%3B9%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmicb.2018.03072%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmicb.2018.03072%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Insights%20on%20Mycobacterium%20leprae%20Efflux%20Pumps%20and%20Their%20Implications%20in%20Drug%20Resistance%20and%20Virulence%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Viveiros%22%7D%5D%2C%22abstractNote%22%3A%22Drug%20resistance%20in%20Mycobacterium%20leprae%20is%20assumed%20to%20be%20due%20to%20genetic%20alterations%20in%20the%20drug%20targets%20and%20reduced%20cell%20wall%20permeability.%20However%2C%20as%20observed%20in%20Mycobacterium%20tuberculosis%2C%20drug%20resistance%20may%20also%20result%20from%20the%20overactivity%20of%20efflux%20systems%2C%20which%20is%20mostly%20unexplored.%20In%20this%20perspective%2C%20we%20discuss%20known%20efflux%20pumps%20involved%20in%20M.%20tuberculosis%20drug%20resistance%20and%20virulence%20and%20investigate%20similar%20regions%20in%20the%20genome%20of%20M.%20leprae.%20In%20silico%20analysis%20reveals%20that%20the%20major%20M.%20tuberculosis%20efflux%20pumps%20known%20to%20be%20associated%20with%20drug%20resistance%20and%20virulence%20have%20been%20retained%20during%20the%20reductive%20evolutionary%20process%20that%20M.%20leprae%20underwent%2C%20e.g.%2C%20RND%20superfamily%2C%20the%20ABC%20transporter%20BacA%2C%20and%20the%20MFS%20P55.%20However%2C%20some%20are%20absent%20%28DinF%2C%20MATE%29%20while%20others%20are%20derepressed%20%28Mmr%2C%20SMR%29%20in%20M.%20leprae%20reflecting%20the%20specific%20environment%20where%20M.%20leprae%20may%20live.%20The%20occurrence%20of%20several%20multidrug%20resistance%20efflux%20transporters%20shared%20between%20M.%20leprae%20and%20M.%20tuberculosis%20reveals%20potential%20implications%20in%20drug%20resistance%20and%20virulence.%20The%20conservation%20of%20the%20described%20efflux%20systems%20in%20M.%20leprae%20upon%20genome%20reduction%20indicates%20that%20these%20systems%20are%20potentially%20required%20for%20its%20intracellular%20survival%20and%20lifestyle.%20They%20potentially%20are%20involved%20in%20M.%20leprae%20drug%20resistance%2C%20which%20could%20hamper%20leprosy%20treatment%20success.%20Studying%20M.%20leprae%20efflux%20pumps%20as%20new%20drug%20targets%20is%20useful%20for%20future%20leprosy%20therapeutics%2C%20enhancing%20the%20global%20efforts%20to%20eradicate%20endemic%20leprosy%20and%20prevent%20the%20emergence%20of%20drug%20resistance%20in%20afflicted%20countries.%22%2C%22date%22%3A%222018%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffmicb.2018.03072%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffmicb.2018.03072%5C%2Ffull%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221664-302X%22%2C%22language%22%3A%22English%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-03T22%3A23%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22W49YLEFB%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Andre%20et%20al.%22%2C%22parsedDate%22%3A%222017-03-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAndre%2C%20E.%2C%20Goeminne%2C%20L.%2C%20Cabibbe%2C%20A.%2C%20Beckert%2C%20P.%2C%20Mukadi%2C%20B.%20K.%2C%20Mathys%2C%20V.%2C%20Gagneux%2C%20S.%2C%20Niemann%2C%20S.%2C%20Ingen%2C%20J.%20V.%20and%20Cambau%2C%20E.%20%282017%29.%20%26lt%3Bb%26gt%3BConsensus%20numbering%20system%20for%20the%20rifampicin%20resistance-associated%20rpoB%20gene%20mutations%20in%20pathogenic%20mycobacteria%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Microbiology%20and%20Infection%20%26lt%3Bi%26gt%3B23%26lt%3B%5C%2Fi%26gt%3B%2C%20167%26%23x2013%3B172%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2016.09.006%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2016.09.006%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Consensus%20numbering%20system%20for%20the%20rifampicin%20resistance-associated%20rpoB%20gene%20mutations%20in%20pathogenic%20mycobacteria%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Andre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Goeminne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Cabibbe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Beckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20Kabamba%22%2C%22lastName%22%3A%22Mukadi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Mathys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Gagneux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Van%22%2C%22lastName%22%3A%22Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222017-03-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2016.09.006%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.clinicalmicrobiologyandinfection.com%5C%2Farticle%5C%2FS1198-743X%2816%2930393-7%5C%2Ffulltext%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198-743X%22%2C%22language%22%3A%22English%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-12T09%3A40%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22JYLD7TLG%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Raharolahy%20et%20al.%22%2C%22parsedDate%22%3A%222016-08-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRaharolahy%2C%20O.%2C%20Ramarozatovo%2C%20L.%20S.%2C%20Ranaivo%2C%20I.%20M.%2C%20Sendrasoa%2C%20F.%20A.%2C%20Andrianarison%2C%20M.%2C%20Andrianarivelo%2C%20M.%20R.%2C%20Cambau%2C%20E.%20and%20Rabenja%2C%20F.%20R.%20%282016%29.%20%26lt%3Bb%26gt%3BA%20Case%20of%20Fluoroquinolone-Resistant%20Leprosy%20Discovered%20after%209%20Years%20of%20Misdiagnosis%26lt%3B%5C%2Fb%26gt%3B.%20Case%20Reports%20in%20Infectious%20Diseases%20%26lt%3Bi%26gt%3B2016%26lt%3B%5C%2Fi%26gt%3B%2C%204632369%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1155%5C%2F2016%5C%2F4632369%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1155%5C%2F2016%5C%2F4632369%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20Case%20of%20Fluoroquinolone-Resistant%20Leprosy%20Discovered%20after%209%20Years%20of%20Misdiagnosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Onivola%22%2C%22lastName%22%3A%22Raharolahy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lala%20S.%22%2C%22lastName%22%3A%22Ramarozatovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irina%20M.%22%2C%22lastName%22%3A%22Ranaivo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fandresena%20A.%22%2C%22lastName%22%3A%22Sendrasoa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malalaniaina%22%2C%22lastName%22%3A%22Andrianarison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mala%20Rakoto%22%2C%22lastName%22%3A%22Andrianarivelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fahafahantsoa%20Rapelanoro%22%2C%22lastName%22%3A%22Rabenja%22%7D%5D%2C%22abstractNote%22%3A%22We%20report%20a%20case%20of%20misdiagnosed%20leprosy%20in%20a%2021-year-old%20Malagasy%20male%2C%20who%2C%20improperly%20treated%2C%20developed%20secondary%20mycobacterial%20resistance%20to%20fluoroquinolone.%20The%20patient%20contracted%20the%20infection%209%20years%20prior%20to%20the%20current%20consultation%2C%20displaying%20on%20the%20right%20thigh%20a%20single%20papulonodular%20lesion%2C%20which%20progressively%20spread%20to%20the%20lower%20leg%2C%20back%2C%20and%20face.%20Initial%20administration%20of%20ciprofloxacin%20and%20prednisolone%20led%20to%20temporary%20and%20fluctuating%20improvement.%20Subsequent%20long-term%20self-medication%20with%20ciprofloxacin%20and%20corticosteroid%20did%20not%20heal%20the%20foul%20and%20nonhealing%20ulcers%20on%20the%20legs%20and%20under%20the%20right%20sole.%20Histopathological%20findings%20were%20compatible%20with%20lepromatous%20leprosy.%20Skin%20biopsy%20was%20positive%20for%20acid-fast%20bacilli%20and%20PCR%20assay%20confirmed%20the%20presence%20of%20a%20fluoroquinolone-resistant%20strain%20of%20Mycobacterium%20leprae%20%28gyrA%20A91V%29.%20After%206%20months%20of%20standard%20regimen%20with%20rifampicin%2C%20clofazimine%2C%20and%20dapsone%2C%20clinical%20outcome%20significantly%20improved.%20Clinical%20characteristics%20and%20possible%20epidemiological%20implications%20are%20discussed.%22%2C%22date%22%3A%222016-08-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1155%5C%2F2016%5C%2F4632369%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.hindawi.com%5C%2Fjournals%5C%2Fcriid%5C%2F2016%5C%2F4632369%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222090-6625%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-11T23%3A32%3A17Z%22%7D%7D%2C%7B%22key%22%3A%2296NQCXTI%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mieras%20et%20al.%22%2C%22parsedDate%22%3A%222016-06-08%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMieras%2C%20L.%2C%20Anthony%2C%20R.%2C%20van%20Brakel%2C%20W.%2C%20Bratschi%2C%20M.%20W.%2C%20van%20den%20Broek%2C%20J.%2C%20Cambau%2C%20E.%2C%20Cavaliero%2C%20A.%2C%20Kasang%2C%20C.%2C%20Perera%2C%20G.%2C%20Reichman%2C%20L.%2C%20Richardus%2C%20J.%20H.%2C%20Saunderson%2C%20P.%2C%20Steinmann%2C%20P.%20and%20Yew%2C%20W.%20W.%20%282016%29.%20%26lt%3Bb%26gt%3BNegligible%20risk%20of%20inducing%20resistance%20in%20Mycobacterium%20tuberculosis%20with%20single-dose%20rifampicin%20as%20post-exposure%20prophylaxis%20for%20leprosy%26lt%3B%5C%2Fb%26gt%3B.%20Infectious%20Diseases%20of%20Poverty%20%26lt%3Bi%26gt%3B5%26lt%3B%5C%2Fi%26gt%3B%2C%2046%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs40249-016-0140-y%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs40249-016-0140-y%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Negligible%20risk%20of%20inducing%20resistance%20in%20Mycobacterium%20tuberculosis%20with%20single-dose%20rifampicin%20as%20post-exposure%20prophylaxis%20for%20leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liesbeth%22%2C%22lastName%22%3A%22Mieras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Anthony%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wim%22%2C%22lastName%22%3A%22van%20Brakel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20W.%22%2C%22lastName%22%3A%22Bratschi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22van%20den%20Broek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arielle%22%2C%22lastName%22%3A%22Cavaliero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christa%22%2C%22lastName%22%3A%22Kasang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geethal%22%2C%22lastName%22%3A%22Perera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lee%22%2C%22lastName%22%3A%22Reichman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20Hendrik%22%2C%22lastName%22%3A%22Richardus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Saunderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Steinmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wing%20Wai%22%2C%22lastName%22%3A%22Yew%22%7D%5D%2C%22abstractNote%22%3A%22Post-exposure%20prophylaxis%20%28PEP%29%20for%20leprosy%20is%20administered%20as%20one%20single%20dose%20of%20rifampicin%20%28SDR%29%20to%20the%20contacts%20of%20newly%20diagnosed%20leprosy%20patients.%20SDR%20reduces%20the%20risk%20of%20developing%20leprosy%20among%20contacts%20by%20around%2060%5Cu00a0%25%20in%20the%20first%202%5Cu20133%20years%20after%20receiving%20SDR.%20In%20countries%20where%20SDR%20is%20currently%20being%20implemented%20under%20routine%20programme%20conditions%20in%20defined%20areas%2C%20questions%20were%20raised%20by%20health%20authorities%20and%20professional%20bodies%20about%20the%20possible%20risk%20of%20inducing%20rifampicin%20resistance%20among%20the%20M.%20tuberculosis%20strains%20circulating%20in%20these%20areas.%20This%20issue%20has%20not%20been%20addressed%20in%20scientific%20literature%20to%20date.%20To%20produce%20an%20authoritative%20consensus%20statement%20about%20the%20risk%20that%20SDR%20would%20induce%20rifampicin-resistant%20tuberculosis%2C%20a%20meeting%20was%20convened%20with%20tuberculosis%20%28TB%29%20and%20leprosy%20experts.%20The%20experts%20carefully%20reviewed%20and%20discussed%20the%20available%20evidence%20regarding%20the%20mechanisms%20and%20risk%20factors%20for%20the%20development%20of%20%28multi%29%20drug-resistance%20in%20M.%20tuberculosis%20with%20a%20view%20to%20the%20special%20situation%20of%20the%20use%20of%20SDR%20as%20PEP%20for%20leprosy.%20They%20concluded%20that%20SDR%20given%20to%20contacts%20of%20leprosy%20patients%2C%20in%20the%20absence%20of%20symptoms%20of%20active%20TB%2C%20poses%20a%20negligible%20risk%20of%20generating%20resistance%20in%20M.%20tuberculosis%20in%20individuals%20and%20at%20the%20population%20level.%20Thus%2C%20the%20benefits%20of%20SDR%20prophylaxis%20in%20reducing%20the%20risk%20of%20developing%20leprosy%20in%20contacts%20of%20new%20leprosy%20patients%20far%20outweigh%20the%20risks%20of%20generating%20drug%20resistance%20in%20M.%20tuberculosis.%22%2C%22date%22%3A%22June%208%2C%202016%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs40249-016-0140-y%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs40249-016-0140-y%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222049-9957%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222017-08-02T16%3A18%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22U4GH9AVW%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reibel%20et%20al.%22%2C%22parsedDate%22%3A%222015-10-06%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BReibel%2C%20F.%2C%20Chauffour%2C%20A.%2C%20Brossier%2C%20F.%2C%20Jarlier%2C%20V.%2C%20Cambau%2C%20E.%20and%20Aubry%2C%20A.%20%282015%29.%20%26lt%3Bb%26gt%3BNew%20Insights%20into%20the%20Geographic%20Distribution%20of%20Mycobacterium%20leprae%20SNP%20Genotypes%20Determined%20for%20Isolates%20from%20Leprosy%20Cases%20Diagnosed%20in%20Metropolitan%20France%20and%20French%20Territories%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Johnson%2C%20C.%20PLOS%20Neglected%20Tropical%20Diseases%20%26lt%3Bi%26gt%3B9%26lt%3B%5C%2Fi%26gt%3B%2C%20e0004141%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0004141%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0004141%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22New%20Insights%20into%20the%20Geographic%20Distribution%20of%20Mycobacterium%20leprae%20SNP%20Genotypes%20Determined%20for%20Isolates%20from%20Leprosy%20Cases%20Diagnosed%20in%20Metropolitan%20France%20and%20French%20Territories%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Reibel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Johnson%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222015-10-6%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0004141%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pntd.0004141%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221935-2735%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-03-26T17%3A54%3A10Z%22%7D%7D%2C%7B%22key%22%3A%22EIHIVTCZ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reibel%20et%20al.%22%2C%22parsedDate%22%3A%222015-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BReibel%2C%20F.%2C%20Cambau%2C%20E.%20and%20Aubry%2C%20A.%20%282015%29.%20%26lt%3Bb%26gt%3BUpdate%20on%20the%20epidemiology%2C%20diagnosis%2C%20and%20treatment%20of%20leprosy%26lt%3B%5C%2Fb%26gt%3B.%20M%26%23xE9%3Bdecine%20et%20Maladies%20Infectieuses%20%26lt%3Bi%26gt%3B45%26lt%3B%5C%2Fi%26gt%3B%2C%20383%26%23x2013%3B393%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2015.09.002%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.medmal.2015.09.002%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Update%20on%20the%20epidemiology%2C%20diagnosis%2C%20and%20treatment%20of%20leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Reibel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22Leprosy%20is%20an%20infectious%20disease%20that%20has%20now%20been%20reported%20for%20more%20than%202000%20years.%20The%20leprosy%20elimination%20goal%20set%20by%20the%20World%20Health%20Organization%20%28WHO%29%2C%20i.e.%20a%20global%20prevalence%20rate%20%26lt%3B%201%20patient%20per%2010%2C000%20population%2C%20was%20achieved%20in%20the%20year%202000%2C%20but%20more%20than%20200%2C000%20new%20case%20patients%20are%20still%20reported%20each%20year%2C%20particularly%20in%20India%2C%20Brazil%2C%20and%20Indonesia.%20Leprosy%20is%20a%20specific%20infection%3A%20%28i%29%20it%20is%20a%20chronic%20infection%20primarily%20affecting%20the%20skin%20and%20peripheral%20nerves%2C%20%28ii%29%20Mycobacterium%20leprae%20is%20one%20of%20the%20last%20bacterial%20species%20of%20medical%20interest%20that%20cannot%20be%20cultured%20in%20vitro%20%28mainly%20because%20of%20its%20reductive%20genome%20evolution%29%2C%20and%20%28iii%29%20transmission%20and%20pathophysiological%20data%20is%20still%20limited.%20The%20various%20presentations%20of%20the%20disease%20%28Ridley-Jopling%20and%20WHO%20classifications%29%20are%20correlated%20with%20the%20patient%26%23039%3Bs%20immune%20response%2C%20bacillary%20load%2C%20and%20by%20the%20delay%20before%20diagnosis.%20Multidrug%20therapy%20%28dapsone%2C%20rifampicin%2C%20with%20or%20without%20clofazimine%29%20has%20been%20recommended%20since%201982%20as%20the%20standard%20treatment%20of%20leprosy%3B%206%20months%20for%20patients%20presenting%20with%20paucibacillary%20leprosy%20and%2012%20months%20for%20patients%20presenting%20with%20multibacillary%20leprosy.%20The%20worldwide%20use%20of%20leprosy%20drugs%20started%20in%20the%201980s%20and%20their%20free%20access%20since%201995%20contributed%20to%20the%20drastic%20decline%20in%20the%20number%20of%20new%20case%20patients.%20Resistant%20strains%20are%20however%20emerging%20despite%20the%20use%20of%20multidrug%20therapy%3B%20identifying%20and%20monitoring%20resistance%20is%20still%20necessary.%22%2C%22date%22%3A%22septembre%202015%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.medmal.2015.09.002%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0399077X1500181X%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220399-077X%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222017-08-02T16%3A28%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22SVWG3WRG%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reibel%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BReibel%2C%20F.%2C%20Cambau%2C%20E.%20and%20Aubry%2C%20A.%20%282015%29.%20%26lt%3Bb%26gt%3BHistoire%20et%20actualit%26%23xE9%3B%20du%20traitement%20de%20la%20l%26%23xE8%3Bpre%26lt%3B%5C%2Fb%26gt%3B.%20Journal%20des%20Anti-Infectieux%20%26lt%3Bi%26gt%3B17%26lt%3B%5C%2Fi%26gt%3B%2C%2091%26%23x2013%3B98%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.antinf.2015.01.004%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.antinf.2015.01.004%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Histoire%20et%20actualit%5Cu00e9%20du%20traitement%20de%20la%20l%5Cu00e8pre%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Reibel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22Histoire%20et%20actualit%5Cu00e9%20du%20traitement%20de%20la%20l%5Cu00e8pre%22%2C%22date%22%3A%222015%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.antinf.2015.01.004%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.em-consulte.com%5C%2Farticle%5C%2F1008047%5C%2Fhistoire-et-actualite-du-traitement-de-la-lepre%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-01T16%3A22%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22HRKPMGKG%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Veziris%20et%20al.%22%2C%22parsedDate%22%3A%222013-11-14%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVeziris%2C%20N.%2C%20Chauffour%2C%20A.%2C%20Escolano%2C%20S.%2C%20Henquet%2C%20S.%2C%20Matsuoka%2C%20M.%2C%20Jarlier%2C%20V.%20and%20Aubry%2C%20A.%20%282013%29.%20%26lt%3Bb%26gt%3BResistance%20of%20M.%20leprae%20to%20Quinolones%3A%20A%20Question%20of%20Relativity%3F%26lt%3B%5C%2Fb%26gt%3B%20PLoS%20Negl%20Trop%20Dis%20%26lt%3Bi%26gt%3B7%26lt%3B%5C%2Fi%26gt%3B%2C%20e2559%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0002559%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0002559%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Resistance%20of%20M.%20leprae%20to%20Quinolones%3A%20A%20Question%20of%20Relativity%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvie%22%2C%22lastName%22%3A%22Escolano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Henquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masanori%22%2C%22lastName%22%3A%22Matsuoka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22Author%20SummaryAlthough%20there%20is%20efficient%20multidrug%20therapy%20to%20cure%20leprosy%2C%20the%20transmission%20of%20M.%20leprae%20is%20still%20active%2C%20leading%20to%20219%2C000%20new%20cases%20in%202011.%20Drug%20resistant%20leprosy%20has%20been%20described%20and%20may%20prevent%20eradication%20of%20the%20disease%2C%20notably%20multidrug%20resistant%20defined%20as%20resistance%20to%20rifampin%2C%20dapsone%20and%20fluoroquinolones%20%28FQ%29.%20Resistance%20to%20FQ%20is%20due%20to%20mutations%20in%20DNA%20gyrase.%20We%20used%20a%20mouse%20model%20to%20measure%20the%20impact%20of%20DNA%20gyrase%20mutations%20on%20in%20vivo%20FQ%20activity.%20All%20the%20FQ%20tested%20showed%20in%20vivo%20activity%20against%20the%20mutant%20tested%20%28A91V%20mutant%20in%20subunit%20A%20of%20DNA%20gyrase%29.%20However%2C%20whereas%20ofloxacin%20was%20less%20active%20than%20the%20control%20treatment%20clarithromycin%2C%20it%20appeared%20that%20latter%20generation%20fluoroquinolones%20moxifloxacin%20and%20garenoxacin%20were%20as%20active%20as%20clarithromycin.%20Our%20results%20demonstrate%20that%20DNA%20gyrase%20mutation%20is%20not%20synonymous%20of%20total%20lack%20of%20in%20vivo%20FQ%20activity%20against%20M.%20leprae.%20Therefore%2C%20as%20for%20M.%20tuberculosis%2C%20in%20vivo%20studies%20are%20mandatory%20in%20order%20to%20measure%20the%20impact%20of%20DNA%20gyrase%20mutations%20on%20treatment%20efficacy%20against%20M.%20leprae.%22%2C%22date%22%3A%22November%2014%2C%202013%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0002559%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.doi.org%5C%2F10.1371%5C%2Fjournal.pntd.0002559%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222015-07-20T16%3A28%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22SI3UU2U6%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gomez%20et%20al.%22%2C%22parsedDate%22%3A%222013-02-15%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGomez%2C%20C.%2C%20Ponien%2C%20P.%2C%20Serradji%2C%20N.%2C%20Lamouri%2C%20A.%2C%20Pantel%2C%20A.%2C%20Capton%2C%20E.%2C%20Jarlier%2C%20V.%2C%20Anquetin%2C%20G.%20and%20Aubry%2C%20A.%20%282013%29.%20%26lt%3Bb%26gt%3BSynthesis%20of%20gatifloxacin%20derivatives%20and%20their%20biological%20activities%20against%20Mycobacterium%20leprae%20and%20Mycobacterium%20tuberculosis%26lt%3B%5C%2Fb%26gt%3B.%20Bioorganic%20%26amp%3B%20Medicinal%20Chemistry%20%26lt%3Bi%26gt%3B21%26lt%3B%5C%2Fi%26gt%3B%2C%20948%26%23x2013%3B956%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.bmc.2012.12.011%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.bmc.2012.12.011%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Synthesis%20of%20gatifloxacin%20derivatives%20and%20their%20biological%20activities%20against%20Mycobacterium%20leprae%20and%20Mycobacterium%20tuberculosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Gomez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prishila%22%2C%22lastName%22%3A%22Ponien%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nawal%22%2C%22lastName%22%3A%22Serradji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aazdine%22%2C%22lastName%22%3A%22Lamouri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alix%22%2C%22lastName%22%3A%22Pantel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Capton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Anquetin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22Novel%203%5Cu2032-piperazinyl%20derivatives%20of%20the%208-hydrogeno%20and%208-methoxy-6-fluoro-1-cyclopropyl-4-quinolone-3-carboxylic%20acid%20scaffolds%20were%20designed%2C%20synthesized%20and%20characterized%20by%201H%2C%2013C%20and%2019F%20NMR%2C%20and%20HRMS.%20The%20activity%20of%20these%20derivatives%20against%20pathogenic%20mycobacteria%20%28M.%20leprae%20and%20M.%20tuberculosis%29%2C%20wild-type%20%28WT%29%20strains%20or%20strains%20harboring%20mutations%20implicated%20in%20quinolone%20resistance%2C%20were%20determined%20by%20measuring%20drug%20concentrations%20inhibiting%20cell%20growth%20%28MIC%29%20and%5C%2For%20DNA%20supercoiling%20by%20DNA%20gyrase%20%28IC50%29%2C%20or%20inducing%2025%25%20DNA%20cleavage%20by%20DNA%20gyrase%20%28CC25%29.%20Compound%204%20%28with%20a%20methoxy%20in%20R8%20and%20a%20secondary%20carbamate%20in%20R3%5Cu2032%29%20and%20compound%205%20%28with%20a%20hydrogen%20in%20R8%20and%20an%20ethyl%20ester%20in%20R3%5Cu2032%29%20displayed%20biological%20activities%20close%20to%20those%20of%20ofloxacin%20but%20inferior%20to%20those%20of%20gatifloxacin%20and%20moxifloxacin%20against%20M.%20tuberculosis%20and%20M.%20leprae%20WT%20DNA%20gyrases%2C%20whereas%20all%20of%20the%20compounds%20were%20less%20active%20in%20inhibiting%20M.%20tuberculosis%20growth%20and%20M.%20leprae%20mutant%20DNA%20gyrases.%20Since%20R3%5Cu2032%20substitutions%20have%20been%20poorly%20investigated%20previously%2C%20our%20results%20may%20help%20to%20design%20new%20quinolone%20derivatives%20in%20the%20future.%22%2C%22date%22%3A%22February%2015%2C%202013%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.bmc.2012.12.011%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0968089612009728%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220968-0896%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-26T18%3A04%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22U272CXV3%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cambau%20et%20al.%22%2C%22parsedDate%22%3A%222012-07-31%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCambau%2C%20E.%2C%20Chauffour-Nevejans%2C%20A.%2C%20Tejmar-Kolar%2C%20L.%2C%20Matsuoka%2C%20M.%20and%20Jarlier%2C%20V.%20%282012%29.%20%26lt%3Bb%26gt%3BDetection%20of%20Antibiotic%20Resistance%20in%20Leprosy%20Using%20GenoType%20LepraeDR%2C%20a%20Novel%20Ready-To-Use%20Molecular%20Test%26lt%3B%5C%2Fb%26gt%3B.%20PLoS%20Negl%20Trop%20Dis%20%26lt%3Bi%26gt%3B6%26lt%3B%5C%2Fi%26gt%3B%2C%20e1739%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0001739%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0001739%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Detection%20of%20Antibiotic%20Resistance%20in%20Leprosy%20Using%20GenoType%20LepraeDR%2C%20a%20Novel%20Ready-To-Use%20Molecular%20Test%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour-Nevejans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liana%22%2C%22lastName%22%3A%22Tejmar-Kolar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masanori%22%2C%22lastName%22%3A%22Matsuoka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22Author%20SummaryAlthough%20leprosy%20is%20a%20curable%20disease%20using%20a%20combination%20of%20antibiotics%20for%20one%20year%2C%20the%20transmission%20is%20still%20active%20with%20230%2C000%20new%20cases%20in%202010.%20Drug%20resistance%20has%20been%20described%20and%20may%20prevent%20eradication%20of%20the%20disease.%20The%20infectious%20agent%20causing%20leprosy%2C%20Mycobacterium%20leprae%2C%20is%20not%20growing%20in%20vitro%20and%20antibiotic%20susceptibility%20testing%20is%20possible%20only%20in%20the%20mouse%20footpad%20model%20that%20requires%20a%20one%20year%20experiment.%20Consequently%20this%20testing%20is%20rarely%20done%20and%20antibiotic%20resistance%20rates%20in%20leprosy%20are%20unknown.%20This%20is%20the%20reason%20why%20we%20endeavored%20to%20set%20a%20new%20diagnosis%20test%20that%20detects%20for%20antibiotic%20resistance%20in%20M.%20leprae.%20The%20test%20is%20based%20on%20the%20method%20of%20a%20DNA%20strip%20test%20with%20a%20multiplex%20PCR%20followed%20by%20reverse%20hybridization.%20It%20was%20developed%20as%20an%20easy-to-use%20test%20and%20it%20will%20be%20available%20in%20endemic%20countries%2C%20where%20these%20kinds%20of%20strip%20tests%20are%20already%20used%20for%20detection%20of%20drug%20resistance%20in%20tuberculosis.%20The%20results%20of%20the%20new%20test%2C%20Genotype%20LepraeDR%2C%20performed%20on%20120%20M.%20leprae%20strains%20were%20concordant%20with%20those%20of%20the%20standard%20PCR%20sequencing%20and%20mouse%20footpad%20susceptibility%20testing.%22%2C%22date%22%3A%22July%2031%2C%202012%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0001739%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdx.doi.org%5C%2F10.1371%5C%2Fjournal.pntd.0001739%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-26T18%3A04%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22WMVT7G3P%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Matrat%20et%20al.%22%2C%22parsedDate%22%3A%222008-02%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMatrat%2C%20S.%2C%20Cambau%2C%20E.%2C%20Jarlier%2C%20V.%20and%20Aubry%2C%20A.%20%282008%29.%20%26lt%3Bb%26gt%3BAre%20All%20the%20DNA%20Gyrase%20Mutations%20Found%20in%20Mycobacterium%20leprae%20Clinical%20Strains%20Involved%20in%20Resistance%20to%20Fluoroquinolones%3F%26lt%3B%5C%2Fb%26gt%3B%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B52%26lt%3B%5C%2Fi%26gt%3B%2C%20745%26%23x2013%3B747%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.01095-07%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.01095-07%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Are%20All%20the%20DNA%20Gyrase%20Mutations%20Found%20in%20Mycobacterium%20leprae%20Clinical%20Strains%20Involved%20in%20Resistance%20to%20Fluoroquinolones%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Matrat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20leprae%20DNA%20gyrases%20carrying%20various%20mutations%2C%20previously%20described%20in%20clinical%20strains%2C%20were%20investigated%20for%20quinolone%20susceptibility%20by%20inhibition%20of%20supercoiling%20and%20DNA%20cleavage%20promotion.%20We%20demonstrated%20that%20the%20gyrA%20mutations%20leading%20to%20G89C%20or%20A91V%20confer%20fluoroquinolone%20resistance%20whereas%20the%20gyrB%20mutation%20leading%20to%20D205N%20does%20not.%22%2C%22date%22%3A%222008-2%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.01095-07%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC2224767%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T15%3A50%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22GS7HFHMA%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Matrat%20et%20al.%22%2C%22parsedDate%22%3A%222007%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMatrat%2C%20S.%2C%20Petrella%2C%20S.%2C%20Cambau%2C%20E.%2C%20Sougakoff%2C%20W.%2C%20Jarlier%2C%20V.%20and%20Aubry%2C%20A.%20%282007%29.%20%26lt%3Bb%26gt%3BExpression%20and%20Purification%20of%20an%20Active%20Form%20of%20the%20%26lt%3Bi%26gt%3BMycobacterium%20leprae%26lt%3B%5C%2Fi%26gt%3B%20DNA%20Gyrase%20and%20Its%20Inhibition%20by%20Quinolones%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B51%26lt%3B%5C%2Fi%26gt%3B%2C%201643%26%23x2013%3B1648%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.01282-06%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.01282-06%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Expression%20and%20Purification%20of%20an%20Active%20Form%20of%20the%20%3Ci%3EMycobacterium%20leprae%3C%5C%2Fi%3E%20DNA%20Gyrase%20and%20Its%20Inhibition%20by%20Quinolones%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ste%5Cu0301phanie%22%2C%22lastName%22%3A%22Matrat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ste%5Cu0301phanie%22%2C%22lastName%22%3A%22Petrella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wladimir%22%2C%22lastName%22%3A%22Sougakoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22ABSTRACT%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20the%20causative%20agent%20of%20leprosy%2C%20is%20noncultivable%20in%20vitro%3B%20therefore%2C%20evaluation%20of%20antibiotic%20activity%20against%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20relies%20mainly%20upon%20the%20mouse%20footpad%20system%2C%20which%20requires%20at%20least%2012%20months%20before%20the%20results%20become%20available.%20We%20have%20developed%20an%20in%20vitro%20assay%20for%20studying%20the%20activities%20of%20quinolones%20against%20the%20DNA%20gyrase%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20We%20overexpressed%20in%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Escherichia%20coli%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20GyrA%20and%20GyrB%20subunits%20separately%20as%20His-tagged%20proteins%20by%20using%20a%20pET%20plasmid%20carrying%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20gyrA%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20and%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20gyrB%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20genes.%20The%20soluble%2097.5-kDa%20GyrA%20and%2074.5-kDa%20GyrB%20subunits%20were%20purified%20by%20nickel%20chelate%20chromatography%20and%20were%20reconstituted%20as%20an%20enzyme%20with%20DNA%20supercoiling%20activity.%20Based%20on%20the%20drug%20concentrations%20that%20inhibited%20DNA%20supercoiling%20by%2050%25%20or%20that%20induced%20DNA%20cleavage%20by%2025%25%2C%20the%2013%20quinolones%20tested%20clustered%20into%20three%20groups.%20Analysis%20of%20the%20quinolone%20structure-activity%20relationship%20demonstrates%20that%20the%20most%20active%20quinolones%20against%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20DNA%20gyrase%20share%20the%20following%20structural%20features%3A%20a%20substituted%20carbon%20at%20position%208%2C%20a%20cyclopropyl%20substituent%20at%20N-1%2C%20a%20fluorine%20at%20C-6%2C%20and%20a%20substituent%20ring%20at%20C-7.%20We%20conclude%20that%20the%20assays%20based%20on%20DNA%20supercoiling%20inhibition%20and%20drug-induced%20DNA%20cleavage%20on%20purified%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20DNA%20gyrase%20are%20rapid%2C%20efficient%2C%20and%20safe%20methods%20for%20the%20screening%20of%20quinolone%20derivatives%20with%20potential%20in%20vivo%20activities%20against%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%22%2C%22date%22%3A%2205%5C%2F2007%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.01282-06%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.asm.org%5C%2Fdoi%5C%2F10.1128%5C%2FAAC.01282-06%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-06-25T14%3A04%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22ARAFMLZH%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Levy%20and%20Ji%22%2C%22parsedDate%22%3A%222006-03%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLevy%2C%20L.%20and%20Ji%2C%20B.%20%282006%29.%20%26lt%3Bb%26gt%3BThe%20mouse%20foot-pad%20technique%20for%20cultivation%20of%20Mycobacterium%20leprae%26lt%3B%5C%2Fb%26gt%3B.%20Lepr%20Rev%20%26lt%3Bi%26gt%3B77%26lt%3B%5C%2Fi%26gt%3B%2C%205%26%23x2013%3B24.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20mouse%20foot-pad%20technique%20for%20cultivation%20of%20Mycobacterium%20leprae%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%22%2C%22lastName%22%3A%22Levy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baohong%22%2C%22lastName%22%3A%22Ji%22%7D%5D%2C%22abstractNote%22%3A%22Although%20multiplication%20of%20Mycobacterium%20leprae%20in%20the%20foot%20pads%20of%20immune-competent%20mice%20is%20limited%2C%20and%20no%20leprosy-like%20lesions%20are%20produced%20in%20these%20animals%2C%20the%20mouse%20foot-pad%20system%20represents%20the%20first%20truly%20useful%20and%20reproducible%20animal%20model%20of%20M.%20leprae%20infection.%20Its%20employment%20has%20enabled%20research%20into%20basic%20questions%20with%20respect%20to%20the%20microbiology%20of%20M.%20leprae%2C%20and%20the%20epidemiology%2C%20treatment%20and%20control%20of%20leprosy.%20The%20mouse%20foot-pad%20technique%20is%20labour-intensive%20and%20time-consuming%2C%20and%20is%20expensive%20in%20terms%20of%20the%20costs%20of%20animal%20purchase%20and%20maintenance.%20In%20addition%2C%20the%20technique%20appears%20to%20be%20rather%20imprecise%20and%20insensitive%2C%20compared%20with%20the%20techniques%20employed%20in%20working%20with%20cultivable%20micro-organisms.%20For%20these%20reasons%2C%20and%20also%20as%20a%20by-product%20of%20the%20success%20of%20multi-drug%20therapy%2C%20the%20technique%20has%20been%20abandoned%20in%20many%20research%20centres.%20Nevertheless%2C%20until%20a%20more%20simple%20and%20sensitive%20technique%20for%20demonstrating%20the%20viability%20of%20M.%20leprae%20is%20developed%2C%20the%20mouse%20foot-pad%20system%20remains%20an%20essential%20tool%20for%20leprosy%20research.%20In%20this%20review%2C%20we%20discuss%20the%20mouse%20foot-pad%20technique%20in%20detail%2C%20analyse%20its%20precision%2C%20point%20out%20its%20shortcomings%2C%20describe%20its%20most%20important%20applications%2C%20and%20prescribe%20a%20method%20by%20which%20to%20assess%20the%20ability%20of%20an%20alternative%20technique%20to%20serve%20in%20place%20of%20this%20established%20technique.%22%2C%22date%22%3A%222006-03%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220305-7518%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-06-25T14%3A09%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22DNH9TYFK%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cambau%20et%20al.%22%2C%22parsedDate%22%3A%222006-01-15%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCambau%2C%20E.%2C%20Carthagena%2C%20L.%2C%20Chauffour%2C%20A.%2C%20Ji%2C%20B.%20and%20Jarlier%2C%20V.%20%282006%29.%20%26lt%3Bb%26gt%3BDihydropteroate%20Synthase%20Mutations%20in%20the%20folP1%20Gene%20Predict%20Dapsone%20Resistance%20in%20Relapsed%20Cases%20of%20Leprosy%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Infectious%20Diseases%20%26lt%3Bi%26gt%3B42%26lt%3B%5C%2Fi%26gt%3B%2C%20238%26%23x2013%3B241%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1086%5C%2F498506%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1086%5C%2F498506%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Dihydropteroate%20Synthase%20Mutations%20in%20the%20folP1%20Gene%20Predict%20Dapsone%20Resistance%20in%20Relapsed%20Cases%20of%20Leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Carthagena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222006-01-15%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1086%5C%2F498506%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Fcid%5C%2Farticle-lookup%5C%2Fdoi%5C%2F10.1086%5C%2F498506%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221058-4838%2C%201537-6591%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-06-25T14%3A07%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22PEFI3JTE%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%222006%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Chauffour%2C%20A.%2C%20Andries%2C%20K.%20and%20Jarlier%2C%20V.%20%282006%29.%20%26lt%3Bb%26gt%3BBactericidal%20Activities%20of%20R207910%20and%20Other%20Newer%20Antimicrobial%20Agents%20against%20%26lt%3Bi%26gt%3BMycobacterium%20leprae%26lt%3B%5C%2Fi%26gt%3B%20in%20Mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B50%26lt%3B%5C%2Fi%26gt%3B%2C%201558%26%23x2013%3B1560%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.50.4.1558-1560.2006%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.50.4.1558-1560.2006%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bactericidal%20Activities%20of%20R207910%20and%20Other%20Newer%20Antimicrobial%20Agents%20against%20%3Ci%3EMycobacterium%20leprae%3C%5C%2Fi%3E%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baohong%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aure%5Cu0301lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Koen%22%2C%22lastName%22%3A%22Andries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22ABSTRACT%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20As%20measured%20by%20a%20proportional%20bactericidal%20technique%20in%20the%20mouse%20footpad%20system%2C%20the%20bactericidal%20activity%20against%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20leprae%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20of%20R207910%20was%20equal%20to%20that%20of%20rifapentine%2C%20rifampin%2C%20or%20moxifloxacin%20and%20significantly%20greater%20than%20those%20of%20minocycline%2C%20PA-824%2C%20and%20linezolid.%20These%20data%20suggest%20that%20R207910%20may%20play%20an%20important%20role%20in%20treatment%20of%20leprosy.%22%2C%22date%22%3A%2204%5C%2F2006%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.50.4.1558-1560.2006%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.asm.org%5C%2Fdoi%5C%2F10.1128%5C%2FAAC.50.4.1558-1560.2006%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-06-25T14%3A08%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22AHCMHUDU%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Honor%5Cu00e9%20et%20al.%22%2C%22parsedDate%22%3A%222001-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHonor%26%23xE9%3B%2C%20N.%2C%20Roche%2C%20P.%20W.%2C%20Grosset%2C%20J.%20H.%20and%20Cole%2C%20S.%20T.%20%282001%29.%20%26lt%3Bb%26gt%3BA%20method%20for%20rapid%20detection%20of%20rifampicin-resistant%20isolates%20of%20Mycobacterium%20leprae%26lt%3B%5C%2Fb%26gt%3B.%20Lepr%20Rev%20%26lt%3Bi%26gt%3B72%26lt%3B%5C%2Fi%26gt%3B%2C%20441%26%23x2013%3B448%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5935%5C%2F0305-7518.20010052%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5935%5C%2F0305-7518.20010052%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20method%20for%20rapid%20detection%20of%20rifampicin-resistant%20isolates%20of%20Mycobacterium%20leprae%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Honor%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%20W.%22%2C%22lastName%22%3A%22Roche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20T.%22%2C%22lastName%22%3A%22Cole%22%7D%5D%2C%22abstractNote%22%3A%22A%20genotypic%20method%20for%20predicting%20rifampicin%20resistance%20in%20Mycobacterium%20leprae%20has%20been%20developed%20and%20rigorously%20tested%20on%20mouse%20footpad-derived%20and%20clinical%20specimens.%20A%20series%20of%20immobilized%20oligonucleotide%20capture%20probes%20can%20discriminate%20between%20wild%20type%20and%20mutant%20rpoB%20alleles%2C%20and%20positive%20controls%20are%20available%20for%20the%20most%20frequent%20mutation%20affecting%20Ser425.%20Two%20different%20non-radioactive%20detection%20formats%20have%20been%20tested%20with%20comparable%20success%20in%20both%20an%20industrialized%20and%20a%20developing%20country.%20The%20standardized%20procedure%20could%20now%20be%20used%20in%20a%20prospective%20study%20of%20potential%20rifampicin%20resistance%20among%20multibacillary%20patients.%22%2C%22date%22%3A%222001-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5935%5C%2F0305-7518.20010052%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220305-7518%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-03T17%3A06%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22GAGYYWQ4%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Grosset%20and%20Cole%22%2C%22parsedDate%22%3A%222001-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGrosset%2C%20J.%20H.%20and%20Cole%2C%20S.%20T.%20%282001%29.%20%26lt%3Bb%26gt%3BGenomics%20and%20the%20chemotherapy%20of%20leprosy%26lt%3B%5C%2Fb%26gt%3B.%20Lepr%20Rev%20%26lt%3Bi%26gt%3B72%26lt%3B%5C%2Fi%26gt%3B%2C%20429%26%23x2013%3B440%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5935%5C%2F0305-7518.20010051%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5935%5C%2F0305-7518.20010051%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Genomics%20and%20the%20chemotherapy%20of%20leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20T.%22%2C%22lastName%22%3A%22Cole%22%7D%5D%2C%22abstractNote%22%3A%22The%20information%20deduced%20from%20the%20genome%20sequence%20of%20Mycobacterium%20leprae%20is%20of%20immense%20value%20for%20the%20chemotherapy%20of%20leprosy.%20Knowing%20the%20complete%20set%20of%20genes%2C%20enzymes%20and%20proteins%20allows%20us%20to%20understand%20why%20some%20drugs%20are%20without%20effect%20whereas%20others%20are%20fully%20active.%20It%20may%20also%20enable%20better%20use%20to%20be%20made%20of%20existing%20drugs%2C%20such%20as%20beta-lactams%2C%20and%20opens%20new%20avenues%20for%20the%20development%20of%20novel%20compounds.%20M.%20leprae%20is%20relatively%20susceptible%20to%20a%20wide%20range%20of%20drugs%2C%20unlike%20the%20highly%20related%20tubercle%20bacillus%2C%20and%20several%20new%20multidrug%20regimens%20are%20in%20clinical%20trials.%20Genomics%20provides%20a%20number%20of%20possible%20explanations%20for%20this%20broader%20susceptibility%20as%20some%20of%20the%20genes%20encoding%20enzymes%20involved%20in%20antibiotic%20inactivation%20have%20decayed%20whereas%20the%20number%20of%20transporters%20available%20to%20contribute%20to%20drug%20efflux%20is%20considerably%20lower%20than%20in%20Mycobacterium%20tuberculosis.%20Several%20leads%20for%20new%20drug%20targets%20have%20been%20uncovered.%22%2C%22date%22%3A%222001-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5935%5C%2F0305-7518.20010051%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220305-7518%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-03T17%3A06%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22QJIJTKPC%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Grosset%22%2C%22parsedDate%22%3A%222001-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGrosset%2C%20J.%20H.%20%282001%29.%20%26lt%3Bb%26gt%3BNewer%20drugs%20in%20leprosy%26lt%3B%5C%2Fb%26gt%3B.%20Int%20J%20Lepr%20Other%20Mycobact%20Dis%20%26lt%3Bi%26gt%3B69%26lt%3B%5C%2Fi%26gt%3B%2C%20S14-18.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Newer%20drugs%20in%20leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22During%20the%20last%2015%20years%2C%20new%20drugs%20active%20against%20Mycobacterium%20leprae%20have%20been%20identified.%20All%20of%20them%20belong%20to%20the%20fluoroquinolone%2C%20cycline%20and%20macrolide%20drug%20families.%20In%20the%20mouse%20model%20and%20in%20humans%2C%20minocycline%2C%20ofloxacin%2C%20and%20clarithromycin%20have%20demonstrated%2C%20individually%20or%20in%20combination%2C%20antileprosy%20activities%20much%20superior%20to%20those%20of%20the%20standard%20drugs%20dapsone%20and%20clofazimine.%20In%20humans%2C%20a%20single%20dose%20of%20the%20combination%20ofloxacin%20400%20mg%20%2B%20minocycline%20100%20mg%20was%20able%20to%20kill%2068%25%20to%2098%25%20of%20viable%20M.%20leprae%20and%20a%20single%20dose%20of%20ROM%2C%20a%20three-drug%20combination%20of%20rifampin%20600%20mg%20%2B%20ofloxacin%20400%20mg%20%2B%20minocycline%20100%20mg%2C%20was%20killing%20more%20than%2099%25%20of%20viable%20M.%20leprae.%20As%20a%20result%20of%20a%20double-blind%2C%20control%2C%20clinical%20trial%2C%20the%20Seventh%20Report%20of%20the%20WHO%20Expert%20Committee%20on%20Leprosy%20recommended%20in%201997%20the%20use%20of%20single-dose%20ROM%20for%20the%20treatment%20of%20patients%20with%20single-lesion%20paucibacillary%20leprosy.%20Recently%20moxifloxacin%2C%20a%20new%20fluoroquinolone%2C%20and%20rifapentine%2C%20a%20long-lasting%20rifamycin%20derivative%2C%20have%20demonstrated%20in%20the%20mouse%20model%20highly%20promising%20antileprosy%20activities%2C%20justifying%20their%20assessment%20in%20humans.%22%2C%22date%22%3A%222001-06%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220148-916X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-03T17%3A06%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22QR5LSJMF%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nguyen%20et%20al.%22%2C%22parsedDate%22%3A%222000-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNguyen%2C%20L.%20N.%2C%20Cartel%2C%20J.%20L.%20and%20Grosset%2C%20J.%20H.%20%282000%29.%20%26lt%3Bb%26gt%3BChemoprophylaxis%20of%20leprosy%20in%20the%20southern%20Marquesas%20with%20a%20single%2025%20mg%5C%2Fkg%20dose%20of%20rifampicin.%20Results%20after%2010%20years%26lt%3B%5C%2Fb%26gt%3B.%20Lepr%20Rev%20%26lt%3Bi%26gt%3B71%20Suppl%26lt%3B%5C%2Fi%26gt%3B%2C%20S33-35%3B%20discussion%20S35-36%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5935%5C%2F0305-7518.20000064%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5935%5C%2F0305-7518.20000064%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Chemoprophylaxis%20of%20leprosy%20in%20the%20southern%20Marquesas%20with%20a%20single%2025%20mg%5C%2Fkg%20dose%20of%20rifampicin.%20Results%20after%2010%20years%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%20N.%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20L.%22%2C%22lastName%22%3A%22Cartel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22In%201988%2C%20a%20programme%20of%20leprosy%20chemoprophylaxis%2C%20employing%20a%20supervised%2C%20single%2025%20mg%5C%2Fkg%20dose%20of%20rifampicin%2C%20was%20implemented%20in%20the%20Southern%20Marquesas%20Islands.%20Of%20the%202786%20inhabitants%2C%202751%20%2898.7%25%29%20were%20treated.%20In%20addition%2C%203144%20South%20Marquesans%20living%20elsewhere%20in%20French%20Polynesia%20were%20administered%20the%20same%20chemoprophylaxis.%20During%20the%20following%2010%20years%2C%20seven%20leprosy%20patients%20were%20detected%20among%20those%20who%20had%20been%20administered%20chemoprophylaxis.%20Of%20these%2C%20two%20were%20very%20likely%20missed%20cases%20of%20leprosy%2C%20and%20cannot%20be%20considered%20a%20failure%20of%20chemoprophylaxis.%20The%20epidemiometric%20projection%20model%2C%20based%20on%20cases%20of%20leprosy%20observed%20in%20the%20Southern%20Marquesas%20during%20the%2020%20years%20preceding%20implementation%20of%20the%20programme%2C%20predicted%20that%2017%20leprosy%20cases%20could%20be%20expected%20in%20the%20South%20Marquesan%20population%20if%20no%20chemoprophylaxis%20were%20given.%20In%20fact%2C%20only%20five%20cases%20were%20detected%20in%20the%20treated%20population%2C%20a%20number%20significantly%20smaller%20than%2017%2C%20suggesting%20that%20the%20chemoprophylaxis%20was%2070%25%20effective%2C%20assuming%20that%20no%20change%20of%20detection%20rate%20would%20have%20occurred%20without%20chemoprophylaxis.%20However%2C%20during%20the%2010%20years%20following%20implementation%20of%20the%20chemoprophylaxis%20programme%2C%20the%20detection%20rate%20in%20the%20Polynesian%20population%20that%20was%20not%20administered%20chemoprophylaxis%20declined%20by%20about%2050%25.%20Therefore%2C%20the%20effectiveness%20of%20the%20chemoprophylaxis%20was%20only%2035-40%25.%22%2C%22date%22%3A%222000-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5935%5C%2F0305-7518.20000064%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220305-7518%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-03T17%3A04%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22HPMU8BC7%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20and%20Grosset%22%2C%22parsedDate%22%3A%222000-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%20and%20Grosset%2C%20J.%20%282000%29.%20%26lt%3Bb%26gt%3BCombination%20of%20rifapentine-moxifloxacin-minocycline%20%28PMM%29%20for%20the%20treatment%20of%20leprosy%26lt%3B%5C%2Fb%26gt%3B.%20Lepr%20Rev%20%26lt%3Bi%26gt%3B71%20Suppl%26lt%3B%5C%2Fi%26gt%3B%2C%20S81-87%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5935%5C%2F0305-7518.20000074%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5935%5C%2F0305-7518.20000074%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Combination%20of%20rifapentine-moxifloxacin-minocycline%20%28PMM%29%20for%20the%20treatment%20of%20leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22To%20further%20the%20development%20of%20a%20multidrug%20regimen%20for%20treatment%20of%20leprosy%20that%20is%20suitable%20for%20monthly%20administration%20and%20fully%20supervisable%2C%20the%20bactericidal%20activities%20against%20Mycobacterium%20leprae%20of%20HMR%203647%20%28HMR%29%2C%20moxifloxacin%20%28MXFX%29%20and%20rifapentine%20%28RPT%29%20were%20measured%20by%20the%20proportional%20bactericide%20technique%20in%20the%20mouse%20footpad%20system%2C%20and%20compared%20with%20those%20of%20the%20established%20antileprosy%20drugs%20clarithromycin%20%28CLARI%29%2C%20ofloxacin%20%28OFLO%29%20and%20rifampicin%20%28RMP%29.%20Administered%20in%20five%20daily%20doses%20of%20100%20mg%20per%20kg%20body%20weight%2C%20HMR%20appeared%20slightly%20more%20bactericidal%20than%20CLARI%2C%20but%20the%20difference%20did%20not%20attain%20statistical%20significance.%20Administered%20as%20single%20doses%2C%20MXFX%20in%20a%20dosage%20of%20150%20mg%20per%20kg%20was%20more%20active%20than%20OFLO%20in%20the%20same%20dosage%2C%20and%20displayed%20the%20same%20level%20of%20activity%20as%20RMP%20in%20a%20dosage%20of%2010%20mg%20per%20kg%3B%20the%20combination%20MXFX-minocycline%20%28MINO%29%20%28MM%29%20was%20more%20bactericidal%20than%20the%20combination%20OFLO-MINO%20%28OM%29%3B%20RPT%20in%20a%20dosage%20of%2010%20mg%20per%20kg%20was%20more%20bactericidal%20than%20RMP%20administered%20in%20the%20same%20dosage%2C%20and%20even%20more%20active%20than%20the%20combination%20RMP-OFLO-MINO%20%28ROM%29%3B%20the%20combination%20RPT-MXFX-MINO%20%28PMM%29%20killed%2099.9%25%20of%20viable%20M.%20leprae%2C%20and%20was%20slightly%20more%20bactericidal%20than%20was%20RPT%20alone%2C%20indicating%20that%20the%20combination%20PMM%20showed%20an%20additive%20effect%20against%20M.%20leprae.%20These%20promising%20results%20justify%20a%20clinical%20trial%20among%20lepromatous%20patients%2C%20in%20which%20MM%20is%20being%20compared%20with%20OM%2C%20and%20PMM%20with%20ROM%2C%20in%20terms%20of%20efficacy%20and%20tolerance.%22%2C%22date%22%3A%222000-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5935%5C%2F0305-7518.20000074%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220305-7518%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A18%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22KBVZ83L5%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Consigny%20et%20al.%22%2C%22parsedDate%22%3A%222000-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BConsigny%2C%20S.%2C%20Bentoucha%2C%20A.%2C%20Bonnafous%2C%20P.%2C%20Grosset%2C%20J.%20and%20Ji%2C%20B.%20%282000%29.%20%26lt%3Bb%26gt%3BBactericidal%20activities%20of%20HMR%203647%2C%20moxifloxacin%2C%20and%20rifapentine%20against%20Mycobacterium%20leprae%20in%20mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B44%26lt%3B%5C%2Fi%26gt%3B%2C%202919%26%23x2013%3B2921%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.44.10.2919-2921.2000%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.44.10.2919-2921.2000%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bactericidal%20activities%20of%20HMR%203647%2C%20moxifloxacin%2C%20and%20rifapentine%20against%20Mycobacterium%20leprae%20in%20mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Consigny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Bentoucha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Bonnafous%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Grosset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%5D%2C%22abstractNote%22%3A%22Bactericidal%20activities%20of%20HMR%203647%20%28HMR%29%2C%20moxifloxacin%20%28MXFX%29%2C%20and%20rifapentine%20%28RPT%29%20against%20Mycobacterium%20leprae%2C%20measured%20by%20the%20proportional%20bactericidal%20technique%20in%20the%20mouse%20footpad%20system%2C%20were%20compared%20with%20those%20of%20the%20established%20antileprosy%20drugs%20clarithromycin%20%28CLARI%29%2C%20ofloxacin%20%28OFLO%29%2C%20and%20rifampin%20%28RMP%29.%20Administered%20in%20five%20daily%20doses%20of%20100%20mg%5C%2Fkg%20of%20body%20weight%2C%20HMR%20appeared%20slightly%20more%20bactericidal%20than%20CLARI.%20In%20a%20single%20dose%2C%20MXFX%20at%20150%20mg%5C%2Fkg%20was%20more%20active%20than%20the%20same%20dose%20of%20OFLO%20and%20displayed%20exactly%20the%20same%20level%20of%20activity%20as%20RMP%20at%2010%20mg%5C%2Fkg%3B%20the%20combination%20MXFX-minocycline%20%28MINO%29%20%28MM%29%20was%20more%20bactericidal%20than%20the%20combination%20OFLO-MINO%20%28OM%29%3B%20RPT%20at%2010%20mg%5C%2Fkg%20was%20more%20bactericidal%20than%20the%20same%20dose%20of%20RMP%20and%20even%20more%20active%20than%20the%20combination%20RMP-OFLO-MINO%20%28ROM%29%3B%20the%20combination%20RPT-MXFX-MINO%20%28PMM%29%20killed%2099.9%25%20of%20viable%20M.%20leprae%20and%20was%20slightly%20more%20bactericidal%20than%20RPT%20alone%2C%20indicating%20that%20the%20combination%20PMM%20showed%20an%20additive%20effect%20against%20M.%20leprae.%22%2C%22date%22%3A%222000-10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.44.10.2919-2921.2000%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A02%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22FZQLU6SF%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20and%20Grosset%22%2C%22parsedDate%22%3A%221999-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%20and%20Grosset%2C%20J.%20H.%20%281999%29.%20%26lt%3Bb%26gt%3BDrugs%20and%20regimens%20for%20preventive%20therapy%20against%20tuberculosis%2C%20disseminated%20Mycobacterium%20avium%20complex%20infection%20and%20leprosy%26lt%3B%5C%2Fb%26gt%3B.%20Int%20J%20Lepr%20Other%20Mycobact%20Dis%20%26lt%3Bi%26gt%3B67%26lt%3B%5C%2Fi%26gt%3B%2C%20S45-55.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Drugs%20and%20regimens%20for%20preventive%20therapy%20against%20tuberculosis%2C%20disseminated%20Mycobacterium%20avium%20complex%20infection%20and%20leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%221999-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220148-916X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A18%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22P9WW92S8%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%221998-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Sow%2C%20S.%2C%20Perani%2C%20E.%2C%20Lienhardt%2C%20C.%2C%20Diderot%2C%20V.%20and%20Grosset%2C%20J.%20%281998%29.%20%26lt%3Bb%26gt%3BBactericidal%20activity%20of%20a%20single-dose%20combination%20of%20ofloxacin%20plus%20minocycline%2C%20with%20or%20without%20rifampin%2C%20against%20Mycobacterium%20leprae%20in%20mice%20and%20in%20lepromatous%20patients%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B42%26lt%3B%5C%2Fi%26gt%3B%2C%201115%26%23x2013%3B1120%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.42.5.1115%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.42.5.1115%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bactericidal%20activity%20of%20a%20single-dose%20combination%20of%20ofloxacin%20plus%20minocycline%2C%20with%20or%20without%20rifampin%2C%20against%20Mycobacterium%20leprae%20in%20mice%20and%20in%20lepromatous%20patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Sow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Perani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lienhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Diderot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22To%20develop%20a%20fully%20supervisable%2C%20monthly%20administered%20regimen%20for%20treatment%20of%20leprosy%2C%20the%20bactericidal%20effect%20of%20a%20single-dose%20combination%20of%20ofloxacin%20%28OFLO%29%20and%20minocycline%20%28MINO%29%2C%20with%20or%20without%20rifampin%20%28RMP%29%2C%20against%20Mycobacterium%20leprae%20was%20studied%20in%20the%20mouse%20footpad%20system%20and%20in%20previously%20untreated%20lepromatous%20leprosy%20patients.%20Bactericidal%20activity%20was%20measured%20by%20the%20proportional%20bactericidal%20method.%20In%20mouse%20experiments%2C%20the%20activity%20of%20a%20single%20dose%20of%20the%20combination%20OFLO-MINO%20was%20dosage%20related%3B%20the%20higher%20dosage%20of%20the%20combination%20displayed%20bactericidal%20activity%20which%20was%20significantly%20inferior%20to%20that%20of%20a%20single%20dose%20of%20RMP%2C%20whereas%20the%20lower%20dosage%20did%20not%20exhibit%20a%20bactericidal%20effect.%20In%20the%20clinical%20trial%2C%2020%20patients%20with%20previously%20untreated%20lepromatous%20leprosy%20were%20treated%20with%20a%20single%20dose%20consisting%20of%20either%20600%20mg%20of%20RMP%20plus%20400%20mg%20of%20OFLO%20and%20100%20mg%20of%20MINO%20or%20400%20mg%20of%20OFLO%20plus%20100%20mg%20of%20MINO.%20The%20OFLO-MINO%20combination%20exhibited%20definite%20bactericidal%20activity%20in%207%20of%2010%20patients%20but%20was%20less%20bactericidal%20than%20the%20RMP-OFLO-MINO%20combination.%20Both%20combinations%20were%20well%20tolerated.%20Because%20of%20these%20promising%20results%2C%20a%20test%20of%20the%20efficacy%20of%20multiple%20doses%20of%20ROM%20in%20a%20larger%20clinical%20trial%20appears%20justified.%22%2C%22date%22%3A%221998-05%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.42.5.1115%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A30%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22QCE36WVX%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%221997-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Jamet%2C%20P.%2C%20Sow%2C%20S.%2C%20Perani%2C%20E.%20G.%2C%20Traore%2C%20I.%20and%20Grosset%2C%20J.%20H.%20%281997%29.%20%26lt%3Bb%26gt%3BHigh%20relapse%20rate%20among%20lepromatous%20leprosy%20patients%20treated%20with%20rifampin%20plus%20ofloxacin%20daily%20for%204%20weeks%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B41%26lt%3B%5C%2Fi%26gt%3B%2C%201953%26%23x2013%3B1956%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.41.9.1953%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.41.9.1953%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22High%20relapse%20rate%20among%20lepromatous%20leprosy%20patients%20treated%20with%20rifampin%20plus%20ofloxacin%20daily%20for%204%20weeks%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Jamet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Sow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20G.%22%2C%22lastName%22%3A%22Perani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Traore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22Fifty-one%20lepromatous%20leprosy%20patients%2C%20all%20of%20whom%20had%20relapsed%20after%20previous%20dapsone%20%28DDS%29%20monotherapy%2C%20were%20treated%20between%201990%20and%201991%20with%20600%20mg%20of%20rifampin%20%28RMP%29%20plus%20400%20mg%20of%20ofloxacin%20%28OFLO%29%20daily%20for%204%20weeks%2C%20and%20the%20great%20majority%20of%20the%20patients%20were%20followed%20up%20at%20least%20once%20a%20year%20after%20completion%20of%20the%20treatment.%20After%20only%20173%20patient-years%20of%20follow-up%2C%205%20relapses%20had%20been%20detected%3B%20the%20overall%20relapse%20rate%20was%2010.0%25%20%28confidence%20limits%2C%201.7%20and%2018.3%25%29%2C%20or%202.9%20relapses%20%28confidence%20limits%2C%200.4%20and%205.4%29%20per%20100%20patient-years.%20The%20unacceptably%20high%20relapse%20rate%20indicated%20that%204%20weeks%20of%20treatment%20with%20daily%20RMP-OFLO%20was%20unable%20to%20reduce%20the%20number%20of%20viable%20Mycobacterium%20leprae%20organisms%20to%20a%20negligible%20level.%20In%20addition%2C%20the%20M.%20leprae%20from%20one%20of%20the%20relapses%20were%20proved%20to%20have%20multiple%20resistance%20to%20DDS%2C%20RMP%2C%20and%20OFLO.%20To%20avoid%20further%20relapses%2C%20the%20follow-up%20was%20terminated%20and%20the%20great%20majority%20of%20the%20patients%20were%20retreated%20with%20the%20standard%202-year%20multidrug%20therapy%20from%201994.%20No%20further%20relapse%20has%20been%20diagnosed%20since%20the%20beginning%20of%20retreatment.%22%2C%22date%22%3A%221997-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.41.9.1953%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A07%3A08Z%22%7D%7D%2C%7B%22key%22%3A%225L7KRJ4E%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mane%20et%20al.%22%2C%22parsedDate%22%3A%221997-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMane%2C%20I.%2C%20Cartel%2C%20J.%20L.%20and%20Grosset%2C%20J.%20H.%20%281997%29.%20%26lt%3Bb%26gt%3BField%20trial%20on%20efficacy%20of%20supervised%20monthly%20dose%20of%20600%20mg%20rifampin%2C%20400%20mg%20ofloxacin%20and%20100%20mg%20minocycline%20for%20the%20treatment%20of%20leprosy%3B%20first%20results%26lt%3B%5C%2Fb%26gt%3B.%20Int%20J%20Lepr%20Other%20Mycobact%20Dis%20%26lt%3Bi%26gt%3B65%26lt%3B%5C%2Fi%26gt%3B%2C%20224%26%23x2013%3B229.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Field%20trial%20on%20efficacy%20of%20supervised%20monthly%20dose%20of%20600%20mg%20rifampin%2C%20400%20mg%20ofloxacin%20and%20100%20mg%20minocycline%20for%20the%20treatment%20of%20leprosy%3B%20first%20results%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Mane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20L.%22%2C%22lastName%22%3A%22Cartel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22In%201995%2C%20a%20field%20trial%20was%20implemented%20in%20Senegal%20in%20order%20to%20evaluate%20the%20efficacy%20of%20a%20regimen%20based%20on%20the%20monthly%20supervised%20intake%20of%20rifampin%20600%20mg%2C%20ofloxacin%20400%20mg%20and%20minocycline%20100%20mg%20to%20treat%20leprosy.%20During%20the%20first%20year%20of%20the%20trial%2C%20220%20patients%20with%20active%20leprosy%20%28newly%20detected%20or%20relapsing%20after%20dapsone%20monotherapy%29%20were%20recruited%3A%20102%20paucibacillary%20%28PB%29%20%2860%20males%20and%2042%20females%29%20and%20118%20multibacillary%20%28MB%29%20%2871%20males%20and%2047%20females%29.%20All%20of%20them%20accepted%20the%20new%20treatment%20%28none%20requested%20to%20be%20preferably%20put%20under%20standard%20WHO%5C%2FMDT%29%2C%20no%20clinical%20sign%20which%20could%20be%20considered%20as%20a%20toxic%20effect%20of%20the%20drug%20was%20noted%2C%20and%20none%20of%20the%20patients%20refused%20to%20continue%20treatment%20because%20of%20any%20clinical%20trouble.%20The%20compliance%20was%20excellent%3A%20the%20113%20patients%20%28PB%20and%20MB%29%20detected%20during%20the%20first%206%20months%20of%20the%20trial%20have%20taken%20six%20monthly%20doses%20in%206%20months%2C%20as%20planned.%20The%20rate%20of%20clearance%20and%20the%20progressive%20decrease%20of%20cutaneous%20lesions%20was%20satisfactory.%20Although%20it%20is%20too%20soon%20to%20give%20comprehensive%20results%2C%20it%20should%20be%20noted%20that%20no%20treatment%20failure%20was%20observed%20in%20the%2056%20PB%20patients%20who%20have%20completed%20treatment%20and%20have%20been%20followed%20up%20for%206%20months.%20The%20long-term%20efficacy%20of%20the%20new%20regimen%20is%20to%20be%20evaluated%20on%20the%20rate%20of%20relapse%20during%20the%20years%20following%20the%20cessation%20of%20treatment.%20If%20that%20relapse%20rate%20is%20acceptable%20%28similar%20to%20that%20observed%20in%20patients%20after%20treatment%20with%20current%20standard%20WHO%5C%2F%20MDT%29%2C%20the%20new%20regimen%20could%20be%20a%20solution%20to%20treat%2C%20for%20instance%2C%20patients%20very%20irregular%20and%5C%2For%20living%20in%20remote%20or%20inaccessible%20areas%20since%20no%20selection%20of%20rifampin-resistant%20Mycobacterium%20leprae%20should%20be%20possible%20%28a%20monthly%20dose%20of%20ofloxacin%20and%20minocycline%20being%20as%20effective%20as%20a%20dose%20of%20dapsone%20and%20clofazimine%20taken%20daily%20for%201%20month%29.%20Nevertheless%2C%20until%20longer%20term%20results%20of%20this%20and%20other%20trials%20become%20available%2C%20there%20is%20no%20justification%20for%20any%20change%20in%20the%20treatment%20strategy%2C%20and%20all%20leprosy%20patients%20should%20be%20put%20under%20standard%20WHO%5C%2FMDT.%22%2C%22date%22%3A%221997-06%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220148-916X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-03T17%3A00%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22M5TC4XTK%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Grosset%22%2C%22parsedDate%22%3A%221997%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGrosset%2C%20J.%20%281997%29.%20%26lt%3Bb%26gt%3BWhither%20short-course%20chemotherapy%20for%20leprosy%3F%26lt%3B%5C%2Fb%26gt%3B%20Indian%20J%20Lepr%20%26lt%3Bi%26gt%3B69%26lt%3B%5C%2Fi%26gt%3B%2C%20119%26%23x2013%3B120.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Whither%20short-course%20chemotherapy%20for%20leprosy%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%221997%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220254-9395%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-03T17%3A00%3A24Z%22%7D%7D%2C%7B%22key%22%3A%222UIDXPCS%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%221996-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Levy%2C%20L.%20and%20Grosset%2C%20J.%20H.%20%281996%29.%20%26lt%3Bb%26gt%3BChemotherapy%20of%20leprosy%3A%20progress%20since%20the%20Orlando%20Congress%2C%20and%20prospects%20for%20the%20future%26lt%3B%5C%2Fb%26gt%3B.%20Int%20J%20Lepr%20Other%20Mycobact%20Dis%20%26lt%3Bi%26gt%3B64%26lt%3B%5C%2Fi%26gt%3B%2C%20S80-88%3B%20discussion%20S88-90.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Chemotherapy%20of%20leprosy%3A%20progress%20since%20the%20Orlando%20Congress%2C%20and%20prospects%20for%20the%20future%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Levy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%221996-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220148-916X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A07%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22BV87B8HM%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%221996-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Jamet%2C%20P.%2C%20Perani%2C%20E.%20G.%2C%20Sow%2C%20S.%2C%20Lienhardt%2C%20C.%2C%20Petinon%2C%20C.%20and%20Grosset%2C%20J.%20H.%20%281996%29.%20%26lt%3Bb%26gt%3BBactericidal%20activity%20of%20single%20dose%20of%20clarithromycin%20plus%20minocycline%2C%20with%20or%20without%20ofloxacin%2C%20against%20Mycobacterium%20leprae%20in%20patients%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B40%26lt%3B%5C%2Fi%26gt%3B%2C%202137%26%23x2013%3B2141%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.40.9.2137%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.40.9.2137%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bactericidal%20activity%20of%20single%20dose%20of%20clarithromycin%20plus%20minocycline%2C%20with%20or%20without%20ofloxacin%2C%20against%20Mycobacterium%20leprae%20in%20patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Jamet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20G.%22%2C%22lastName%22%3A%22Perani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Sow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lienhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Petinon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22Fifty%20patients%20with%20newly%20diagnosed%20lepromatous%20leprosy%20were%20allocated%20randomly%20to%20one%20of%20five%20groups%20and%20treated%20with%20either%20a%20month-long%20standard%20regimen%20of%20multidrug%20therapy%20%28MDT%29%20for%20multibacillary%20leprosy%2C%20a%20single%20dose%20of%20600%20mg%20of%20rifampin%2C%20a%20month-long%20regimen%20with%20the%20dapsone%20%28DDS%29%20and%20clofazimine%20%28CLO%29%20components%20of%20the%20standard%20MDT%2C%20or%20a%20single%20dose%20of%202%2C000%20mg%20of%20clarithromycin%20%28CLARI%29%20plus%20200%20mg%20of%20minocycline%20%28MINO%29%2C%20with%20or%20without%20the%20addition%20of%20800%20mg%20of%20ofloxacin%20%28OFLO%29.%20At%20the%20end%20of%201%20month%2C%20clinical%20improvement%20accompanied%20by%20significant%20decreases%20of%20morphological%20indexes%20in%20skin%20smears%20was%20observed%20in%20about%20half%20of%20the%20patients%20of%20each%20group.%20A%20significant%20bactericidal%20effect%20was%20demonstrated%20in%20the%20great%20majority%20of%20patients%20in%20all%20five%20groups%20by%20inoculating%20the%20footpads%20of%20mice%20with%20organisms%20recovered%20from%20biopsy%20samples%20obtained%20before%20and%20after%20treatment.%20Rifampin%20proved%20to%20be%20a%20bactericidal%20drug%20against%20Mycobacterium%20leprae%20more%20potent%20than%20any%20combination%20of%20the%20other%20drugs.%20A%20single%20dose%20of%20CLARI-MINO%2C%20with%20or%20without%20OFLO%2C%20displayed%20a%20degree%20of%20bactericidal%20activity%20similar%20to%20that%20of%20a%20regimen%20daily%20of%20doses%20of%20DDS-CLO%20for%201%20month%2C%20suggesting%20that%20it%20may%20be%20possible%20to%20replace%20the%20DDS%20and%20CLO%20components%20of%20the%20MDT%20with%20a%20monthly%20dose%20of%20CLARI-MINO%2C%20with%20or%20without%20OFLO.%20However%2C%20gastrointestinal%20adverse%20events%20were%20quite%20frequent%20among%20patients%20treated%20with%20CLARI-MINO%2C%20with%20or%20without%20OFLO%2C%20and%20may%20be%20attributed%20to%20the%20higher%20dosage%20of%20CLARI%20or%20MINO%20or%20to%20the%20combination%20of%20CLARI-MINO%20plus%20OFLO.%20In%20future%20trials%2C%20therefore%2C%20we%20propose%20to%20reduce%20the%20dosages%20of%20the%20drugs%20to%201%2C000%20mg%20of%20CLARI%2C%20100%20mg%20of%20MINO%2C%20and%20400%20mg%20of%20OFLO.%22%2C%22date%22%3A%221996-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.40.9.2137%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A30%3A27Z%22%7D%7D%2C%7B%22key%22%3A%225CBJN2CW%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%221996-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Perani%2C%20E.%20G.%2C%20Petinom%2C%20C.%20and%20Grosset%2C%20J.%20H.%20%281996%29.%20%26lt%3Bb%26gt%3BBactericidal%20activities%20of%20combinations%20of%20new%20drugs%20against%20Mycobacterium%20leprae%20in%20nude%20mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B40%26lt%3B%5C%2Fi%26gt%3B%2C%20393%26%23x2013%3B399%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.40.2.393%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.40.2.393%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bactericidal%20activities%20of%20combinations%20of%20new%20drugs%20against%20Mycobacterium%20leprae%20in%20nude%20mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20G.%22%2C%22lastName%22%3A%22Perani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Petinom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22The%20bactericidal%20activities%20of%2012%20regimens%20with%20various%20combinations%20of%20new%20drugs%20%28clarithromycin%20%5BCLARI%5D%2C%20minocycline%20%5BMINO%5D%2C%20and%20ofloxacin%20%5BOFLO%5D%29%20and%20the%20standard%20antileprosy%20drugs%2C%20especially%20rifampin%20%28RMP%29%2C%20were%20compared%20in%20nude%20mice%20with%20established%20Mycobacterium%20leprae%20infection.%20The%20longest%20duration%20of%20treatment%20was%2024%20weeks%20for%20intermittent%20%28once%20every%204%20weeks%29%20therapy%20and%208%20weeks%20for%20daily%20therapy.%20Bactericidal%20effects%20were%20monitored%20by%20titrating%20the%20proportion%20of%20viable%20M.%20leprae%20isolates%20by%20subinoculating%20the%20organisms%20into%20the%20footpads%20of%20immunocompetent%20and%20nude%20mice.%20The%20results%20indicate%20that%20RMP%20was%20more%20bactericidal%20than%20any%20combination%20of%20the%20new%20drugs.%20A%20single%20dose%20of%20CLARI-MINO%2C%20with%20or%20without%20OFLO%2C%20displayed%20bactericidal%20activity%20as%20great%20as%20that%20of%204%20weeks%20of%20daily%20treatment%20with%20dapsone%20%28DDS%29%20plus%20clofazimine%20%28CLO%29%3B%20thus%2C%20intermittent%20CLARI-MINO%2C%20with%20or%20without%20OFLO%2C%20may%20replace%20DDS%20and%20CLO%20of%20the%20standard%20multidrug%20regimen%2C%20and%20these%20will%20become%20regimens%20that%20can%20be%20administered%20monthly%20and%20under%20full%20supervision.%20Additional%20evidence%20that%20this%20may%20be%20the%20case%20is%20provided%20by%20the%20finding%20that%20intermittent%20RMP-CLARI-MINO%20or%20RMP-CLARI-MINO-OFLO%20administered%20for%2012%20or%2024%20weeks%20was%20as%20active%20as%20the%20standard%20multidrug%20regimen.%20While%20the%20intermittent%20treatment%20always%20displayed%20significantly%20greater%20bactericidal%20activity%20than%20the%20same%20number%20of%20doses%20of%20daily%20treatment%2C%20daily%20treatment%20with%20CLARI-MINO%20and%20CLARI-MINO-OFLO%20were%20more%20active%20than%20the%20drugs%20given%20as%20intermittent%20treatment%20for%20the%20same%20duration%3B%20therefore%2C%20unless%20these%20combinations%20are%20to%20be%20administered%20together%20with%20intermittent%20RMP%2C%20they%20should%20be%20given%20daily%2C%20especially%20for%20the%20treatment%20of%20RMP-resistant%20cases%20of%20infection.%20Finally%2C%2012%20weeks%20of%20daily%20treatment%20with%20DDS-CLO%20was%20more%20bactericidal%20than%20had%20been%20expected%2C%20suggesting%20that%20it%20may%20not%20be%20necessary%20to%20administer%20the%20standard%20multidrug%20regimen%20for%20multibacillary%20leprosy%20for%20as%20long%20as%2024%20months%20in%20order%20to%20minimize%20the%20risk%20of%20developing%20RMP%20resistance.%22%2C%22date%22%3A%221996-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.40.2.393%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A30%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22PJNNS7UZ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%221994-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Perani%2C%20E.%20G.%2C%20Petinom%2C%20C.%2C%20N%26%23x2019%3BDeli%2C%20L.%20and%20Grosset%2C%20J.%20H.%20%281994%29.%20%26lt%3Bb%26gt%3BClinical%20trial%20of%20ofloxacin%20alone%20and%20in%20combination%20with%20dapsone%20plus%20clofazimine%20for%20treatment%20of%20lepromatous%20leprosy%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%2C%20662%26%23x2013%3B667%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.38.4.662%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.38.4.662%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20trial%20of%20ofloxacin%20alone%20and%20in%20combination%20with%20dapsone%20plus%20clofazimine%20for%20treatment%20of%20lepromatous%20leprosy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20G.%22%2C%22lastName%22%3A%22Perani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Petinom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22N%27Deli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20H.%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22Twenty-four%20patients%20with%20newly%20diagnosed%20lepromatous%20leprosy%20were%20allocated%20randomly%20to%20three%20groups%20and%20treated%20for%2056%20days%20with%20400%20mg%20of%20ofloxacin%20daily%2C%20800%20mg%20of%20ofloxacin%20daily%2C%20or%20400%20mg%20of%20ofloxacin%2C%20100%20mg%20of%20dapsone%2C%20and%2050%20mg%20of%20clofazimine%20daily%20plus%20300%20mg%20of%20clofazimine%20once%20every%2028%20days.%20The%20patients%20in%20all%20three%20groups%20demonstrated%20remarkable%20clinical%20improvements%2C%20accompanied%20by%20rapid%20decline%20of%20the%20morphological%20index%20in%20skin%20smears%20during%20treatment.%20More%20than%2099%2C%20%26gt%3B%2099.99%2C%20and%20%26gt%3B%2099.99%25%20of%20the%20viable%20Mycobacterium%20leprae%20organisms%20had%20been%20killed%20by%2014%2C%2028%2C%20and%2056%20days%20of%20treatment%2C%20respectively%2C%20as%20measured%20by%20inoculation%20into%20the%20footpads%20of%20immunocompetent%20and%20nude%20mice%20of%20organisms%20recovered%20from%20skin%20biopsy%20specimens%20obtained%20before%20and%20during%20treatment.%20Mild%20to%20moderate%20elevations%20of%20the%20serum%20glutamic%20pyruvic%20transaminase%20level%20were%20observed%20in%20four%20patients%2C%20all%20after%2028%20days%20of%20treatment%2C%20which%20returned%20to%20normal%20after%20the%20trial%20had%20been%20completed.%20Clinical%20improvement%2C%20bactericidal%20activity%2C%20and%20hepatotoxicity%20did%20not%20differ%20significantly%20among%20the%20three%20groups.%20Ofloxacin%20displayed%20powerful%20bactericidal%20activity%20against%20M.%20leprae%20in%20leprosy%20patients%20and%20may%20be%20an%20important%20component%20of%20new%20multidrug%20regimens%20for%20the%20treatment%20of%20leprosy.%20Its%20optimal%20dosage%20appears%20to%20be%20400%20mg%20daily%2C%20and%20combination%20with%20dapsone%20and%20clofazimine%20does%20not%20enhance%20its%20activity.%22%2C%22date%22%3A%221994-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.38.4.662%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-15T10%3A30%3A23Z%22%7D%7D%5D%7D
Fomba, A., Haidara, F. C., Kodio, M., Arama, C., Cambau, E., Chauffour, A., Veziris, N., Broeckling, B. E., Warren, A. K., Cauchoix, B., Alcaïs, A., Marsollier, L., Assé, H., Jackson, M., Sow, S. O., Faye, O., Jarlier, V., Cole, S. T., Avanzi, C., Aubry, A. and Johnson, R. C. (2025). Bedaquiline Activity against Leprosy. New England Journal of Medicine 392, 2174–2176, http://doi.org/10.1056/NEJMc2412487.
Chauffour, A., Cambau, E., Pethe, K., Veziris, N. and Aubry, A. (2025). Unprecedented in vivo activity of telacebec against Mycobacterium leprae Ed. Steinmann, P. PLoS Negl Trop Dis 19, e0013076, http://doi.org/10.1371/journal.pntd.0013076.
Hasker, E., Assoumani, Y., Randrianantoandro, A., Ramboarina, S., Braet, S. M., Cauchoix, B., Baco, A., Mzembaba, A., Salim, Z., Amidy, M., Grillone, S., Attoumani, N., Grillone, S. H., Ronse, M., Peeters Grietens, K., Rakoto-Andrianarivelo, M., Harinjatovo, H., Supply, P., Snijders, R., Hoof, C., Tsoumanis, A., Suffys, P., Rasamoelina, T., Corstjens, P., Ortuno-Gutierrez, N., Geluk, A., Cambau, E. and De Jong, B. C. (2024). Post-exposure prophylaxis in leprosy (PEOPLE): a cluster randomised trial. The Lancet Global Health 12, e1017–e1026, http://doi.org/10.1016/S2214-109X(24)00062-7.
Mengeot, L., Jachiet, M., Bourrat, E., Mahé, A., Cambau, E., Bernard, E., Pasqualini, C., Chamouine, A., Truong, J., Dumaine, C., Bertolotti, A. and Franco, J. (2024). Effective management of severe chronic erythema nodosum leprosum in adolescent patient using ustekinumab and apremilast: A case report. Acad Dermatol Venereol 38, http://doi.org/10.1111/jdv.19552.
Chauffour, A., Lounis, N., Andries, K., Jarlier, V., Veziris, N. and Aubry, A. (2023). Minimal effective dose of bedaquiline administered orally and activity of a long acting formulation of bedaquiline in the murine model of leprosy Ed. Converse, P. J. PLoS Negl Trop Dis 17, e0011379, http://doi.org/10.1371/journal.pntd.0011379.
Jaume, L., Hau, E., Monsel, G., Mahé, A., Bertolotti, A., Petit, A., Le, B., Chauveau, M., Duhamel, E., Maisonobe, T., Bagot, M., Bouaziz, J.-D., Mougari, F., Cambau, E., Jachiet, M. and Groupe d’infectiologie en dermatologie et des infections sexuellement transmissibles (GrIDIST) (2023). Methotrexate as a corticosteroid-sparing agent in leprosy reactions: A French multicenter retrospective study Ed. Poonawala, H. PLoS Negl Trop Dis 17, e0011238, http://doi.org/10.1371/journal.pntd.0011238.
Kirga, K. A., Nadlaou, B., Mahamat, A., Cambau, E., Penlap, V. and Godreuil, S. (2023). Genotypic characterization of Mycobacterium leprae strains resistant to rifampicin and ofloxacin in three health districts in Chad. J Drug Delivery Ther 13, 7–11, http://doi.org/10.22270/jddt.v13i3.5748.
Cambau, E. (2023). La lèpre aujourd’hui : de gros progrès mais des résistances. Bulletin de l’Académie Nationale de Médecine 207, 1053–1063, http://doi.org/10.1016/j.banm.2023.04.017.
Jouet, A., Braet, S. M., Gaudin, C., Bisch, G., Vasconcellos, S., Epaminondas Nicacio De Oliveira Do Livramento, R. E., Prado Palacios, Y. Y., Fontes, A. B., Lucena, N., Rosa, P., Moraes, M., La, K., Badalato, N., Lenoir, E., Ferré, A., Clément, M., Hasker, E., Grillone, S. H., Abdou, W., Said, A., Assoumani, Y., Attoumani, N., Laurent, Y., Cambau, E., De Jong, B. C., Suffys, P. N. and Supply, P. (2023). Hi-plex deep amplicon sequencing for identification, high-resolution genotyping and multidrug resistance prediction of Mycobacterium leprae directly from patient biopsies by using Deeplex Myc-Lep. eBioMedicine 93, 104649, http://doi.org/10.1016/j.ebiom.2023.104649.
Marijke Braet, S., Jouet, A., Aubry, A., Van Dyck-Lippens, M., Lenoir, E., Assoumani, Y., Baco, A., Mzembaba, A., Cambau, E., Vasconcellos, S. E. G., Rigouts, L., Suffys, P. N., Hasker, E., Supply, P. and de Jong, B. C. (2022). Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study. The Lancet Microbe 3, e693–e700, http://doi.org/10.1016/S2666-5247(22)00117-3.
Aubry, A., Sammarco Rosa, P., Chauffour, A., Fletcher, M. L., Cambau, E. and Avanzi, C. (2022). Drug resistance in leprosy: An update following 70years of chemotherapy. Infectious Diseases Now 52, 243–251, http://doi.org/10.1016/j.idnow.2022.04.001.
Chauffour, A., Morel, F., Reibel, F., Petrella, S., Mayer, C., Cambau, E. and Aubry, A. (2021). A systematic review of Mycobacterium leprae DNA gyrase mutations and their impact on fluoroquinolone resistance. Clinical Microbiology and Infection 27, 1601–1612, http://doi.org/10.1016/j.cmi.2021.07.007.
Ortuño-Gutiérrez, N., Mzembaba, A., Ramboarina, S., Andriamira, R., Baco, A., Braet, S., Younoussa, A., Cauchoix, B., Salim, Z., Amidy, M., Grillone, S., Rasamoelina, T., Cambau, E., Geluk, A., de Jong, B. C., Richardus, J. H. and Hasker, E. (2021). Exploring clustering of leprosy in the Comoros and Madagascar: A geospatial analysis. International Journal of Infectious Diseases 108, 96–101, http://doi.org/10.1016/j.ijid.2021.05.014.
Rousset, L., Sokal, A., Vignon-Pennamen, M.-D., Pagis, V., Rybojad, M., Lecorche, E., Mougari, F., Bagot, M., Bouaziz, J.-D. and Jachiet, M. (2020). Association d’une lèpre borderline tuberculoïde et d’une tuberculose : un cas et revue de la littérature. Annales de Dermatologie et de Vénéréologie 147, 886–891, http://doi.org/10.1016/j.annder.2020.09.571.
Avanzi, C., Lécorché, E., Rakotomalala, F. A., Benjak, A., Rapelanoro Rabenja, F., Ramarozatovo, L. S., Cauchoix, B., Rakoto-Andrianarivelo, M., Tió-Coma, M., Leal-Calvo, T., Busso, P., Boy-Röttger, S., Chauffour, A., Rasamoelina, T., Andrianarison, A., Sendrasoa, F., Spencer, J. S., Singh, P., Dashatwar, D. R., Narang, R., Berland, J.-L., Jarlier, V., Salgado, C. G., Moraes, M. O., Geluk, A., Randrianantoandro, A., Cambau, E. and Cole, S. T. (2020). Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros. Frontiers in Microbiology 11, URL: https://www.frontiersin.org/article/10.3389/fmicb.2020.00711 [Accessed March 2022].
Baron, V., Forfait, C., Colot, J., Carzola, C., Descloux, E., Cauchoix, B., Cambau, E., Gaumery, J., Grangeon, J. and Klement, E. (2019). Épidémiologie de la lèpre en Nouvelle-Calédonie de 1983 à 2017. BEH 400–405, URL: https://www.santepubliquefrance.fr/import/epidemiologie-de-la-lepre-en-nouvelle-caledonie-de-1983-a-2017 [Accessed February 2022].
Cambau, E., Saunderson, P., Matsuoka, M., Cole, S. T., Kai, M., Suffys, P., Rosa, P. S., Williams, D., Gupta, U. D., Lavania, M., Cardona-Castro, N., Miyamoto, Y., Hagge, D., Srikantam, A., Hongseng, W., Indropo, A., Vissa, V., Johnson, R. C., Cauchoix, B., Pannikar, V. K., Cooreman, E. a. W. D., Pemmaraju, V. R. R., Gillini, L., Kriswamati, A., Al-Samie, A. R., Issoufou, A., Tiendrebeogo, A., Kingalu, A., Randrianantoandro, A., Kumar, A., Chauffour, A., Win, A. A., Pandey, B., Agrawal, C. M., Widaningrum, C., Schmotzer, C., Kafando, C., Bhandari, C. M., Sema, C., Vidanagama, D. S., Scollard, D. M., Beyene, D., Morelo, E. F., Kassa, E. D., Ramarolahy, E. B., Claco, E., Villalon, E. E., Sidibe, F., Sakho, F., Abdoulaye, F., Guilengue, F. F., Gajete, F., Babu, G. R., Moussa, G., Thakur, G. D., Cabanos, G., Sock, G., Clugston, G., Zaidy, H., Watanabe, H., Kawuma, H. J., Mallari, I. B., Goulart, I. M. B., Ahamed, I., Subbanna, J., Houzeo, J. G., Luengu, J. N. M., Bertolli, J., Lloyd-Owen, J., Matheu, J., Brunelli, J. P., Alzate, J. C. B., Neupane, Kapil Dev, Osuga, K., Yamaguchi, K., Azam, K., Lin, K. M., Momoudu, K., Kyaw, K., Bide, L., Doanh, L. H., My, L. H., Shah, M., Kodio, M., Sidibe, M., Ebenezer, M., Grossi, M. A. de F., Balagon, M. F., Canlonon, M., Makino, M., Htoo, M. M., Ahmed, M. J., Nadine, M.-M., Roferos, F. O., Krismawati, H., Thida, M., Htoon, M. T., Neupane, K. D., Phuc, N. H. N., Van, N. H., Hai, N. P. N., Ishii, N., Soe, O., Amiel, O., Tossou, O., Konare, O., Joshi, P. L., Rao, P. V. R., Krishnamurthy, P., Brennan, P. J., Busso, P., Bhatia, R., Andrianarivelo, M. R., Ramdas, D. R., Chabi, R., Gusmao, R., DjupuriIzwardy, R., Soares, R. C. F. R., Jhadav, R., Buhrer, S., Cho, S.-N. R., Jianping, S., Lzumi, S., Barua, S., Chaitanya, S., Tiendrebeogo, S. M. R., Khang, T. H., Gillis, T. P., Mori, T., Vijayalakshmi, V., Kamara, V. D., Wei, W., Smith, W. C. S., Li, W., Lew, W., Al-Qubati, Y., Suzuki, Y. and Nanba, Y. (2018). Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009–15. Clinical Microbiology and Infection 24, 1305–1310, http://doi.org/10.1016/j.cmi.2018.02.022.
Chauffour, A., Lecorche, E., Reibel, F., Mougari, F., Raskine, L., Aubry, A., Jarlier, V. and Cambau, E. (2018). Prospective study on antimicrobial resistance in leprosy cases diagnosed in France from 2001 to 2015. Clinical Microbiology and Infection 24, 1213.e5-1213.e8, http://doi.org/10.1016/j.cmi.2018.06.004.
Mieras, L. F., Taal, A. T., van Brakel, W. H., Cambau, E., Saunderson, P. R., Smith, W. C. S., Prakoeswa, C. R. S., Astari, L., Scollard, D. M., do Nascimento, D. C., Grosset, J., Kar, H. K., Izumi, S., Gillini, L., Virmond, M. C. L. and Sturkenboom, M. G. G. (2018). An enhanced regimen as post-exposure chemoprophylaxis for leprosy: PEP++. BMC Infectious Diseases 18, 506, http://doi.org/10.1186/s12879-018-3402-4.
Cambau, E. (2018). Antileprosy drugs: mode of action and mechanisms. In: International textbook of leprosy, URL: https://internationaltextbookofleprosy.org/chapter/anti-leprosy-drugs-modes-action-and-mechanisms-resistance-mycobacterium-leprae [Accessed May 2022].
Machado, D., Lecorche, E., Mougari, F., Cambau, E. and Viveiros, M. (2018). Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence. Front Microbiol 9, http://doi.org/10.3389/fmicb.2018.03072.
Andre, E., Goeminne, L., Cabibbe, A., Beckert, P., Mukadi, B. K., Mathys, V., Gagneux, S., Niemann, S., Ingen, J. V. and Cambau, E. (2017). Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria. Clinical Microbiology and Infection 23, 167–172, http://doi.org/10.1016/j.cmi.2016.09.006.
Raharolahy, O., Ramarozatovo, L. S., Ranaivo, I. M., Sendrasoa, F. A., Andrianarison, M., Andrianarivelo, M. R., Cambau, E. and Rabenja, F. R. (2016). A Case of Fluoroquinolone-Resistant Leprosy Discovered after 9 Years of Misdiagnosis. Case Reports in Infectious Diseases 2016, 4632369, http://doi.org/10.1155/2016/4632369.
Mieras, L., Anthony, R., van Brakel, W., Bratschi, M. W., van den Broek, J., Cambau, E., Cavaliero, A., Kasang, C., Perera, G., Reichman, L., Richardus, J. H., Saunderson, P., Steinmann, P. and Yew, W. W. (2016). Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy. Infectious Diseases of Poverty 5, 46, http://doi.org/10.1186/s40249-016-0140-y.
Reibel, F., Chauffour, A., Brossier, F., Jarlier, V., Cambau, E. and Aubry, A. (2015). New Insights into the Geographic Distribution of Mycobacterium leprae SNP Genotypes Determined for Isolates from Leprosy Cases Diagnosed in Metropolitan France and French Territories Ed. Johnson, C. PLOS Neglected Tropical Diseases 9, e0004141, http://doi.org/10.1371/journal.pntd.0004141.
Reibel, F., Cambau, E. and Aubry, A. (2015). Update on the epidemiology, diagnosis, and treatment of leprosy. Médecine et Maladies Infectieuses 45, 383–393, http://doi.org/10.1016/j.medmal.2015.09.002.
Reibel, F., Cambau, E. and Aubry, A. (2015). Histoire et actualité du traitement de la lèpre. Journal des Anti-Infectieux 17, 91–98, http://doi.org/10.1016/j.antinf.2015.01.004.
Veziris, N., Chauffour, A., Escolano, S., Henquet, S., Matsuoka, M., Jarlier, V. and Aubry, A. (2013). Resistance of M. leprae to Quinolones: A Question of Relativity? PLoS Negl Trop Dis 7, e2559, http://doi.org/10.1371/journal.pntd.0002559.
Gomez, C., Ponien, P., Serradji, N., Lamouri, A., Pantel, A., Capton, E., Jarlier, V., Anquetin, G. and Aubry, A. (2013). Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry 21, 948–956, http://doi.org/10.1016/j.bmc.2012.12.011.
Cambau, E., Chauffour-Nevejans, A., Tejmar-Kolar, L., Matsuoka, M. and Jarlier, V. (2012). Detection of Antibiotic Resistance in Leprosy Using GenoType LepraeDR, a Novel Ready-To-Use Molecular Test. PLoS Negl Trop Dis 6, e1739, http://doi.org/10.1371/journal.pntd.0001739.
Matrat, S., Cambau, E., Jarlier, V. and Aubry, A. (2008). Are All the DNA Gyrase Mutations Found in Mycobacterium leprae Clinical Strains Involved in Resistance to Fluoroquinolones? Antimicrob Agents Chemother 52, 745–747, http://doi.org/10.1128/AAC.01095-07.
Matrat, S., Petrella, S., Cambau, E., Sougakoff, W., Jarlier, V. and Aubry, A. (2007). Expression and Purification of an Active Form of the Mycobacterium leprae DNA Gyrase and Its Inhibition by Quinolones. Antimicrob Agents Chemother 51, 1643–1648, http://doi.org/10.1128/AAC.01282-06.
Levy, L. and Ji, B. (2006). The mouse foot-pad technique for cultivation of Mycobacterium leprae. Lepr Rev 77, 5–24.
Cambau, E., Carthagena, L., Chauffour, A., Ji, B. and Jarlier, V. (2006). Dihydropteroate Synthase Mutations in the folP1 Gene Predict Dapsone Resistance in Relapsed Cases of Leprosy. Clinical Infectious Diseases 42, 238–241, http://doi.org/10.1086/498506.
Ji, B., Chauffour, A., Andries, K. and Jarlier, V. (2006). Bactericidal Activities of R207910 and Other Newer Antimicrobial Agents against Mycobacterium leprae in Mice. Antimicrob Agents Chemother 50, 1558–1560, http://doi.org/10.1128/AAC.50.4.1558-1560.2006.
Honoré, N., Roche, P. W., Grosset, J. H. and Cole, S. T. (2001). A method for rapid detection of rifampicin-resistant isolates of Mycobacterium leprae. Lepr Rev 72, 441–448, http://doi.org/10.5935/0305-7518.20010052.
Grosset, J. H. and Cole, S. T. (2001). Genomics and the chemotherapy of leprosy. Lepr Rev 72, 429–440, http://doi.org/10.5935/0305-7518.20010051.
Grosset, J. H. (2001). Newer drugs in leprosy. Int J Lepr Other Mycobact Dis 69, S14-18.
Nguyen, L. N., Cartel, J. L. and Grosset, J. H. (2000). Chemoprophylaxis of leprosy in the southern Marquesas with a single 25 mg/kg dose of rifampicin. Results after 10 years. Lepr Rev 71 Suppl, S33-35; discussion S35-36, http://doi.org/10.5935/0305-7518.20000064.
Ji, B. and Grosset, J. (2000). Combination of rifapentine-moxifloxacin-minocycline (PMM) for the treatment of leprosy. Lepr Rev 71 Suppl, S81-87, http://doi.org/10.5935/0305-7518.20000074.
Consigny, S., Bentoucha, A., Bonnafous, P., Grosset, J. and Ji, B. (2000). Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice. Antimicrob Agents Chemother 44, 2919–2921, http://doi.org/10.1128/AAC.44.10.2919-2921.2000.
Ji, B. and Grosset, J. H. (1999). Drugs and regimens for preventive therapy against tuberculosis, disseminated Mycobacterium avium complex infection and leprosy. Int J Lepr Other Mycobact Dis 67, S45-55.
Ji, B., Sow, S., Perani, E., Lienhardt, C., Diderot, V. and Grosset, J. (1998). Bactericidal activity of a single-dose combination of ofloxacin plus minocycline, with or without rifampin, against Mycobacterium leprae in mice and in lepromatous patients. Antimicrob Agents Chemother 42, 1115–1120, http://doi.org/10.1128/AAC.42.5.1115.
Ji, B., Jamet, P., Sow, S., Perani, E. G., Traore, I. and Grosset, J. H. (1997). High relapse rate among lepromatous leprosy patients treated with rifampin plus ofloxacin daily for 4 weeks. Antimicrob Agents Chemother 41, 1953–1956, http://doi.org/10.1128/AAC.41.9.1953.
Mane, I., Cartel, J. L. and Grosset, J. H. (1997). Field trial on efficacy of supervised monthly dose of 600 mg rifampin, 400 mg ofloxacin and 100 mg minocycline for the treatment of leprosy; first results. Int J Lepr Other Mycobact Dis 65, 224–229.
Grosset, J. (1997). Whither short-course chemotherapy for leprosy? Indian J Lepr 69, 119–120.
Ji, B., Levy, L. and Grosset, J. H. (1996). Chemotherapy of leprosy: progress since the Orlando Congress, and prospects for the future. Int J Lepr Other Mycobact Dis 64, S80-88; discussion S88-90.
Ji, B., Jamet, P., Perani, E. G., Sow, S., Lienhardt, C., Petinon, C. and Grosset, J. H. (1996). Bactericidal activity of single dose of clarithromycin plus minocycline, with or without ofloxacin, against Mycobacterium leprae in patients. Antimicrob Agents Chemother 40, 2137–2141, http://doi.org/10.1128/AAC.40.9.2137.
Ji, B., Perani, E. G., Petinom, C. and Grosset, J. H. (1996). Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice. Antimicrob Agents Chemother 40, 393–399, http://doi.org/10.1128/AAC.40.2.393.
Ji, B., Perani, E. G., Petinom, C., N’Deli, L. and Grosset, J. H. (1994). Clinical trial of ofloxacin alone and in combination with dapsone plus clofazimine for treatment of lepromatous leprosy. Antimicrob Agents Chemother 38, 662–667, http://doi.org/10.1128/AAC.38.4.662.
Catégories
Documents Tout le CNR-MyRMA

Publications – Buruli

1368488 ulcerans 1 heidelberg-university-faculty-of-medicine 50 date desc 1 262 https://cnrmyrma.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22T9ZY5DEX%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Phillips%20et%20al.%22%2C%22parsedDate%22%3A%222020-04-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPhillips%2C%20R.%20O.%2C%20Robert%2C%20J.%2C%20Abass%2C%20K.%20M.%2C%20Thompson%2C%20W.%2C%20Sarfo%2C%20F.%20S.%2C%20Wilson%2C%20T.%2C%20Sarpong%2C%20G.%2C%20Gateau%2C%20T.%2C%20Chauty%2C%20A.%2C%20Omollo%2C%20R.%2C%20Ochieng%20Otieno%2C%20M.%2C%20Egondi%2C%20T.%20W.%2C%20Ampadu%2C%20E.%20O.%2C%20Agossadou%2C%20D.%2C%20Marion%2C%20E.%2C%20Ganlonon%2C%20L.%2C%20Wansbrough-Jones%2C%20M.%2C%20Grosset%2C%20J.%2C%20Macdonald%2C%20J.%20M.%2C%20Treadwell%2C%20T.%2C%20Saunderson%2C%20P.%2C%20Paintsil%2C%20A.%2C%20Lehman%2C%20L.%2C%20Frimpong%2C%20M.%2C%20Sarpong%2C%20N.%20F.%2C%20Saizonou%2C%20R.%2C%20Tiendrebeogo%2C%20A.%2C%20Ohene%2C%20S.-A.%2C%20Stienstra%2C%20Y.%2C%20Asiedu%2C%20K.%20B.%2C%20van%20der%20Werf%2C%20T.%20S.%2C%20Osei%20Mireku%2C%20S.%2C%20Abotsi%2C%20J.%2C%20Adu%20Poku%2C%20J.%20K.%2C%20Asamoah-Frimpong%2C%20R.%2C%20Osei-Wusu%2C%20B.%2C%20Sarpong%2C%20E.%2C%20Konadu%2C%20B.%2C%20Opoku%2C%20E.%2C%20Forson%2C%20M.%2C%20Ndogyele%2C%20M.%2C%20Ofori%2C%20E.%2C%20Aboagye%2C%20F.%2C%20Berko%2C%20T.%2C%20Amofa%2C%20G.%2C%20Nsiah%2C%20A.%2C%20Mensah-Bonsu%2C%20J.%2C%20Ofori%20Nyarko%2C%20J.%2C%20Amoako%2C%20Y.%20A.%2C%20Koranteng%20Tannor%2C%20E.%2C%20Boakye-Appiah%2C%20J.%2C%20Dzibordzi%20Loglo%2C%20A.%2C%20Sarpong-Duah%2C%20M.%2C%20Agbavor%2C%20B.%2C%20Ardent%2C%20M.%20F.%2C%20Yamadjako%2C%20A.%2C%20Adanmado%20Gersande%2C%20N.%2C%20Adeye%2C%20A.%2C%20Kindjinou%2C%20M.%2C%20Akpolan%2C%20Kiki%2C%20M.%2C%20Sodjinou%2C%20E.%2C%20Guegnard%2C%20C.%2C%20Klis%2C%20S.-A.%2C%20Velding%2C%20K.%2C%20Omansen%2C%20T.%2C%20Ofori-Adjei%2C%20D.%2C%20Eyangoh%2C%20S.%2C%20Knell%2C%20A.%20and%20Faber%2C%20W.%20%282020%29.%20%26lt%3Bb%26gt%3BRifampicin%20and%20clarithromycin%20%28extended%20release%29%20versus%20rifampicin%20and%20streptomycin%20for%20limited%20Buruli%20ulcer%20lesions%3A%20a%20randomised%2C%20open-label%2C%20non-inferiority%20phase%203%20trial%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20%26lt%3Bi%26gt%3B395%26lt%3B%5C%2Fi%26gt%3B%2C%201259%26%23x2013%3B1267%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS0140-6736%2820%2930047-7%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS0140-6736%2820%2930047-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rifampicin%20and%20clarithromycin%20%28extended%20release%29%20versus%20rifampicin%20and%20streptomycin%20for%20limited%20Buruli%20ulcer%20lesions%3A%20a%20randomised%2C%20open-label%2C%20non-inferiority%20phase%203%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20O%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kabiru%20Mohamed%22%2C%22lastName%22%3A%22Abass%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%22%2C%22lastName%22%3A%22Thompson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fred%20Stephen%22%2C%22lastName%22%3A%22Sarfo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tuah%22%2C%22lastName%22%3A%22Wilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Godfred%22%2C%22lastName%22%3A%22Sarpong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Gateau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annick%22%2C%22lastName%22%3A%22Chauty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%22%2C%22lastName%22%3A%22Omollo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Ochieng%20Otieno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thaddaeus%20W%22%2C%22lastName%22%3A%22Egondi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edwin%20O%22%2C%22lastName%22%3A%22Ampadu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Didier%22%2C%22lastName%22%3A%22Agossadou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Marion%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Line%22%2C%22lastName%22%3A%22Ganlonon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Wansbrough-Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Grosset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20M%22%2C%22lastName%22%3A%22Macdonald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Terry%22%2C%22lastName%22%3A%22Treadwell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Saunderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Paintsil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Lehman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Frimpong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanaa%20Francisca%22%2C%22lastName%22%3A%22Sarpong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raoul%22%2C%22lastName%22%3A%22Saizonou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Tiendrebeogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sally-Ann%22%2C%22lastName%22%3A%22Ohene%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ymkje%22%2C%22lastName%22%3A%22Stienstra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kingsley%20B%22%2C%22lastName%22%3A%22Asiedu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tjip%20S%22%2C%22lastName%22%3A%22van%20der%20Werf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Osei%20Mireku%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justice%22%2C%22lastName%22%3A%22Abotsi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20Ken%22%2C%22lastName%22%3A%22Adu%20Poku%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Asamoah-Frimpong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bright%22%2C%22lastName%22%3A%22Osei-Wusu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edward%22%2C%22lastName%22%3A%22Sarpong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beatrice%22%2C%22lastName%22%3A%22Konadu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ernest%22%2C%22lastName%22%3A%22Opoku%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Forson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathias%22%2C%22lastName%22%3A%22Ndogyele%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Ofori%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felicity%22%2C%22lastName%22%3A%22Aboagye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Berko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%22%2C%22lastName%22%3A%22Amofa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anastasia%22%2C%22lastName%22%3A%22Nsiah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joyce%22%2C%22lastName%22%3A%22Mensah-Bonsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Ofori%20Nyarko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yaw%20Ampem%22%2C%22lastName%22%3A%22Amoako%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elliot%22%2C%22lastName%22%3A%22Koranteng%20Tannor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justice%22%2C%22lastName%22%3A%22Boakye-Appiah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aloysius%22%2C%22lastName%22%3A%22Dzibordzi%20Loglo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mabel%22%2C%22lastName%22%3A%22Sarpong-Duah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernadette%22%2C%22lastName%22%3A%22Agbavor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20Fran%5Cu00e7oise%22%2C%22lastName%22%3A%22Ardent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Yamadjako%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Adanmado%20Gersande%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ambroise%22%2C%22lastName%22%3A%22Adeye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martial%22%2C%22lastName%22%3A%22Kindjinou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Akpolan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Kiki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Espoir%22%2C%22lastName%22%3A%22Sodjinou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9mence%22%2C%22lastName%22%3A%22Guegnard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandor-Adrian%22%2C%22lastName%22%3A%22Klis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kristien%22%2C%22lastName%22%3A%22Velding%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Till%22%2C%22lastName%22%3A%22Omansen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Ofori-Adjei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Eyangoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alan%22%2C%22lastName%22%3A%22Knell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%22%2C%22lastName%22%3A%22Faber%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnBuruli%20ulcer%20is%20a%20neglected%20tropical%20disease%20caused%20by%20Mycobacterium%20ulcerans%20infection%20that%20damages%20the%20skin%20and%20subcutis.%20It%20is%20most%20prevalent%20in%20western%20and%20central%20Africa%20and%20Australia.%20Standard%20antimicrobial%20treatment%20with%20oral%20rifampicin%2010%20mg%5C%2Fkg%20plus%20intramuscular%20streptomycin%2015%20mg%5C%2Fkg%20once%20daily%20for%208%20weeks%20%28RS8%29%20is%20highly%20effective%2C%20but%20streptomycin%20injections%20are%20painful%20and%20potentially%20harmful.%20We%20aimed%20to%20compare%20the%20efficacy%20and%20tolerability%20of%20fully%20oral%20rifampicin%2010%20mg%5C%2Fkg%20plus%20clarithromycin%2015%20mg%5C%2Fkg%20extended%20release%20once%20daily%20for%208%20weeks%20%28RC8%29%20with%20that%20of%20RS8%20for%20treatment%20of%20early%20Buruli%20ulcer%20lesions.%5CnMethods%5CnWe%20did%20an%20open-label%2C%20non-inferiority%2C%20randomised%20%281%3A1%20with%20blocks%20of%20six%29%2C%20multicentre%2C%20phase%203%20clinical%20trial%20comparing%20fully%20oral%20RC8%20with%20RS8%20in%20patients%20with%20early%2C%20limited%20Buruli%20ulcer%20lesions.%20There%20were%20four%20trial%20sites%20in%20hospitals%20in%20Ghana%20%28Agogo%2C%20Tepa%2C%20Nkawie%2C%20Dunkwa%29%20and%20one%20in%20Benin%20%28Pob%5Cu00e8%29.%20Participants%20were%20included%20if%20they%20were%20aged%205%20years%20or%20older%20and%20had%20typical%20Buruli%20ulcer%20with%20no%20more%20than%20one%20lesion%20%28caterories%20I%20and%20II%29%20no%20larger%20than%2010%20cm%20in%20diameter.%20The%20trial%20was%20open%20label%2C%20and%20neither%20the%20investigators%20who%20took%20measurements%20of%20the%20lesions%20nor%20the%20attending%20doctors%20were%20masked%20to%20treatment%20assignment.%20The%20primary%20clinical%20endpoint%20was%20lesion%20healing%20%28ie%2C%20full%20epithelialisation%20or%20stable%20scar%29%20without%20recurrence%20at%2052%20weeks%20after%20start%20of%20antimicrobial%20therapy.%20The%20primary%20endpoint%20and%20safety%20were%20assessed%20in%20the%20intention-to-treat%20population.%20A%20sample%20size%20of%20332%20participants%20was%20calculated%20to%20detect%20inferiority%20of%20RC8%20by%20a%20margin%20of%2012%25.%20This%20study%20was%20registered%20with%20ClinicalTrials.gov%2C%20NCT01659437.%5CnFindings%5CnBetween%20Jan%201%2C%202013%2C%20and%20Dec%2031%2C%202017%2C%20participants%20were%20recruited%20to%20the%20trial.%20We%20stopped%20recruitment%20after%20310%20participants.%20Median%20age%20of%20participants%20was%2014%20years%20%28IQR%2010%5Cu201329%29%20and%20153%20%2852%25%29%20were%20female.%20297%20patients%20had%20PCR-confirmed%20Buruli%20ulcer%3B%20151%20%2851%25%29%20were%20assigned%20to%20RS8%20treatment%2C%20and%20146%20%2849%25%29%20received%20oral%20RC8%20treatment.%20In%20the%20RS8%20group%2C%20lesions%20healed%20in%20144%20%2895%25%2C%2095%25%20CI%2091%20to%2098%29%20of%20151%20patients%2C%20whereas%20lesions%20healed%20in%20140%20%2896%25%2C%2091%20to%2099%29%20of%20146%20patients%20in%20the%20RC8%20group.%20The%20difference%20in%20proportion%2C%20%5Cu22120%5Cu00b75%25%20%28%5Cu20135%5Cu00b72%20to%204%5Cu00b72%29%2C%20was%20not%20significantly%20greater%20than%20zero%20%28p%3D0%5Cu00b759%29%2C%20showing%20that%20RC8%20treatment%20is%20non-inferior%20to%20RS8%20treatment%20for%20lesion%20healing%20at%2052%20weeks.%20Treatment-related%20adverse%20events%20were%20recorded%20in%2020%20%2813%25%29%20patients%20receiving%20RS8%20and%20in%20nine%20%287%25%29%20patients%20receiving%20RC8.%20Most%20adverse%20events%20were%20grade%201%5Cu20132%2C%20but%20one%20%281%25%29%20patient%20receiving%20RS8%20developed%20serious%20ototoxicity%20and%20ended%20treatment%20after%206%20weeks.%20No%20patients%20needed%20surgical%20resection.%20Four%20patients%20%28two%20in%20each%20study%20group%29%20had%20skin%20grafts.%5CnInterpretation%5CnFully%20oral%20RC8%20regimen%20was%20non-inferior%20to%20RS8%20for%20treatment%20of%20early%2C%20limited%20Buruli%20ulcer%20and%20was%20associated%20with%20fewer%20adverse%20events.%20Therefore%2C%20we%20propose%20that%20fully%20oral%20RC8%20should%20be%20the%20preferred%20therapy%20for%20early%2C%20limited%20lesions%20of%20Buruli%20ulcer.%5CnFunding%5CnWHO%20with%20additional%20support%20from%20MAP%20International%2C%20American%20Leprosy%20Missions%2C%20Fondation%20Raoul%20Follereau%20France%2C%20Buruli%20ulcer%20Groningen%20Foundation%2C%20Sanofi-Pasteur%2C%20and%20BuruliVac.%22%2C%22date%22%3A%222020-04-18%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS0140-6736%2820%2930047-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0140673620300477%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220140-6736%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T09%3A58%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22SBB4JW6V%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chauffour%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChauffour%2C%20A.%2C%20Robert%2C%20J.%2C%20Veziris%2C%20N.%2C%20Aubry%2C%20A.%2C%20Pethe%2C%20K.%20and%20Jarlier%2C%20V.%20%282020%29.%20%26lt%3Bb%26gt%3BTelacebec%20%28Q203%29-containing%20intermittent%20oral%20regimens%20sterilized%20mice%20infected%20with%20Mycobacterium%20ulcerans%20after%20only%2016%20doses%26lt%3B%5C%2Fb%26gt%3B.%20PLOS%20Neglected%20Tropical%20Diseases%20%26lt%3Bi%26gt%3B14%26lt%3B%5C%2Fi%26gt%3B%2C%20e0007857%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0007857%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0007857%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Telacebec%20%28Q203%29-containing%20intermittent%20oral%20regimens%20sterilized%20mice%20infected%20with%20Mycobacterium%20ulcerans%20after%20only%2016%20doses%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Pethe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22Buruli%20ulcer%20%28BU%29%2C%20caused%20by%20Mycobacterium%20ulcerans%2C%20is%20currently%20treated%20with%20a%20daily%20combination%20of%20rifampin%20and%20either%20injectable%20streptomycin%20or%20oral%20clarithromycin.%20An%20intermittent%20oral%20regimen%20would%20facilitate%20treatment%20supervision.%20We%20first%20evaluated%20the%20bactericidal%20activity%20of%20newer%20antimicrobials%20against%20M.%20ulcerans%20using%20a%20BU%20animal%20model.%20The%20imidazopyridine%20amine%20telacebec%20%28Q203%29%20exhibited%20high%20bactericidal%20activity%20whereas%20tedizolid%20%28an%20oxazolidinone%20closely%20related%20to%20linezolid%29%2C%20selamectin%20and%20ivermectin%20%28two%20avermectine%20compounds%29%20and%20the%20benzothiazinone%20PBTZ169%20were%20not%20active.%20Consequently%2C%20telacebec%20was%20evaluated%20for%20its%20bactericidal%20and%20sterilizing%20activities%20in%20combined%20intermittent%20regimens.%20Telacebec%20given%20twice%20a%20week%20in%20combination%20with%20a%20long-half-life%20compound%2C%20either%20rifapentine%20or%20bedaquiline%2C%20sterilized%20mouse%20footpads%20in%208%20weeks%2C%20i.e.%20after%20a%20total%20of%20only%2016%20doses%2C%20and%20prevented%20relapse%20during%20a%20period%20of%2020%20weeks%20after%20the%20end%20of%20treatment.%20These%20results%20are%20very%20promising%20for%20future%20intermittent%20oral%20regimens%20which%20would%20greatly%20simplify%20BU%20treatment%20in%20the%20field.%22%2C%22date%22%3A%2231%20ao%5Cu00fbt%202020%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0007857%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.plos.org%5C%2Fplosntds%5C%2Farticle%3Fid%3D10.1371%5C%2Fjournal.pntd.0007857%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221935-2735%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T10%3A50%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22I3MSQAQL%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Scherr%20et%20al.%22%2C%22parsedDate%22%3A%222018-12-18%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BScherr%2C%20N.%2C%20Bieri%2C%20R.%2C%20Thomas%2C%20S.%20S.%2C%20Chauffour%2C%20A.%2C%20Kalia%2C%20N.%20P.%2C%20Schneide%2C%20P.%2C%20Ruf%2C%20M.-T.%2C%20Lamelas%2C%20A.%2C%20Manimekalai%2C%20M.%20S.%20S.%2C%20Gr%26%23xFC%3Bber%2C%20G.%2C%20Ishii%2C%20N.%2C%20Suzuki%2C%20K.%2C%20Tanner%2C%20M.%2C%20Moraski%2C%20G.%20C.%2C%20Miller%2C%20M.%20J.%2C%20Witschel%2C%20M.%2C%20Jarlier%2C%20V.%2C%20Pluschke%2C%20G.%20and%20Pethe%2C%20K.%20%282018%29.%20%26lt%3Bb%26gt%3BTargeting%20the%20Mycobacterium%20ulcerans%20cytochrome%20bc%201%26%23x202F%3B%3A%20aa%203%20for%20the%20treatment%20of%20Buruli%20ulcer%26lt%3B%5C%2Fb%26gt%3B.%20Nature%20Communications%20%26lt%3Bi%26gt%3B9%26lt%3B%5C%2Fi%26gt%3B%2C%205370%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-018-07804-8%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-018-07804-8%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Targeting%20the%20Mycobacterium%20ulcerans%20cytochrome%20bc%201%20%3A%20aa%203%20for%20the%20treatment%20of%20Buruli%20ulcer%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Scherr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raphael%22%2C%22lastName%22%3A%22Bieri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sangeeta%20S.%22%2C%22lastName%22%3A%22Thomas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nitin%20Pal%22%2C%22lastName%22%3A%22Kalia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Schneide%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Th%5Cu00e9r%5Cu00e8se%22%2C%22lastName%22%3A%22Ruf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Araceli%22%2C%22lastName%22%3A%22Lamelas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malathy%20S.%20S.%22%2C%22lastName%22%3A%22Manimekalai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerhard%22%2C%22lastName%22%3A%22Gr%5Cu00fcber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norihisa%22%2C%22lastName%22%3A%22Ishii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Koichi%22%2C%22lastName%22%3A%22Suzuki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Tanner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Garrett%20C.%22%2C%22lastName%22%3A%22Moraski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%20J.%22%2C%22lastName%22%3A%22Miller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Witschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerd%22%2C%22lastName%22%3A%22Pluschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Pethe%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20ulcerans%20is%20the%20causative%20agent%20of%20Buruli%20ulcer%20%28BU%29.%20Existing%20anti-tubercular%20drugs%20have%20been%20used%20to%20treat%20the%20condition%20with%20varying%20success.%20Here%2C%20the%20authors%20show%20that%20a%20clinical-stage%20drug%20candidate%20for%20tuberculosis%2C%20Q203%2C%20is%20effective%20at%20killing%20M.%20ulcerans%20and%20is%20a%20promising%20therapeutic%20candidate%20for%20BU.%22%2C%22date%22%3A%222018-12-18%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-018-07804-8%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-018-07804-8%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222041-1723%22%2C%22language%22%3A%22En%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222019-04-05T14%3A56%3A21Z%22%7D%7D%2C%7B%22key%22%3A%223Z54DDAJ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chauffour%20et%20al.%22%2C%22parsedDate%22%3A%222016-10-18%22%2C%22numChildren%22%3A6%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChauffour%2C%20A.%2C%20Robert%2C%20J.%2C%20Veziris%2C%20N.%2C%20Aubry%2C%20A.%20and%20Jarlier%2C%20V.%20%282016%29.%20%26lt%3Bb%26gt%3BSterilizing%20Activity%20of%20Fully%20Oral%20Intermittent%20Regimens%20against%20Mycobacterium%20ulcerans%20Infection%20in%20Mice%26lt%3B%5C%2Fb%26gt%3B.%20PLOS%20Neglected%20Tropical%20Diseases%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%2C%20e0005066%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0005066%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0005066%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Sterilizing%20Activity%20of%20Fully%20Oral%20Intermittent%20Regimens%20against%20Mycobacterium%20ulcerans%20Infection%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22Author%20Summary%20Buruli%20ulcer%2C%20caused%20by%20Mycobacterium%20ulcerans%2C%20is%20the%20third%20most%20frequent%20disease%20due%20to%20a%20bacteria%20of%20the%20mycobacteria%20family%2C%20after%20tuberculosis%20and%20leprosy.%20The%20disease%20consists%20of%20a%20cutaneous%20infection%20leading%20to%20skin%20ulcerations%20that%20can%20cause%20severe%20and%20debilitating%20scars.%20It%20occurs%20mostly%20in%20Africa%20where%20access%20to%20healthcare%20is%20still%20difficult.%20Until%20recently%2C%20surgery%20was%20the%20only%20way%20to%20treat%20Buruli%20ulcer.%20Recently%2C%20a%20medical%20treatment%20based%20on%20two%20antibiotics%20%28rifampin%20and%20streptomycin%29%20was%20found%20to%20be%20active%20in%20an%20experimental%20infection%20model%20and%20was%20recommended%20by%20WHO%20in%202004%20for%20humans.%20A%20drawback%20of%20this%20new%20medical%20approach%20is%20a%20long%20and%20daily%20administration%20%282%20months%29%20of%20streptomycin%2C%20an%20aminoglycoside%2C%20which%20requires%20daily%20injections%20and%20can%20have%20secondary%20effects.%20In%20our%20research%2C%20we%20sought%20to%20find%20a%20fully%20oral%20and%20intermittent%20treatment%20to%20facilitate%20the%20management%20of%20the%20patients%20on%20the%20field.%20The%20antibiotics%20combinations%20we%20studied%20were%20efficient%20in%20our%20model%20and%20would%20need%20now%20to%20be%20tested%20on%20the%20field.%22%2C%22date%22%3A%2218%20oct.%202016%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0005066%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fjournals.plos.org%5C%2Fplosntds%5C%2Farticle%3Fid%3D10.1371%5C%2Fjournal.pntd.0005066%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221935-2735%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-11T23%3A51%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22UQA4EI2T%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruf%20et%20al.%22%2C%22parsedDate%22%3A%222012-02-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRuf%2C%20M.-T.%2C%20Sch%26%23xFC%3Btte%2C%20D.%2C%20Chauffour%2C%20A.%2C%20Jarlier%2C%20V.%2C%20Ji%2C%20B.%20and%20Pluschke%2C%20G.%20%282012%29.%20%26lt%3Bb%26gt%3BChemotherapy-Associated%20Changes%20of%20Histopathological%20Features%20of%20Mycobacterium%20ulcerans%20Lesions%20in%20a%20Buruli%20Ulcer%20Mouse%20Model%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B56%26lt%3B%5C%2Fi%26gt%3B%2C%20687%26%23x2013%3B696%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.05543-11%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.05543-11%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Chemotherapy-Associated%20Changes%20of%20Histopathological%20Features%20of%20Mycobacterium%20ulcerans%20Lesions%20in%20a%20Buruli%20Ulcer%20Mouse%20Model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Th%5Cu00e9r%5Cu00e8se%22%2C%22lastName%22%3A%22Ruf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%22%2C%22lastName%22%3A%22Sch%5Cu00fctte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baohong%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerd%22%2C%22lastName%22%3A%22Pluschke%22%7D%5D%2C%22abstractNote%22%3A%22Combination%20chemotherapy%20with%20rifampin%20and%20streptomycin%20%28RIF-STR%29%20for%208%20weeks%20is%20currently%20recommended%20by%20the%20WHO%20as%20the%20first-line%20treatment%20for%20Mycobacterium%20ulcerans%20infection%20%28Buruli%20ulcer%29.%20To%20gain%20better%20insight%20into%20the%20mode%20of%20action%20of%20these%20antibiotics%20against%20established%20M.%20ulcerans%20infection%20foci%20and%20to%20characterize%20recovery%20of%20local%20immune%20responses%20during%20chemotherapy%2C%20we%20conducted%20a%20detailed%20histopathological%20study%20of%20M.%20ulcerans-infected%20and%20RIF-STR-treated%20mice.%20Mice%20were%20inoculated%20with%20M.%20ulcerans%20in%20the%20footpad%20and%2011%20weeks%20later%20treated%20with%20RIF-STR.%20Development%20of%20lesions%20during%20the%20first%2011%20weeks%20after%20infection%20and%20subsequent%20differences%20in%20disease%20progression%20between%20RIF-STR-treated%20and%20untreated%20mice%20were%20studied.%20Changes%20in%20histopathological%20features%2C%20footpad%20swelling%2C%20and%20number%20of%20CFU%20were%20analyzed.%20After%20inoculation%20with%20M.%20ulcerans%2C%20massive%20infiltrates%20dominated%20by%20polymorphonuclear%20leukocytes%20developed%20at%20the%20inoculation%20site%20but%20did%20not%20prevent%20bacterial%20multiplication.%20Huge%20clusters%20of%20extracellular%20bacteria%20located%20in%20large%20necrotic%20areas%20and%20surrounded%20by%20dead%20leukocytes%20developed%20in%20the%20untreated%20mice.%20Chemotherapy%20with%20RIF-STR%20led%20to%20a%20rapid%20drop%20in%20CFU%20associated%20with%20loss%20of%20solid%20Ziehl-Neelsen%20staining%20of%20acid-fast%20bacilli.%20Development%20of%20B-lymphocyte%20clusters%20and%20of%20macrophage%20accumulations%20surrounding%20the%20mycobacteria%20demonstrated%20the%20resolution%20of%20local%20immune%20suppression.%20Results%20demonstrate%20that%20the%20experimental%20M.%20ulcerans%20mouse%20infection%20model%20will%20be%20a%20valuable%20tool%20to%20investigate%20efficacy%20of%20new%20treatment%20regimens%20and%20of%20candidate%20vaccines.%22%2C%22date%22%3A%2202%5C%2F01%5C%2F2012%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.05543-11%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F56%5C%2F2%5C%2F687%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-27T14%3A02%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22GX85AMQ9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Marsollier%20et%20al.%22%2C%22parsedDate%22%3A%222010%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMarsollier%2C%20L.%2C%20Aubry%2C%20A.%2C%20Carbonnelle%2C%20E.%2C%20Canaan%2C%20S.%2C%20Cambau%2C%20E.%20and%20Herrmann%2C%20J.-L.%20%282010%29.%20%26lt%3Bb%26gt%3BLes%20Mycobact%26%23xE9%3Brioses%20cutan%26%23xE9%3Bes%20dues%20%26%23xE0%3B%20Mycobacterium%20ulcerans%2C%20Mycobacterium%20marinum%2C%20Mycobacterium%20abscessus%2C%20Mycobacterium%20chelonae%20et%20autres%20mycobact%26%23xE9%3Bries%20non%20tuberculeuses%26lt%3B%5C%2Fb%26gt%3B%2C%20%26lt%3Bi%26gt%3BL%26%23x2019%3BEncyclop%26%23xE9%3Bdie%20M%26%23xE9%3Bdico-chirurgicale%26lt%3B%5C%2Fi%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22encyclopediaArticle%22%2C%22title%22%3A%22Les%20Mycobact%5Cu00e9rioses%20cutan%5Cu00e9es%20dues%20%5Cu00e0%20Mycobacterium%20ulcerans%2C%20Mycobacterium%20marinum%2C%20Mycobacterium%20abscessus%2C%20Mycobacterium%20chelonae%20et%20autres%20mycobact%5Cu00e9ries%20non%20tuberculeuses%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%22%2C%22lastName%22%3A%22Marsollier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Carbonnelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%22%2C%22lastName%22%3A%22Canaan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J-L%22%2C%22lastName%22%3A%22Herrmann%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22encyclopediaTitle%22%3A%22L%27Encyclop%5Cu00e9die%20M%5Cu00e9dico-chirurgicale%22%2C%22date%22%3A%222010%22%2C%22ISBN%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222016-02-26T17%3A46%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22W54VDTBF%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%222009-07-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Chauffour%2C%20A.%2C%20Aubry%2C%20A.%2C%20Robert%2C%20J.%2C%20Ibrahim%2C%20M.%20and%20Jarlier%2C%20V.%20%282009%29.%20%26lt%3Bb%26gt%3BImpacts%20of%20Dosing%20Frequency%20of%20the%20Combination%20Rifampin-Streptomycin%20on%20Its%20Bactericidal%20and%20Sterilizing%20Activities%20against%20Mycobacterium%20ulcerans%20in%20Mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B53%26lt%3B%5C%2Fi%26gt%3B%2C%202955%26%23x2013%3B2959%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00011-09%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00011-09%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Impacts%20of%20Dosing%20Frequency%20of%20the%20Combination%20Rifampin-Streptomycin%20on%20Its%20Bactericidal%20and%20Sterilizing%20Activities%20against%20Mycobacterium%20ulcerans%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baohong%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Murad%22%2C%22lastName%22%3A%22Ibrahim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22Because%20of%20operational%20limitations%2C%20a%20significant%20proportion%20of%20the%20health%20centers%20at%20the%20peripheral%20level%20are%20able%20to%20provide%20treatment%20to%20Buruli%20ulcer%20patients%20with%20the%20combination%20rifampin%20%28rifampicin%29-streptomycin%20%28RIF-STR%29%20only%20five%20times%20weekly%20%285%5C%2F7%29%20instead%20of%20seven%20times%20weekly%20%287%5C%2F7%29%2C%20as%20recommended.%20The%20objective%20of%20this%20experiment%20is%20to%20assess%20the%20impacts%20of%20various%20dosing%20frequencies%20of%20the%20combination%20on%20its%20bactericidal%20and%20sterilizing%20activities%20against%20Mycobacterium%20ulcerans%20in%20mice.%20The%20results%20demonstrate%20that%20the%20bactericidal%20activities%20did%20not%20differ%20significantly%20among%20five%20dosing%20frequencies%20of%20the%20combination%2C%20ranging%20from%20seven%20times%20to%20twice%20weekly%2C%20whereas%20the%20sterilizing%20activities%20differed%20widely.%20RIF-STR%207%5C%2F7%20was%20the%20only%20regimen%20that%20was%20able%20to%20sterilize%20the%20infection%20after%204%20to%208%20weeks%20of%20treatment%3B%20the%20sterilizing%20activities%20associated%20with%20reduced%20dosing%20frequencies%20were%20significantly%20diminished%2C%20and%208%20weeks%20of%205%5C%2F7%20administration%20yielded%20a%20relapse%20rate%20greater%20than%20the%20generally%20accepted%20level%20of%205%25.%20We%20recommend%20that%20the%20duration%20of%20treatment%20with%205%5C%2F7%20administration%20be%20prolonged%20beyond%208%20weeks%20and%20that%20additional%20experiments%20with%20mice%20be%20carried%20out%2C%20with%20sufficient%20statistical%20power%20to%20compare%20the%20relapse%20rates%20of%20M.%20ulcerans%20infection%20between%208%20weeks%20of%207%5C%2F7%20administration%20and%2010%20and%2012%20weeks%20of%205%5C%2F7%20administration%20of%20RIF-STR.%22%2C%22date%22%3A%2207%5C%2F01%5C%2F2009%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.00011-09%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F53%5C%2F7%5C%2F2955%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-02T21%3A31%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22F9GATMVI%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%222008-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Chauffour%2C%20A.%2C%20Robert%2C%20J.%20and%20Jarlier%2C%20V.%20%282008%29.%20%26lt%3Bb%26gt%3BBactericidal%20and%20Sterilizing%20Activities%20of%20Several%20Orally%20Administered%20Combined%20Regimens%20against%20Mycobacterium%20ulcerans%20in%20Mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B52%26lt%3B%5C%2Fi%26gt%3B%2C%201912%26%23x2013%3B1916%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00193-08%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00193-08%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bactericidal%20and%20Sterilizing%20Activities%20of%20Several%20Orally%20Administered%20Combined%20Regimens%20against%20Mycobacterium%20ulcerans%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baohong%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22Treatment%20with%20rifampin-clarithromycin%20or%20moxifloxacin-clarithromycin%20for%208%20weeks%20displayed%20promising%20bactericidal%20activity%20against%20Mycobacterium%20ulcerans%20in%20mice%3B%20none%20of%20the%20mice%20treated%20with%20rifampin-clarithromycin%20relapsed%2C%20whereas%2059%25%20of%20those%20treated%20with%20moxifloxacin-clarithromycin%20relapsed%20after%20treatment%20was%20stopped.%20The%20bactericidal%20and%20sterilizing%20activities%20of%20the%20five-times-weekly%20%285%5C%2F7%29%20administration%20of%205%20mg%20of%20rifapentine%5C%2Fkg%20of%20body%20weight%2C%20either%20alone%20or%20in%20combination%2C%20were%20virtually%20identical%20to%20those%20of%20the%20corresponding%20regimens%20with%2010%20mg%20of%20rifampin%5C%2Fkg%20of%20body%20weight%3B%20however%2C%20because%20of%20the%20long%20half-life%20of%20rifapentine%2C%20accumulation%20of%20the%20drug%20after%205%5C%2F7%20administration%20is%20a%20concern.%20The%20bactericidal%20activity%20of%2020%20mg%5C%2Fkg%20rifapentine%20in%20monotherapy%20or%2020%20mg%5C%2Fkg%20rifapentine%20in%20combination%20with%20150%20mg%5C%2Fkg%20streptomycin%20or%20200%20mg%5C%2Fkg%20moxifloxacin%20administered%20twice%20weekly%20was%20as%20effective%20as%20the%20corresponding%20regimens%20containing%2010%20mg%5C%2Fkg%20rifampin%20administered%205%5C%2F7%2C%20suggesting%20that%20Buruli%20ulcer%20might%20be%20treated%20with%20intermittently%20administered%20rifapentine-containing%20combinations.%22%2C%22date%22%3A%222008-6%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.00193-08%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC2415803%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T15%3A50%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22C8BSMNA9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%222007-10-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Chauffour%2C%20A.%2C%20Robert%2C%20J.%2C%20Lefran%26%23xE7%3Bois%2C%20S.%20and%20Jarlier%2C%20V.%20%282007%29.%20%26lt%3Bb%26gt%3BOrally%20Administered%20Combined%20Regimens%20for%20Treatment%20of%20Mycobacterium%20ulcerans%20Infection%20in%20Mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B51%26lt%3B%5C%2Fi%26gt%3B%2C%203737%26%23x2013%3B3739%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00730-07%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00730-07%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Orally%20Administered%20Combined%20Regimens%20for%20Treatment%20of%20Mycobacterium%20ulcerans%20Infection%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baohong%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Lefran%5Cu00e7ois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22Eight%20weeks%20of%20treatment%20with%20rifampin-streptomycin%20sterilizes%20Mycobacterium%20ulcerans%20infection%20in%20mice.%20Because%20the%20bactericidal%20activity%20against%20M.%20ulcerans%20of%20the%20combination%20rifampin-moxifloxacin%2C%20rifampin-clarithromycin%2C%20or%20moxifloxacin-clarithromycin%20was%20similar%20to%20that%20of%20rifampin-streptomycin%2C%20these%20combinations%20might%20be%20considered%20as%20alternative%2C%20orally%20administered%20combined%20regimens%20for%20treatment%20of%20Buruli%20ulcer%20in%20humans.%22%2C%22date%22%3A%2210%5C%2F01%5C%2F2007%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.00730-07%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F51%5C%2F10%5C%2F3737%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T16%3A31%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22TMFTEJND%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lefran%5Cu00e7ois%20et%20al.%22%2C%22parsedDate%22%3A%222007-02-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLefran%26%23xE7%3Bois%2C%20S.%2C%20Robert%2C%20J.%2C%20Chauffour%2C%20A.%2C%20Ji%2C%20B.%20and%20Jarlier%2C%20V.%20%282007%29.%20%26lt%3Bb%26gt%3BCuring%20Mycobacterium%20ulcerans%20Infection%20in%20Mice%20with%20a%20Combination%20of%20Rifampin-Streptomycin%20or%20Rifampin-Amikacin%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B51%26lt%3B%5C%2Fi%26gt%3B%2C%20645%26%23x2013%3B650%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00821-06%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00821-06%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Curing%20Mycobacterium%20ulcerans%20Infection%20in%20Mice%20with%20a%20Combination%20of%20Rifampin-Streptomycin%20or%20Rifampin-Amikacin%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Lefran%5Cu00e7ois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baohong%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22The%20curing%20activities%20of%20various%20durations%20of%20treatment%20with%20a%20combination%20of%20rifampin%20%28RIF%29%20and%20either%20streptomycin%20%28STR%29%20or%20amikacin%20%28AMK%29%20in%20murine%20Mycobacterium%20ulcerans%20infection%20were%20compared%20in%20two%20experiments.%20In%20the%20first%20experiment%2C%20treatment%20was%20begun%201%20week%20after%20infection%2C%20when%20the%20inflammatory%20footpad%20lesion%20had%20not%20yet%20occurred%20%28preventive%20model%29%2C%20and%20in%20the%20second%20experiment%2C%20treatment%20was%20begun%206%20weeks%20after%20infection%2C%20when%20inflammatory%20footpad%20lesions%20were%20established%20%28curative%20model%29.%20In%20the%20first%20experiment%2C%204%20weeks%20of%20treatment%20with%20daily%20RIF-STR%20or%20RIF-AMK%20was%20able%20to%20postpone%20the%20occurrence%20of%20footpad%20lesion%20by%2012%20weeks%20%28RIF-STR%29%20or%2017%20weeks%20%28RIF-AMK%29%2C%20thus%20demonstrating%20their%20promising%20bactericidal%20activities%2C%20but%20neither%20treatment%20was%20able%20to%20prevent%20the%20late%20occurrence%20of%20footpad%20lesions.%20In%20the%20second%20experiment%2C%20the%20overall%20cure%20rates%2C%20as%20assessed%20by%20the%20lack%20of%20rebound%20of%20inflammatory%20lesions%20or%20remultiplication%20of%20M.%20ulcerans%2C%20were%20only%2062%25%20after%202%20weeks%20of%20treatment%20with%20RIF%20and%20an%20aminoglycoside%20and%2085%25%20after%204%20weeks%3B%20but%20the%20cure%20rate%20reached%20100%25%20after%208%20or%2012%20weeks%20of%20treatment.%20The%20cure%20rates%20were%20slightly%20higher%20with%20the%20AMK-containing%20combination%20than%20with%20the%20STR-containing%20combination%2C%20but%20the%20difference%20was%20at%20the%20limit%20of%20significance%20%28P%20%3D%200.07%29.%20These%20results%20show%20that%20in%20the%20murine%20model%20of%20Buruli%20ulcer%2C%208%20weeks%20is%20the%20optimal%20duration%20of%20treatment%20with%20a%20combination%20of%20RIF%20and%20an%20aminoglycoside.%22%2C%22date%22%3A%2202%5C%2F01%5C%2F2007%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.00821-06%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F51%5C%2F2%5C%2F645%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T16%3A31%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22MW46EVQT%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ji%20et%20al.%22%2C%22parsedDate%22%3A%222006-06-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJi%2C%20B.%2C%20Lefran%26%23xE7%3Bois%2C%20S.%2C%20Robert%2C%20J.%2C%20Chauffour%2C%20A.%2C%20Truffot%2C%20C.%20and%20Jarlier%2C%20V.%20%282006%29.%20%26lt%3Bb%26gt%3BIn%20Vitro%20and%20In%20Vivo%20Activities%20of%20Rifampin%2C%20Streptomycin%2C%20Amikacin%2C%20Moxifloxacin%2C%20R207910%2C%20Linezolid%2C%20and%20PA-824%20against%20Mycobacterium%20ulcerans%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B50%26lt%3B%5C%2Fi%26gt%3B%2C%201921%26%23x2013%3B1926%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00052-06%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.00052-06%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22In%20Vitro%20and%20In%20Vivo%20Activities%20of%20Rifampin%2C%20Streptomycin%2C%20Amikacin%2C%20Moxifloxacin%2C%20R207910%2C%20Linezolid%2C%20and%20PA-824%20against%20Mycobacterium%20ulcerans%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baohong%22%2C%22lastName%22%3A%22Ji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Lefran%5Cu00e7ois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Truffot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%5D%2C%22abstractNote%22%3A%22Seven%20antimicrobials%20were%20tested%20in%20vitro%20against%2029%20clinical%20isolates%20of%20Mycobacterium%20ulcerans.%20R207910%20demonstrated%20the%20lowest%20MIC50%20and%20MIC90%2C%20followed%20by%20moxifloxacin%20%28MXF%29%2C%20streptomycin%20%28STR%29%2C%20rifampin%20%28RIF%29%2C%20amikacin%20%28AMK%29%2C%20linezolid%20%28LZD%29%2C%20and%20PA-824.%20All%20but%20PA-824%20demonstrated%20an%20MIC90%20significantly%20less%20than%20the%20clinically%20achievable%20peak%20serum%20level.%20Administered%20as%20monotherapy%20to%20mice%2C%20RIF%2C%20STR%2C%20AMK%2C%20MXF%2C%20R207910%2C%20and%20LZD%20demonstrated%20some%20degree%20of%20bactericidal%20activity%2C%20whereas%20PA-824%20failed%20to%20prevent%20mortality%20and%20to%20reduce%20the%20mean%20number%20of%20CFU%20in%20the%20footpads.%20Because%204%20or%208%20weeks%20of%20treatment%20by%20the%20combinations%20RIF-MXF%2C%20RIF-R207910%2C%20and%20RIF-LZD%20displayed%20bactericidal%20effects%20similar%20to%20those%20of%20RIF-STR%20and%20RIF-AMK%2C%20these%20three%20combinations%20might%20be%20considered%20as%20orally%20administered%20combined%20regimens%20for%20treatment%20of%20Buruli%20ulcer.%20Taking%20into%20account%20the%20cost%2C%20potential%20toxicity%2C%20and%20availability%2C%20the%20combination%20RIF-MXF%20appears%20more%20feasible%20for%20application%20in%20the%20field%3B%20additional%20experiments%20with%20mice%20are%20warranted%20to%20define%20further%20its%20activity%20against%20M.%20ulcerans.%20In%20addition%2C%20a%20pilot%20clinical%20trial%20is%20proposed%20to%20test%20the%20efficacy%20of%20RIF-MXF%20for%20treatment%20of%20Buruli%20ulcer.%22%2C%22date%22%3A%2206%5C%2F01%5C%2F2006%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.00052-06%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F50%5C%2F6%5C%2F1921%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T16%3A31%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22RQI3G6BD%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dega%20et%20al.%22%2C%22parsedDate%22%3A%222002-10-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDega%2C%20H.%2C%20Bentoucha%2C%20A.%2C%20Robert%2C%20J.%2C%20Jarlier%2C%20V.%20and%20Grosset%2C%20J.%20%282002%29.%20%26lt%3Bb%26gt%3BBactericidal%20Activity%20of%20Rifampin-Amikacin%20against%20Mycobacterium%20ulcerans%20in%20Mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B46%26lt%3B%5C%2Fi%26gt%3B%2C%203193%26%23x2013%3B3196%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.46.10.3193-3196.2002%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.46.10.3193-3196.2002%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bactericidal%20Activity%20of%20Rifampin-Amikacin%20against%20Mycobacterium%20ulcerans%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herve%22%2C%22lastName%22%3A%22Dega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdelhalim%22%2C%22lastName%22%3A%22Bentoucha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22To%20identify%20the%20most%20active%20curative%20treatment%20of%20Buruli%20ulcer%2C%20two%20regimens%20incorporating%20the%20use%20of%20rifampin%20%28RIF%29%20were%20compared%20with%20the%20use%20of%20RIF%20alone%20in%20a%20mouse%20footpad%20model%20of%20Mycobacterium%20ulcerans%20infection.%20Treatments%20began%20after%20footpad%20swelling%20from%20infection%20and%20continued%20for%2012%20weeks%20with%20five%20doses%20weekly%20of%20one%20of%20the%20following%20regimens%3A%20%28i%29%2010%20mg%20of%20RIF%5C%2Fkg%20alone%3B%20%28ii%29%2010%20mg%20of%20RIF%5C%2Fkg%20and%20100%20mg%20of%20amikacin%20%28AMK%29%5C%2Fkg%3B%20and%20%28iii%29%2010%20mg%20of%20RIF%5C%2Fkg%2C%20100%20mg%20of%20clarithromycin%20%28CLR%29%5C%2Fkg%2C%20and%2050%20mg%20of%20sparfloxacin%20%28SPX%29%5C%2Fkg.%20The%20activity%20of%20each%20regimen%20was%20assessed%20in%20terms%20of%20the%20reduction%20of%20the%20average%20lesion%20index%20and%20acid-fast%20bacillus%20%28AFB%29%20and%20CFU%20counts.%20All%20three%20regimens%20displayed%20various%20degrees%20of%20bactericidal%20activity%20against%20M.%20ulcerans.%20The%20ranking%20of%20bactericidal%20activity%20was%20found%20to%20be%20as%20follows%3A%20RIF-AMK%20%26gt%3B%20RIF-CLR-SPX%20%26gt%3B%20RIF.%20RIF-AMK%20was%20able%20to%20cure%20M.%20ulcerans-infected%20mice%20and%20prevent%20relapse%2026%20weeks%20after%20completion%20of%20treatment.%20To%20determine%20the%20impact%20of%20different%20rhythms%20of%20administration%20of%20RIF-AMK%20on%20the%20suppression%20of%20M.ulcerans%20growth%2C%20mice%20were%20given%20the%20RIF-AMK%20combination%20for%204%20weeks%20but%20doses%20were%20administered%20either%205%20days%20a%20week%20or%20twice%20or%20once%20weekly.%20After%20completion%20of%20treatment%2C%20the%20mice%20were%20kept%20under%20supervision%20for%2030%20additional%20weeks.%20M.%20ulcerans%20was%20considered%20to%20have%20grown%20in%20the%20footpad%20if%20swelling%20was%20visually%20observed%20and%20harvests%20contained%20more%20than%205%20%5Cu00d7%20105%20AFB%20per%20footpad.%20The%20proportion%20of%20mice%20in%20which%20growth%20of%20M.%20ulcerans%20occurred%2C%20irrespective%20of%20drug%20dosage%2C%20was%20compared%20with%20the%20control%20mice%20to%20determine%20the%20proportion%20of%20M.%20ulcerans%20killed.%20Each%20dosage%20of%20RIF-AMK%20was%20bactericidal%20for%20M.%20ulcerans%20%28P%20%26lt%3B%200.001%29%2C%20but%20the%20effect%20was%20significantly%20stronger%20in%20mice%20treated%205%20days%20per%20week.%20The%20promising%20results%20of%20RIF-AMK%20treatment%20in%20M.%20ulcerans-infected%20mice%20support%20the%20clinical%20trial%20that%20is%20currently%20in%20progress%20under%20World%20Health%20Organization%20auspices%20in%20Ghana.%22%2C%22date%22%3A%2210%5C%2F01%5C%2F2002%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.46.10.3193-3196.2002%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F46%5C%2F10%5C%2F3193%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T16%3A30%3A54Z%22%7D%7D%2C%7B%22key%22%3A%226Q4IS636%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bentoucha%20et%20al.%22%2C%22parsedDate%22%3A%222001-11-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBentoucha%2C%20A.%2C%20Robert%2C%20J.%2C%20Dega%2C%20H.%2C%20Lounis%2C%20N.%2C%20Jarlier%2C%20V.%20and%20Grosset%2C%20J.%20%282001%29.%20%26lt%3Bb%26gt%3BActivities%20of%20New%20Macrolides%20and%20Fluoroquinolones%20against%20Mycobacterium%20ulcerans%20Infection%20in%20Mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B45%26lt%3B%5C%2Fi%26gt%3B%2C%203109%26%23x2013%3B3112%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.45.11.3109-3112.2001%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.45.11.3109-3112.2001%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Activities%20of%20New%20Macrolides%20and%20Fluoroquinolones%20against%20Mycobacterium%20ulcerans%20Infection%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdelhalim%22%2C%22lastName%22%3A%22Bentoucha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herve%22%2C%22lastName%22%3A%22Dega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nacer%22%2C%22lastName%22%3A%22Lounis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22Mice%20infected%20in%20the%20left%20hind%20footpad%20with%205%20log10acid-fast%20bacilli%20of%20Mycobacterium%20ulcerans%20were%20divided%20into%20an%20untreated%20control%20group%20and%2017%20treatment%20groups%20that%20received%20one%20of%20the%20following%20regimens%20for%204%20weeks%20%28all%20doses%20in%20milligrams%20per%20kilogram%29%3A%20100%20mg%20of%20azithromycin%20%28AZM%29%2C%20100%20mg%20of%20clarithromycin%20%28CLR%29%2C%20or%2050%20mg%20of%20AZM%20for%20a%20duration%20of%205%20days%20a%20week%20%28daily%29%2C%20three%20times%20a%20week%2C%20or%20once%20weekly.%20In%20addition%2C%20the%20following%20regimens%20were%20administered%20daily%3A%20100%20mg%20of%20telithromycin%20%28TLM%29%2C%20sparfloxacin%20%28SPX%29%2C%20or%20moxifloxacin%20%28MOX%29%3B%20200%20mg%20of%20levofloxacin%20%28LVX%29%3B%20100%20mg%20of%20streptomycin%20%28STR%29%20or%20amikacin%20%28AMK%29%3B%2010%20mg%20of%20rifampin%20%28RIF%29%3B%20and%20the%20combination%20of%2010%20mg%20of%20RIF%20and%20100%20mg%20of%20AMK%20%28RIF%2BAMK%29.%20After%20completion%20of%20treatment%2C%20mice%20were%20observed%20for%2030%20weeks.%20The%20effectiveness%20of%20treatment%20regimens%20was%20assessed%20in%20terms%20of%20the%20delay%20in%20median%20time%20to%20footpad%20swelling%20in%20treated%20mice%20compared%20with%20that%20in%20the%20untreated%20controls.%20Clear-cut%20bactericidal%20activity%2C%20i.e.%2C%20an%20observed%20delay%20in%20footpad%20swelling%20that%20exceeded%20the%20period%20of%20treatment%2C%20was%20observed%20in%20the%20STR-%2C%20AMK-%2C%20and%20RIF%2BAMK-treated%20mice.%20However%2C%20all%20mice%20treated%20with%20either%20AMK%20or%20STR%20alone%20had%20swollen%20footpads%20before%20the%20end%20of%20the%2030-week%20observation%20period%2C%20suggesting%20regrowth%20of%20M.%20ulcerans.%20In%20contrast%2C%2050%25%20of%20the%20mice%20treated%20with%20the%20RIF%2BAMK%20combination%20exhibited%20no%20lesion%20even%20after%2030%20weeks%2C%20suggesting%20cure.%20The%20remaining%20regimens%20could%20be%20assigned%20to%20one%20of%20three%20groups%3A%20%28i%29%20no%20activity%20%2850%20mg%20of%20AZM%2C%20100%20mg%20of%20AZM%20thrice%20weekly%2C%20TLM%2C%20and%20LVX%29%3B%20%28ii%29%20bacteriostatic%20activity%2C%20i.e.%2C%20a%20delay%20in%20footpad%20swelling%20shorter%20than%20the%204-week%20treatment%20duration%20%28100%20mg%20of%20AZM%20daily%20or%20once%20weekly%2C%20CLR%20thrice%20or%20once%20weekly%2C%20and%20MOX%29%3B%20or%20%28iii%29%20weak%20bactericidal%20activity%20%28CLR%20daily%20and%20SPX%29.%20The%20RIF%2BAMK%20combination%20and%20possibly%20RIF%2BSTR%20warrant%20further%20study%20for%20the%20treatment%20of%20M.%20ulceransinfection%20in%20humans.%22%2C%22date%22%3A%2211%5C%2F01%5C%2F2001%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.45.11.3109-3112.2001%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F45%5C%2F11%5C%2F3109%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T16%3A30%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22ADCZWI6K%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dega%20et%20al.%22%2C%22parsedDate%22%3A%222000-09-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDega%2C%20H.%2C%20Robert%2C%20J.%2C%20Bonnafous%2C%20P.%2C%20Jarlier%2C%20V.%20and%20Grosset%2C%20J.%20%282000%29.%20%26lt%3Bb%26gt%3BActivities%20of%20Several%20Antimicrobials%20againstMycobacterium%20ulcerans%20Infection%20in%20Mice%26lt%3B%5C%2Fb%26gt%3B.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B44%26lt%3B%5C%2Fi%26gt%3B%2C%202367%26%23x2013%3B2372%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.44.9.2367-2372.2000%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FAAC.44.9.2367-2372.2000%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Activities%20of%20Several%20Antimicrobials%20againstMycobacterium%20ulcerans%20Infection%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herve%22%2C%22lastName%22%3A%22Dega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascale%22%2C%22lastName%22%3A%22Bonnafous%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Jarlier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Grosset%22%7D%5D%2C%22abstractNote%22%3A%22Mycobacterium%20ulcerans%20inoculated%20into%20the%20footpads%20of%20mice%20at%206%20%5Cu00d7%20103%20CFU%20was%20shown%20to%20have%20a%20generation%20time%20of%206.5%20days%20when%20estimated%20from%20weekly%20changes%20in%20microscopic%20counts%20of%20acid-fast%20bacilli%20%28AFB%29%20and%207.5%20days%20when%20calculated%20from%20actual%20CFU%20enumerated%20on%20Lowenstein-Jensen%20egg%20medium%20incubated%20at%2032%5Cu00b0C.%20Footpads%20became%20swollen%20at%20week%2010%20%28W10%29%20after%20infection%2C%20and%20all%20infected%20control%20mice%20were%20dead%20at%20W15%20after%20infection.%20Daily%20%285%20days%5C%2Fweek%29%20treatment%20with%20100%20mg%20of%20clarithromycin%20%28CLR%29%5C%2Fkg%20of%20body%20weight%20beginning%20the%20day%20after%20infection%20prevented%20swelling%20of%20footpads%20at%20W10.%20When%20initiation%20of%20treatment%20was%20delayed%20until%20obvious%20footpad%20swelling%20was%20observed%2C%20there%20was%20a%20reduction%20in%20both%20the%20increase%20in%20AFB%20counts%20and%20deterioration%20of%20swollen%20footpads%20and%20also%20a%20prolonged%20survival%20of%20the%20mice%20to%20W18.%20Mice%20infected%20in%20the%20hind%20footpads%20with%205%20%5Cu00d7%20105%20CFU%20of%20M.%20ulcerans%20were%20divided%20into%20an%20untreated%20control%20group%20and%20six%20treatment%20groups%20that%20received%20one%20of%20the%20following%20therapies%20for%208%20weeks%3A%20100%20mg%20of%20CLR%5C%2Fkg%2C%2025%20mg%20of%20minocycline%20%28MIN%29%5C%2Fkg%2C%2050%20mg%20of%20sparfloxacin%20%28SPX%29%5C%2Fkg%2C%2010%20mg%20of%20rifampin%20%28RIF%29%5C%2Fkg%2C%2010%20mg%20of%20rifabutin%20%28RBT%29%5C%2Fkg%2C%20or%20100%20mg%20of%20amikacin%20%28AMK%29%5C%2Fkg.%20After%20completion%20of%20therapy%2C%20treated%20animals%20were%20observed%20for%20an%20additional%2017%20weeks.%20All%20control%20mice%20and%20mice%20treated%20with%20CLR%2C%20MIN%2C%20or%20SPX%20exhibited%20swollen%20footpads%20during%20the%20observation%20period.%20In%20contrast%2C%20of%20those%20animals%20treated%20with%20RIF%2C%20RBT%2C%20or%20AMK%2C%20none%20had%20footpad%20swelling%20and%20all%20inoculated%20cultures%20done%20after%20the%20W17%20observation%20remained%20negative.%20These%20results%20suggest%20that%20RIF%2C%20RBT%2C%20and%20AMK%20may%20be%20effective%20in%20the%20treatment%20of%20human%20infection%20with%20M.%20ulcerans.%22%2C%22date%22%3A%2209%5C%2F01%5C%2F2000%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2FAAC.44.9.2367-2372.2000%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Faac.asm.org%5C%2Fcontent%5C%2F44%5C%2F9%5C%2F2367%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222013-09-09T16%3A30%3A34Z%22%7D%7D%5D%7D
Phillips, R. O., Robert, J., Abass, K. M., Thompson, W., Sarfo, F. S., Wilson, T., Sarpong, G., Gateau, T., Chauty, A., Omollo, R., Ochieng Otieno, M., Egondi, T. W., Ampadu, E. O., Agossadou, D., Marion, E., Ganlonon, L., Wansbrough-Jones, M., Grosset, J., Macdonald, J. M., Treadwell, T., Saunderson, P., Paintsil, A., Lehman, L., Frimpong, M., Sarpong, N. F., Saizonou, R., Tiendrebeogo, A., Ohene, S.-A., Stienstra, Y., Asiedu, K. B., van der Werf, T. S., Osei Mireku, S., Abotsi, J., Adu Poku, J. K., Asamoah-Frimpong, R., Osei-Wusu, B., Sarpong, E., Konadu, B., Opoku, E., Forson, M., Ndogyele, M., Ofori, E., Aboagye, F., Berko, T., Amofa, G., Nsiah, A., Mensah-Bonsu, J., Ofori Nyarko, J., Amoako, Y. A., Koranteng Tannor, E., Boakye-Appiah, J., Dzibordzi Loglo, A., Sarpong-Duah, M., Agbavor, B., Ardent, M. F., Yamadjako, A., Adanmado Gersande, N., Adeye, A., Kindjinou, M., Akpolan, Kiki, M., Sodjinou, E., Guegnard, C., Klis, S.-A., Velding, K., Omansen, T., Ofori-Adjei, D., Eyangoh, S., Knell, A. and Faber, W. (2020). Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial. The Lancet 395, 1259–1267, http://doi.org/10.1016/S0140-6736(20)30047-7.
Chauffour, A., Robert, J., Veziris, N., Aubry, A., Pethe, K. and Jarlier, V. (2020). Telacebec (Q203)-containing intermittent oral regimens sterilized mice infected with Mycobacterium ulcerans after only 16 doses. PLOS Neglected Tropical Diseases 14, e0007857, http://doi.org/10.1371/journal.pntd.0007857.
Scherr, N., Bieri, R., Thomas, S. S., Chauffour, A., Kalia, N. P., Schneide, P., Ruf, M.-T., Lamelas, A., Manimekalai, M. S. S., Grüber, G., Ishii, N., Suzuki, K., Tanner, M., Moraski, G. C., Miller, M. J., Witschel, M., Jarlier, V., Pluschke, G. and Pethe, K. (2018). Targeting the Mycobacterium ulcerans cytochrome bc 1 : aa 3 for the treatment of Buruli ulcer. Nature Communications 9, 5370, http://doi.org/10.1038/s41467-018-07804-8.
Chauffour, A., Robert, J., Veziris, N., Aubry, A. and Jarlier, V. (2016). Sterilizing Activity of Fully Oral Intermittent Regimens against Mycobacterium ulcerans Infection in Mice. PLOS Neglected Tropical Diseases 10, e0005066, http://doi.org/10.1371/journal.pntd.0005066.
Ruf, M.-T., Schütte, D., Chauffour, A., Jarlier, V., Ji, B. and Pluschke, G. (2012). Chemotherapy-Associated Changes of Histopathological Features of Mycobacterium ulcerans Lesions in a Buruli Ulcer Mouse Model. Antimicrob Agents Chemother 56, 687–696, http://doi.org/10.1128/AAC.05543-11.
Marsollier, L., Aubry, A., Carbonnelle, E., Canaan, S., Cambau, E. and Herrmann, J.-L. (2010). Les Mycobactérioses cutanées dues à Mycobacterium ulcerans, Mycobacterium marinum, Mycobacterium abscessus, Mycobacterium chelonae et autres mycobactéries non tuberculeuses, L’Encyclopédie Médico-chirurgicale.
Ji, B., Chauffour, A., Aubry, A., Robert, J., Ibrahim, M. and Jarlier, V. (2009). Impacts of Dosing Frequency of the Combination Rifampin-Streptomycin on Its Bactericidal and Sterilizing Activities against Mycobacterium ulcerans in Mice. Antimicrob Agents Chemother 53, 2955–2959, http://doi.org/10.1128/AAC.00011-09.
Ji, B., Chauffour, A., Robert, J. and Jarlier, V. (2008). Bactericidal and Sterilizing Activities of Several Orally Administered Combined Regimens against Mycobacterium ulcerans in Mice. Antimicrob Agents Chemother 52, 1912–1916, http://doi.org/10.1128/AAC.00193-08.
Ji, B., Chauffour, A., Robert, J., Lefrançois, S. and Jarlier, V. (2007). Orally Administered Combined Regimens for Treatment of Mycobacterium ulcerans Infection in Mice. Antimicrob Agents Chemother 51, 3737–3739, http://doi.org/10.1128/AAC.00730-07.
Lefrançois, S., Robert, J., Chauffour, A., Ji, B. and Jarlier, V. (2007). Curing Mycobacterium ulcerans Infection in Mice with a Combination of Rifampin-Streptomycin or Rifampin-Amikacin. Antimicrob Agents Chemother 51, 645–650, http://doi.org/10.1128/AAC.00821-06.
Ji, B., Lefrançois, S., Robert, J., Chauffour, A., Truffot, C. and Jarlier, V. (2006). In Vitro and In Vivo Activities of Rifampin, Streptomycin, Amikacin, Moxifloxacin, R207910, Linezolid, and PA-824 against Mycobacterium ulcerans. Antimicrob Agents Chemother 50, 1921–1926, http://doi.org/10.1128/AAC.00052-06.
Dega, H., Bentoucha, A., Robert, J., Jarlier, V. and Grosset, J. (2002). Bactericidal Activity of Rifampin-Amikacin against Mycobacterium ulcerans in Mice. Antimicrob Agents Chemother 46, 3193–3196, http://doi.org/10.1128/AAC.46.10.3193-3196.2002.
Bentoucha, A., Robert, J., Dega, H., Lounis, N., Jarlier, V. and Grosset, J. (2001). Activities of New Macrolides and Fluoroquinolones against Mycobacterium ulcerans Infection in Mice. Antimicrob Agents Chemother 45, 3109–3112, http://doi.org/10.1128/AAC.45.11.3109-3112.2001.
Dega, H., Robert, J., Bonnafous, P., Jarlier, V. and Grosset, J. (2000). Activities of Several Antimicrobials againstMycobacterium ulcerans Infection in Mice. Antimicrob Agents Chemother 44, 2367–2372, http://doi.org/10.1128/AAC.44.9.2367-2372.2000.
Catégories
Documents Tout le CNR-MyRMA

Publications – Tuberculose

Seules les publications les plus récentes sont présentées – Pour voir plus de publications aller à la page de recherche : toutes les publications
Only the most recent publications are displayed – to see more, go to the search page : all publications

1368488 tuberculosis 1 heidelberg-university-faculty-of-medicine 50 date desc 1 245 https://cnrmyrma.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A250%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22MN3GCTHI%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lecorche%20et%20al.%22%2C%22parsedDate%22%3A%222026%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLecorche%2C%20E.%2C%20Billard-Pomares%2C%20T.%2C%20Alaoui%2C%20F.%20M.-E.%2C%20Gallois%2C%20E.%2C%20Fihman%2C%20V.%2C%20Carr%26%23xEB%3Br%2C%20A.%2C%20Djamdjian%2C%20L.%2C%20Camelena%2C%20F.%2C%20Mougari%2C%20F.%2C%20Carbonnelle%2C%20E.%20and%20Woerther%2C%20P.-L.%20%282026%29.%20%26lt%3Bb%26gt%3BImpact%20of%20delayed%20incubation%20on%20mycobacterial%20blood%20culture%20recovery%20with%20the%20BACTEC%20Myco%5C%2FF%20Lytic%20system%26lt%3B%5C%2Fb%26gt%3B.%20Diagnostic%20Microbiology%20and%20Infectious%20Disease%20%26lt%3Bi%26gt%3B114%26lt%3B%5C%2Fi%26gt%3B%2C%20117217%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.diagmicrobio.2025.117217%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.diagmicrobio.2025.117217%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Impact%20of%20delayed%20incubation%20on%20mycobacterial%20blood%20culture%20recovery%20with%20the%20BACTEC%20Myco%5C%2FF%20Lytic%20system%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Typhaine%22%2C%22lastName%22%3A%22Billard-Pomares%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fatma%20Magdoud-El%22%2C%22lastName%22%3A%22Alaoui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Gallois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Fihman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00e9lie%22%2C%22lastName%22%3A%22Carr%5Cu00ebr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Djamdjian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Camelena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Etienne%22%2C%22lastName%22%3A%22Carbonnelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul-Louis%22%2C%22lastName%22%3A%22Woerther%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2203%5C%2F2026%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.diagmicrobio.2025.117217%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0732889325005395%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2207328893%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-12-26T10%3A56%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22MKI3FS3M%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Saluzzo%20et%20al.%22%2C%22parsedDate%22%3A%222026%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSaluzzo%2C%20F.%2C%20Cabibbe%2C%20A.%20M.%2C%20Anthony%2C%20R.%2C%20Aubry%2C%20A.%2C%20Drobniewski%2C%20F.%2C%20Holicka%2C%20Y.%2C%20Lillebaek%2C%20T.%2C%20Macedo%2C%20R.%2C%20Mansj%26%23xF6%3B%2C%20M.%2C%20Sz%26%23xE9%3Bl%2C%20V.%2C%20%26%23x17D%3Bmak%2C%20L.%2C%20Cirillo%2C%20D.%20M.%20and%20Groenheit%2C%20R.%20%282026%29.%20%26lt%3Bb%26gt%3BDiagnostic%20algorithms%20for%20tuberculosis%20in%20Europe%3A%20insights%20from%20the%20European%20Reference%20Laboratory%20Network%20for%20Tuberculosis%20%28ERLTB-Net%29%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Regional%20Health%20-%20Europe%20%26lt%3Bi%26gt%3B60%26lt%3B%5C%2Fi%26gt%3B%2C%20101516%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.lanepe.2025.101516%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.lanepe.2025.101516%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Diagnostic%20algorithms%20for%20tuberculosis%20in%20Europe%3A%20insights%20from%20the%20European%20Reference%20Laboratory%20Network%20for%20Tuberculosis%20%28ERLTB-Net%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Saluzzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%20Maurizio%22%2C%22lastName%22%3A%22Cabibbe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Anthony%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francis%22%2C%22lastName%22%3A%22Drobniewski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yen%22%2C%22lastName%22%3A%22Holicka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Troels%22%2C%22lastName%22%3A%22Lillebaek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22Macedo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikael%22%2C%22lastName%22%3A%22Mansj%5Cu00f6%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viktoria%22%2C%22lastName%22%3A%22Sz%5Cu00e9l%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ljiljana%22%2C%22lastName%22%3A%22%5Cu017dmak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%20M.%22%2C%22lastName%22%3A%22Cirillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%22%2C%22lastName%22%3A%22Groenheit%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2201%5C%2F2026%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.lanepe.2025.101516%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2666776225003084%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2226667762%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-01-23T10%3A23%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22UHTR8XPZ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fouchet%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-17%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFouchet%2C%20T.%2C%20Nait%20Chabane%2C%20M.%2C%20Allam%2C%20C.%2C%20Awad%2C%20Z.%2C%20Mougari%2C%20F.%2C%20Hartmann%2C%20A.%2C%20Rochelet%2C%20M.%20and%20Cambau%2C%20E.%20%282025%29.%20%26lt%3Bb%26gt%3BClinical%20evaluation%20of%20the%20diagnostic%20performances%20and%20treatment%20monitoring%20of%20the%20new%20PATHFAST%20TB%20LAM%20Ag%20assay%20in%20sputum%20specimens%20of%20patients%20with%20tuberculosis%20or%20with%20nontuberculous%20mycobacteria%20pulmonary%20disease%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Miller%2C%20M.%20B.%20J%20Clin%20Microbiol%20%26lt%3Bi%26gt%3B63%26lt%3B%5C%2Fi%26gt%3B%2C%20e01269-25%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fjcm.01269-25%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fjcm.01269-25%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20evaluation%20of%20the%20diagnostic%20performances%20and%20treatment%20monitoring%20of%20the%20new%20PATHFAST%20TB%20LAM%20Ag%20assay%20in%20sputum%20specimens%20of%20patients%20with%20tuberculosis%20or%20with%20nontuberculous%20mycobacteria%20pulmonary%20disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theo%22%2C%22lastName%22%3A%22Fouchet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%22%2C%22lastName%22%3A%22Nait%20Chabane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Allam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zeina%22%2C%22lastName%22%3A%22Awad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fa%5Cu00efza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Hartmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Murielle%22%2C%22lastName%22%3A%22Rochelet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Melissa%20B.%22%2C%22lastName%22%3A%22Miller%22%7D%5D%2C%22abstractNote%22%3A%22ABSTRACT%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diagnosing%20pulmonary%20tuberculosis%20%28TB%29%20and%20monitoring%20treatment%20remain%20challenging.%20New%20tools%20such%20as%20the%20PATHFAST%20TB%20LAM%20assay%20%28PHC%20Corporation%2C%20formerly%20LSI%20Medience%20Corporation%2C%20Tokyo%2C%20Japan%3B%20distributed%20by%20BioSynex%2C%20France%3B%20PF-LAM%29%20may%20complement%20microscopy%2C%20culture%2C%20and%20NAAT.%20PF-LAM%20is%20an%20immunoassay%20quantifying%20lipoarabinomannan%20%28LAM%29%2C%20a%20mycobacterial%20cell%20wall%20component%2C%20in%20sputum%20within%201%20hour%20using%20an%20automated%20chemiluminescent%20reader.%20Diagnostic%20performance%20was%20first%20assessed%20on%20100%20sputum%20samples%3A%2040%20culture-positive%20for%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20complex%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%28MTBC%29%2C%2040%20culture-positive%20for%20nontuberculous%20mycobacteria%20%28NTM%29%2C%20and%2020%20culture-negative%20for%20both.%20We%20then%20tested%2061%20longitudinal%20sputum%20samples%20from%2019%20pulmonary%20TB%20patients%20under%20treatment.%20Four%20additional%20samples%20from%20one%20patient%20with%20NTM%20pulmonary%20disease%20%28NTM-PD%29%20were%20also%20tested.%20PF-LAM%20showed%2075%25%20sensitivity%20for%20MTBC%20detection%2C%20with%20a%20strong%20correlation%20between%20LAM%20concentration%20and%20culture%20time-to-positivity%20%28Spearman%20%5Cu03c1%20%3D%200.915%2C%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%26lt%3B%200.0001%29.%20Specificity%20was%2095%25%20on%20culture-negative%20specimens.%20The%20test%20was%20also%20positive%20for%2026%5C%2F40%20%2865%25%29%20NTM-culture-positive%20samples.%20Notably%2C%2019%20of%20these%2026%20samples%20were%20obtained%20from%20NTM-PD%20patients%2C%20yielding%2073%25%20sensitivity%20for%20NTM-PD%20detection.%20The%20assay%5Cu2019s%20potential%20for%20treatment%20monitoring%20was%20demonstrated%20by%20significant%20negative%20correlations%20between%20LAM%20concentration%20and%20%28a%29%20treatment%20duration%20%28%5Cu03c1%3D%5Cu20130.434%2C%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3D%200.0012%29%20and%20%28b%29%20time%20to%20positive%20culture%20%28%5Cu03c1%3D%5Cu20130.665%2C%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%26lt%3B%200.0001%29.%20PF-LAM%20is%20a%20rapid%20and%20easy-to-use%20test%20for%20diagnosing%20pulmonary%20TB.%20While%20NTM%20cross-reactivity%20reduces%20specificity%2C%20it%20may%20provide%20diagnostic%20value%20for%20NTM-PD.%20Results%20on%20monitoring%20TB%20treatment%20are%20promising%20as%20no%20test%20is%20currently%20available%20for%20this%20indication.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20IMPORTANCE%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Effective%20monitoring%20of%20the%20treatment%20response%20is%20essential%20for%20successful%20tuberculosis%20%28TB%29%20management%20as%20prolonged%20therapies%20require%20accurate%20evaluation%20to%20prevent%20relapse%2C%20treatment%20failure%2C%20or%20drug%20resistance.%20This%20study%20highlights%20the%20diagnostic%20and%20treatment-monitoring%20potential%20of%20the%20PATHFAST%20TB%20LAM%20Ag%20assay%2C%20which%20quantifies%20lipoarabinomannan%20%28LAM%29%20concentrations%20in%20sputum%20samples%20and%20correlates%20with%20bacterial%20load.%20For%20the%20first%20time%2C%20we%20also%20demonstrate%20the%20assay%5Cu2019s%20applicability%20for%20detecting%20and%20monitoring%20nontuberculous%20mycobacterial%20%28NTM%29%20pulmonary%20diseases%2C%20which%20are%20increasingly%20prevalent%20in%20industrialized%20countries.%20The%20semi-automated%2C%20rapid%20format%20%28%26lt%3B17%20minutes%29%20of%20the%20PATHFAST%20TB%20LAM%20Ag%20assay%20provides%20a%20simple%20and%20reliable%20approach%20for%20assessing%20bacillary%20load%20during%20treatment%2C%20representing%20a%20promising%20tool%20for%20improving%20patient%20management%20and%20diagnostic%20efficiency%20in%20both%20TB%20and%20NTM-PD.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Effective%20monitoring%20of%20the%20treatment%20response%20is%20essential%20for%20successful%20tuberculosis%20%28TB%29%20management%20as%20prolonged%20therapies%20require%20accurate%20evaluation%20to%20prevent%20relapse%2C%20treatment%20failure%2C%20or%20drug%20resistance.%20This%20study%20highlights%20the%20diagnostic%20and%20treatment-monitoring%20potential%20of%20the%20PATHFAST%20TB%20LAM%20Ag%20assay%2C%20which%20quantifies%20lipoarabinomannan%20%28LAM%29%20concentrations%20in%20sputum%20samples%20and%20correlates%20with%20bacterial%20load.%20For%20the%20first%20time%2C%20we%20also%20demonstrate%20the%20assay%5Cu2019s%20applicability%20for%20detecting%20and%20monitoring%20nontuberculous%20mycobacterial%20%28NTM%29%20pulmonary%20diseases%2C%20which%20are%20increasingly%20prevalent%20in%20industrialized%20countries.%20The%20semi-automated%2C%20rapid%20format%20%28%26lt%3B17%20minutes%29%20of%20the%20PATHFAST%20TB%20LAM%20Ag%20assay%20provides%20a%20simple%20and%20reliable%20approach%20for%20assessing%20bacillary%20load%20during%20treatment%2C%20representing%20a%20promising%20tool%20for%20improving%20patient%20management%20and%20diagnostic%20efficiency%20in%20both%20TB%20and%20NTM-PD.%22%2C%22date%22%3A%222025-12-17%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2Fjcm.01269-25%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.asm.org%5C%2Fdoi%5C%2F10.1128%5C%2Fjcm.01269-25%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220095-1137%2C%201098-660X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-12-26T10%3A41%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22884FBB68%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Aguilar-P%5Cu00e9rez%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-22%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAguilar-P%26%23xE9%3Brez%2C%20C.%2C%20Lenaerts%2C%20A.%20J.%2C%20Villellas%2C%20C.%2C%20Guillemont%2C%20J.%2C%20Dallow%2C%20J.%2C%20Painter%2C%20H.%2C%20Ammerman%2C%20N.%20C.%2C%20Hassan%2C%20A.%2C%20Golovkine%2C%20G.%2C%20Brock%2C%20L.%2C%20Sordello%2C%20S.%2C%20Chauffour%2C%20A.%2C%20Aubry%2C%20A.%2C%20Mai%2C%20T.%20C.%2C%20Wong%2C%20S.%2C%20Clark%2C%20T.%20G.%2C%20Nam%2C%20K.%2C%20Kim%2C%20J.%2C%20Choi%2C%20J.%2C%20Crabbe%2C%20M.%2C%20Esquivias%2C%20J.%2C%20Lounis%2C%20N.%2C%20Stoops%2C%20B.%2C%20Amssoms%2C%20K.%2C%20Bartolome-Nebreda%2C%20J.%20M.%2C%20Gruppo%2C%20V.%2C%20Robertson%2C%20G.%20T.%2C%20Veziris%2C%20N.%2C%20Upton%2C%20A.%20M.%2C%20Nuermberger%2C%20E.%20L.%2C%20Cox%2C%20V.%2C%20Ballell%2C%20L.%2C%20Baeten%2C%20B.%2C%20Koul%2C%20A.%2C%20Pym%2C%20A.%20S.%2C%20Wall%2C%20R.%20J.%20and%20Lamprecht%2C%20D.%20A.%20%282025%29.%20%26lt%3Bb%26gt%3BThe%20role%20of%20cytochrome%20bc1%20inhibitors%20in%20future%20tuberculosis%20treatment%20regimens%26lt%3B%5C%2Fb%26gt%3B.%20Nat%20Commun%20%26lt%3Bi%26gt%3B16%26lt%3B%5C%2Fi%26gt%3B%2C%209344%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-025-64427-6%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-025-64427-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20role%20of%20cytochrome%20bc1%20inhibitors%20in%20future%20tuberculosis%20treatment%20regimens%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clara%22%2C%22lastName%22%3A%22Aguilar-P%5Cu00e9rez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20J.%22%2C%22lastName%22%3A%22Lenaerts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Villellas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%22%2C%22lastName%22%3A%22Guillemont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Dallow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannah%22%2C%22lastName%22%3A%22Painter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%20C.%22%2C%22lastName%22%3A%22Ammerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anis%22%2C%22lastName%22%3A%22Hassan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Golovkine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Brock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvie%22%2C%22lastName%22%3A%22Sordello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Cuc%22%2C%22lastName%22%3A%22Mai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Wong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taane%20G.%22%2C%22lastName%22%3A%22Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiyean%22%2C%22lastName%22%3A%22Nam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeongjun%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinho%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marjolein%22%2C%22lastName%22%3A%22Crabbe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Esquivias%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nacer%22%2C%22lastName%22%3A%22Lounis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bart%22%2C%22lastName%22%3A%22Stoops%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katie%22%2C%22lastName%22%3A%22Amssoms%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%20M.%22%2C%22lastName%22%3A%22Bartolome-Nebreda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronica%22%2C%22lastName%22%3A%22Gruppo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20T.%22%2C%22lastName%22%3A%22Robertson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20M.%22%2C%22lastName%22%3A%22Upton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20L.%22%2C%22lastName%22%3A%22Nuermberger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivian%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lluis%22%2C%22lastName%22%3A%22Ballell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benny%22%2C%22lastName%22%3A%22Baeten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anil%22%2C%22lastName%22%3A%22Koul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%20S.%22%2C%22lastName%22%3A%22Pym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Wall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%20A.%22%2C%22lastName%22%3A%22Lamprecht%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Tuberculosis%20%28TB%29%20remains%20the%20foremost%20cause%20of%20death%20from%20infectious%20diseases%20globally%2C%20prompting%20ongoing%20efforts%20to%20improve%20treatment%20options.%20This%20includes%20developing%20compounds%20with%20novel%20modes%20of%20action%20and%20identifying%20optimal%20treatment%20regimens%20that%20allow%20for%20treatment%20shortening.%20One%20promising%20strategy%20involves%20targeting%20cytochrome%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20bc%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20oxidase%20in%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20a%20key%20enzyme%20in%20the%20respiratory%20chain.%20In%20this%20study%2C%20we%20evaluate%20the%20potential%20of%20cytochrome%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20bc%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20inhibitors%20as%20partner%20drugs%20in%20TB%20combination%20regimens.%20Using%20a%20relapsing%20mouse%20model%2C%20we%20demonstrate%20that%20these%20inhibitors%20enhance%20regimen%20sterilisation%20and%20significantly%20reduce%20the%20time%20required%20for%20effective%20treatment.%20We%20also%20propose%20several%20novel%20combination%20strategies%20for%20both%20multidrug-resistant%20and%20drug-sensitive%20TB%2C%20where%20cytochrome%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20bc%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20inhibitors%20contribute%20to%20sterilisation%20and%20improved%20treatment%20outcomes.%20Furthermore%2C%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20clinical%20isolates%20exhibited%20heightened%20susceptibility%20to%20cytochrome%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20bc%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20inhibitors%20compared%20to%20laboratory-adapted%20strains%2C%20highlighting%20the%20importance%20of%20using%20clinical%20isolates%20in%20TB%20drug%20discovery%20to%20better%20reflect%20the%20diversity%20of%20TB%20populations.%20These%20findings%20emphasise%20the%20potential%20of%20cytochrome%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20bc%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20inhibition%20in%20the%20development%20of%20more%20effective%20and%20shorter%20treatment%20regimens%20for%20TB%2C%20supporting%20the%20need%20for%20further%20clinical%20investigation.%22%2C%22date%22%3A%222025-10-22%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-025-64427-6%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-025-64427-6%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222041-1723%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-12-26T10%3A36%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22J8DRRQV9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kherabi%20et%20al.%22%2C%22parsedDate%22%3A%222025-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKherabi%2C%20Y.%2C%20Skouvig%20Pedersen%2C%20O.%2C%20Lange%2C%20C.%2C%20B%26%23xE9%3Bn%26%23xE9%3Bzit%2C%20F.%2C%20Chesov%2C%20D.%2C%20Codecasa%2C%20L.%20R.%2C%20Dudnyk%2C%20A.%2C%20Kiria%2C%20N.%2C%20Konstantynovska%2C%20O.%2C%20Marigot-Outtandy%2C%20D.%2C%20Panciu%2C%20T.-C.%2C%20Poignon%2C%20C.%2C%20Sasi%2C%20S.%2C%20Schaub%2C%20D.%2C%20Solodovnikova%2C%20V.%2C%20Vasiliauskait%26%23xE8%3B%2C%20L.%2C%20Yeghiazaryan%2C%20L.%2C%20G%26%23xFC%3Bnther%2C%20G.%2C%20Guglielmetti%2C%20L.%20and%20TBnet%5C%2FESGMYC%20XDR-TB%20Study%20Group%20%282025%29.%20%26lt%3Bb%26gt%3BTreatment%20outcomes%20of%20extensively%20drug-resistant%20tuberculosis%20in%20Europe%3A%20a%20retrospective%20cohort%20study%26lt%3B%5C%2Fb%26gt%3B.%20Lancet%20Reg%20Health%20Eur%20%26lt%3Bi%26gt%3B56%26lt%3B%5C%2Fi%26gt%3B%2C%20101380%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.lanepe.2025.101380%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.lanepe.2025.101380%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Treatment%20outcomes%20of%20extensively%20drug-resistant%20tuberculosis%20in%20Europe%3A%20a%20retrospective%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yousra%22%2C%22lastName%22%3A%22Kherabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ole%22%2C%22lastName%22%3A%22Skouvig%20Pedersen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22B%5Cu00e9n%5Cu00e9zit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dumitru%22%2C%22lastName%22%3A%22Chesov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luigi%20Ruffo%22%2C%22lastName%22%3A%22Codecasa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrii%22%2C%22lastName%22%3A%22Dudnyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nana%22%2C%22lastName%22%3A%22Kiria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olha%22%2C%22lastName%22%3A%22Konstantynovska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dhiba%22%2C%22lastName%22%3A%22Marigot-Outtandy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Traian-Constantin%22%2C%22lastName%22%3A%22Panciu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corentin%22%2C%22lastName%22%3A%22Poignon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sirje%22%2C%22lastName%22%3A%22Sasi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dagmar%22%2C%22lastName%22%3A%22Schaub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Varvara%22%2C%22lastName%22%3A%22Solodovnikova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laima%22%2C%22lastName%22%3A%22Vasiliauskait%5Cu00e8%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lusine%22%2C%22lastName%22%3A%22Yeghiazaryan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22TBnet%5C%2FESGMYC%20XDR-TB%20Study%20Group%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20In%202021%2C%20World%20Health%20Organization%20revised%20of%20definition%20of%20extensive%20drug-resistant%20tuberculosis.%20We%20aimed%20to%20determine%20treatment%20outcomes%20of%20individuals%20affected%20by%20extensively%20drug-resistant%20tuberculosis%20in%20Europe.%5CnMETHODS%3A%20This%20observational%2C%20retrospective%20cohort%20study%20included%20patients%20diagnosed%20with%20extensively%20drug-resistant%20tuberculosis%20in%20the%20World%20Health%20Organization%20European%20Region%20from%202017%20to%202023.%20Participating%20centres%20collected%20consecutive%2C%20detailed%20individual%20data%20for%20extensively%20drug-resistant%20tuberculosis%20patients.%20Data%20were%20analysed%20with%20meta-%20and%20regression%20methods%2C%20accounting%20for%20between-country%20heterogeneity.%5CnFINDINGS%3A%20Among%2011%2C003%20patients%20with%20multidrug-resistant%5C%2Frifampicin-resistant%20tuberculosis%2C%20188%20%281%5Cu00b77%25%29%20from%2016%20countries%20had%20extensively%20drug-resistant%20tuberculosis.%20Of%20these%2C%2048%5Cu00b74%25%20harboured%20strains%20with%20resistance%20to%20bedaquiline%20%28n%20%3D%2091%5C%2F188%29%2C%2034%5Cu00b70%25%20to%20linezolid%20%28n%20%3D%2064%5C%2F188%29%2C%20and%2017%5Cu00b76%25%20to%20both%20%28n%20%3D%2033%5C%2F188%29.%20The%20individual%20composition%20of%20anti-tuberculosis%20regimens%20was%20highly%20variable%2C%20with%20151%20different%20drug%20combinations.%20Among%20the%20156%5C%2F188%20%2883%5Cu00b70%25%29%20patients%20with%20available%20treatment%20outcomes%2C%20the%20pooled%20percentage%20of%20successful%20outcomes%20was%2040%5Cu00b72%25%20%2895%25%20confidence%20interval%20%5B95%25%20CI%5D%2028%5Cu00b74%25-53%5Cu00b72%25%29.%20In%20patients%20with%20unsuccessful%20treatment%20outcomes%20%28101%5C%2F156%29%2C%20most%20experienced%20treatment%20failure%20%28n%20%3D%2057%5C%2F156%20%5Bpooled%20proportion%2037%5Cu00b71%25%5D%2C%2095%25%20CI%3A%2026%5Cu00b71%25-49%5Cu00b77%25%29%20or%20death%20%28n%20%3D%2030%5C%2F156%20%5Bpooled%20proportion%2021%5Cu00b73%25%5D%2C%2095%25%20CI%3A%2015%5Cu00b77%25-28%5Cu00b72%25%29.%20After%20adjustment%20for%20disease%20severity%2C%20each%20additional%20likely%20effective%20drug%20decreased%20the%20odds%20of%20unsuccessful%20outcomes%20%28adjusted%20odds%20ratio%3A%200%5Cu00b765%2C%2095%25%20CI%3A%200%5Cu00b745-0%5Cu00b796%29%20%28p%20%3D%200%5Cu00b7026%29%2C%20whereas%20being%20treated%20in%20an%20upper-middle-income%20country%20increased%20the%20odds%20of%20unsuccessful%20outcomes%20compared%20with%20being%20treated%20in%20a%20high-income%20country%20%28adjusted%20odds%20ratio%3A%2013%5Cu00b77%2C%2095%25%20CI%3A%203%5Cu00b77-50%5Cu00b72%29%20%28p%20%26lt%3B%200%5Cu00b7001%29.%20Compared%20with%20other%20levels%20of%20drug%20resistance%2C%20treatment%20outcomes%20were%20significantly%20worse%20for%20extensively%20drug-resistant%20tuberculosis.%5CnINTERPRETATION%3A%20Only%20four%20out%20of%20ten%20patients%20affected%20by%20extensively%20drug-resistant%20tuberculosis%20achieved%20successful%20treatment%20outcomes.%20These%20findings%20highlight%20the%20need%20for%20adequate%2C%20individualised%20treatment%20regimens%20and%20optimised%20drug%20susceptibility%20testing.%5CnFUNDING%3A%20None.%22%2C%22date%22%3A%222025-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.lanepe.2025.101380%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222666-7762%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-08-21T13%3A36%3A00Z%22%7D%7D%2C%7B%22key%22%3A%227N5LTZQU%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Benhard%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-31%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBenhard%2C%20J.%2C%20Monsel%2C%20G.%2C%20Dub%26%23xE9%3Be%2C%20V.%2C%20Pavese%2C%20P.%2C%20Rasoldier%2C%20V.%2C%20Garrait%2C%20V.%2C%20Talleux%2C%20M.%2C%20Vuotto%2C%20F.%2C%20Gueneau%2C%20R.%2C%20Pouget-Abadie%2C%20X.%2C%20Thy%2C%20M.%2C%20Palacios%2C%20C.%2C%20Bachir%2C%20M.%2C%20Djossou%2C%20F.%2C%20Tunesi%2C%20S.%2C%20Jachym%2C%20M.%20F.%2C%20Pourcher%2C%20V.%2C%20Veziris%2C%20N.%20and%20Bourgarit%2C%20A.%20%282025%29.%20%26lt%3Bb%26gt%3BStandardized%20Infliximab%20Regimen%20to%20Treat%20Severe%20Central%20Nervous%20System%20Tuberculosis%3A%20A%20Case%20Series%20of%2018%20Patients%26lt%3B%5C%2Fb%26gt%3B.%20Open%20Forum%20Infectious%20Diseases%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%2C%20ofaf450%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofaf450%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofaf450%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Standardized%20Infliximab%20Regimen%20to%20Treat%20Severe%20Central%20Nervous%20System%20Tuberculosis%3A%20A%20Case%20Series%20of%2018%20Patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johan%22%2C%22lastName%22%3A%22Benhard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gentiane%22%2C%22lastName%22%3A%22Monsel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Dub%5Cu00e9e%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Pavese%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vero%22%2C%22lastName%22%3A%22Rasoldier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Garrait%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Talleux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fanny%22%2C%22lastName%22%3A%22Vuotto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Gueneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%22%2C%22lastName%22%3A%22Pouget-Abadie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Thy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christia%22%2C%22lastName%22%3A%22Palacios%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marwa%22%2C%22lastName%22%3A%22Bachir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%22%2C%22lastName%22%3A%22Djossou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Tunesi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%20Fr%5Cu00e9chet%22%2C%22lastName%22%3A%22Jachym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Pourcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Bourgarit%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Morbidity%20associated%20with%20central%20nervous%20system%20tuberculosis%20%28CNS%20TB%29%20remains%20high%20due%20to%20persistent%20inflammation%20despite%20standard-of-care%20%28SOC%29%20treatment%2C%20including%20antituberculosis%20therapy%20and%20corticosteroids.%20Tumor%20necrosis%20factor%20alpha%20%28TNF-%5Cu03b1%29%20is%20a%20key%20cytokine%20driving%20this%20inflammatory%20response%2C%20and%20a%20limited%20number%20of%20case%20reports%20suggest%20that%20TNF-%5Cu03b1%20inhibitors%20may%20improve%20outcomes.%20We%20report%20the%201-year%20outcome%20of%20a%20cohort%20of%20consecutive%20patients%20treated%20with%20infliximab%20for%20severe%20CNS%20TB.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Following%20the%20guidance%20provided%20by%20the%20French%20Tuberculosis%20Consilium%2C%20a%20standardized%20regimen%20of%20intravenous%20infliximab%20at%205%5Cu2005mg%5C%2Fkg%20per%20dose%20was%20used%20to%20treat%20CNS%20TB%20unresponsive%20to%20SOC.%20We%20retrospectively%20included%20consecutive%20patients%20who%20received%20at%20least%201%20infliximab%20injection%20for%20CNS%20TB%20from%202017%20to%20September%202021.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Eighteen%20patients%20with%20CNS%20TB%2C%2094%25%20with%20tuberculous%20meningitis%2C%20were%20included.%20Most%20had%20severe%20disease%3A%2082%25%20were%20classified%20as%20British%20Medical%20Research%20Council%20grade%20II%20or%20III%2C%20and%2044%25%20required%20intensive%20care%20unit%20admission.%20All%20demonstrated%20clinical%20and%20radiological%20worsening%20despite%20SOC%3B%20in%2089%25%20due%20to%20paradoxical%20reaction.%20At%20infliximab%20initiation%2C%20symptoms%20remained%20disabling%2C%20with%20a%20median%20modified%20Rankin%20scale%20%28mRS%29%20score%20of%203.5%20%28interquartile%20range%2C%203%5Cu20134%29.%20One%20month%20after%20the%20first%20infusion%2C%2038%25%20showed%20improved%20mRS%20scores%2C%20increasing%20to%2078%25%20at%201%5Cu2005year.%20One-year%20survival%20was%2094%25%3B%201%20death%20occurred%2012%5Cu2005months%20after%20a%20single%20infliximab%20dose%20and%20was%20unrelated%20to%20TB%20treatment.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Infliximab%20may%20represent%20a%20promising%20adjunctive%20treatment%20for%20CNS%20TB%20unresponsive%20to%20SOC%2C%20including%20paradoxical%20reaction.%20Prospective%20studies%20are%20needed%20to%20confirm%20these%20findings.%22%2C%22date%22%3A%222025-07-31%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fofid%5C%2Fofaf450%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Fofid%5C%2Farticle%5C%2Fdoi%5C%2F10.1093%5C%2Fofid%5C%2Fofaf450%5C%2F8232409%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222328-8957%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-09-30T15%3A04%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22G5G79UG2%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guglielmetti%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuglielmetti%2C%20L.%2C%20Khan%2C%20U.%2C%20Vel%26%23xE1%3Bsquez%2C%20G.%20E.%2C%20Gouillou%2C%20M.%2C%20Ali%2C%20M.%20H.%2C%20Amjad%2C%20S.%2C%20Kamal%2C%20F.%2C%20Abubakirov%2C%20A.%2C%20Ardizzoni%2C%20E.%2C%20Baudin%2C%20E.%2C%20Bektassov%2C%20S.%2C%20Berry%2C%20C.%2C%20Bonnet%2C%20M.%2C%20Chavan%2C%20V.%2C%20Coutisson%2C%20S.%2C%20Dakenova%2C%20Z.%2C%20de%20Jong%2C%20B.%20C.%2C%20Dinh%2C%20L.%20V.%2C%20Ferlazzo%2C%20G.%2C%20Kirakosyan%2C%20O.%2C%20Lachenal%2C%20N.%2C%20Lecca%2C%20L.%2C%20McIlleron%2C%20H.%2C%20Mikanda%2C%20K.%20K.%2C%20Mucching-Toscano%2C%20S.%2C%20Mulders%2C%20W.%2C%20Mushtaque%2C%20H.%2C%20Nahid%2C%20P.%2C%20Nguyen%2C%20D.%20V.%2C%20Nguyen%2C%20N.%20V.%2C%20Oyewusi%2C%20L.%2C%20Motta%2C%20I.%2C%20Panda%2C%20S.%2C%20Patil%2C%20Sandip%2C%20Pham%2C%20T.%20H.%2C%20Phan%2C%20D.%20T.%2C%20Phan%2C%20H.%20T.%20T.%2C%20Phillips%2C%20P.%20P.%20J.%2C%20Ruiz%2C%20J.%2C%20Rupasinghe%2C%20Praharshinie%2C%20Salahuddin%2C%20N.%2C%20Sanchez-Garavito%2C%20E.%2C%20Seung%2C%20K.%20J.%2C%20Asfaw%2C%20M.%20T.%2C%20Vargas%20Vasquez%2C%20D.%2C%20Rich%2C%20M.%20L.%2C%20Varaine%2C%20F.%2C%20Mitnick%2C%20C.%20D.%2C%20Arora%2C%20G.%2C%20Ashara%2C%20V.%2C%20Bhattacharjee%2C%20S.%2C%20Borkar%2C%20R.%2C%20Chincholikar%2C%20N.%2C%20Choudhary%2C%20N.%2C%20Davuluri%2C%20P.%2C%20Desai%2C%20N.%2C%20Dipika%2C%20Dhongade%2C%20S.%2C%20Dulani%2C%20D.%2C%20Ghule%2C%20S.%2C%20Hirani%2C%20N.%2C%20Hurali%2C%20P.%2C%20Irani%2C%20R.%2C%20Jadhav%2C%20K.%2C%20Jadhav%2C%20P.%2C%20Jadhav%2C%20R.%2C%20Joseph%2C%20N.%2C%20Joshi%2C%20A.%2C%20Joshi%2C%20P.%2C%20K%2C%20A.%2C%20K%2C%20S.%2C%20Kamble%2C%20M.%2C%20Kate%2C%20R.%2C%20Keer%2C%20T.%2C%20S%20Kenche%2C%20M.%2C%20Khandare%2C%20H.%2C%20Koli%2C%20P.%2C%20Kulkarni%2C%20A.%2C%20Patra%2C%20S.%20K.%2C%20Kuwar%2C%20A.%2C%20Lande%2C%20P.%2C%20Mane%2C%20N.%2C%20Masalge%2C%20P.%2C%20Mishra%2C%20P.%2C%20Mitkari%2C%20R.%2C%20More%2C%20A.%2C%20Munot%2C%20P.%2C%20Murgesh%2C%20R.%2C%20Muthe%2C%20S.%2C%20Nakashe%2C%20N.%2C%20Natarajan%2C%20D.%2C%20Paril%2C%20S.%2C%20Patil%2C%20Supriya%2C%20Patil%2C%20V.%2C%20Patwardhan%2C%20V.%2C%20Posture%2C%20V.%2C%20Pradeshi%2C%20A.%2C%20Prasad%2C%20V.%2C%20Pundir%2C%20B.%2C%20Rajendran%2C%20S.%2C%20Randhit%2C%20Y.%2C%20Rekart%2C%20M.%2C%20Samant%2C%20P.%2C%20Shaikh%2C%20H.%2C%20Sharma%2C%20A.%2C%20Sharma%2C%20N.%2C%20Sharma%2C%20S.%2C%20Shinde%2C%20N.%2C%20Shinde%2C%20S.%2C%20Shingare%2C%20G.%2C%20Shulka%2C%20A.%2C%20Shriwas%2C%20A.%2C%20Sonawane%2C%20L.%2C%20Sudhindra%2C%20U.%2C%20Suryavanshi%2C%20D.%2C%20Thakare%2C%20A.%2C%20Udare%2C%20D.%2C%20Vaidya%2C%20G.%2C%20Wagh%2C%20R.%2C%20Isenova%2C%20L.%2C%20Konigratbayeva%2C%20G.%2C%20Nurtayeva%2C%20G.%2C%20Zekeshov%2C%20N.%2C%20Chenu%2C%20R.%2C%20Garba%2C%20S.%2C%20Tozzi%2C%20D.%2C%20Yuya-Septoh%2C%20F.-J.%2C%20Thi%20Tuyet%20Mai%2C%20B.%2C%20Thi%20Hai%2C%20D.%2C%20Thi%20Thuy%2C%20D.%2C%20Thi%20Oanh%2C%20L.%2C%20Do%2C%20B.%20T.%2C%20Nguyen%2C%20D.%20T.%2C%20Nguyen%2C%20P.%20H.%2C%20Nguyen%2C%20T.%20M.%20A.%2C%20Nguyen%2C%20Thi%20Thuy%20Hanh%2C%20Nguyen%2C%20T.%20K.%20N.%2C%20Nguyen%2C%20T.%20N.%2C%20Nguyen%2C%20V.%20K.%2C%20Nog%2C%20N.%2C%20Pham%2C%20T.%20N.%2C%20Pham%2C%20T.%20L.%2C%20Pham%2C%20T.%20A.%2C%20Phung%2C%20T.%20B.%2C%20Tran%2C%20B.%20T.%2C%20Trinh%2C%20M.%20T.%2C%20Chang%2C%20E.%2C%20Coit%2C%20J.%2C%20Do%2C%20J.-M.%2C%20LaHood%2C%20A.%2C%20O%26%23x2019%3BBrien%2C%20K.%2C%20Okunbor%2C%20E.%2C%20Osso%2C%20E.%2C%20Ch%26%23xE1%3Bvez%2C%20V.%2C%20Larco%2C%20P.%2C%20Mendoza%2C%20D.%2C%20Robles%2C%20C.%2C%20Rojas%2C%20A.%2C%20Salazar%2C%20J.%2C%20Santos%2C%20G.%2C%20Sosa%2C%20J.%2C%20Ticona%2C%20C.%2C%20Carranza%2C%20S.%2C%20Delgado%2C%20D.%2C%20Galarza%2C%20C.%2C%20Murga%2C%20G.%2C%20Ramos%2C%20E.%2C%20Cantaro%2C%20K.%2C%20Huerta%2C%20A.%2C%20Maldonado%2C%20J.%2C%20Nu%26%23xF1%3Bez%2C%20R.%2C%20Panduro%2C%20K.%2C%20Rafael%2C%20R.%2C%20Abdul%2C%20A.%2C%20Abedin%2C%20S.%2C%20Afreen%2C%20E.%2C%20Ahmed%2C%20Sohail%2C%20Ahmed%2C%20U.%2C%20Ali%20Shah%2C%20J.%2C%20Ashraf%2C%20A.%2C%20Aslam%2C%20F.%2C%20Bashir%2C%20Z.%2C%20Fayyaz%2C%20S.%2C%20Hafeez%2C%20K.%2C%20Hamid%2C%20M.%2C%20Hassan%2C%20B.%2C%20Hussain%2C%20M.%2C%20Irfan%2C%20M.%2C%20Omar%2C%20M.%2C%20Parveen%2C%20S.%2C%20Sunail%2C%20S.%2C%20Farooq%2C%20M.%2C%20Mazhar%2C%20B.%2C%20Munir%2C%20S.%2C%20Sonia%2C%20N.%2C%20Yaseen%2C%20M.%2C%20Zubair%2C%20M.%2C%20Zehra%2C%20F.%2C%20Zulfiqar%2C%20I.%2C%20Abbasi%2C%20T.%2C%20Akbar%20Abro%2C%20G.%2C%20Ahmed%2C%20M.%2C%20Ahmed%2C%20N.%2C%20Hammad%20Ali%2C%20M.%2C%20Ali%2C%20N.%2C%20Danish%2C%20R.%2C%20Farhat%2C%20A.%2C%20Gill%2C%20S.%2C%20Hafeez%2C%20M.%2C%20Hussain%2C%20G.%2C%20Inayat%2C%20H.%2C%20Johnson%2C%20S.%2C%20Kamal%2C%20F.%2C%20Kamran%2C%20A.%2C%20Kumar%2C%20Sanjeet%2C%20Maheshwari%2C%20M.%2C%20Mamsa%2C%20S.%2C%20Massey%2C%20S.%2C%20Mehmood%2C%20A.%2C%20Memon%2C%20A.%2C%20Ali%20Mirani%2C%20A.%2C%20Naz%2C%20S.%2C%20Rafique%20Qureshi%2C%20T.%2C%20Roop%20Moazzam%20Sheikh%2C%20Y.%2C%20Rafi%20Siddiqui%2C%20M.%2C%20Singh%2C%20B.%2C%20Soomro%2C%20M.%2C%20Ardizzoni%2C%20E.%2C%20Rigouts%2C%20L.%2C%20Rupasinghe%2C%20Praha%2C%20Aftab%2C%20A.%2C%20Ahmed%2C%20Saman%2C%20Adnan%20Alamgir%2C%20M.%2C%20Ali%2C%20Ayaz%2C%20Ali%2C%20Azhar%2C%20Ahmed%20Ali%2C%20S.%2C%20Ali%2C%20S.%2C%20Altaf%2C%20S.%2C%20Amjad%2C%20S.%2C%20Sahiba%20Arshad%2C%20M.%2C%20Ausim%2C%20S.%2C%20Basit%2C%20A.%2C%20Ezik%2C%20H.%2C%20Hussain%2C%20H.%2C%20Hyder%2C%20S.%2C%20Inayat%2C%20S.%2C%20Janmohammed%2C%20A.%2C%20Jaseem%2C%20K.%2C%20Jawed%2C%20A.%2C%20Maniar%2C%20L.%2C%20Kumar%2C%20P.%2C%20Kumar%2C%20Susheel%2C%20Latif%2C%20R.%2C%20Liaqat%2C%20S.%2C%20Ammar%20Nasser%2C%20M.%2C%20Shakeel%2C%20M.%2C%20Shaikh%2C%20S.%2C%20Siddiqui%2C%20A.%2C%20Singh%2C%20J.%2C%20Sivan%2C%20K.%2C%20Taimoor%2C%20M.%2C%20Zia%2C%20N.%2C%20Li%2C%20I.%2C%20Otepbergenova%2C%20M.%2C%20Dinh%2C%20T.%20H.%2C%20Do%2C%20Thi%20Thu%2C%20Do%2C%20Thu%20Thuong%2C%20Le%2C%20T.%20N.%2C%20Nguyen%2C%20K.%20C.%2C%20Nguyen%2C%20T.%20T.%2C%20Nguyen%2C%20V.%20H.%2C%20Abildayeva%2C%20G.%2C%20Maryash%2C%20O.%2C%20Telegina%2C%20E.%2C%20Tursynbekova%2C%20L.%2C%20Amanzholova%2C%20Z.%2C%20Bektassova%2C%20P.%2C%20Belgozhanova%2C%20A.%2C%20Birimkulova%2C%20N.%2C%20Dyusebayeva%2C%20N.%2C%20Erkut%2C%20N.%2C%20Gusmanov%2C%20A.%2C%20Kassenova%2C%20B.%2C%20Kassym%2C%20A.%2C%20Khazhidinov%2C%20K.%2C%20Lee%2C%20T.%2C%20Magzumova%2C%20A.%2C%20Mussabayeva%2C%20M.%2C%20Omarova%2C%20G.%2C%20Ryapolova%2C%20N.%2C%20Sagyndykova%2C%20L.%2C%20Serekbay%2C%20A.%2C%20Stambekova%2C%20A.%2C%20Tanatarova%2C%20G.%2C%20Uaisov%2C%20Z.%2C%20Zhantuarova%2C%20Z.%2C%20Zhumakairova%2C%20G.%2C%20Arlyapova%2C%20N.%2C%20Bogus%2C%20J.%2C%20Cain%2C%20M.%2C%20Carmona%2C%20M.%2C%20Flanagan%2C%20C.%2C%20McAnaw%2C%20S.%2C%20Scharff%2C%20A.%2C%20Soni%2C%20S.%2C%20Striplin%2C%20M.%2C%20Abebe%2C%20S.%2C%20Alakaye%2C%20J.%2C%20Bulane%2C%20A.%2C%20Custodio%2C%20M.%2C%20Hajison%2C%20P.%2C%20Hetsa%2C%20M.%2C%20Holtzman%2C%20D.%2C%20Khesa%2C%20M.%2C%20Lethola%2C%20M.%2C%20Lebitsa%2C%20T.%2C%20Mahamo%2C%20M.%2C%20Makaka%2C%20J.%2C%20Matoko%2C%20M.%2C%20Mpinda%2C%20S.%2C%20Mohoang%2C%20P.%2C%20Monyaesa%2C%20D.%2C%20Nkundayirazo%2C%20P.%2C%20Ntsane%20Sesomo%20Mohale%2C%20M.%2C%20Ntsibane%2C%20S.%2C%20Phate%2C%20S.%2C%20Radebe%20%28Retsepile%20Tlali%29%2C%20M.%2C%20Rakhetsi%2C%20M.%2C%20Ranoosi%2C%20T.%2C%20Tamirat%2C%20M.%2C%20Thokoana%2C%20M.%2C%20Alegre%2C%20E.%2C%20Aguilar%2C%20C.%2C%20Armuto%2C%20L.%2C%20Barreda%2C%20N.%2C%20Barreto%2C%20M.%2C%20Cabrera%2C%20S.%2C%20Calderon%2C%20R.%2C%20Castro%2C%20M.%2C%20Chavez%2C%20J.%2C%20Chavez%2C%20L.%2C%20Cheje%2C%20H.%2C%20Cori%2C%20L.%2C%20D%26%23xE1%3Bvalos%2C%20D.%2C%20de%20la%20Gala%2C%20S.%2C%20Delgadillo%2C%20K.%2C%20Diaz%2C%20H.%2C%20Flores%2C%20X.%2C%20Galarza%2C%20J.%2C%20Garc%26%23xED%3Ba%2C%20D.%2C%20Garcia%2C%20F.%2C%20Gaspar%2C%20M.%2C%20Godos%2C%20R.%2C%20Gomez%2C%20P.%2C%20Gonzales%2C%20L.%2C%20Guerrero%2C%20L.%2C%20Inga%2C%20S.%2C%20Jasaycucho%2C%20J.%2C%20Martel%2C%20B.%2C%20Pro%20Martinez%2C%20A.%2C%20Molina%2C%20R.%2C%20Mugruza%2C%20R.%2C%20Mundaca%2C%20H.%2C%20Nuahan%2C%20M.%2C%20Ore%2C%20K.%2C%20Panduro%2C%20L.%2C%20Pe%26%23xF1%3Ba%2C%20O.%2C%20Perea%2C%20S.%2C%20Pinedo%2C%20C.%2C%20Ponce%2C%20Y.%2C%20Quinte%2C%20C.%2C%20Qui%26%23xF1%3Bones%2C%20M.%2C%20Ramos%2C%20A.%2C%20Ramirez%2C%20E.%2C%20Reynoso%2C%20R.%2C%20Reyes%2C%20C.%2C%20Reyes%2C%20J.%2C%20Riccio%2C%20V.%2C%20Robles%2C%20B.%2C%20Rojas%2C%20K.%2C%20Sanabria%2C%20O.%2C%20Saravia%2C%20M.%2C%20Saravia%2C%20S.%2C%20Senador%2C%20L.%2C%20Soberon%2C%20J.%2C%20Soncco%2C%20E.%2C%20Soto%2C%20M.%2C%20Suarez%2C%20C.%2C%20Suarez%2C%20M.%2C%20Suarez%2C%20V.%2C%20Torpoco%2C%20E.%2C%20Torres%2C%20O.%2C%20Torrez%2C%20C.%2C%20Tunque%2C%20G.%2C%20Ugarte%2C%20A.%2C%20Vaderrama%2C%20G.%2C%20Valdivia%2C%20W.%2C%20Valdivia%2C%20Y.%2C%20Valverde%2C%20I.%2C%20Vargas%2C%20C.%2C%20Vargas%2C%20J.%2C%20Vasquez%2C%20E.%2C%20Veliz%2C%20J.%2C%20Villa%2C%20D.%2C%20Villafuerte%2C%20S.%2C%20Villar%2C%20G.%2C%20Villegas%2C%20S.%2C%20Wong%2C%20M.%2C%20Yataco%2C%20R.%2C%20Pham%2C%20H.%2C%20Truong%2C%20H.%2C%20Nguyen%2C%20H.%2C%20Huy%2C%20V.%2C%20Nguyen%2C%20V.%20S.%2C%20Nguyen%2C%20T.%20M.%20K.%2C%20Minh%2C%20T.%2C%20Bui%2C%20D.%20T.%20T.%2C%20Truong%2C%20V.%20V.%2C%20Nguyen%2C%20Thi%20Thu%20Ha%2C%20Coutisson%2C%20S.%2C%20Atger%2C%20M.%2C%20Nadia%20Baya%2C%20S.%2C%20Bekhiet%2C%20M.%2C%20Boissi%26%23xE8%3Bre%2C%20V.%2C%20Caboclo%2C%20R.%2C%20Chaudhry%2C%20M.%2C%20Cloez%2C%20S.%2C%20Collin%2C%20S.%2C%20Delifer%2C%20C.%2C%20Demaisons%2C%20S.%2C%20Ducher%2C%20V.%2C%20Hewison%2C%20C.%2C%20Ibrahim%2C%20M.%2C%20Lebeau%2C%20K.%2C%20Mazmanian%2C%20M.%2C%20Mirzayeva%2C%20R.%2C%20Moreau%2C%20M.%2C%20Moschioni%2C%20M.%2C%20P%26%23xE2%3Bquet%2C%20A.%2C%20Perrin%2C%20C.%2C%20Pichon%2C%20L.%2C%20Roussel%2C%20J.%2C%20Scotton%2C%20M.%2C%20Austin%2C%20A.%20and%20Sun%2C%20P.%20%282025%29.%20%26lt%3Bb%26gt%3BBedaquiline%2C%20delamanid%2C%20linezolid%2C%20and%20clofazimine%20for%20rifampicin-resistant%20and%20fluoroquinolone-resistant%20tuberculosis%20%28endTB-Q%29%3A%20an%20open-label%2C%20multicentre%2C%20stratified%2C%20non-inferiority%2C%20randomised%2C%20controlled%2C%20phase%203%20trial%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Respiratory%20Medicine%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2213-2600%2825%2900194-8%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2213-2600%2825%2900194-8%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Bedaquiline%2C%20delamanid%2C%20linezolid%2C%20and%20clofazimine%20for%20rifampicin-resistant%20and%20fluoroquinolone-resistant%20tuberculosis%20%28endTB-Q%29%3A%20an%20open-label%2C%20multicentre%2C%20stratified%2C%20non-inferiority%2C%20randomised%2C%20controlled%2C%20phase%203%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Uzma%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gustavo%20E%22%2C%22lastName%22%3A%22Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maelenn%22%2C%22lastName%22%3A%22Gouillou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%20Hammad%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samreen%22%2C%22lastName%22%3A%22Amjad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farees%22%2C%22lastName%22%3A%22Kamal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanzhan%22%2C%22lastName%22%3A%22Abubakirov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Ardizzoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Baudin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sagit%22%2C%22lastName%22%3A%22Bektassov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Berry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maryline%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vijay%22%2C%22lastName%22%3A%22Chavan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvine%22%2C%22lastName%22%3A%22Coutisson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhanna%22%2C%22lastName%22%3A%22Dakenova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%20Catherine%22%2C%22lastName%22%3A%22de%20Jong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luong%20Van%22%2C%22lastName%22%3A%22Dinh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriella%22%2C%22lastName%22%3A%22Ferlazzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ohanna%22%2C%22lastName%22%3A%22Kirakosyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Lachenal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonid%22%2C%22lastName%22%3A%22Lecca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22McIlleron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kwabisha%20Kunda%22%2C%22lastName%22%3A%22Mikanda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergio%22%2C%22lastName%22%3A%22Mucching-Toscano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wim%22%2C%22lastName%22%3A%22Mulders%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hebah%22%2C%22lastName%22%3A%22Mushtaque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Payam%22%2C%22lastName%22%3A%22Nahid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dong%20Van%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nhung%20Viet%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lawrence%22%2C%22lastName%22%3A%22Oyewusi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilaria%22%2C%22lastName%22%3A%22Motta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samiran%22%2C%22lastName%22%3A%22Panda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandip%22%2C%22lastName%22%3A%22Patil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thuong%20Huu%22%2C%22lastName%22%3A%22Pham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dat%20Thuong%22%2C%22lastName%22%3A%22Phan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ha%20Thi%20Thu%22%2C%22lastName%22%3A%22Phan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20P%20J%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimena%22%2C%22lastName%22%3A%22Ruiz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Praharshinie%22%2C%22lastName%22%3A%22Rupasinghe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naseem%22%2C%22lastName%22%3A%22Salahuddin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Epifanio%22%2C%22lastName%22%3A%22Sanchez-Garavito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kwonjune%20J%22%2C%22lastName%22%3A%22Seung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meseret%20Tamirat%22%2C%22lastName%22%3A%22Asfaw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dante%22%2C%22lastName%22%3A%22Vargas%20Vasquez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20L%22%2C%22lastName%22%3A%22Rich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francis%22%2C%22lastName%22%3A%22Varaine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%20D%22%2C%22lastName%22%3A%22Mitnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gurpreet%22%2C%22lastName%22%3A%22Arora%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valay%22%2C%22lastName%22%3A%22Ashara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonali%22%2C%22lastName%22%3A%22Bhattacharjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rakshanda%22%2C%22lastName%22%3A%22Borkar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Namita%22%2C%22lastName%22%3A%22Chincholikar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikita%22%2C%22lastName%22%3A%22Choudhary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Praveen%22%2C%22lastName%22%3A%22Davuluri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neha%22%2C%22lastName%22%3A%22Desai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Dipika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sunil%22%2C%22lastName%22%3A%22Dhongade%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Drishti%22%2C%22lastName%22%3A%22Dulani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sheetal%22%2C%22lastName%22%3A%22Ghule%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nilma%22%2C%22lastName%22%3A%22Hirani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prakash%22%2C%22lastName%22%3A%22Hurali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reeana%22%2C%22lastName%22%3A%22Irani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiran%22%2C%22lastName%22%3A%22Jadhav%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pritesh%22%2C%22lastName%22%3A%22Jadhav%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Radhika%22%2C%22lastName%22%3A%22Jadhav%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nidhin%22%2C%22lastName%22%3A%22Joseph%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akshay%22%2C%22lastName%22%3A%22Joshi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pranav%22%2C%22lastName%22%3A%22Joshi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akhilraj%22%2C%22lastName%22%3A%22K%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sagar%22%2C%22lastName%22%3A%22K%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madhavi%22%2C%22lastName%22%3A%22Kamble%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rashmi%22%2C%22lastName%22%3A%22Kate%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tanvi%22%2C%22lastName%22%3A%22Keer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madhuri%22%2C%22lastName%22%3A%22S%20Kenche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harsha%22%2C%22lastName%22%3A%22Khandare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pranesha%22%2C%22lastName%22%3A%22Koli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Apurva%22%2C%22lastName%22%3A%22Kulkarni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sagar%20Kumar%22%2C%22lastName%22%3A%22Patra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abhishek%22%2C%22lastName%22%3A%22Kuwar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prakash%22%2C%22lastName%22%3A%22Lande%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nana%22%2C%22lastName%22%3A%22Mane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Priya%22%2C%22lastName%22%3A%22Masalge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Priya%22%2C%22lastName%22%3A%22Mishra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rishabh%22%2C%22lastName%22%3A%22Mitkari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajit%22%2C%22lastName%22%3A%22More%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pracheta%22%2C%22lastName%22%3A%22Munot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramya%22%2C%22lastName%22%3A%22Murgesh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sagar%22%2C%22lastName%22%3A%22Muthe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nupur%22%2C%22lastName%22%3A%22Nakashe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dwaragesh%22%2C%22lastName%22%3A%22Natarajan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sharad%22%2C%22lastName%22%3A%22Paril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Supriya%22%2C%22lastName%22%3A%22Patil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vaishali%22%2C%22lastName%22%3A%22Patil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vaijayanti%22%2C%22lastName%22%3A%22Patwardhan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivek%22%2C%22lastName%22%3A%22Posture%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anil%22%2C%22lastName%22%3A%22Pradeshi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanya%22%2C%22lastName%22%3A%22Prasad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bhavya%22%2C%22lastName%22%3A%22Pundir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarathi%22%2C%22lastName%22%3A%22Rajendran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yogesh%22%2C%22lastName%22%3A%22Randhit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Rekart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pradnya%22%2C%22lastName%22%3A%22Samant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanif%22%2C%22lastName%22%3A%22Shaikh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ashutosh%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neela%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sharda%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nilesh%22%2C%22lastName%22%3A%22Shinde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suvarna%22%2C%22lastName%22%3A%22Shinde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gauri%22%2C%22lastName%22%3A%22Shingare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abhay%22%2C%22lastName%22%3A%22Shulka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aniket%22%2C%22lastName%22%3A%22Shriwas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lokesh%22%2C%22lastName%22%3A%22Sonawane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Urmila%22%2C%22lastName%22%3A%22Sudhindra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dipali%22%2C%22lastName%22%3A%22Suryavanshi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akshay%22%2C%22lastName%22%3A%22Thakare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Danashree%22%2C%22lastName%22%3A%22Udare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gayatri%22%2C%22lastName%22%3A%22Vaidya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rani%22%2C%22lastName%22%3A%22Wagh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lyazzat%22%2C%22lastName%22%3A%22Isenova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gulbakhar%22%2C%22lastName%22%3A%22Konigratbayeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gulnar%22%2C%22lastName%22%3A%22Nurtayeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nurlan%22%2C%22lastName%22%3A%22Zekeshov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Chenu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Souna%22%2C%22lastName%22%3A%22Garba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daiane%22%2C%22lastName%22%3A%22Tozzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francis-Jaudel%22%2C%22lastName%22%3A%22Yuya-Septoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bui%22%2C%22lastName%22%3A%22Thi%20Tuyet%20Mai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dang%22%2C%22lastName%22%3A%22Thi%20Hai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dinh%22%2C%22lastName%22%3A%22Thi%20Thuy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lai%22%2C%22lastName%22%3A%22Thi%20Oanh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bang%20Tam%22%2C%22lastName%22%3A%22Do%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dinh%20Tuyen%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Phuong%20Hoang%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Mai%20Anh%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Thuy%20Hanh%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Kieu%20Ninh%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Nhien%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Van%20Khiem%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nog%22%2C%22lastName%22%3A%22Nog%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thanh%20Nam%22%2C%22lastName%22%3A%22Pham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Lan%22%2C%22lastName%22%3A%22Pham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thu%20Anh%22%2C%22lastName%22%3A%22Pham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Bich%22%2C%22lastName%22%3A%22Phung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bao%20Trung%22%2C%22lastName%22%3A%22Tran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Minh%20Trang%22%2C%22lastName%22%3A%22Trinh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eva%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Coit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacquelyn-My%22%2C%22lastName%22%3A%22Do%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Allison%22%2C%22lastName%22%3A%22LaHood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelsey%22%2C%22lastName%22%3A%22O%27Brien%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enoma%22%2C%22lastName%22%3A%22Okunbor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elna%22%2C%22lastName%22%3A%22Osso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Ch%5Cu00e1vez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Piero%22%2C%22lastName%22%3A%22Larco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Mendoza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Robles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angelo%22%2C%22lastName%22%3A%22Rojas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janet%22%2C%22lastName%22%3A%22Salazar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Santos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%22%2C%22lastName%22%3A%22Sosa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cesar%22%2C%22lastName%22%3A%22Ticona%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shirley%22%2C%22lastName%22%3A%22Carranza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diego%22%2C%22lastName%22%3A%22Delgado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cemir%22%2C%22lastName%22%3A%22Galarza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gladys%22%2C%22lastName%22%3A%22Murga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Ramos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelly%22%2C%22lastName%22%3A%22Cantaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrely%22%2C%22lastName%22%3A%22Huerta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Maldonado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roberto%22%2C%22lastName%22%3A%22Nu%5Cu00f1ez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katherine%22%2C%22lastName%22%3A%22Panduro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruth%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amaan%22%2C%22lastName%22%3A%22Abdul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Abedin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eraj%22%2C%22lastName%22%3A%22Afreen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sohail%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ubaid%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinsar%22%2C%22lastName%22%3A%22Ali%20Shah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azka%22%2C%22lastName%22%3A%22Ashraf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faisal%22%2C%22lastName%22%3A%22Aslam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zahida%22%2C%22lastName%22%3A%22Bashir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saba%22%2C%22lastName%22%3A%22Fayyaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiren%22%2C%22lastName%22%3A%22Hafeez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meherunissa%22%2C%22lastName%22%3A%22Hamid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Basmah%22%2C%22lastName%22%3A%22Hassan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muzamil%22%2C%22lastName%22%3A%22Hussain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Irfan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Omar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shafiqua%22%2C%22lastName%22%3A%22Parveen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sharoon%22%2C%22lastName%22%3A%22Sunail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Farooq%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Batool%22%2C%22lastName%22%3A%22Mazhar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sana%22%2C%22lastName%22%3A%22Munir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neelofer%22%2C%22lastName%22%3A%22Sonia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Yaseen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Zubair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fatima%22%2C%22lastName%22%3A%22Zehra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iqra%22%2C%22lastName%22%3A%22Zulfiqar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tazeen%22%2C%22lastName%22%3A%22Abbasi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ghulam%22%2C%22lastName%22%3A%22Akbar%20Abro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mushtaque%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazir%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Hammad%20Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazakat%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rao%22%2C%22lastName%22%3A%22Danish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayesha%22%2C%22lastName%22%3A%22Farhat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sunaina%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Hafeez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ghulam%22%2C%22lastName%22%3A%22Hussain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Habib%22%2C%22lastName%22%3A%22Inayat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farees%22%2C%22lastName%22%3A%22Kamal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adil%22%2C%22lastName%22%3A%22Kamran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjeet%22%2C%22lastName%22%3A%22Kumar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mahveer%22%2C%22lastName%22%3A%22Maheshwari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shahid%22%2C%22lastName%22%3A%22Mamsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sumera%22%2C%22lastName%22%3A%22Massey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Asif%22%2C%22lastName%22%3A%22Mehmood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aaisha%22%2C%22lastName%22%3A%22Memon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayaz%22%2C%22lastName%22%3A%22Ali%20Mirani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shafaque%22%2C%22lastName%22%3A%22Naz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tanzeel%22%2C%22lastName%22%3A%22Rafique%20Qureshi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yash%22%2C%22lastName%22%3A%22Roop%20Moazzam%20Sheikh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Rafi%20Siddiqui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bhom%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mustajab%22%2C%22lastName%22%3A%22Soomro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Ardizzoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leen%22%2C%22lastName%22%3A%22Rigouts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Praha%22%2C%22lastName%22%3A%22Rupasinghe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annum%22%2C%22lastName%22%3A%22Aftab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saman%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Adnan%20Alamgir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayaz%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azhar%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shahzaib%22%2C%22lastName%22%3A%22Ahmed%20Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sakhawat%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanam%22%2C%22lastName%22%3A%22Altaf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samreen%22%2C%22lastName%22%3A%22Amjad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mahnoor%22%2C%22lastName%22%3A%22Sahiba%20Arshad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sadia%22%2C%22lastName%22%3A%22Ausim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdul%22%2C%22lastName%22%3A%22Basit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haroon%22%2C%22lastName%22%3A%22Ezik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hira%22%2C%22lastName%22%3A%22Hussain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sibtain%22%2C%22lastName%22%3A%22Hyder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shahzad%22%2C%22lastName%22%3A%22Inayat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aleeza%22%2C%22lastName%22%3A%22Janmohammed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Komal%22%2C%22lastName%22%3A%22Jaseem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aqsa%22%2C%22lastName%22%3A%22Jawed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lamis%22%2C%22lastName%22%3A%22Maniar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pardeep%22%2C%22lastName%22%3A%22Kumar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susheel%22%2C%22lastName%22%3A%22Kumar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reema%22%2C%22lastName%22%3A%22Latif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Liaqat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Ammar%20Nasser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Shakeel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shahzaib%22%2C%22lastName%22%3A%22Shaikh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anique%22%2C%22lastName%22%3A%22Siddiqui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jetmal%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Koushalia%22%2C%22lastName%22%3A%22Sivan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Momal%22%2C%22lastName%22%3A%22Taimoor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nabeel%22%2C%22lastName%22%3A%22Zia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inessa%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Merei%22%2C%22lastName%22%3A%22Otepbergenova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thu%20Huong%22%2C%22lastName%22%3A%22Dinh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Thu%22%2C%22lastName%22%3A%22Do%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thu%20Thuong%22%2C%22lastName%22%3A%22Do%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Nguyet%22%2C%22lastName%22%3A%22Le%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%20Cuong%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Thuy%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Van%20Hung%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaukhar%22%2C%22lastName%22%3A%22Abildayeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Orazbayeva%22%2C%22lastName%22%3A%22Maryash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elena%22%2C%22lastName%22%3A%22Telegina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lyailya%22%2C%22lastName%22%3A%22Tursynbekova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhanelya%22%2C%22lastName%22%3A%22Amanzholova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Perizat%22%2C%22lastName%22%3A%22Bektassova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anel%22%2C%22lastName%22%3A%22Belgozhanova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazerke%22%2C%22lastName%22%3A%22Birimkulova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nurgul%22%2C%22lastName%22%3A%22Dyusebayeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nilay%22%2C%22lastName%22%3A%22Erkut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnur%22%2C%22lastName%22%3A%22Gusmanov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Banu%22%2C%22lastName%22%3A%22Kassenova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aigerim%22%2C%22lastName%22%3A%22Kassym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kanat%22%2C%22lastName%22%3A%22Khazhidinov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tatyana%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azhar%22%2C%22lastName%22%3A%22Magzumova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moldir%22%2C%22lastName%22%3A%22Mussabayeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gulnar%22%2C%22lastName%22%3A%22Omarova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadezhda%22%2C%22lastName%22%3A%22Ryapolova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lyazzat%22%2C%22lastName%22%3A%22Sagyndykova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Asel%22%2C%22lastName%22%3A%22Serekbay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Assel%22%2C%22lastName%22%3A%22Stambekova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gulmira%22%2C%22lastName%22%3A%22Tanatarova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zinatdin%22%2C%22lastName%22%3A%22Uaisov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhanel%22%2C%22lastName%22%3A%22Zhantuarova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gulnara%22%2C%22lastName%22%3A%22Zhumakairova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nataliya%22%2C%22lastName%22%3A%22Arlyapova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joshua%22%2C%22lastName%22%3A%22Bogus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meredith%22%2C%22lastName%22%3A%22Cain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Merida%22%2C%22lastName%22%3A%22Carmona%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clare%22%2C%22lastName%22%3A%22Flanagan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22McAnaw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alyssa%22%2C%22lastName%22%3A%22Scharff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonya%22%2C%22lastName%22%3A%22Soni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megan%22%2C%22lastName%22%3A%22Striplin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seyfu%22%2C%22lastName%22%3A%22Abebe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johnson%22%2C%22lastName%22%3A%22Alakaye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Atang%22%2C%22lastName%22%3A%22Bulane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Custodio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Precious%22%2C%22lastName%22%3A%22Hajison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malefetsane%22%2C%22lastName%22%3A%22Hetsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Holtzman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matlotliso%22%2C%22lastName%22%3A%22Khesa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Makatleho%22%2C%22lastName%22%3A%22Lethola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Talime%22%2C%22lastName%22%3A%22Lebitsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Mahamo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joalane%22%2C%22lastName%22%3A%22Makaka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mokenyakenya%22%2C%22lastName%22%3A%22Matoko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephane%22%2C%22lastName%22%3A%22Mpinda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Polo%22%2C%22lastName%22%3A%22Mohoang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Monyaesa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Nkundayirazo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mabohlokoa%22%2C%22lastName%22%3A%22Ntsane%20Sesomo%20Mohale%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seabata%22%2C%22lastName%22%3A%22Ntsibane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebakeng%22%2C%22lastName%22%3A%22Phate%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathemba%22%2C%22lastName%22%3A%22Radebe%20%28Retsepile%20Tlali%29%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moliehi%22%2C%22lastName%22%3A%22Rakhetsi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tello%22%2C%22lastName%22%3A%22Ranoosi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meseret%22%2C%22lastName%22%3A%22Tamirat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mahooe%22%2C%22lastName%22%3A%22Thokoana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ericka%22%2C%22lastName%22%3A%22Alegre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Aguilar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lourdes%22%2C%22lastName%22%3A%22Armuto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Barreda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Barreto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%22%2C%22lastName%22%3A%22Cabrera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%22%2C%22lastName%22%3A%22Calderon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milagros%22%2C%22lastName%22%3A%22Castro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jelina%22%2C%22lastName%22%3A%22Chavez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Chavez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haydee%22%2C%22lastName%22%3A%22Cheje%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lesli%22%2C%22lastName%22%3A%22Cori%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22D%5Cu00e1valos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvana%22%2C%22lastName%22%3A%22de%20la%20Gala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Delgadillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannely%22%2C%22lastName%22%3A%22Diaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ximena%22%2C%22lastName%22%3A%22Flores%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimmy%22%2C%22lastName%22%3A%22Galarza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dalicxa%22%2C%22lastName%22%3A%22Garc%5Cu00eda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fanny%22%2C%22lastName%22%3A%22Garcia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miriam%22%2C%22lastName%22%3A%22Gaspar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roselena%22%2C%22lastName%22%3A%22Godos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pamela%22%2C%22lastName%22%3A%22Gomez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luz%22%2C%22lastName%22%3A%22Gonzales%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lizsery%22%2C%22lastName%22%3A%22Guerrero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sadith%22%2C%22lastName%22%3A%22Inga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%22%2C%22lastName%22%3A%22Jasaycucho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Martel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%22%2C%22lastName%22%3A%22Pro%20Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Molina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Mugruza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansel%22%2C%22lastName%22%3A%22Mundaca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Merilyn%22%2C%22lastName%22%3A%22Nuahan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Ore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liliana%22%2C%22lastName%22%3A%22Panduro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Pe%5Cu00f1a%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Perea%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cynthia%22%2C%22lastName%22%3A%22Pinedo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yhomay%22%2C%22lastName%22%3A%22Ponce%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Quinte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maritza%22%2C%22lastName%22%3A%22Qui%5Cu00f1ones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alicia%22%2C%22lastName%22%3A%22Ramos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elmer%22%2C%22lastName%22%3A%22Ramirez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rosina%22%2C%22lastName%22%3A%22Reynoso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cynthia%22%2C%22lastName%22%3A%22Reyes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%22%2C%22lastName%22%3A%22Reyes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Riccio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bryan%22%2C%22lastName%22%3A%22Robles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Rojas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oswaldo%22%2C%22lastName%22%3A%22Sanabria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Saravia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susana%22%2C%22lastName%22%3A%22Saravia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liz%22%2C%22lastName%22%3A%22Senador%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%22%2C%22lastName%22%3A%22Soberon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%22%2C%22lastName%22%3A%22Soncco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maribel%22%2C%22lastName%22%3A%22Soto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Suarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milagros%22%2C%22lastName%22%3A%22Suarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronica%22%2C%22lastName%22%3A%22Suarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erika%22%2C%22lastName%22%3A%22Torpoco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oscar%22%2C%22lastName%22%3A%22Torres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Torrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Tunque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aida%22%2C%22lastName%22%3A%22Ugarte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gissela%22%2C%22lastName%22%3A%22Vaderrama%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%22%2C%22lastName%22%3A%22Valdivia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yesica%22%2C%22lastName%22%3A%22Valdivia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabel%22%2C%22lastName%22%3A%22Valverde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cynthia%22%2C%22lastName%22%3A%22Vargas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janet%22%2C%22lastName%22%3A%22Vargas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elvia%22%2C%22lastName%22%3A%22Vasquez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%22%2C%22lastName%22%3A%22Veliz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dioselinda%22%2C%22lastName%22%3A%22Villa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sheyla%22%2C%22lastName%22%3A%22Villafuerte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geraldine%22%2C%22lastName%22%3A%22Villar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Villegas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milagros%22%2C%22lastName%22%3A%22Wong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rosa%22%2C%22lastName%22%3A%22Yataco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hang%22%2C%22lastName%22%3A%22Pham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hieu%22%2C%22lastName%22%3A%22Truong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hai%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vo%22%2C%22lastName%22%3A%22Huy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Van%20Song%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Minh%20Khai%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Trung%22%2C%22lastName%22%3A%22Minh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Duyen%20Thanh%20Thao%22%2C%22lastName%22%3A%22Bui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Van%20Vinh%22%2C%22lastName%22%3A%22Truong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Thu%20Ha%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvine%22%2C%22lastName%22%3A%22Coutisson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melchior%22%2C%22lastName%22%3A%22Atger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Nadia%20Baya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marwa%22%2C%22lastName%22%3A%22Bekhiet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronique%22%2C%22lastName%22%3A%22Boissi%5Cu00e8re%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roberta%22%2C%22lastName%22%3A%22Caboclo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marhaba%22%2C%22lastName%22%3A%22Chaudhry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Cloez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Collin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9line%22%2C%22lastName%22%3A%22Delifer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shana%22%2C%22lastName%22%3A%22Demaisons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Ducher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Hewison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%22%2C%22lastName%22%3A%22Ibrahim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kristen%22%2C%22lastName%22%3A%22Lebeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Merry%22%2C%22lastName%22%3A%22Mazmanian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rada%22%2C%22lastName%22%3A%22Mirzayeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monica%22%2C%22lastName%22%3A%22Moschioni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Audrey%22%2C%22lastName%22%3A%22P%5Cu00e2quet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Perrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Pichon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanne%22%2C%22lastName%22%3A%22Roussel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martina%22%2C%22lastName%22%3A%22Scotton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ariana%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pearl%22%2C%22lastName%22%3A%22Sun%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnPre-extensively%20drug-resistant%20%28pre-XDR%29%20tuberculosis%20%28ie%2C%20multidrug-resistant%20or%20rifampicin-resistant%20with%20additional%20resistance%20to%20any%20fluoroquinolone%29%20is%20difficult%20to%20treat.%20endTB-Q%20aimed%20to%20evaluate%20the%20efficacy%20and%20safety%20of%20bedaquiline%2C%20delamanid%2C%20linezolid%2C%20and%20clofazimine%20%28BDLC%29%20compared%20with%20the%20standard%20of%20care%20for%20patients%20with%20pre-XDR%20tuberculosis.%5CnMethods%5CnThis%20open-label%2C%20multicentre%2C%20stratified%2C%20non-inferiority%2C%20randomised%2C%20controlled%2C%20phase%203%20trial%20was%20conducted%20in%20ten%20hospitals%20in%20India%2C%20Kazakhstan%2C%20Lesotho%2C%20Pakistan%2C%20Peru%2C%20and%20Viet%20Nam.%20Participants%20aged%2015%20years%20or%20older%20who%20had%20pulmonary%20tuberculosis%20with%20resistance%20to%20rifampicin%20and%20fluoroquinolones%20were%20included.%20Participants%20were%20randomly%20assigned%20%282%3A1%29%20to%20the%20BDLC%20group%20%28all-oral%20bedaquiline%20400%20mg%20once%20per%20day%20for%202%20weeks%20followed%20by%20200%20mg%20three%20times%20per%20week%2C%20delamanid%20100%20mg%20twice%20per%20day%2C%20linezolid%20600%20mg%20once%20per%20day%20for%2016%20weeks%20and%20then%20either%20300%20mg%20once%20per%20day%20or%20600%20mg%20three%20times%20per%20week%2C%20and%20clofazimine%20100%20mg%20once%20per%20day%29%20or%20the%20control%20group%20%28individualised%20WHO-recommended%20longer%20standard%20of%20care%29.%20Randomisation%20was%20stratified%20by%20country%20and%20baseline%20disease%20extent.%20BDLC%20was%20administered%20for%2039%20weeks%20%289-month%20regimen%29%20for%20extensive%20disease%20and%2024%20weeks%20%286-month%20regimen%29%20for%20limited%20disease%20and%20extended%20to%209%20months%20for%20those%20with%20a%20positive%20culture%20at%208%20weeks%20or%20later%20or%20a%20missing%208-week%20culture%20result.%20Site%20staff%20and%20participants%20were%20not%20masked%2C%20whereas%20investigators%20and%20laboratory%20staff%20were%20masked%20to%20treatment%20assignment.%20The%20primary%20endpoint%20was%20favourable%20outcome%20%28two%20consecutive%2C%20negative%20cultures%20including%20one%20between%20weeks%2065%20and%2073%3B%20or%20favourable%20bacteriological%2C%20radiological%2C%20and%20clinical%20evolution%29%20at%20week%2073%20after%20randomisation%20in%20the%20modified%20intention-to-treat%20%28mITT%29%20and%20per-protocol%20populations.%20We%20report%20the%20risk%20differences%20adjusted%20for%20stratification%20variables%2C%20with%20a%20non-inferiority%20margin%20of%20%5Cu201312%25.%20This%20trial%20is%20registered%20with%20ClinicalTrials.gov%2C%20NCT03896685.%5CnFindings%5CnBetween%20April%204%2C%202020%2C%20and%20March%2028%2C%202023%2C%201030%20individuals%20were%20screened%20and%20324%20%2831%25%29%20were%20randomly%20assigned%20%28219%20to%20the%20BDLC%20group%20and%20105%20to%20the%20control%20group%29.%20114%20%2846%25%29%20participants%20were%20female%20and%20133%20%2854%25%29%20were%20male.%20Median%20age%20was%2030%5Cu00b75%20years%20%28IQR%2021%5Cu00b76%5Cu201343%5Cu00b70%29.%20157%20%2864%25%29%20participants%20had%20extensive%20disease%20at%20baseline.%20In%20the%20BDLC%20group%2C%2047%20%2829%25%29%20of%20163%20were%20assigned%20to%20receive%20the%206-month%20regimen%20and%20116%20%2871%25%29%20the%209-month%20regimen.%20The%20core%20regimen%20of%20BDLC%20plus%20one%20or%20more%20other%20drugs%20was%20used%20for%2076%20%2891%25%29%20of%2084%20participants%20in%20the%20control%20group.%20At%20week%2073%2C%20favourable%20outcome%20was%20reached%20by%20141%20%2887%25%29%20participants%20in%20the%20BDLC%20group%20versus%2075%20%2889%25%29%20in%20the%20control%20group%20in%20the%20mITT%20population%20%28adjusted%20risk%20difference%200%5Cu00b72%25%20%5B95%25%20CI%20%5Cu20139%5Cu00b71%20to%209%5Cu00b75%5D%3B%20pnon-inferiority%3D0%5Cu00b70051%29%20and%20by%20138%20%2888%25%29%20of%20157%20versus%2071%20%2893%25%29%20of%2076%20in%20the%20per-protocol%20population%20%28adjusted%20risk%20difference%20%5Cu20133%5Cu00b75%25%20%5B%5Cu201312%5Cu00b78%20to%205%5Cu00b79%5D%3B%20pnon-inferiority%3D0%5Cu00b7037%29.%20Overall%20non-inferiority%20was%20not%20shown.%20145%20%2868%25%29%20of%20213%20participants%20in%20the%20BDLC%20group%20and%2077%20%2873%25%29%20of%20105%20in%20the%20control%20group%20had%20at%20least%20one%20grade%203%20or%20higher%20adverse%20event%2C%20with%20eight%20%284%25%29%20and%20two%20%282%25%29%20all-cause%20deaths%20by%20week%2073%2C%20respectively.%5CnInterpretation%5CnThe%20shortened%20BDLC%20strategy%20was%20not%20non-inferior%20to%20the%20control.%20Accumulating%20evidence%20suggests%20that%20this%20patient%20population%20might%20require%20longer%2C%20reinforced%20regimens.%5CnFunding%5CnUnitaid%2C%20M%5Cu00e9decins%20Sans%20Fronti%5Cu00e8res%2C%20Partners%20In%20Health%2C%20Interactive%20Research%20and%20Development%2C%20Ram%5Cu00f3n%20Areces%20Foundation%2C%20the%20Jung%20Foundation%20for%20Science%20and%20Research%2C%20Research%20Foundation-Flanders.%5CnTranslations%5CnFor%20the%20Hindi%2C%20Marathi%2C%20Spanish%2C%20Vietnamese%2C%20Russian%2C%20Urdu%20and%20French%20translations%20of%20the%20abstract%20see%20Supplementary%20Materials%20section.%22%2C%22date%22%3A%222025-07-16%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2213-2600%2825%2900194-8%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS2213260025001948%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222213-2600%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-08-21T13%3A27%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22348MPEYW%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Serge%20Diagbouga%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSerge%20Diagbouga%2C%20P.%2C%20Djibougou%2C%20A.%20D.%2C%20Pease%2C%20C.%2C%20Alcaide%2C%20A.%2C%20Berthoux%2C%20A.%2C%20Bruiners%2C%20N.%2C%20Cirillo%2C%20D.%20M.%2C%20Combary%2C%20A.%2C%20Falchero%2C%20N.%2C%20Handler%2C%20D.%2C%20Kabor%26%23xE9%3B%2C%20A.%2C%20Lardizabal%2C%20A.%2C%20Lopes%2C%20A.%2C%20Loubet%2C%20M.%2C%20Manivet%2C%20P.%2C%20Margain%2C%20C.%2C%20Meunier%2C%20V.%2C%20Mougari%2C%20F.%2C%20Onyuka%2C%20A.%2C%20Rivoiron%2C%20S.%2C%20Sagna%2C%20T.%2C%20Sanvert%2C%20M.%2C%20Sawadogo%2C%20L.%2C%20Simpor%26%23xE9%3B%2C%20J.%2C%20Cambau%2C%20E.%20and%20Gennaro%2C%20M.%20L.%20%282025%29.%20%26lt%3Bb%26gt%3BPreliminary%20performance%20of%20the%20VIDAS%20TB-IGRA%20as%20an%20aid%20in%20the%20diagnosis%20of%20individuals%20infected%20with%20%26lt%3Bi%26gt%3BMycobacterium%20tuberculosis%26lt%3B%5C%2Fi%26gt%3B%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Miller%2C%20M.%20B.%20J%20Clin%20Microbiol%20%26lt%3Bi%26gt%3B63%26lt%3B%5C%2Fi%26gt%3B%2C%20e01641-24%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fjcm.01641-24%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fjcm.01641-24%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Preliminary%20performance%20of%20the%20VIDAS%20TB-IGRA%20as%20an%20aid%20in%20the%20diagnosis%20of%20individuals%20infected%20with%20%3Ci%3EMycobacterium%20tuberculosis%3C%5C%2Fi%3E%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Potiandi%22%2C%22lastName%22%3A%22Serge%20Diagbouga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arthur%20Diakourga%22%2C%22lastName%22%3A%22Djibougou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Pease%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ariana%22%2C%22lastName%22%3A%22Alcaide%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Audrey%22%2C%22lastName%22%3A%22Berthoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalie%22%2C%22lastName%22%3A%22Bruiners%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%20Maria%22%2C%22lastName%22%3A%22Cirillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ardjouma%22%2C%22lastName%22%3A%22Combary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%22%2C%22lastName%22%3A%22Falchero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Deborah%22%2C%22lastName%22%3A%22Handler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoinette%22%2C%22lastName%22%3A%22Kabor%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alfred%22%2C%22lastName%22%3A%22Lardizabal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%22%2C%22lastName%22%3A%22Lopes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marissa%22%2C%22lastName%22%3A%22Loubet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Manivet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clemence%22%2C%22lastName%22%3A%22Margain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valerie%22%2C%22lastName%22%3A%22Meunier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alberta%22%2C%22lastName%22%3A%22Onyuka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Rivoiron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tani%22%2C%22lastName%22%3A%22Sagna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Sanvert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9on%22%2C%22lastName%22%3A%22Sawadogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Simpor%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Laura%22%2C%22lastName%22%3A%22Gennaro%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Melissa%20B.%22%2C%22lastName%22%3A%22Miller%22%7D%5D%2C%22abstractNote%22%3A%22ABSTRACT%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20preliminary%20study%20compares%20VIDAS%20TB-IGRA%20%28bioM%5Cu00e9rieux%2C%20Marcy-l%26%23039%3BEtoile%2C%20France%29%20with%20the%20established%20QuantiFERON-TB%20Gold%20Plus%20%28QFT-Plus%29%20%28Qiagen%2C%20Hilden%2C%20Germany%29%20to%20evaluate%20diagnostic%20performance%20for%20the%20diagnosis%20of%20individuals%20infected%20with%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20complex%20%28latent%20infection%20and%20disease%29.%20The%20study%20was%20multi-center%20and%20performed%20between%202%20October%202019%20and%204%20February%202020.%20Participants%20were%20divided%20into%20tuberculosis%20%28TB%29%20disease%2C%20high-risk%2C%20and%20low-risk%20populations.%20The%20confirmed%20TB%20disease%20population%20included%20104%20patients.%20The%20high-risk%20population%20included%20162%20individuals%20with%20flagged%20risk%20factors%20on%20a%20questionnaire%20but%20without%20objective%20clinical%20confirmation%20of%20TB.%20The%20low-risk%20population%20included%20117%20healthy%20blood%20donors%20from%20the%20French%20National%20Blood%20Bank.%20Positive%20and%20negative%20percent%20agreement%20%28PPA%20and%20NPA%29%20were%20determined%20between%20the%20VIDAS%20TB-IGRA%20and%20QFT-Plus.%20In%20the%20TB%20disease%20population%2C%20sensitivity%20was%20measured%20against%20bacterial%20culture%20and%20PCR.%20The%20VIDAS%20TB-IGRA%20produced%20fewer%20indeterminate%20results%20than%20the%20QFT-Plus%20%281%5C%2F104%20vs%2023%5C%2F104%29%20in%20the%20TB%20disease%20population%20and%20exhibited%20a%20sensitivity%20of%2095.0%25%20against%20bacterial%20culture.%20Furthermore%2C%20a%2098.2%25%20PPA%20was%20obtained%20in%20comparison%20to%20QFT-Plus.%20In%20the%20low-risk%20population%2C%20the%20VIDAS%20TB-IGRA%20demonstrated%20high%20specificity%20%2894.9%25%29%20and%20a%20strong%20NPA%20%2898.2%25%29%20compared%20to%20QFT-Plus.%20In%20the%20high-risk%20population%2C%20the%20VIDAS%20TB-IGRA%20exhibited%20a%20strong%20PPA%20%2894.4%25%29%20with%20the%20QFT-Plus.%20A%20lower%20NPA%20was%20observed%20%2885.2%25%29%20compared%20to%20QFT-Plus%2C%20which%20may%20be%20due%20to%20a%20higher%20sensitivity%20demonstrated%20in%20the%20TB%20disease%20population.%20The%20fully%20automated%20VIDAS%20TB-IGRA%20is%20a%20promising%20aid%20in%20the%20diagnosis%20of%20individuals%20infected%20with%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%28latent%20infection%20and%20active%20disease%29.%20It%20exhibits%20higher%20sensitivity%20while%20maintaining%20specificity%20and%20produces%20fewer%20indeterminate%20interpretations%20than%20QFT-Plus.%20Its%20easy-to-use%2C%20single-patient%20format%20may%20lead%20to%20increased%20TB%20testing%20to%20aid%20in%20the%20adequate%20diagnosis%20and%20management%20of%20the%20disease.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20IMPORTANCE%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20study%20presents%20a%20comprehensive%20evaluation%20of%20the%20VIDAS%20TB-IGRA%20diagnostic%20test.%20This%20test%20is%20compared%20with%20the%20established%20QuantiFERON-TB%20Gold%20Plus%20to%20assess%20its%20effectiveness%20in%20diagnosing%20both%20latent%20and%20active%20tuberculosis%20%28TB%29%20infections.%20The%20study%20highlights%20the%20VIDAS%20TB-IGRA%5Cu2019s%20higher%20sensitivity%2C%20fewer%20indeterminate%20results%2C%20and%20robust%20performance%20across%20different%20patient%20populations%2C%20including%20those%20with%20confirmed%20TB%20disease%2C%20high-risk%2C%20and%20low-risk%20groups.%20The%20findings%20suggest%20that%20the%20VIDAS%20TB-IGRA%20could%20enhance%20TB%20diagnosis%20and%20management%2C%20offering%20a%20fully%20automated%2C%20easy-to-use%20solution%20that%20reduces%20human%20error%20and%20result%20variability.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20This%20study%20presents%20a%20comprehensive%20evaluation%20of%20the%20VIDAS%20TB-IGRA%20diagnostic%20test.%20This%20test%20is%20compared%20with%20the%20established%20QuantiFERON-TB%20Gold%20Plus%20to%20assess%20its%20effectiveness%20in%20diagnosing%20both%20latent%20and%20active%20tuberculosis%20%28TB%29%20infections.%20The%20study%20highlights%20the%20VIDAS%20TB-IGRA%5Cu2019s%20higher%20sensitivity%2C%20fewer%20indeterminate%20results%2C%20and%20robust%20performance%20across%20different%20patient%20populations%2C%20including%20those%20with%20confirmed%20TB%20disease%2C%20high-risk%2C%20and%20low-risk%20groups.%20The%20findings%20suggest%20that%20the%20VIDAS%20TB-IGRA%20could%20enhance%20TB%20diagnosis%20and%20management%2C%20offering%20a%20fully%20automated%2C%20easy-to-use%20solution%20that%20reduces%20human%20error%20and%20result%20variability.%22%2C%22date%22%3A%222025-06-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2Fjcm.01641-24%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.asm.org%5C%2Fdoi%5C%2F10.1128%5C%2Fjcm.01641-24%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220095-1137%2C%201098-660X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-09-30T15%3A02%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22UG42N69S%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Seddon%20et%20al.%22%2C%22parsedDate%22%3A%222025-06-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSeddon%2C%20J.%20A.%2C%20Achar%2C%20J.%2C%20Malik%2C%20A.%20A.%2C%20Hughes%2C%20J.%2C%20Burzynski%2C%20J.%2C%20Chen%2C%20C.%2C%20Denholm%2C%20J.%20T.%2C%20Dravniece%2C%20G.%2C%20Fox%2C%20G.%20J.%2C%20Furin%2C%20J.%2C%20Geliukh%2C%20E.%2C%20Goncharova%2C%20O.%2C%20Guglielmetti%2C%20L.%2C%20Harries%2C%20A.%20D.%2C%20Hesseling%2C%20A.%20C.%2C%20Nguyen%2C%20B.%20H.%2C%20Kavenga%2C%20F.%2C%20Khan%2C%20U.%2C%20Kherabi%2C%20Y.%2C%20Kiria%2C%20N.%2C%20Kock%2C%20Y.%2C%20Liu%2C%20Q.%2C%20Mesic%2C%20A.%2C%20Moore%2C%20D.%20A.%20J.%2C%20Mubanga%2C%20A.%2C%20Naidoo%2C%20L.%2C%20Nilsen%2C%20D.%2C%20Piubello%2C%20A.%2C%20Reuter%2C%20A.%2C%20Rich%2C%20M.%20L.%2C%20Satyanarayana%2C%20S.%2C%20Schaaf%2C%20H.%20S.%2C%20Schoeman%2C%20I.%2C%20Skrahina%2C%20A.%2C%20Udwadia%2C%20Z.%2C%20Khan%2C%20P.%20Y.%2C%20Esmail%2C%20H.%20and%20Martinez%2C%20L.%20%282025%29.%20%26lt%3Bb%26gt%3BManagement%20of%20individuals%20exposed%20to%20multidrug-resistant%20or%20rifampicin-resistant%20tuberculosis%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Infectious%20Diseases%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2825%2900157-4%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2825%2900157-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Management%20of%20individuals%20exposed%20to%20multidrug-resistant%20or%20rifampicin-resistant%20tuberculosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20A%22%2C%22lastName%22%3A%22Seddon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jay%22%2C%22lastName%22%3A%22Achar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amyn%20A%22%2C%22lastName%22%3A%22Malik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Hughes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Burzynski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cheng%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justin%20T%22%2C%22lastName%22%3A%22Denholm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunta%22%2C%22lastName%22%3A%22Dravniece%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Greg%20J%22%2C%22lastName%22%3A%22Fox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Furin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Evgenia%22%2C%22lastName%22%3A%22Geliukh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Goncharova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%20D%22%2C%22lastName%22%3A%22Harries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anneke%20C%22%2C%22lastName%22%3A%22Hesseling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Binh%20Hoa%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fungai%22%2C%22lastName%22%3A%22Kavenga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Uzma%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yousra%22%2C%22lastName%22%3A%22Kherabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nana%22%2C%22lastName%22%3A%22Kiria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yulene%22%2C%22lastName%22%3A%22Kock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiao%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anita%22%2C%22lastName%22%3A%22Mesic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A%20J%22%2C%22lastName%22%3A%22Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angel%22%2C%22lastName%22%3A%22Mubanga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lenny%22%2C%22lastName%22%3A%22Naidoo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%22%2C%22lastName%22%3A%22Nilsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alberto%22%2C%22lastName%22%3A%22Piubello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Reuter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20L%22%2C%22lastName%22%3A%22Rich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Srinath%22%2C%22lastName%22%3A%22Satyanarayana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%20Simon%22%2C%22lastName%22%3A%22Schaaf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ingrid%22%2C%22lastName%22%3A%22Schoeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alena%22%2C%22lastName%22%3A%22Skrahina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zarir%22%2C%22lastName%22%3A%22Udwadia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Palwasha%20Y%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanif%22%2C%22lastName%22%3A%22Esmail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonardo%22%2C%22lastName%22%3A%22Martinez%22%7D%5D%2C%22abstractNote%22%3A%22Individuals%20exposed%20to%20a%20person%20with%20infectious%20multidrug-resistant%20or%20rifampicin-resistant%20%28MDR-RR%29%20tuberculosis%20are%20at%20risk%20of%20developing%20tuberculosis%20disease.%20Historically%2C%20insufficient%20empirical%20evidence%20for%20preventive%20treatment%20in%20this%20group%20has%20permitted%20inadequate%20guidance%20for%20clinical%20decision%20making.%20However%2C%20several%20high-quality%20studies%20have%20been%20published%20detailing%20preventive%20treatment%20options%20for%20these%20contacts%20at%20high%20risk.%20In%20this%20Review%2C%20we%20discuss%20the%20management%20of%20individuals%20exposed%20to%20patients%20with%20infectious%20MDR-RR%20tuberculosis.%20We%20pay%20particular%20attention%20to%20the%20entire%20spectrum%20of%20clinical%20care%20for%20this%20population%2C%20including%20baseline%20assessment%2C%20possible%20preventive%20treatments%2C%20follow-up%2C%20and%20shared%20decision%20making.%20We%20discuss%20the%20available%20evidence%2C%20the%20rationales%20for%20different%20management%20strategies%2C%20and%20the%20interactions%20with%20%28and%20implications%20of%29%20secondary%20comorbidities%20such%20as%20HIV%20or%20malnutrition.%22%2C%22date%22%3A%222025-06-06%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS1473-3099%2825%2900157-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1473309925001574%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221473-3099%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-08-21T13%3A31%3A56Z%22%7D%7D%2C%7B%22key%22%3A%22P98GJIV5%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bonnet%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-22%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBonnet%2C%20I.%2C%20Orgeur%2C%20M.%2C%20Brossier%2C%20F.%2C%20Sayes%2C%20F.%2C%20Frigui%2C%20W.%2C%20Madacki%2C%20J.%2C%20Varet%2C%20H.%2C%20Chauffour%2C%20A.%2C%20Aubry%2C%20A.%2C%20Veziris%2C%20N.%2C%20Sougakoff%2C%20W.%2C%20Brosch%2C%20R.%20and%20Tournebize%2C%20R.%20%282025%29.%20%26lt%3Bb%26gt%3BEvaluation%20of%20the%20role%20of%20%26lt%3Bi%26gt%3BwhiB6%26lt%3B%5C%2Fi%26gt%3B%20and%20%26lt%3Bi%26gt%3BkdpDE%26lt%3B%5C%2Fi%26gt%3B%20in%20the%20dominant%20multidrug-resistant%20clone%20%26lt%3Bi%26gt%3BMycobacterium%20tuberculosis%26lt%3B%5C%2Fi%26gt%3B%20B0%5C%2FW148%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Doucet-Populaire%2C%20F.%20C.%20Microbiol%20Spectr%20e03224-24%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fspectrum.03224-24%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fspectrum.03224-24%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evaluation%20of%20the%20role%20of%20%3Ci%3EwhiB6%3C%5C%2Fi%3E%20and%20%3Ci%3EkdpDE%3C%5C%2Fi%3E%20in%20the%20dominant%20multidrug-resistant%20clone%20%3Ci%3EMycobacterium%20tuberculosis%3C%5C%2Fi%3E%20B0%5C%2FW148%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mickael%22%2C%22lastName%22%3A%22Orgeur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fadel%22%2C%22lastName%22%3A%22Sayes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wafa%22%2C%22lastName%22%3A%22Frigui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Madacki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Varet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wladimir%22%2C%22lastName%22%3A%22Sougakoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roland%22%2C%22lastName%22%3A%22Brosch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%5Cu00e9gis%22%2C%22lastName%22%3A%22Tournebize%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Florence%20Claude%22%2C%22lastName%22%3A%22Doucet-Populaire%22%7D%5D%2C%22abstractNote%22%3A%22ABSTRACT%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Multidrug-resistant%20%28MDR%29%20strains%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20represent%20an%20obstacle%20to%20eradicating%20tuberculosis%20%28TB%29%20due%20to%20the%20low%20treatment%20success%20rate%20of%20MDR%20TB.%20Among%20them%2C%20the%20MDR%20B0%5C%2FW148%20clone%20has%20recently%20evolved%20from%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Beijing%20lineage%202%20and%20is%20widely%20disseminated%20in%20Russia%20and%20Europe.%20To%20get%20more%20insights%20into%20the%20genetic%20factors%20underlying%20the%20evolutionary%20success%20of%20the%20MDR%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20B0%5C%2FW148%20clone%20in%20addition%20to%20environmental%20and%20patient-related%20features%2C%20we%20focused%20on%20two%20mutations%20specific%20to%20this%20clone%20that%20are%20found%20in%20the%20transcriptional%20regulators%20WhiB6%20and%20KdpDE%20and%20investigated%20in%20a%20H37Rv%20strain%20background%20the%20transcriptional%20profile%20associated%20with%20these%20mutations%20and%20their%20impact%20on%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20vitro%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20and%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20vivo%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20growth%20characteristics.%20Through%20the%20construction%20and%20use%20of%20H37Rv%5Cu2206%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20whiB6%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20H37Rv%5Cu2206%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20kdpDE%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20and%20complemented%20strains%2C%20neither%20mutation%20impaired%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20vitro%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20growth%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20standard%20mycobacterial%20growth%20media.%20The%20mutation%20T51P%20in%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20whiB6%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20prevented%20the%20upregulation%20of%209%20genes%20in%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20esx-1%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20core%20region%20and%2044%20genes%20elsewhere%20in%20the%20genome%2C%20while%20the%20deletion%20of%20two%20nucleotides%20in%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20kdpD%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20leads%20to%20a%20fusion%20protein%20of%20KdpD%20with%20KdpE%20that%20inhibits%20the%20transcriptional%20activity%20of%20KdpE.%20Neither%20mutation%20led%20to%20hypervirulence%20in%20a%20mouse%20infection%20model.%20These%20results%20point%20to%20the%20role%20of%20other%20MDR%20B0%5C%2FW148%20specific%20mutations%20in%20the%20wide%20geographic%20diffusion%20of%20this%20clone%20and%5C%2For%20put%20in%20question%20a%20hypothesized%20hypervirulence%20as%20a%20driving%20factor%20for%20this%20large%20dissemination.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20IMPORTANCE%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Human%20tuberculosis%20%28TB%29%2C%20caused%20by%20the%20bacterium%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20remains%20a%20global%20public%20health%20issue%20estimated%20to%20have%20been%20responsible%20for%201.25%20million%20deaths%20in%202023.%20Multidrug-resistant%20%28MDR%29%20strains%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20resistant%20to%20rifampicin%20and%20isoniazid%2C%20lead%20to%20lower%20treatment%20success.%20Among%20them%2C%20the%20MDR%20B0%5C%2FW148%20clone%20has%20widely%20disseminated%20in%20Russia%20and%20Europe.%20To%20get%20more%20insights%20into%20the%20genetic%20factors%20underlying%20the%20evolutionary%20success%20of%20this%20clone%2C%20we%20investigated%20two%20strain-specific%20mutations%20found%20in%20the%20transcriptional%20regulators%20WhiB6%20and%20KdpDE.%20By%20constructing%20and%20analyzing%20laboratory%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20strains%20carrying%20these%20specific%20mutations%2C%20we%20found%20numerous%20changes%20in%20their%20transcriptional%20profiles%2C%20whereas%20we%20observed%20only%20a%20little%20impact%20of%20these%20mutations%20on%20the%20virulence%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20a%20mouse%20infection%20model.%20Our%20study%20provides%20new%20insights%20into%20the%20transcriptional%20landscape%20of%20the%20selected%20MDR%20strains%2C%20although%20no%20direct%20connection%20to%20virulence%20could%20be%20established.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Human%20tuberculosis%20%28TB%29%2C%20caused%20by%20the%20bacterium%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20remains%20a%20global%20public%20health%20issue%20estimated%20to%20have%20been%20responsible%20for%201.25%20million%20deaths%20in%202023.%20Multidrug-resistant%20%28MDR%29%20strains%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20resistant%20to%20rifampicin%20and%20isoniazid%2C%20lead%20to%20lower%20treatment%20success.%20Among%20them%2C%20the%20MDR%20B0%5C%2FW148%20clone%20has%20widely%20disseminated%20in%20Russia%20and%20Europe.%20To%20get%20more%20insights%20into%20the%20genetic%20factors%20underlying%20the%20evolutionary%20success%20of%20this%20clone%2C%20we%20investigated%20two%20strain-specific%20mutations%20found%20in%20the%20transcriptional%20regulators%20WhiB6%20and%20KdpDE.%20By%20constructing%20and%20analyzing%20laboratory%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20strains%20carrying%20these%20specific%20mutations%2C%20we%20found%20numerous%20changes%20in%20their%20transcriptional%20profiles%2C%20whereas%20we%20observed%20only%20a%20little%20impact%20of%20these%20mutations%20on%20the%20virulence%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20a%20mouse%20infection%20model.%20Our%20study%20provides%20new%20insights%20into%20the%20transcriptional%20landscape%20of%20the%20selected%20MDR%20strains%2C%20although%20no%20direct%20connection%20to%20virulence%20could%20be%20established.%22%2C%22date%22%3A%222025-05-22%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2Fspectrum.03224-24%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.asm.org%5C%2Fdoi%5C%2F10.1128%5C%2Fspectrum.03224-24%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222165-0497%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-05-23T07%3A24%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22WTTLP6PD%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sadowski%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSadowski%2C%20E.%2C%20Pietrancosta%2C%20N.%2C%20Veyron-Churlet%2C%20R.%2C%20Boucher%2C%20J.-L.%2C%20Pionneau%2C%20C.%2C%20Clodic%2C%20G.%2C%20Matheron%2C%20L.%2C%20Poch%2C%20O.%2C%20Mayer%2C%20C.%2C%20Sachon%2C%20E.%20and%20Aubry%2C%20A.%20%282025%29.%20%26lt%3Bb%26gt%3BCharacterization%20of%20the%20Orphan%20Cytochrome%20P450%20CYP135B1%20from%20%26lt%3Bi%26gt%3BMycobacterium%20tuberculosis%26lt%3B%5C%2Fi%26gt%3B%26%23x202F%3B%3A%20Involvement%20in%20Metabolism%20but%20Not%20in%20the%20Antibacterial%20Activity%20of%20the%20Antitubercular%20Drug%20SQ109%26lt%3B%5C%2Fb%26gt%3B.%20ACS%20Infect%20Dis%20%26lt%3Bi%26gt%3B11%26lt%3B%5C%2Fi%26gt%3B%2C%20869%26%23x2013%3B881%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsinfecdis.4c00893%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsinfecdis.4c00893%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Characterization%20of%20the%20Orphan%20Cytochrome%20P450%20CYP135B1%20from%20%3Ci%3EMycobacterium%20tuberculosis%3C%5C%2Fi%3E%20%3A%20Involvement%20in%20Metabolism%20but%20Not%20in%20the%20Antibacterial%20Activity%20of%20the%20Antitubercular%20Drug%20SQ109%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Sadowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Pietrancosta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Veyron-Churlet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Luc%22%2C%22lastName%22%3A%22Boucher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9dric%22%2C%22lastName%22%3A%22Pionneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Clodic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucr%5Cu00e8ce%22%2C%22lastName%22%3A%22Matheron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Poch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudine%22%2C%22lastName%22%3A%22Mayer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Sachon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-04-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1021%5C%2Facsinfecdis.4c00893%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubs.acs.org%5C%2Fdoi%5C%2F10.1021%5C%2Facsinfecdis.4c00893%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222373-8227%2C%202373-8227%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-05-09T12%3A38%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22QG4CZPV6%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Verma%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVerma%2C%20A.%20K.%2C%20Kim%2C%20R.%20Q.%2C%20Lamprecht%2C%20D.%20A.%2C%20Aguilar-P%26%23xE9%3Brez%2C%20C.%2C%20Wong%2C%20S.%2C%20Veziris%2C%20N.%2C%20Aubry%2C%20A.%2C%20Bartolom%26%23xE9%3B-Nebreda%2C%20J.%20M.%2C%20Carbajo%2C%20R.%20J.%2C%20Wetzel%2C%20J.%20and%20Lamers%2C%20M.%20H.%20%282025%29.%20%26lt%3Bb%26gt%3BStructural%20and%20mechanistic%20study%20of%20a%20novel%20inhibitor%20analogue%20of%20M.%20tuberculosis%20cytochrome%20bc1%3Aaa3%26lt%3B%5C%2Fb%26gt%3B.%20npj%20Drug%20Discov%20%26lt%3Bi%26gt%3B2%26lt%3B%5C%2Fi%26gt%3B%2C%206%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs44386-025-00008-3%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs44386-025-00008-3%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Structural%20and%20mechanistic%20study%20of%20a%20novel%20inhibitor%20analogue%20of%20M.%20tuberculosis%20cytochrome%20bc1%3Aaa3%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amit%20K.%22%2C%22lastName%22%3A%22Verma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robbert%20Q.%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%20A.%22%2C%22lastName%22%3A%22Lamprecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clara%22%2C%22lastName%22%3A%22Aguilar-P%5Cu00e9rez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Wong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%20M.%22%2C%22lastName%22%3A%22Bartolom%5Cu00e9-Nebreda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rodrigo%20J.%22%2C%22lastName%22%3A%22Carbajo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennefer%22%2C%22lastName%22%3A%22Wetzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meindert%20H.%22%2C%22lastName%22%3A%22Lamers%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Drug-resistant%20tuberculosis%20%28TB%29%20continues%20to%20challenge%20treatment%20options%2C%20necessitating%20the%20exploration%20of%20new%20compounds%20of%20novel%20targets.%20The%20mycobacterial%20respiratory%20complex%20cytochrome%20bc%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3Aaa%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%203%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20has%20emerged%20as%20a%20promising%20target%2C%20exemplified%20by%20the%20success%20of%20first-in-class%20inhibitor%20Q203%20in%20phase%202%20clinical%20trials.%20However%2C%20to%20fully%20exploit%20the%20potential%20of%20this%20target%20and%20to%20identify%20the%20best-in-class%20inhibitor%20more%20compounds%20need%20evaluation.%20Here%2C%20we%20introduce%20JNJ-2901%2C%20a%20novel%20Q203%20analogue%2C%20that%20demonstrates%20activity%20against%20multidrug-resistant%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20clinical%20strains%20at%20sub-nanomolar%20concentration%20and%204-log%20reduction%20in%20bacterial%20burden%20in%20a%20mouse%20model%20of%20TB%20infection.%20Inhibitory%20studies%20on%20purified%20enzymes%20validate%20the%20nanomolar%20inhibitions%20observed%20in%20mycobacterial%20cells.%20Additionally%2C%20cryo-EM%20structure%20analysis%20of%20cytochrome%20bc%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3Aaa%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%203%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20bound%20to%20JNJ-2901%20reveals%20the%20binding%20pocket%20at%20the%20menaquinol%20oxidation%20site%20%28Qp%29%2C%20akin%20to%20other%20substate%20analogue%20inhibitors%20like%20Q203%20and%20TB47.%20Validation%20of%20the%20binding%20site%20is%20further%20achieved%20by%20generating%20and%20isolating%20the%20JNJ-2901%20resistant%20mutations%20in%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20followed%20by%20purification%20and%20resistance%20analysis%20of%20the%20resistant%20cytochrome%20bc%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3Aaa%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%203%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20complex.%20Our%20comprehensive%20work%20lays%20the%20foundation%20for%20further%20clinical%20validations%20of%20JNJ-2901.%22%2C%22date%22%3A%222025-04-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1038%5C%2Fs44386-025-00008-3%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs44386-025-00008-3%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%223005-1452%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-05-09T12%3A36%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22M5HX4KAL%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lange%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLange%2C%20C.%2C%20Bothamley%2C%20G.%2C%20G%26%23xFC%3Bnther%2C%20G.%2C%20Guglielmetti%2C%20L.%2C%20Kontsevaya%2C%20I.%2C%20Kuksa%2C%20L.%2C%20Lange%2C%20B.%2C%20Lorent%2C%20N.%2C%20Saluzzo%2C%20F.%2C%20Sester%2C%20M.%2C%20Tebruegge%2C%20M.%2C%20Tunesi%2C%20S.%20and%20Tweed%2C%20C.%20%282025%29.%20%26lt%3Bb%26gt%3BA%20Year%20in%20Review%20on%20Tuberculosis%20and%20Non-tuberculous%20Mycobacteria%20Disease%3A%20A%202025%20Update%20for%20Clinicians%20and%20Scientists%26lt%3B%5C%2Fb%26gt%3B.%20PAI%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%2C%201%26%23x2013%3B45%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.20411%5C%2Fpai.v10i2.791%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.20411%5C%2Fpai.v10i2.791%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20Year%20in%20Review%20on%20Tuberculosis%20and%20Non-tuberculous%20Mycobacteria%20Disease%3A%20A%202025%20Update%20for%20Clinicians%20and%20Scientists%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Graham%22%2C%22lastName%22%3A%22Bothamley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irina%22%2C%22lastName%22%3A%22Kontsevaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liga%22%2C%22lastName%22%3A%22Kuksa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalie%22%2C%22lastName%22%3A%22Lorent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Saluzzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martina%22%2C%22lastName%22%3A%22Sester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Tebruegge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Tunesi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Conor%22%2C%22lastName%22%3A%22Tweed%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%20In%20the%20field%20of%20tuberculosis%20and%20non-tuberculous%20mycobacterial%20%28NTM%29%20disease%20we%20are%20looking%20back%20on%20an%20exciting%20year%202024%20with%20more%20than%2010%2C000%20publications%20listed%20in%20PubMed.%20%5CnMethods%3A%20Our%20aim%2C%20to%20review%20the%20scientific%20literature%20of%20the%20year%202024%2C%20is%20challenged%20by%20the%20enormous%20number%20of%20publications.%20Therefore%2C%20if%20your%20article%20is%20not%20included%20or%20your%20favorite%20field%20of%20mycobacteriology%20not%20covered%2C%20please%20forgive%20us.%20Our%20%5Cu201cYear%20in%20Review%5Cu201d%20is%20very%20much%20clinically%20oriented%20with%20lesser%20emphasis%20on%20basic%20science%2C%20microbiology%2C%20and%20biotechnology.%20%5CnResults%3A%20Members%20of%20the%20steering%20committee%20of%20the%20Tuberculosis%20Network%20European%20Trials%20group%20%28TBnet%3B%20www.tbnet.eu%29%20report%20on%20139%20publications%20in%20the%20fields%20of%20epidemiology%2C%20prevention%2C%20diagnosis%2C%20and%20treatment%20of%20tuberculosis%20and%20NTM%20diseases%20published%20in%202024%20that%20we%20found%20particularly%20important.%20We%20report%20publications%20separately%20for%20tuberculosis%20in%20children%20and%20adults%20and%20for%20NTM%20disease%20and%20provide%20a%20brief%20overview%20of%20newer%20technologies%20in%20the%20diagnostic%20pipeline.%20Furthermore%2C%20we%20summarize%20priorities%20for%20tuberculosis%20and%20NTM%20disease%20research%2C%20development%2C%20and%20implementation%2C%20all%20of%20which%20represent%20the%20perspective%20of%20our%20combined%20clinical%20experience.%20%5CnConclusions%3A%20This%20Year%20in%20Review%20provides%20a%20concise%20summary%20of%20the%20clinically%20relevant%20highlights%20of%20the%20published%20literature%20in%20tuberculosis%20and%20NTM%20diseases%20in%202024.%22%2C%22date%22%3A%222025-03-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.20411%5C%2Fpai.v10i2.791%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.paijournal.com%5C%2Findex.php%5C%2Fpaijournal%5C%2Farticle%5C%2Fview%5C%2F791%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222469-2964%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-05-09T13%3A30%3A56Z%22%7D%7D%2C%7B%22key%22%3A%22BY43HBWY%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kuksa%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKuksa%2C%20L.%2C%20Andrejak%2C%20C.%2C%20Haecker%2C%20B.%2C%20Bothamley%2C%20G.%2C%20Calcagno%2C%20A.%2C%20Cirillo%2C%20D.%20M.%2C%20Duarte%2C%20R.%2C%20Fatima%2C%20R.%2C%20Ferlazzo%2C%20G.%2C%20Guglielmetti%2C%20L.%2C%20G%26%23xFC%3Bnther%2C%20G.%2C%20Hewison%2C%20C.%2C%20Horsburgh%2C%20C.%20R.%2C%20J%26%23xE4%3Bger%2C%20T.%2C%20Kalancha%2C%20Y.%2C%20Otto-Knapp%2C%20R.%2C%20Kranzer%2C%20K.%2C%20Lillebaek%2C%20T.%2C%20Marks%2C%20G.%2C%20Middelkoop%2C%20K.%2C%20Motta%2C%20I.%2C%20Rabinova%2C%20V.%2C%20Sommerfeld%2C%20P.%2C%20Tattevin%2C%20P.%20and%20Lange%2C%20C.%20%282025%29.%20%26lt%3Bb%26gt%3BUrgent%20request%20for%20pretomanid%20label%20expansion%20to%20align%20with%20WHO%20guidelines%20and%20improve%20treatment%20accessibility%20and%20efficacy%26lt%3B%5C%2Fb%26gt%3B.%20IJTLD%20OPEN%20%26lt%3Bi%26gt%3B2%26lt%3B%5C%2Fi%26gt%3B%2C%20117%26%23x2013%3B119%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtldopen.25.0152%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtldopen.25.0152%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Urgent%20request%20for%20pretomanid%20label%20expansion%20to%20align%20with%20WHO%20guidelines%20and%20improve%20treatment%20accessibility%20and%20efficacy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Kuksa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Haecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Bothamley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Calcagno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.M.%22%2C%22lastName%22%3A%22Cirillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Duarte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Fatima%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Ferlazzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Hewison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.R.%22%2C%22lastName%22%3A%22Horsburgh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22J%5Cu00e4ger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Kalancha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Otto-Knapp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Kranzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Lillebaek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Marks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Middelkoop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Motta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Rabinova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Sommerfeld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Tattevin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lange%22%7D%5D%2C%22abstractNote%22%3A%22Pretomanid%20is%20a%20key%20anti-TB%20drug%20included%20in%20the%20WHO%20list%20of%20essential%20medications.%20The%20current%20EMA-approved%20label%20for%20pretomanid%20restricts%20its%20use%20to%20the%20regimen%20comprising%20bedaquiline%2C%20pretomanid%20and%20linezolid%20%28BPaL%29%20and%20only%20for%20extensively%20drug-resistant-TB%20or%20multidrug-resistant%20%5Cn%20TB%2C%20%5Cu201cwhen%20antibiotics%20used%20for%20the%20latter%20form%20of%20TB%20do%20not%20work%20or%20cause%20unacceptable%20side%20effects.%5Cu201d%20This%20restricted%20use%20implies%20that%20the%20older%2C%20prolonged%20and%20poorly%20tolerated%20regimens%20remain%20the%20recommended%20treatment%20for%20most%20cases%20of%20drug-resistant%20TB.%20The%20authors%2C%20representing%20%5Cn%20many%20respiratory%20groups%20and%20societies%2C%20call%20for%20the%20label%20expansion%20of%20pretomanid%20to%20align%20with%20global%20guidelines%2C%20allowing%20for%20broader%20use.%22%2C%22date%22%3A%222025-03-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtldopen.25.0152%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ingentaconnect.com%5C%2Fcontent%5C%2F10.5588%5C%2Fijtldopen.25.0152%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%223005-7590%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-05-09T13%3A31%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22SV4N7KNK%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guglielmetti%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-30%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuglielmetti%2C%20L.%2C%20Khan%2C%20U.%2C%20Vel%26%23xE1%3Bsquez%2C%20G.%20E.%2C%20Gouillou%2C%20M.%2C%20Abubakirov%2C%20A.%2C%20Baudin%2C%20E.%2C%20Berikova%2C%20E.%2C%20Berry%2C%20C.%2C%20Bonnet%2C%20M.%2C%20Cellamare%2C%20M.%2C%20Chavan%2C%20V.%2C%20Cox%2C%20V.%2C%20Dakenova%2C%20Z.%2C%20De%20Jong%2C%20B.%20C.%2C%20Ferlazzo%2C%20G.%2C%20Karabayev%2C%20A.%2C%20Kirakosyan%2C%20O.%2C%20Kiria%2C%20N.%2C%20Kunda%2C%20M.%2C%20Lachenal%2C%20N.%2C%20Lecca%2C%20L.%2C%20McIlleron%2C%20H.%2C%20Motta%2C%20I.%2C%20Toscano%2C%20S.%20M.%2C%20Mushtaque%2C%20H.%2C%20Nahid%2C%20P.%2C%20Oyewusi%2C%20L.%2C%20Panda%2C%20S.%2C%20Patil%2C%20S.%2C%20Phillips%2C%20P.%20P.%20J.%2C%20Ruiz%2C%20J.%2C%20Salahuddin%2C%20N.%2C%20Garavito%2C%20E.%20S.%2C%20Seung%2C%20K.%20J.%2C%20Ticona%2C%20E.%2C%20Trippa%2C%20L.%2C%20Vasquez%2C%20D.%20E.%20V.%2C%20Wasserman%2C%20S.%2C%20Rich%2C%20M.%20L.%2C%20Varaine%2C%20F.%20and%20Mitnick%2C%20C.%20D.%20%282025%29.%20%26lt%3Bb%26gt%3BOral%20Regimens%20for%20Rifampin-Resistant%2C%20Fluoroquinolone-Susceptible%20Tuberculosis%26lt%3B%5C%2Fb%26gt%3B.%20N%20Engl%20J%20Med%20%26lt%3Bi%26gt%3B392%26lt%3B%5C%2Fi%26gt%3B%2C%20468%26%23x2013%3B482%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1056%5C%2FNEJMoa2400327%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1056%5C%2FNEJMoa2400327%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Oral%20Regimens%20for%20Rifampin-Resistant%2C%20Fluoroquinolone-Susceptible%20Tuberculosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Uzma%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gustavo%20E.%22%2C%22lastName%22%3A%22Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maelenn%22%2C%22lastName%22%3A%22Gouillou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanzhan%22%2C%22lastName%22%3A%22Abubakirov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Baudin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elmira%22%2C%22lastName%22%3A%22Berikova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Berry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maryline%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matteo%22%2C%22lastName%22%3A%22Cellamare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vijay%22%2C%22lastName%22%3A%22Chavan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivian%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhanna%22%2C%22lastName%22%3A%22Dakenova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%20Catherine%22%2C%22lastName%22%3A%22De%20Jong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriella%22%2C%22lastName%22%3A%22Ferlazzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aydarkhan%22%2C%22lastName%22%3A%22Karabayev%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ohanna%22%2C%22lastName%22%3A%22Kirakosyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nana%22%2C%22lastName%22%3A%22Kiria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikanda%22%2C%22lastName%22%3A%22Kunda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Lachenal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonid%22%2C%22lastName%22%3A%22Lecca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22McIlleron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilaria%22%2C%22lastName%22%3A%22Motta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergio%20Mucching%22%2C%22lastName%22%3A%22Toscano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hebah%22%2C%22lastName%22%3A%22Mushtaque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Payam%22%2C%22lastName%22%3A%22Nahid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lawrence%22%2C%22lastName%22%3A%22Oyewusi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samiran%22%2C%22lastName%22%3A%22Panda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandip%22%2C%22lastName%22%3A%22Patil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20P.%20J.%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimena%22%2C%22lastName%22%3A%22Ruiz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naseem%22%2C%22lastName%22%3A%22Salahuddin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Epifanio%20Sanchez%22%2C%22lastName%22%3A%22Garavito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kwonjune%20J.%22%2C%22lastName%22%3A%22Seung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%22%2C%22lastName%22%3A%22Ticona%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Trippa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dante%20E.%20Vargas%22%2C%22lastName%22%3A%22Vasquez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%22%2C%22lastName%22%3A%22Wasserman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20L.%22%2C%22lastName%22%3A%22Rich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francis%22%2C%22lastName%22%3A%22Varaine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%20D.%22%2C%22lastName%22%3A%22Mitnick%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025-01-30%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1056%5C%2FNEJMoa2400327%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.nejm.org%5C%2Fdoi%5C%2F10.1056%5C%2FNEJMoa2400327%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220028-4793%2C%201533-4406%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-02-13T10%3A18%3A03Z%22%7D%7D%2C%7B%22key%22%3A%222A6Z64ZV%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Goletti%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGoletti%2C%20D.%2C%20Banaei%2C%20N.%2C%20Batra%2C%20R.%2C%20Berger%2C%20A.%20E.%2C%20Blazevic%2C%20A.%2C%20Botelho-Nevers%2C%20E.%2C%20Breen%2C%20R.%2C%20Bruiners%2C%20N.%2C%20Cambau%2C%20E.%2C%20Carbonnelle%2C%20E.%2C%20Daley%2C%20C.%20L.%2C%20Descotes-Genon%2C%20C.%2C%20Gennaro%2C%20F.%20D.%2C%20Doucet-Populaire%2C%20F.%2C%20Esmail%2C%20A.%2C%20Guzman%2C%20J.%20D.%20E.%2C%20Fontana%2C%20L.%2C%20Gennaro%2C%20M.%20L.%2C%20Handler%2C%20D.%2C%20Torres%2C%20R.%20M.%20H.%2C%20Hoft%2C%20D.%2C%20Ismail%2C%20N.%2C%20Isnard%2C%20M.%2C%20Kenny%2C%20J.%2C%20Lardizabal%2C%20A.%2C%20Lesage%2C%20F.%20X.%2C%20Lopes%2C%20A.%2C%20Vidal%2C%20W.%20L.%20L.%2C%20Contreras%2C%20R.%20M.%2C%20Manivet%2C%20P.%2C%20Marotte%2C%20H.%2C%20M%26%23xE9%3Bcha%26%23xEF%3B%2C%20F.%2C%20Medjahed-Artebasse%2C%20A.%2C%20Meldau%2C%20R.%2C%20M%26%23xE9%3Brieux%2C%20Y.%2C%20Morel%2C%20J.%2C%20Mougari%2C%20F.%2C%20Oelofse%2C%20S.%2C%20Palmieri%2C%20F.%2C%20Perrot%2C%20J.%20L.%2C%20Petruccioli%2C%20E.%2C%20Pride%2C%20D.%20T.%2C%20Tuaillon%2C%20E.%2C%20Upton%2C%20C.%2C%20Vanker%2C%20N.%20and%20Dheda%2C%20K.%20%282025%29.%20%26lt%3Bb%26gt%3BAccuracy%20of%20VIDAS%26%23xAE%3B%20TB-IGRA%20in%20TB%20patients%20and%20individuals%20with%20different%20thresholds%20of%20exposure%26lt%3B%5C%2Fb%26gt%3B.%20International%20Journal%20of%20Infectious%20Diseases%20108318%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2025.108318%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2025.108318%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Accuracy%20of%20VIDAS%5Cu00ae%20TB-IGRA%20in%20TB%20patients%20and%20individuals%20with%20different%20thresholds%20of%20exposure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delia%22%2C%22lastName%22%3A%22Goletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niaz%22%2C%22lastName%22%3A%22Banaei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rahul%22%2C%22lastName%22%3A%22Batra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20Emmanuelle%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azra%22%2C%22lastName%22%3A%22Blazevic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisabeth%22%2C%22lastName%22%3A%22Botelho-Nevers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronan%22%2C%22lastName%22%3A%22Breen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalie%22%2C%22lastName%22%3A%22Bruiners%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Etienne%22%2C%22lastName%22%3A%22Carbonnelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20L.%22%2C%22lastName%22%3A%22Daley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9cile%22%2C%22lastName%22%3A%22Descotes-Genon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesco%20Di%22%2C%22lastName%22%3A%22Gennaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Doucet-Populaire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aliasgar%22%2C%22lastName%22%3A%22Esmail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%20Dolores%20Estrada%22%2C%22lastName%22%3A%22Guzman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luc%22%2C%22lastName%22%3A%22Fontana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Laura%22%2C%22lastName%22%3A%22Gennaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Deborah%22%2C%22lastName%22%3A%22Handler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rosa%20Mar%5Cu00eda%20Herrera%22%2C%22lastName%22%3A%22Torres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Hoft%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nahed%22%2C%22lastName%22%3A%22Ismail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margaux%22%2C%22lastName%22%3A%22Isnard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Kenny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alfred%22%2C%22lastName%22%3A%22Lardizabal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%20Xavier%22%2C%22lastName%22%3A%22Lesage%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%22%2C%22lastName%22%3A%22Lopes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Williams%20Luciano%20L%5Cu00f3pez%22%2C%22lastName%22%3A%22Vidal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rene%20Machado%22%2C%22lastName%22%3A%22Contreras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Manivet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hubert%22%2C%22lastName%22%3A%22Marotte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22M%5Cu00e9cha%5Cu00ef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amel%22%2C%22lastName%22%3A%22Medjahed-Artebasse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Meldau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yves%22%2C%22lastName%22%3A%22M%5Cu00e9rieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzette%22%2C%22lastName%22%3A%22Oelofse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrizio%22%2C%22lastName%22%3A%22Palmieri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Luc%22%2C%22lastName%22%3A%22Perrot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Petruccioli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20T.%22%2C%22lastName%22%3A%22Pride%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edouard%22%2C%22lastName%22%3A%22Tuaillon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caryn%22%2C%22lastName%22%3A%22Upton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naadira%22%2C%22lastName%22%3A%22Vanker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keertan%22%2C%22lastName%22%3A%22Dheda%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2212%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ijid.2025.108318%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1201971225005351%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2212019712%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-12-26T10%3A40%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22GYDNQB7I%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Soutou%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSoutou%2C%20M.%20A.%2C%20Allam%2C%20C.%2C%20Abi%20Fadel%2C%20M.%2C%20Najjar%2C%20J.%2C%20Guyeux%2C%20C.%2C%20Cambau%2C%20E.%20and%20Sola%2C%20C.%20%282025%29.%20%26lt%3Bb%26gt%3BAn%20insight%20into%20the%20characterization%20of%20L2%20Beijing%20multi-drug%20resistant%20tuberculosis%3A%20Description%20of%20resistance-associated-variants%20and%20discovery%20of%20Modern%207%20L2%20sublineage%26lt%3B%5C%2Fb%26gt%3B.%20Infection%2C%20Genetics%20and%20Evolution%20%26lt%3Bi%26gt%3B134%26lt%3B%5C%2Fi%26gt%3B%2C%20105797%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.meegid.2025.105797%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.meegid.2025.105797%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22An%20insight%20into%20the%20characterization%20of%20L2%20Beijing%20multi-drug%20resistant%20tuberculosis%3A%20Description%20of%20resistance-associated-variants%20and%20discovery%20of%20Modern%207%20L2%20sublineage%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%20Antar%22%2C%22lastName%22%3A%22Soutou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Allam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%22%2C%22lastName%22%3A%22Abi%20Fadel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josette%22%2C%22lastName%22%3A%22Najjar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Guyeux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Sola%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2210%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.meegid.2025.105797%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1567134825000863%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2215671348%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-09-30T14%3A59%3A12Z%22%7D%7D%2C%7B%22key%22%3A%22CYXSH9MM%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nkomo%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNkomo%2C%20T.%2C%20Udwadia%2C%20Z.%2C%20Vambe%2C%20D.%2C%20Van%20Rie%2C%20A.%2C%20Thi%2C%20S.%20S.%2C%20Stillo%2C%20J.%2C%20Stambekova%2C%20A.%2C%20Sinha%2C%20A.%2C%20Rich%2C%20M.%20L.%2C%20Reuter%2C%20A.%2C%20Patel%2C%20J.%2C%20Otto-Knapp%2C%20R.%2C%20Motta%2C%20I.%2C%20Mesic%2C%20A.%2C%20McKenna%2C%20L.%2C%20Maru%2C%20S.%2C%20Lessem%2C%20E.%2C%20Lange%2C%20C.%2C%20Kiria%2C%20N.%2C%20Kherabi%2C%20Y.%2C%20G%26%23xFC%3Bnther%2C%20G.%2C%20Guglielmetti%2C%20L.%2C%20Decroo%2C%20T.%2C%20Chen%2C%20L.%2C%20Ashesh%2C%20A.%2C%20Abubakirov%2C%20A.%20and%20Furin%2C%20J.%20%282025%29.%20%26lt%3Bb%26gt%3BClinical%20best%20practices%20for%20caring%20for%20people%20with%20expanded%20resistance%20to%20newer%20TB%20drugs%26lt%3B%5C%2Fb%26gt%3B.%20IJTLD%20Open%20%26lt%3Bi%26gt%3B2%26lt%3B%5C%2Fi%26gt%3B%2C%20315%26%23x2013%3B323%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtldopen.25.0240%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtldopen.25.0240%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20best%20practices%20for%20caring%20for%20people%20with%20expanded%20resistance%20to%20newer%20TB%20drugs%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Nkomo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Z.%22%2C%22lastName%22%3A%22Udwadia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Vambe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Van%20Rie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.S.%22%2C%22lastName%22%3A%22Thi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Stillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Stambekova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Sinha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.L.%22%2C%22lastName%22%3A%22Rich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Reuter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Patel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Otto-Knapp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Motta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Mesic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22McKenna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Maru%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Lessem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Kiria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Kherabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Decroo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Ashesh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Abubakirov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Furin%22%7D%5D%2C%22abstractNote%22%3A%22SUMMARY%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20BACKGROUND%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Strains%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20with%20resistance%20to%20the%20new%20and%20repurposed%20drugs%20included%20in%20the%20all-oral%20shorter%20TB%20regimens%20recommended%20by%20WHO%20for%20the%20treatment%20of%20multidrug-resistant%5C%2Frifampicin-resistant%20TB%20%28MDR%5C%2FRR-TB%29%20are%20becoming%20increasingly%20common%20globally.%20When%20strains%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20have%20resistance%20to%20one%20or%20more%20of%20these%20drugs%20%28bedaquiline%2C%20linezolid%2C%20third-generation%20fluoroquinolones%2C%20delamanid%2C%20pretomanid%2C%20or%20clofazimine%29%2C%20they%20are%20more%20challenging%20to%20treat.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20METHODS%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20absence%20of%20trial%20data%20on%20how%20to%20care%20for%20these%20individuals%2C%20a%20group%20of%20clinical%2C%20programmatic%20and%20civil%20society%20experts%20came%20together%20to%20generate%20a%20series%20of%20best%20clinical%20practices.%20These%20practices%20are%20based%20on%20the%20published%20literature%20and%20on%20experience%20caring%20for%20individuals%20with%20these%20forms%20of%20TB.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20RESULTS%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20discuss%20best%20clinical%20practices%20in%20the%20following%20areas%3A%201%29%20drug%20susceptibility%20testing%3B%202%29%20regimen%20design%3B%203%29%20adverse%20event%20monitoring%20and%20management%3B%204%29%20special%20populations%3B%205%29%20shared%20decision%20making%20and%20informed%20consent%3B%206%29%20holistic%20packages%20of%20support%3B%20and%207%29%20pre-approval%20access%5C%2Fcompassionate%20use%20of%20newer%20TB%20compounds.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20CONCLUSION%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20While%20we%20await%20systematic%20studies%20of%20treatment%20approaches%20to%20generate%20the%20necessary%20evidence%20base%2C%20the%20clinical%20practices%20described%20here%20can%20be%20used%20to%20guide%20the%20programmatic%20care%20of%20people%20with%20strains%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M.%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20that%20have%20expanded%20resistance%22%2C%22date%22%3A%2206%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtldopen.25.0240%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.theunion.org%5C%2Flookup%5C%2Fdoi%5C%2F10.5588%5C%2Fijtldopen.25.0240%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%223005-7590%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-02-26T11%3A04%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22MP73UHH5%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22M%5Cu00e9cha%5Cu00ef%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BM%26%23xE9%3Bcha%26%23xEF%3B%2C%20F.%2C%20Beugre%2C%20E.%2C%20Billard-Pomares%2C%20T.%2C%20Mougari%2C%20F.%2C%20Wyplosz%2C%20B.%2C%20Cambau%2C%20E.%20and%20Vignier%2C%20N.%20%282025%29.%20%26lt%3Bb%26gt%3BUsefulness%20of%20the%20GeneXpert%20MTB%5C%2FRIF%20Ct%20for%20predicting%20tuberculosis%20infectiousness%26lt%3B%5C%2Fb%26gt%3B.%20Infectious%20Diseases%20Now%20%26lt%3Bi%26gt%3B55%26lt%3B%5C%2Fi%26gt%3B%2C%20105061%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.idnow.2025.105061%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.idnow.2025.105061%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Usefulness%20of%20the%20GeneXpert%20MTB%5C%2FRIF%20Ct%20for%20predicting%20tuberculosis%20infectiousness%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22M%5Cu00e9cha%5Cu00ef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Beugre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Billard-Pomares%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Wyplosz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Vignier%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2206%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.idnow.2025.105061%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2666991925000405%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2226669919%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-12-26T10%3A44%3A52Z%22%7D%7D%2C%7B%22key%22%3A%222MQ4DBXT%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Scudeller%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BScudeller%2C%20L.%2C%20Gkrania-Klotsas%2C%20E.%2C%20Pa%26%23xF1%3Bo%20Pardo%2C%20J.%20R.%2C%20Kostyanev%2C%20T.%2C%20Langendam%2C%20M.%2C%20Molina%2C%20J.%2C%20Nagavci%2C%20B.%2C%20Paul%2C%20M.%2C%20Scudeller%2C%20L.%2C%20Stahl%2C%20J.%20P.%2C%20Sutter%2C%20S.%20T.%2C%20Zervos%2C%20M.%2C%20Cambau%2C%20E.%2C%20Fitzpatrick%2C%20F.%2C%20Friedland%2C%20J.%20S.%2C%20Kantele%2C%20A.%2C%20Sahin%2C%20G.%20%26%23xD6%3B.%2C%20Pardo%2C%20J.%20R.%20P.%2C%20Skov%2C%20R.%20L.%20and%20Zinkernagel%2C%20A.%20%282025%29.%20%26lt%3Bb%26gt%3BScope%20and%20aims%20of%20European%20society%20of%20clinical%20microbiology%20and%20infectious%20diseases%20guidelines%3A%20a%20white%20paper%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Microbiology%20and%20Infection%20%26lt%3Bi%26gt%3B31%26lt%3B%5C%2Fi%26gt%3B%2C%20778%26%23x2013%3B782%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2024.11.033%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2024.11.033%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Scope%20and%20aims%20of%20European%20society%20of%20clinical%20microbiology%20and%20infectious%20diseases%20guidelines%3A%20a%20white%20paper%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luigia%22%2C%22lastName%22%3A%22Scudeller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Effrossyni%22%2C%22lastName%22%3A%22Gkrania-Klotsas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%20Ramon%22%2C%22lastName%22%3A%22Pa%5Cu00f1o%20Pardo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tomislav%22%2C%22lastName%22%3A%22Kostyanev%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Langendam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%22%2C%22lastName%22%3A%22Molina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Blin%22%2C%22lastName%22%3A%22Nagavci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mical%22%2C%22lastName%22%3A%22Paul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luigia%22%2C%22lastName%22%3A%22Scudeller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Paul%22%2C%22lastName%22%3A%22Stahl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20Tschudin%22%2C%22lastName%22%3A%22Sutter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcus%22%2C%22lastName%22%3A%22Zervos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fidelma%22%2C%22lastName%22%3A%22Fitzpatrick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jon%20S.%22%2C%22lastName%22%3A%22Friedland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anu%22%2C%22lastName%22%3A%22Kantele%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00fclsen%20%5Cu00d6zkaya%22%2C%22lastName%22%3A%22Sahin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%20Ramon%20Pano%22%2C%22lastName%22%3A%22Pardo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20Leo%22%2C%22lastName%22%3A%22Skov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annelies%22%2C%22lastName%22%3A%22Zinkernagel%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2205%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2024.11.033%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1198743X24005640%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198743X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-02-20T17%3A16%3A33Z%22%7D%7D%2C%7B%22key%22%3A%22XRN4SZWD%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guglielmetti%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuglielmetti%2C%20L.%2C%20Panda%2C%20S.%2C%20Abubakirov%2C%20A.%2C%20Salahuddin%2C%20N.%2C%20Perrin%2C%20C.%20and%20Mitnick%2C%20C.%20D.%20%282025%29.%20%26lt%3Bb%26gt%3BEquitable%2C%20personalised%20medicine%20for%20tuberculosis%3A%20treating%20patients%2C%20not%20diseases%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Respiratory%20Medicine%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%2C%20382%26%23x2013%3B385%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2213-2600%2825%2900080-3%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2213-2600%2825%2900080-3%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Equitable%2C%20personalised%20medicine%20for%20tuberculosis%3A%20treating%20patients%2C%20not%20diseases%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samiran%22%2C%22lastName%22%3A%22Panda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanzhan%22%2C%22lastName%22%3A%22Abubakirov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naseem%22%2C%22lastName%22%3A%22Salahuddin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Perrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%20D%22%2C%22lastName%22%3A%22Mitnick%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2205%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2213-2600%2825%2900080-3%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2213260025000803%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2222132600%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-05-09T13%3A32%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22BLP8X3WW%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gerussi%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGerussi%2C%20V.%2C%20Petersen%2C%20T.%2C%20Bonnet%2C%20I.%2C%20Aubry%2C%20A.%2C%20Bachir%2C%20M.%2C%20Gyde%2C%20E.%2C%20Morel%2C%20F.%2C%20Poignon%2C%20C.%2C%20Rached%2C%20B.%2C%20Pourcher%2C%20V.%2C%20Rioux%2C%20C.%2C%20Vallois%2C%20D.%2C%20Veziris%2C%20N.%2C%20Robert%2C%20J.%20and%20Guglielmetti%2C%20L.%20%282025%29.%20%26lt%3Bb%26gt%3BEvaluation%20of%20High-Dose%20Isoniazid%20in%20Multidrug-Resistant%20Tuberculosis%20Treatment%26lt%3B%5C%2Fb%26gt%3B.%20Emerg%20Infect%20Dis%20%26lt%3Bi%26gt%3B31%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid3103.241473%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid3103.241473%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evaluation%20of%20High-Dose%20Isoniazid%20in%20Multidrug-Resistant%20Tuberculosis%20Treatment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentina%22%2C%22lastName%22%3A%22Gerussi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tania%22%2C%22lastName%22%3A%22Petersen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marwa%22%2C%22lastName%22%3A%22Bachir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esther%22%2C%22lastName%22%3A%22Gyde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corentin%22%2C%22lastName%22%3A%22Poignon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brigitte%22%2C%22lastName%22%3A%22Rached%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Pourcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Rioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Doroth%5Cu00e9e%22%2C%22lastName%22%3A%22Vallois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2203%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3201%5C%2Feid3103.241473%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwwwnc.cdc.gov%5C%2Feid%5C%2Farticle%5C%2F31%5C%2F3%5C%2F24-1473_article%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221080-6040%2C%201080-6059%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-03-04T14%3A01%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22MV2MSRDB%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guthmann%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuthmann%2C%20J.-P.%2C%20Robert%2C%20J.%2C%20Viriot%2C%20D.%20and%20Parent%20Du%20Chatelet%2C%20I.%20%282025%29.%20%26lt%3Bb%26gt%3BIncidence%2C%20severity%20and%20treatment%20outcome%20of%20tuberculosis%20in%20the%20era%20of%20the%20COVID-19%20pandemic%2C%20France%2C%202018%26%23x2013%3B2023%26lt%3B%5C%2Fb%26gt%3B.%20Journal%20of%20Epidemiology%20and%20Population%20Health%20%26lt%3Bi%26gt%3B73%26lt%3B%5C%2Fi%26gt%3B%2C%20202795%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jeph.2024.202795%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jeph.2024.202795%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Incidence%2C%20severity%20and%20treatment%20outcome%20of%20tuberculosis%20in%20the%20era%20of%20the%20COVID-19%20pandemic%2C%20France%2C%202018%5Cu20132023%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Paul%22%2C%22lastName%22%3A%22Guthmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Viriot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Parent%20Du%20Chatelet%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2202%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jeph.2024.202795%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2950433324006049%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2229504333%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-02-13T10%3A17%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22JW4QBU8M%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kunst%20et%20al.%22%2C%22parsedDate%22%3A%222024-12-13%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKunst%2C%20H.%2C%20Lange%2C%20B.%2C%20Hovardovska%2C%20O.%2C%20Bockey%2C%20A.%2C%20Zenner%2C%20D.%2C%20Andersen%2C%20A.%20B.%2C%20Hargreaves%2C%20S.%2C%20Pareek%2C%20M.%2C%20Friedland%2C%20J.%20S.%2C%20Wejse%2C%20C.%2C%20Bothamley%2C%20G.%2C%20Guglielmetti%2C%20L.%2C%20Chesov%2C%20D.%2C%20Tiberi%2C%20S.%2C%20Matteelli%2C%20A.%2C%20Mandalakas%2C%20A.%20M.%2C%20Heyckendorf%2C%20J.%2C%20Eimer%2C%20J.%2C%20Malhotra%2C%20A.%2C%20Zamora%2C%20J.%2C%20Vasiliu%2C%20A.%2C%20Lange%2C%20C.%20and%20for%20the%20TBnet%20%282024%29.%20%26lt%3Bb%26gt%3BTuberculosis%20in%20adult%20migrants%20in%20Europe%3A%20a%20TBnet%20consensus%20statement%26lt%3B%5C%2Fb%26gt%3B.%20Eur%20Respir%20J%202401612%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.01612-2024%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.01612-2024%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Tuberculosis%20in%20adult%20migrants%20in%20Europe%3A%20a%20TBnet%20consensus%20statement%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heinke%22%2C%22lastName%22%3A%22Kunst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Hovardovska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annabelle%22%2C%22lastName%22%3A%22Bockey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Zenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aase%20B%22%2C%22lastName%22%3A%22Andersen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sally%22%2C%22lastName%22%3A%22Hargreaves%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manish%22%2C%22lastName%22%3A%22Pareek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jon%20S%22%2C%22lastName%22%3A%22Friedland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chrsitain%22%2C%22lastName%22%3A%22Wejse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Graham%22%2C%22lastName%22%3A%22Bothamley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dima%22%2C%22lastName%22%3A%22Chesov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Tiberi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alberto%22%2C%22lastName%22%3A%22Matteelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20M%22%2C%22lastName%22%3A%22Mandalakas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Heyckendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Eimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akanksha%22%2C%22lastName%22%3A%22Malhotra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Javier%22%2C%22lastName%22%3A%22Zamora%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anca%22%2C%22lastName%22%3A%22Vasiliu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22for%20the%20TBnet%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Global%20migration%20has%20increased%20in%20recent%20decades%20due%20to%20war%2C%20conflict%2C%20persecutions%2C%20and%20natural%20disasters%2C%20but%20also%20secondary%20to%20increased%20opportunities%20related%20to%20work%20or%20study.%20Migrants%5Cu2019%20risk%20of%20tuberculosis%20%28TB%29%20differs%20by%20reasons%20for%20migration%2C%20socioeconomic%20status%2C%20mode%20of%20travel%20and%20TB%20risk%20in%20transit%2C%20TB%20incidence%20and%20healthcare%20provision%20in%20country%20of%20origin.%20Despite%20advances%20in%20TB%20care%20for%20migrants%20and%20new%20treatment%20strategies%2C%20decisions%20for%20the%20management%20of%20migrants%20at%20risk%20of%20TB%20often%20rely%20on%20expert%20opinions%2C%20rather%20than%20clinical%20evidence.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%20systematic%20literature%20search%20was%20conducted%2C%20studies%20were%20mapped%20to%20different%20recommendation%20groups%20and%20included%20studies%20were%20synthesized%20by%20meta-analysis%20where%20appropriate.%20Current%20evidence%20on%20diagnosis%20of%20active%20TB%20in%20migrants%20entering%20the%20European%20Union%20%5C%2FEuropean%20Economic%20Area%20%28EU%5C%2FEEA%29%20%26amp%3BUK%20including%20the%20clinical%20presentation%20and%20diagnostic%20delay%2C%20treatment%20outcomes%20of%20drug%20susceptible%20TB%2C%20prevalence%20and%20treatment%20outcomes%20of%20multidrug%5C%2Frifampicin-resistant%20%28MDR%5C%2FRR%29-TB%20and%20TB%5C%2FHIV%20co-infection%20was%20summarised.%20A%20consensus%20process%20was%20used%20based%20on%20the%20evidence.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20document%20a%20higher%20vulnerability%20of%20migrants%20for%20TB%2C%20including%20an%20increased%20risk%20of%20extrapulmonary%20TB%2C%20MDR%5C%2FRR-TB%2C%20TB%5C%2FHIV%20co-infection%20and%20worse%20TB%20treatment%20outcomes%20compared%20to%20host%20populations.%20Consensus%20recommendations%20include%20screening%20of%20migrants%20for%20TB%5C%2F%20latent%20TB%20infection%20%28LTBI%29%20according%20to%20country%20data%3B%20a%20minimal%20package%20for%20TB%20care%20in%20drug%20susceptible%20and%20MDR%5C%2FRR-TB%3B%20implementation%20of%20migrant-sensitive%20strategies%3B%20free%20healthcare%20and%20preventive%20treatment%20for%20migrants%20with%20HIV%20co-infection.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Dedicated%20care%20for%20TB%20prevention%20and%20treatment%20in%20migrant%20populations%20within%20the%20EU%5C%2FEEA%20%26amp%3BUK%20is%20essential.%22%2C%22date%22%3A%222024-12-13%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1183%5C%2F13993003.01612-2024%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fpublications.ersnet.org%5C%2Flookup%5C%2Fdoi%5C%2F10.1183%5C%2F13993003.01612-2024%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220903-1936%2C%201399-3003%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-26T17%3A11%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22IHKWS8TE%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Maitre%20et%20al.%22%2C%22parsedDate%22%3A%222024-10-16%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMaitre%2C%20T.%2C%20Godmer%2C%20A.%2C%20Mory%2C%20C.%2C%20Chauffour%2C%20A.%2C%20Mai%2C%20T.%20C.%2C%20El%20Helali%2C%20N.%2C%20Aubry%2C%20A.%20and%20Veziris%2C%20N.%20%282024%29.%20%26lt%3Bb%26gt%3BLevofloxacin%20activity%20at%20increasing%20doses%20in%20a%20murine%20model%20of%20fluoroquinolone-susceptible%20and%20-resistant%20tuberculosis%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Wasserman%2C%20S.%20Antimicrob%20Agents%20Chemother%20e00583-24%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Faac.00583-24%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Faac.00583-24%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Levofloxacin%20activity%20at%20increasing%20doses%20in%20a%20murine%20model%20of%20fluoroquinolone-susceptible%20and%20-resistant%20tuberculosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Maitre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Godmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9line%22%2C%22lastName%22%3A%22Mory%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thi%20Cuc%22%2C%22lastName%22%3A%22Mai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Najoua%22%2C%22lastName%22%3A%22El%20Helali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Sean%22%2C%22lastName%22%3A%22Wasserman%22%7D%5D%2C%22abstractNote%22%3A%22ABSTRACT%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20High-dose%20levofloxacin%20was%20explored%20in%20a%20clinical%20trial%20against%20multidrug-resistant%20tuberculosis%20and%20failed%20to%20show%20increased%20efficacy.%20In%20this%20study%2C%20we%20used%20a%20murine%20model%20to%20explore%20the%20efficacy%20of%20a%20dose%20increase%20in%20levofloxacin%20monotherapy%20beyond%20the%20maximum%20dose%20evaluated%20in%20humans.%20A%20total%20of%20120%204-week-old%20female%20BALB%5C%2Fc%20mice%20were%20intravenously%20infected%20with%2010%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%206%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20CFU%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20H37Rv%20wild-type%20%28WT%29%20or%20isogenic%20H37Rv%20mutants%20harboring%20GyrA%20A90V%20or%20D94G%20substitutions%3B%20the%20MICs%20were%200.25%2C%204%2C%20and%206%20%5Cu00b5g%5C%2FmL%2C%20respectively.%20Levofloxacin%20250%20and%20500%20mg%5C%2Fkg%20were%20given%20every%2012%20h%20%28q12h%29%20orally%20for%204%20weeks.%20Pharmacokinetic%20parameters%20were%20determined%20after%20five%20doses.%20These%20two%20regimens%20decreased%20lung%20bacillary%20load%20in%20mice%20infected%20with%20H37Rv%20WT%20but%20not%20in%20mice%20infected%20with%20the%20A90V%20and%20D94G%20mutants.%20Levofloxacin%20250%20mg%5C%2Fkg%20q12h%20in%20mice%20generated%20pharmacokinetic%20parameters%20equivalent%20to%201%2C000%20mg%5C%2Fd%20in%20humans%2C%20whereas%20500%20mg%5C%2Fkg%20q12h%20generated%20a%20twofold%20greater%20exposure%20than%20the%20highest%20equivalent%20dose%20tested%20in%20humans%20%281%2C500%20mg%5C%2Fd%29.%20In%20our%20dose%5Cu2013response%20model%2C%20the%20effective%20concentration%20at%2050%25%20%28EC%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2050%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29%20produced%20an%20AUC%5C%2FMIC%20%28AUC%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200%5Cu201324h%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5C%2FMIC%29%20ratio%20of%20167.9%20%5Cu00b1%2027.5%2C%20and%20at%20EC%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2080%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20it%20was%20281.2%20%5Cu00b1%2097.3.%20Based%20on%20this%20model%2C%20high-dose%20levofloxacin%20regimens%20above%201%2C000%20mg%5C%2Fd%20are%20not%20expected%20to%20cause%20a%20significant%20increase%20in%20bactericidal%20activity.%20This%20study%20suggests%20no%20benefit%20of%20high-dose%20levofloxacin%20above%201%2C000%20mg%5C%2Fd%20in%20the%20treatment%20of%20fluoroquinolone-susceptible%20or%20-resistant%20tuberculosis.%22%2C%22date%22%3A%222024-10-16%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2Faac.00583-24%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.asm.org%5C%2Fdoi%5C%2F10.1128%5C%2Faac.00583-24%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-10-17T10%3A19%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22ULGLVJW6%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Godefroy%20et%20al.%22%2C%22parsedDate%22%3A%222024-07-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGodefroy%2C%20N.%2C%20Monsel%2C%20G.%2C%20Jaur%26%23xE9%3Bguiberry%2C%20S.%2C%20Henry%2C%20B.%2C%20V%26%23xE9%3Bziris%2C%20N.%2C%20Aubry%2C%20A.%2C%20Robert%2C%20J.%2C%20Jachym%2C%20M.%2C%20Caumes%2C%20E.%20and%20Pourcher%2C%20V.%20%282024%29.%20%26lt%3Bb%26gt%3BLessons%20learned%20from%20treating%20drug-resistant%20TB%20and%20how%20to%20apply%20these%20to%20drug-susceptible%20TB%26lt%3B%5C%2Fb%26gt%3B.%20int%20j%20tuberc%20lung%20dis%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%2C%20357%26%23x2013%3B359%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.23.0548%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.23.0548%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lessons%20learned%20from%20treating%20drug-resistant%20TB%20and%20how%20to%20apply%20these%20to%20drug-susceptible%20TB%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Godefroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Monsel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Jaur%5Cu00e9guiberry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Henry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22V%5Cu00e9ziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Jachym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Caumes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Pourcher%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024-07-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtld.23.0548%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ingentaconnect.com%5C%2Fcontent%5C%2F10.5588%5C%2Fijtld.23.0548%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221027-3719%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-07-17T14%3A19%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22V67C548F%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rupasinghe%20et%20al.%22%2C%22parsedDate%22%3A%222024-05-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRupasinghe%2C%20P.%2C%20Ashraf%2C%20A.%2C%20Barreda%2C%20N.%2C%20Parveen%2C%20S.%2C%20Zubair%2C%20M.%2C%20Calderon%2C%20R.%2C%20Asif%2C%20S.%2C%20Hirani%2C%20N.%2C%20Chingisova%2C%20L.%2C%20Bulane%2C%20A.%2C%20Hang%2C%20P.%20T.%2C%20Ha%2C%20D.%20T.%2C%20Ardizzoni%2C%20E.%2C%20Kursheed%2C%20N.%2C%20De%20Rijk%2C%20W.%20B.%2C%20Rigouts%2C%20L.%2C%20Guglielmetti%2C%20L.%2C%20Mitnick%2C%20C.%20and%20De%20Jong%2C%20B.%20C.%20%282024%29.%20%26lt%3Bb%26gt%3BReduced%20critical%20concentration%20might%20not%20have%20improved%20MGIT-based%20DST%26%23x2019%3Bs%20sensitivity%20to%20rifampicin%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Wasserman%2C%20S.%20Antimicrob%20Agents%20Chemother%20%26lt%3Bi%26gt%3B68%26lt%3B%5C%2Fi%26gt%3B%2C%20e01701-23%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Faac.01701-23%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Faac.01701-23%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reduced%20critical%20concentration%20might%20not%20have%20improved%20MGIT-based%20DST%5Cu2019s%20sensitivity%20to%20rifampicin%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Praharshinie%22%2C%22lastName%22%3A%22Rupasinghe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azka%22%2C%22lastName%22%3A%22Ashraf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Barreda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shafiqua%22%2C%22lastName%22%3A%22Parveen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Zubair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%22%2C%22lastName%22%3A%22Calderon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sunil%22%2C%22lastName%22%3A%22Asif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nilma%22%2C%22lastName%22%3A%22Hirani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Layila%22%2C%22lastName%22%3A%22Chingisova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Atang%22%2C%22lastName%22%3A%22Bulane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pham%20Thu%22%2C%22lastName%22%3A%22Hang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Doan%20Thu%22%2C%22lastName%22%3A%22Ha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Ardizzoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazia%22%2C%22lastName%22%3A%22Kursheed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Willem%20Bram%22%2C%22lastName%22%3A%22De%20Rijk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leen%22%2C%22lastName%22%3A%22Rigouts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carol%22%2C%22lastName%22%3A%22Mitnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%20C.%22%2C%22lastName%22%3A%22De%20Jong%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Sean%22%2C%22lastName%22%3A%22Wasserman%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024-05-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2Faac.01701-23%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.asm.org%5C%2Fdoi%5C%2F10.1128%5C%2Faac.01701-23%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220066-4804%2C%201098-6596%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-10-18T16%3A22%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22RHYL4NM9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Paulowski%20et%20al.%22%2C%22parsedDate%22%3A%222024-04-16%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPaulowski%2C%20L.%2C%20Filip%2C%20R.%2C%20Jankovic%20Makek%2C%20M.%2C%20Guglielmetti%2C%20L.%2C%20Goletti%2C%20D.%2C%20Van%20Ingen%2C%20J.%2C%20Kranzer%2C%20K.%2C%20Maurer%2C%20F.%20P.%20and%20on%20behalf%20of%20ESGMYC%20%282024%29.%20%26lt%3Bb%26gt%3BImpact%20of%20the%20COVID-19%20pandemic%20on%20the%20real-world%20diagnostic%20infrastructure%20for%20tuberculosis%26%23x2014%3BAn%20ESGMYC%20collaborative%20study%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Wang%2C%20M.-S.%20PLoS%20ONE%20%26lt%3Bi%26gt%3B19%26lt%3B%5C%2Fi%26gt%3B%2C%20e0291404%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0291404%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0291404%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Impact%20of%20the%20COVID-19%20pandemic%20on%20the%20real-world%20diagnostic%20infrastructure%20for%20tuberculosis%5Cu2014An%20ESGMYC%20collaborative%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Paulowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxana%22%2C%22lastName%22%3A%22Filip%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mateja%22%2C%22lastName%22%3A%22Jankovic%20Makek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delia%22%2C%22lastName%22%3A%22Goletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22Van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Kranzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%20P.%22%2C%22lastName%22%3A%22Maurer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22on%20behalf%20of%20ESGMYC%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Mao-Shui%22%2C%22lastName%22%3A%22Wang%22%7D%5D%2C%22abstractNote%22%3A%22We%20determined%20the%20impact%20of%20the%20COVID-19%20pandemic%20on%20mycobacterial%20diagnostic%20services.%2040%20laboratories%20from%2022%20countries%20completed%20an%20online%20questionnaire%20covering%20the%20redeployment%20of%20the%20laboratory%20infrastructure%20and%5C%2For%20staff%20for%20SARS-CoV-2%20testing%2C%20staff%20shortages%20and%20supply%20chain%20disruptions.%2028%20laboratories%20reported%20monthly%20numbers%20of%20samples%20processed%20for%20mycobacterial%20investigations%20and%20monthly%20numbers%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20complex%20%28MTBC%29%20PCRs%20performed%20between%20October%201st%202018%20and%20October%2031st%202020.%20More%20than%20half%20%2823%5C%2F40%29%20of%20the%20participating%20TB%20laboratories%20reported%20having%20performed%20COVID-19%20diagnostics%20in%20the%20early%20phase%20of%20the%20pandemic%2C%20in%20part%20with%20negative%20impact%20on%20the%20mycobacterial%20service%20activities.%20All%20participating%20laboratories%20reported%20shortages%20of%20consumables%20and%20laboratory%20equipment%20due%20to%20supply%20chain%20issues.%20Average%20monthly%20sample%20numbers%20decreased%20by%2024%25%20between%20January%202020%20and%20October%202020%20compared%20to%20pre-pandemic%20averages.%20At%20the%20end%20of%20the%20study%20period%2C%20most%20participating%20laboratories%20had%20not%20returned%20to%20pre-pandemic%20average%20MTBC%20PCR%20throughput.%22%2C%22date%22%3A%222024-4-16%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0291404%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pone.0291404%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221932-6203%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-26T17%3A13%3A54Z%22%7D%7D%2C%7B%22key%22%3A%222HSDN9QD%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Veziris%20et%20al.%22%2C%22parsedDate%22%3A%222024-03-19%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVeziris%2C%20N.%2C%20Aubry%2C%20A.%2C%20Bonnet%2C%20I.%2C%20Petersen%2C%20T.%2C%20Poignon%2C%20C.%2C%20Gyd%26%23xE9%3B%2C%20E.%2C%20Guglielmetti%2C%20L.%20and%20Robert%2C%20J.%20%282024%29.%20%26lt%3Bb%26gt%3BActualit%26%23xE9%3Bs%20sur%20la%20tuberculose%20%26%23xE0%3B%20bacilles%20multir%26%23xE9%3Bsistants%20aux%20antibiotiques%20et%20ses%20nouveaux%20traitements%26lt%3B%5C%2Fb%26gt%3B.%20Bull%20%26%23xC9%3Bpid%20Hebdo%20127%26%23x2013%3B131%2C%20URL%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fbeh.santepubliquefrance.fr%5C%2Fbeh%5C%2F2024%5C%2F6-7%5C%2F2024_6-7_4.html%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fbeh.santepubliquefrance.fr%5C%2Fbeh%5C%2F2024%5C%2F6-7%5C%2F2024_6-7_4.html%26lt%3B%5C%2Fa%26gt%3B%20%5BAccessed%20March%202024%5D.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Actualit%5Cu00e9s%20sur%20la%20tuberculose%20%5Cu00e0%20bacilles%20multir%5Cu00e9sistants%20aux%20antibiotiques%20et%20ses%20nouveaux%20traitements%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T%22%2C%22lastName%22%3A%22Petersen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Poignon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E%22%2C%22lastName%22%3A%22Gyd%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%22%2C%22lastName%22%3A%22Robert%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024-03-19%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fbeh.santepubliquefrance.fr%5C%2Fbeh%5C%2F2024%5C%2F6-7%5C%2F2024_6-7_4.html%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22French%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-03-19T17%3A03%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22RYJ5THDR%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22B%5Cu00e9rot%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BB%26%23xE9%3Brot%2C%20V.%2C%20Monsel%2C%20G.%2C%20Lecorche%2C%20E.%2C%20Halabi-Tawil%2C%20M.%2C%20Maalouf%2C%20D.%2C%20Pourcher%2C%20V.%2C%20Aubry%2C%20A.%2C%20Cambaud%2C%20E.%2C%20Petit%2C%20A.%20and%20Caumes%2C%20E.%20%282024%29.%20%26lt%3Bb%26gt%3BClinical%20relevance%20and%20prognostic%20impact%20of%20the%20classification%20between%20multibacillary%20and%20paucibacillary%20forms%20of%20cutaneous%20tuberculosis%3A%20A%2024-year%20retrospective%20multicenter%20study%26lt%3B%5C%2Fb%26gt%3B.%20Annales%20de%20Dermatologie%20et%20de%20V%26%23xE9%3Bn%26%23xE9%3Br%26%23xE9%3Bologie%20%26lt%3Bi%26gt%3B151%26lt%3B%5C%2Fi%26gt%3B%2C%20103324%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annder.2024.103324%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annder.2024.103324%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20relevance%20and%20prognostic%20impact%20of%20the%20classification%20between%20multibacillary%20and%20paucibacillary%20forms%20of%20cutaneous%20tuberculosis%3A%20A%2024-year%20retrospective%20multicenter%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22B%5Cu00e9rot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Monsel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Halabi-Tawil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Maalouf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Pourcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Petit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Caumes%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2212%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.annder.2024.103324%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0151963824000802%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2201519638%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-26T17%3A04%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22P7NUG964%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guyeux%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuyeux%2C%20C.%2C%20Senelle%2C%20G.%2C%20Le%20Meur%2C%20A.%2C%20Supply%2C%20P.%2C%20Gaudin%2C%20C.%2C%20Phelan%2C%20J.%20E.%2C%20Clark%2C%20T.%20G.%2C%20Rigouts%2C%20L.%2C%20De%20Jong%2C%20B.%2C%20Sola%2C%20C.%20and%20Refr%26%23xE9%3Bgier%2C%20G.%20%282024%29.%20%26lt%3Bb%26gt%3BNewly%20Identified%20Mycobacterium%20africanum%20Lineage%2010%2C%20Central%20Africa%26lt%3B%5C%2Fb%26gt%3B.%20Emerg%20Infect%20Dis%20%26lt%3Bi%26gt%3B30%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid3003.231466%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid3003.231466%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Newly%20Identified%20Mycobacterium%20africanum%20Lineage%2010%2C%20Central%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Guyeux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaetan%22%2C%22lastName%22%3A%22Senelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrien%22%2C%22lastName%22%3A%22Le%20Meur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Supply%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cyril%22%2C%22lastName%22%3A%22Gaudin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jody%20E.%22%2C%22lastName%22%3A%22Phelan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taane%20G%22%2C%22lastName%22%3A%22Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leen%22%2C%22lastName%22%3A%22Rigouts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%22%2C%22lastName%22%3A%22De%20Jong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Sola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guislaine%22%2C%22lastName%22%3A%22Refr%5Cu00e9gier%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2210%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3201%5C%2Feid3003.231466%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwwwnc.cdc.gov%5C%2Feid%5C%2Farticle%5C%2F30%5C%2F3%5C%2F23-1466_article%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221080-6040%2C%201080-6059%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222025-04-03T14%3A39%3A03Z%22%7D%7D%2C%7B%22key%22%3A%229L3HNICX%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gedeon%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGedeon%2C%20A.%2C%20Yab%2C%20E.%2C%20Dinut%2C%20A.%2C%20Sadowski%2C%20E.%2C%20Capton%2C%20E.%2C%20Dreneau%2C%20A.%2C%20Petit%2C%20J.%2C%20Gioia%2C%20B.%2C%20Piveteau%2C%20C.%2C%20Djaout%2C%20K.%2C%20Lecat%2C%20E.%2C%20Wehenkel%2C%20A.%20M.%2C%20Gubellini%2C%20F.%2C%20Mechaly%2C%20A.%2C%20Alzari%2C%20P.%20M.%2C%20Deprez%2C%20B.%2C%20Baulard%2C%20A.%2C%20Aubry%2C%20A.%2C%20Willand%2C%20N.%20and%20Petrella%2C%20S.%20%282024%29.%20%26lt%3Bb%26gt%3BMolecular%20mechanism%20of%20a%20triazole-containing%20inhibitor%20of%20Mycobacterium%20tuberculosis%20DNA%20gyrase%26lt%3B%5C%2Fb%26gt%3B.%20iScience%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%2C%20110967%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.isci.2024.110967%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.isci.2024.110967%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Molecular%20mechanism%20of%20a%20triazole-containing%20inhibitor%20of%20Mycobacterium%20tuberculosis%20DNA%20gyrase%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Gedeon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Yab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurelia%22%2C%22lastName%22%3A%22Dinut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Sadowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Capton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurore%22%2C%22lastName%22%3A%22Dreneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julienne%22%2C%22lastName%22%3A%22Petit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruna%22%2C%22lastName%22%3A%22Gioia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Piveteau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kamel%22%2C%22lastName%22%3A%22Djaout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Estelle%22%2C%22lastName%22%3A%22Lecat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20Marie%22%2C%22lastName%22%3A%22Wehenkel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Gubellini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ariel%22%2C%22lastName%22%3A%22Mechaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pedro%20M.%22%2C%22lastName%22%3A%22Alzari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beno%5Cu00eet%22%2C%22lastName%22%3A%22Deprez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Baulard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Willand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Petrella%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2210%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.isci.2024.110967%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2589004224021928%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2225890042%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-26T17%3A06%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22Q8Q2WRP9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22G%5Cu00fcnther%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BG%26%23xFC%3Bnther%2C%20G.%2C%20Guglielmetti%2C%20L.%2C%20Kherabi%2C%20Y.%2C%20Duarte%2C%20R.%20and%20Lange%2C%20C.%20%282024%29.%20%26lt%3Bb%26gt%3BAvailability%20of%20drugs%20and%20resistance%20testing%20for%20bedaquiline%2C%20pretomanid%2C%20linezolid%2C%20and%20moxifloxacin%20%28BPaL%28M%29%29%20regimen%20for%20rifampicin-resistant%20tuberculosis%20in%20Europe%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Microbiology%20and%20Infection%20%26lt%3Bi%26gt%3B30%26lt%3B%5C%2Fi%26gt%3B%2C%201197.e1-1197.e4%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2024.03.009%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2024.03.009%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Availability%20of%20drugs%20and%20resistance%20testing%20for%20bedaquiline%2C%20pretomanid%2C%20linezolid%2C%20and%20moxifloxacin%20%28BPaL%28M%29%29%20regimen%20for%20rifampicin-resistant%20tuberculosis%20in%20Europe%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yousra%22%2C%22lastName%22%3A%22Kherabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Duarte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2209%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2024.03.009%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1198743X24001216%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198743X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-12-26T17%3A14%3A59Z%22%7D%7D%2C%7B%22key%22%3A%224PJRSDDI%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lange%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLange%2C%20C.%2C%20Kherabi%2C%20Y.%2C%20Guglielmetti%2C%20L.%2C%20Duarte%2C%20R.%20and%20G%26%23xFC%3Bnther%2C%20G.%20%282024%29.%20%26lt%3Bb%26gt%3BAvailability%20of%20drugs%20and%20resistance%20testing%20for%20bedaquiline%2C%20pretomanid%2C%20linezolid%2C%20and%20moxifloxacin%20%28BPaL%28M%29%29%20regimen%20for%20rifampicin-resistant%20tuberculosis%20in%20Europe%3A%20author%26%23x2019%3Bs%20response%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Microbiology%20and%20Infection%20%26lt%3Bi%26gt%3B30%26lt%3B%5C%2Fi%26gt%3B%2C%201207%26%23x2013%3B1208%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2024.06.009%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2024.06.009%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Availability%20of%20drugs%20and%20resistance%20testing%20for%20bedaquiline%2C%20pretomanid%2C%20linezolid%2C%20and%20moxifloxacin%20%28BPaL%28M%29%29%20regimen%20for%20rifampicin-resistant%20tuberculosis%20in%20Europe%3A%20author%27s%20response%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yousra%22%2C%22lastName%22%3A%22Kherabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Duarte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2209%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2024.06.009%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1198743X24002891%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198743X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-10-17T10%3A25%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22VNSB8L8Y%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Friesen%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFriesen%2C%20I.%2C%20Saluzzo%2C%20F.%2C%20Groenheit%2C%20R.%2C%20Aubry%2C%20A.%2C%20Anthony%2C%20R.%2C%20Niemann%2C%20S.%2C%20Mathys%2C%20V.%2C%20Cirillo%2C%20D.%20M.%2C%20Indra%2C%20A.%2C%20Mathys%2C%20V.%2C%20Atanasova%2C%20Y.%2C%20Obrovac%2C%20M.%2C%20%26%23x17D%3Bmak%2C%20L.%2C%20Pieridou%2C%20D.%2C%20Dvo%26%23x159%3B%26%23xE1%3Bkov%2C%20V.%2C%20Troels%20Lilleb%26%23xE6%3Bk%2C%20Kummik%2C%20T.%2C%20Klaos%2C%20K.%2C%20Soini%2C%20H.%2C%20Haanper%26%23xE4%3B-Heikkinen%2C%20M.%2C%20Mentula%2C%20S.%2C%20J%26%23xE9%3Br%26%23xF4%3Bme%2C%20R.%2C%20Cambau%2C%20E.%2C%20Niemann%2C%20S.%2C%20Panayotis%2C%20I.%2C%20Papaventsis%2C%20D.%2C%20Bakos%2C%20%26%23xC1%3B.%2C%20Sz%26%23xE9%3Bl%2C%20V.%2C%20L%26%23x151%3Brinczi%2C%20L.%20K.%2C%20Fitzgibbon%2C%20M.%2C%20Boyle%2C%20B.%2C%20Cirillo%2C%20D.%20M.%2C%20Giannoni%2C%20F.%2C%20Pole%2C%20I.%2C%20Norvai%26%23x161%3Ba%2C%20I.%2C%20Vasiliauskaite%2C%20L.%2C%20Perrin%2C%20M.%2C%20Deguara%2C%20C.%2C%20Anthony%2C%20R.%2C%20Mengshoel%2C%20A.%20T.%2C%20Augustynowicz-Kope%26%23x107%3B%2C%20E.%2C%20Macedo%2C%20R.%2C%20Coriu%2C%20R.%20M.%2C%20Porvaznik%2C%20I.%2C%20Klemen%2C%20%26%23x160%3B.%2C%20Herrera-Le%26%23xF3%3Bn%2C%20L.%2C%20Groenheit%2C%20R.%20and%20Werngren%2C%20J.%20%282024%29.%20%26lt%3Bb%26gt%3BRe%3A%20%26%23x201C%3BAvailability%20of%20drugs%20and%20resistance%20testing%20for%20BPaLM%20regimen%20for%20rifampicin-resistant%20tuberculosis%20in%20Europe%26%23x201D%3B%20by%20Lange%20et%20al.%26lt%3B%5C%2Fb%26gt%3B%20Clinical%20Microbiology%20and%20Infection%20S1198743X24002775%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2024.06.001%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2024.06.001%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Re%3A%20%5Cu2018Availability%20of%20drugs%20and%20resistance%20testing%20for%20BPaLM%20regimen%20for%20rifampicin-resistant%20tuberculosis%20in%20Europe%5Cu2019%20by%20Lange%20et%20al.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inna%22%2C%22lastName%22%3A%22Friesen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Saluzzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%22%2C%22lastName%22%3A%22Groenheit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Anthony%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mathys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%20Maria%22%2C%22lastName%22%3A%22Cirillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Indra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mathys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuliana%22%2C%22lastName%22%3A%22Atanasova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mihaela%22%2C%22lastName%22%3A%22Obrovac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ljiljiana%22%2C%22lastName%22%3A%22%5Cu017dmak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Despo%22%2C%22lastName%22%3A%22Pieridou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%5Cu011bra%22%2C%22lastName%22%3A%22Dvo%5Cu0159%5Cu00e1kov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Troels%20Lilleb%5Cu00e6k%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiina%22%2C%22lastName%22%3A%22Kummik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kadri%22%2C%22lastName%22%3A%22Klaos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanna%22%2C%22lastName%22%3A%22Soini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marjo%22%2C%22lastName%22%3A%22Haanper%5Cu00e4-Heikkinen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silja%22%2C%22lastName%22%3A%22Mentula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ioannidis%22%2C%22lastName%22%3A%22Panayotis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dimitrios%22%2C%22lastName%22%3A%22Papaventsis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%5Cu00c1gnes%22%2C%22lastName%22%3A%22Bakos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vikt%5Cu00f3ria%22%2C%22lastName%22%3A%22Sz%5Cu00e9l%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilla%20Katalin%22%2C%22lastName%22%3A%22L%5Cu0151rinczi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margaret%22%2C%22lastName%22%3A%22Fitzgibbon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Breida%22%2C%22lastName%22%3A%22Boyle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%20Maria%22%2C%22lastName%22%3A%22Cirillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Federico%22%2C%22lastName%22%3A%22Giannoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilva%22%2C%22lastName%22%3A%22Pole%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inga%22%2C%22lastName%22%3A%22Norvai%5Cu0161a%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laima%22%2C%22lastName%22%3A%22Vasiliauskaite%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Perrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catriona%22%2C%22lastName%22%3A%22Deguara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Anthony%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20Torunn%22%2C%22lastName%22%3A%22Mengshoel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ewa%22%2C%22lastName%22%3A%22Augustynowicz-Kope%5Cu0107%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22Macedo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxana%20Mihaela%22%2C%22lastName%22%3A%22Coriu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Igor%22%2C%22lastName%22%3A%22Porvaznik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%5Cu0160pela%22%2C%22lastName%22%3A%22Klemen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Herrera-Le%5Cu00f3n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%22%2C%22lastName%22%3A%22Groenheit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jim%22%2C%22lastName%22%3A%22Werngren%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%226%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2024.06.001%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1198743X24002775%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198743X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-07-17T14%3A23%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22TGPHGG7Y%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Maitre%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMaitre%2C%20T.%2C%20Baulard%2C%20A.%2C%20Aubry%2C%20A.%20and%20Veziris%2C%20N.%20%282024%29.%20%26lt%3Bb%26gt%3BOptimizing%20the%20use%20of%20current%20antituberculosis%20drugs%20to%20overcome%20drug%20resistance%20in%20Mycobacterium%20tuberculosis%26lt%3B%5C%2Fb%26gt%3B.%20Infectious%20Diseases%20Now%20%26lt%3Bi%26gt%3B54%26lt%3B%5C%2Fi%26gt%3B%2C%20104807%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.idnow.2023.104807%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.idnow.2023.104807%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Optimizing%20the%20use%20of%20current%20antituberculosis%20drugs%20to%20overcome%20drug%20resistance%20in%20Mycobacterium%20tuberculosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Maitre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Baulard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2202%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.idnow.2023.104807%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2666991923001690%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2226669919%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-11-13T09%3A44%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22V2XSRDIF%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Maitre%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMaitre%2C%20T.%2C%20Guglielmetti%2C%20L.%2C%20Robert%2C%20J.%2C%20Aubry%2C%20A.%20and%20Veziris%2C%20N.%20%282024%29.%20%26lt%3Bb%26gt%3BAvanc%26%23xE9%3Bes%20dans%20l%26%23x2019%3Bantibioth%26%23xE9%3Brapie%20de%20la%20tuberculose%26lt%3B%5C%2Fb%26gt%3B.%20Rev%20Prat%20%26lt%3Bi%26gt%3B74%26lt%3B%5C%2Fi%26gt%3B%2C%20239%26%23x2013%3B244.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Avanc%5Cu00e9es%20dans%20l%5Cu2019antibioth%5Cu00e9rapie%20de%20la%20tuberculose%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T%22%2C%22lastName%22%3A%22Maitre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-03-19T17%3A06%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22WVC2IXYE%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Campbell%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-22%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCampbell%2C%20J.%20R.%2C%20Brode%2C%20S.%20K.%2C%20Barry%2C%20P.%2C%20Bastos%2C%20M.%20L.%2C%20Bonnet%2C%20M.%2C%20Guglielmetti%2C%20L.%2C%20Kempker%2C%20R.%2C%20Klimuk%2C%20D.%2C%20Labor%26%23xED%3Bn%2C%20R.%20L.%2C%20Milanov%2C%20V.%2C%20Singla%2C%20R.%2C%20Skrahina%2C%20A.%2C%20Trajman%2C%20A.%2C%20Van%20Der%20Werf%2C%20T.%20S.%2C%20Viiklepp%2C%20P.%20and%20Menzies%2C%20D.%20%282023%29.%20%26lt%3Bb%26gt%3BAssociation%20of%20indicators%20of%20extensive%20disease%20and%20rifampin-resistant%20tuberculosis%20treatment%20outcomes%3A%20an%20individual%20participant%20data%20meta-analysis%26lt%3B%5C%2Fb%26gt%3B.%20Thorax%20thorax-2023-220249%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fthorax-2023-220249%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fthorax-2023-220249%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20indicators%20of%20extensive%20disease%20and%20rifampin-resistant%20tuberculosis%20treatment%20outcomes%3A%20an%20individual%20participant%20data%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathon%20R%22%2C%22lastName%22%3A%22Campbell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20K%22%2C%22lastName%22%3A%22Brode%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pennan%22%2C%22lastName%22%3A%22Barry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mayara%20Lisboa%22%2C%22lastName%22%3A%22Bastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maryline%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Russell%22%2C%22lastName%22%3A%22Kempker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dzmitry%22%2C%22lastName%22%3A%22Klimuk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%20Laniado%22%2C%22lastName%22%3A%22Labor%5Cu00edn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vladimir%22%2C%22lastName%22%3A%22Milanov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rupak%22%2C%22lastName%22%3A%22Singla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alena%22%2C%22lastName%22%3A%22Skrahina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anete%22%2C%22lastName%22%3A%22Trajman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tjip%20S%22%2C%22lastName%22%3A%22Van%20Der%20Werf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Piret%22%2C%22lastName%22%3A%22Viiklepp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dick%22%2C%22lastName%22%3A%22Menzies%22%7D%5D%2C%22abstractNote%22%3A%22Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Indicators%20of%20extensive%20disease%5Cu2014acid%20fast%20bacilli%20%28AFB%29%20smear%20positivity%20and%20lung%20cavitation%5Cu2014have%20been%20inconsistently%20associated%20with%20clinical%20rifampin-resistant%5C%2Fmultidrug-resistant%20tuberculosis%20%28RR%5C%2FMDR-TB%29%20outcomes.%20We%20evaluated%20the%20association%20of%20these%20indicators%20with%20end-of-treatment%20outcomes.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20did%20an%20individual%20participant%20data%20meta-analysis%20of%20people%20treated%20for%20RR%5C%2FMDR-TB%20with%20longer%20regimens%20with%20documented%20AFB%20smear%20and%20chest%20radiography%20findings.%20We%20compared%20people%20AFB%20smear-negative%20without%20cavities%20to%20people%3A%20%281%29%20smear-negative%20with%20lung%20cavities%3B%20%282%29%20smear-positive%20without%20lung%20cavities%20and%20%283%29%20AFB%20smear-positive%20with%20lung%20cavities.%20Using%20multivariable%20logistic%20regression%20accounting%20for%20demographic%2C%20treatment%20and%20clinical%20factors%2C%20we%20calculated%20adjusted%20ORs%20%28aOR%29%20for%20any%20unfavourable%20outcome%20%28death%2C%20lost%20to%20follow-up%2C%20failure%5C%2Frecurrence%29%2C%20and%20mortality%20and%20treatment%20failure%5C%2Frecurrence%20alone.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20included%205596%20participants%3B%20included%20participants%20significantly%20differed%20from%20excluded%20participants.%20Overall%2C%20774%20%2813.8%25%29%20were%20AFB%20smear-negative%20without%20cavities%2C%20647%20%2811.6%25%29%20only%20had%20cavities%2C%201424%20%2825.4%25%29%20were%20AFB%20smear-positive%20alone%20and%202751%20%2849.2%25%29%20were%20AFB%20smear-positive%20with%20cavities.%20The%20median%20age%20was%2037%20years%20%28IQR%3A%2028%5Cu201347%29%2C%203580%20%2864%25%29%20were%20male%20and%20686%20%2812.5%25%29%20had%20HIV.%20Compared%20with%20participants%20AFB%20smear-negative%20without%20cavities%2C%20aOR%20%2895%25%20CI%29%20for%20any%20unfavourable%20outcome%20was%201.0%20%280.8%20to%201.4%29%20for%20participants%20smear-negative%20with%20lung%20cavities%2C%201.2%20%280.9%20to%201.5%29%20if%20smear-positive%20without%20cavities%20and%201.6%20%281.3%20to%202.0%29%20if%20AFB%20smear-positive%20with%20lung%20cavities.%20Odds%20were%20only%20significantly%20increased%20for%20mortality%20%281.5%2C%2095%25%20CI%201.1%20to%202.1%29%20and%20failure%5C%2Frecurrence%20%282.2%2C%2095%25%20CI%201.5%20to%203.3%29%20among%20participants%20AFB%20smear-positive%20with%20lung%20cavities.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Only%20the%20combination%20of%20AFB%20smear-positivity%20and%20lung%20cavitation%20was%20associated%20with%20unfavourable%20outcomes%2C%20suggesting%20they%20may%20benefit%20from%20stronger%20regimens.%22%2C%22date%22%3A%222023-12-22%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fthorax-2023-220249%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fthorax.bmj.com%5C%2Flookup%5C%2Fdoi%5C%2F10.1136%5C%2Fthorax-2023-220249%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220040-6376%2C%201468-3296%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-12-31T15%3A24%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22AYT74SVL%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Du%20Cros%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDu%20Cros%2C%20P.%2C%20Greig%2C%20J.%2C%20Alffenaar%2C%20J.-W.%20C.%2C%20Cross%2C%20G.%20B.%2C%20Cousins%2C%20C.%2C%20Berry%2C%20C.%2C%20Khan%2C%20U.%2C%20Phillips%2C%20P.%20P.%20J.%2C%20Vel%26%23xE1%3Bsquez%2C%20G.%20E.%2C%20Furin%2C%20J.%2C%20Spigelman%2C%20M.%2C%20Denholm%2C%20J.%20T.%2C%20Thi%2C%20S.%20S.%2C%20Tiberi%2C%20S.%2C%20Huang%2C%20G.%20K.%20L.%2C%20Marks%2C%20G.%20B.%2C%20Turkova%2C%20A.%2C%20Guglielmetti%2C%20L.%2C%20Chew%2C%20K.%20L.%2C%20Nguyen%2C%20H.%20T.%2C%20Ong%2C%20C.%20W.%20M.%2C%20Brigden%2C%20G.%2C%20Singh%2C%20K.%20P.%2C%20Motta%2C%20I.%2C%20Lange%2C%20C.%2C%20Seddon%2C%20J.%20A.%2C%20Nyang%26%23x2019%3Bwa%2C%20B.-T.%2C%20Maug%2C%20A.%20K.%20J.%2C%20Gler%2C%20M.%20T.%2C%20Dooley%2C%20K.%20E.%2C%20Quelapio%2C%20M.%2C%20Tsogt%2C%20B.%2C%20Menzies%2C%20D.%2C%20Cox%2C%20V.%2C%20Upton%2C%20C.%20M.%2C%20Skrahina%2C%20A.%2C%20McKenna%2C%20L.%2C%20Horsburgh%2C%20C.%20R.%2C%20Dheda%2C%20K.%20and%20Marais%2C%20B.%20J.%20%282023%29.%20%26lt%3Bb%26gt%3BStandards%20for%20clinical%20trials%20for%20treating%20TB%26lt%3B%5C%2Fb%26gt%3B.%20int%20j%20tuberc%20lung%20dis%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%2C%20885%26%23x2013%3B898%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.23.0341%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.23.0341%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Standards%20for%20clinical%20trials%20for%20treating%20TB%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Du%20Cros%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Greig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.-W.%20C.%22%2C%22lastName%22%3A%22Alffenaar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20B.%22%2C%22lastName%22%3A%22Cross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Cousins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Berry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22U.%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%20P.%20J.%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20E.%22%2C%22lastName%22%3A%22Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Furin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Spigelman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20T.%22%2C%22lastName%22%3A%22Denholm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20S.%22%2C%22lastName%22%3A%22Thi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Tiberi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20K.%20L.%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20B.%22%2C%22lastName%22%3A%22Marks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Turkova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20L.%22%2C%22lastName%22%3A%22Chew%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%20T.%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20W.%20M.%22%2C%22lastName%22%3A%22Ong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Brigden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20P.%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Motta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20A.%22%2C%22lastName%22%3A%22Seddon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B-T.%22%2C%22lastName%22%3A%22Nyang%5Cu2019wa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20K.%20J.%22%2C%22lastName%22%3A%22Maug%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20T.%22%2C%22lastName%22%3A%22Gler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20E.%22%2C%22lastName%22%3A%22Dooley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Quelapio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Tsogt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Menzies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20M.%22%2C%22lastName%22%3A%22Upton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Skrahina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22McKenna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20R.%22%2C%22lastName%22%3A%22Horsburgh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Dheda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20J.%22%2C%22lastName%22%3A%22Marais%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20value%2C%20speed%20of%20completion%20and%20robustness%20of%20the%20evidence%20generated%20by%20TB%20treatment%20trials%20could%20be%20improved%20by%20implementing%20standards%20for%20best%20practice.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20METHODS%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%20global%20panel%20of%20experts%20participated%20in%20a%20Delphi%20process%2C%20using%20a%207-point%20Likert%20scale%20%5Cn%20to%20score%20and%20revise%20draft%20standards%20until%20consensus%20was%20reached.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20RESULTS%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Eleven%20standards%20were%20defined%3A%20Standard%201%2C%20high%20quality%20data%20on%20TB%20regimens%20are%20essential%20to%20inform%20clinical%20and%20programmatic%20management%3B%20Standard%202%2C%20the%20research%20questions%20addressed%20by%20TB%20trials%20should%20be%20%5Cn%20relevant%20to%20affected%20communities%2C%20who%20should%20be%20included%20in%20all%20trial%20stages%3B%20Standard%203%2C%20trials%20should%20make%20every%20effort%20to%20be%20as%20inclusive%20as%20possible%3B%20Standard%204%2C%20the%20most%20efficient%20trial%20designs%20should%20be%20considered%20to%20improve%20the%20evidence%20base%20as%20quickly%20and%20cost%20effectively%20as%20possible%2C%20%5Cn%20without%20compromising%20quality%3B%20Standard%205%2C%20trial%20governance%20should%20be%20in%20line%20with%20accepted%20good%20clinical%20practice%3B%20Standard%206%2C%20trials%20should%20investigate%20and%20report%20strategies%20that%20promote%20optimal%20engagement%20in%20care%3B%20Standard%207%2C%20where%20possible%2C%20TB%20trials%20should%20include%20pharmacokinetic%20and%20pharmacodynamic%20%5Cn%20components%3B%20Standard%208%2C%20outcomes%20should%20include%20frequency%20of%20disease%20recurrence%20and%20post-treatment%20sequelae%3B%20Standard%209%2C%20TB%20trials%20should%20aim%20to%20harmonise%20key%20outcomes%20and%20data%20structures%20across%20studies%3B%20Standard%2010%2C%20TB%20trials%20should%20include%20biobanking%3B%20Standard%2011%2C%20treatment%20trials%20should%20%5Cn%20invest%20in%20capacity%20strengthening%20of%20local%20trial%20and%20TB%20programme%20staff.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20CONCLUSION%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20These%20standards%20should%20improve%20the%20efficiency%20and%20effectiveness%20of%20evidence%20generation%2C%20as%20well%20as%20the%20translation%20of%20research%20into%20policy%20and%20practice.%22%2C%22date%22%3A%222023-12-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtld.23.0341%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ingentaconnect.com%5C%2Fcontent%5C%2F10.5588%5C%2Fijtld.23.0341%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221027-3719%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-12-31T15%3A25%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22NLTQM49X%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patil%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-30%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPatil%2C%20S.%20B.%2C%20Tamirat%2C%20M.%2C%20Khazhidinov%2C%20K.%2C%20Ardizzoni%2C%20E.%2C%20Atger%2C%20M.%2C%20Austin%2C%20A.%2C%20Baudin%2C%20E.%2C%20Bekhit%2C%20M.%2C%20Bektasov%2C%20S.%2C%20Berikova%2C%20E.%2C%20Bonnet%2C%20M.%2C%20Caboclo%2C%20R.%2C%20Chaudhry%2C%20M.%2C%20Chavan%2C%20V.%2C%20Cloez%2C%20S.%2C%20Coit%2C%20J.%2C%20Coutisson%2C%20S.%2C%20Dakenova%2C%20Z.%2C%20De%20Jong%2C%20B.%20C.%2C%20Delifer%2C%20C.%2C%20Demaisons%2C%20S.%2C%20Do%2C%20J.%20M.%2C%20Dos%20Santos%20Tozzi%2C%20D.%2C%20Ducher%2C%20V.%2C%20Ferlazzo%2C%20G.%2C%20Gouillou%2C%20M.%2C%20Khan%2C%20U.%2C%20Kunda%2C%20M.%2C%20Lachenal%2C%20N.%2C%20LaHood%2C%20A.%20N.%2C%20Lecca%2C%20L.%2C%20Mazmanian%2C%20M.%2C%20McIlleron%2C%20H.%2C%20Moreau%2C%20M.%2C%20Moschioni%2C%20M.%2C%20Nahid%2C%20P.%2C%20Osso%2C%20E.%2C%20Oyewusi%2C%20L.%2C%20Panda%2C%20S.%2C%20P%26%23xE2%3Bquet%2C%20A.%2C%20Thuong%20Huu%2C%20P.%2C%20Pichon%2C%20L.%2C%20Rich%2C%20M.%20L.%2C%20Rupasinghe%2C%20P.%2C%20Salahuddin%2C%20N.%2C%20Sanchez%20Garavito%2C%20E.%2C%20Seung%2C%20K.%20J.%2C%20Vel%26%23xE1%3Bsquez%2C%20G.%20E.%2C%20Vallet%2C%20M.%2C%20Varaine%2C%20F.%2C%20Yuya-Septoh%2C%20F.%20J.%2C%20Mitnick%2C%20C.%20D.%20and%20Guglielmetti%2C%20L.%20%282023%29.%20%26lt%3Bb%26gt%3BEvaluating%20newly%20approved%20drugs%20in%20combination%20regimens%20for%20multidrug-resistant%20tuberculosis%20with%20fluoroquinolone%20resistance%20%28endTB-Q%29%3A%20study%20protocol%20for%20a%20multi-country%20randomized%20controlled%20trial%26lt%3B%5C%2Fb%26gt%3B.%20Trials%20%26lt%3Bi%26gt%3B24%26lt%3B%5C%2Fi%26gt%3B%2C%20773%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13063-023-07701-6%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13063-023-07701-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evaluating%20newly%20approved%20drugs%20in%20combination%20regimens%20for%20multidrug-resistant%20tuberculosis%20with%20fluoroquinolone%20resistance%20%28endTB-Q%29%3A%20study%20protocol%20for%20a%20multi-country%20randomized%20controlled%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20B.%22%2C%22lastName%22%3A%22Patil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Tamirat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Khazhidinov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Ardizzoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Atger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Baudin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Bekhit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Bektasov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Berikova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Caboclo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Chaudhry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Chavan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Cloez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Coit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Coutisson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Z.%22%2C%22lastName%22%3A%22Dakenova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20C.%22%2C%22lastName%22%3A%22De%20Jong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Delifer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Demaisons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20M.%22%2C%22lastName%22%3A%22Do%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Dos%20Santos%20Tozzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Ducher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Ferlazzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Gouillou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22U.%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Kunda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Lachenal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20N.%22%2C%22lastName%22%3A%22LaHood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Lecca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Mazmanian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22McIlleron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Moschioni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Nahid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Osso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Oyewusi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Panda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22P%5Cu00e2quet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Thuong%20Huu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Pichon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20L.%22%2C%22lastName%22%3A%22Rich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Rupasinghe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Salahuddin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Sanchez%20Garavito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20J.%22%2C%22lastName%22%3A%22Seung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20E.%22%2C%22lastName%22%3A%22Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Vallet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Varaine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%20J.%22%2C%22lastName%22%3A%22Yuya-Septoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20D.%22%2C%22lastName%22%3A%22Mitnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Treatment%20for%20fluoroquinolone-resistant%20multidrug-resistant%5C%2Frifampicin-resistant%20tuberculosis%20%28pre-XDR%20TB%29%20often%20lasts%20longer%20than%20treatment%20for%20less%20resistant%20strains%2C%20yields%20worse%20efficacy%20results%2C%20and%20causes%20substantial%20toxicity.%20The%20newer%20anti-tuberculosis%20drugs%2C%20bedaquiline%20and%20delamanid%2C%20and%20repurposed%20drugs%20clofazimine%20and%20linezolid%2C%20show%20great%20promise%20for%20combination%20in%20shorter%2C%20less-toxic%2C%20and%20effective%20regimens.%20To%20date%2C%20there%20has%20been%20no%20randomized%2C%20internally%20and%20concurrently%20controlled%20trial%20of%20a%20shorter%2C%20all-oral%20regimen%20comprising%20these%20newer%20and%20repurposed%20drugs%20sufficiently%20powered%20to%20produce%20results%20for%20pre-XDR%20TB%20patients.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20endTB-Q%20is%20a%20phase%20III%2C%20multi-country%2C%20randomized%2C%20controlled%2C%20parallel%2C%20open-label%20clinical%20trial%20evaluating%20the%20efficacy%20and%20safety%20of%20a%20treatment%20strategy%20for%20patients%20with%20pre-XDR%20TB.%20Study%20participants%20are%20randomized%202%3A1%20to%20experimental%20or%20control%20arms%2C%20respectively.%20The%20experimental%20arm%20contains%20bedaquiline%2C%20linezolid%2C%20clofazimine%2C%20and%20delamanid.%20The%20control%20comprises%20the%20contemporaneous%20WHO%20standard%20of%20care%20for%20pre-XDR%20TB.%20Experimental%20arm%20duration%20is%20determined%20by%20a%20composite%20of%20smear%20microscopy%20and%20chest%20radiographic%20imaging%20at%20baseline%20and%20re-evaluated%20at%206%5Cu00a0months%20using%20sputum%20culture%20results%3A%20participants%20with%20less%20extensive%20disease%20receive%206%5Cu00a0months%20and%20participants%20with%20more%20extensive%20disease%20receive%209%5Cu00a0months%20of%20treatment.%20Randomization%20is%20stratified%20by%20country%20and%20by%20participant%20extent-of-TB-disease%20phenotype%20defined%20according%20to%20screening%5C%2Fbaseline%20characteristics.%20Study%20participation%20lasts%20up%20to%20104%5Cu00a0weeks%20post%20randomization.%20The%20primary%20objective%20is%20to%20assess%20whether%20the%20efficacy%20of%20experimental%20regimens%20at%2073%5Cu00a0weeks%20is%20non-inferior%20to%20that%20of%20the%20control.%20A%20sample%20size%20of%20324%20participants%20across%202%20arms%20affords%20at%20least%2080%25%20power%20to%20show%20the%20non-inferiority%2C%20with%20a%20one-sided%20alpha%20of%200.025%20and%20a%20non-inferiority%20margin%20of%2012%25%2C%20against%20the%20control%20in%20both%20modified%20intention-to-treat%20and%20per-protocol%20populations.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Discussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20internally%20controlled%20study%20of%20shortened%20treatment%20for%20pre-XDR%20TB%20will%20provide%20urgently%20needed%20data%20and%20evidence%20for%20clinical%20and%20policy%20decision-making%20around%20the%20treatment%20of%20pre-XDR%20TB%20with%20a%20four-drug%2C%20all-oral%2C%20shortened%20regimen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Trial%20registration%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20ClinicalTrials.Gov%20NCT03896685.%20Registered%20on%201%20April%202018%3B%20the%20record%20was%20last%20updated%20for%20study%20protocol%20version%204.3%20on%2017%20March%202023.%22%2C%22date%22%3A%222023-11-30%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13063-023-07701-6%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Ftrialsjournal.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs13063-023-07701-6%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221745-6215%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-12-31T15%3A25%3A49Z%22%7D%7D%2C%7B%22key%22%3A%229EZSBXQY%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sahal%20et%20al.%22%2C%22parsedDate%22%3A%222023-10-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSahal%2C%20M.%20R.%2C%20Senelle%2C%20G.%2C%20La%2C%20K.%2C%20Panda%2C%20T.%20W.%2C%20Taura%2C%20D.%20W.%2C%20Guyeux%2C%20C.%2C%20Cambau%2C%20E.%20and%20Sola%2C%20C.%20%282023%29.%20%26lt%3Bb%26gt%3BMycobacterium%20tuberculosis%20complex%20drug-resistance%2C%20phylogenetics%2C%20and%20evolution%20in%20Nigeria%3A%20Comparison%20with%20Ghana%20and%20Cameroon%26lt%3B%5C%2Fb%26gt%3B%20Ed.%20Rayner%2C%20S.%20PLoS%20Negl%20Trop%20Dis%20%26lt%3Bi%26gt%3B17%26lt%3B%5C%2Fi%26gt%3B%2C%20e0011619%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0011619%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0011619%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mycobacterium%20tuberculosis%20complex%20drug-resistance%2C%20phylogenetics%2C%20and%20evolution%20in%20Nigeria%3A%20Comparison%20with%20Ghana%20and%20Cameroon%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammed%20Rabiu%22%2C%22lastName%22%3A%22Sahal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaetan%22%2C%22lastName%22%3A%22Senelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22La%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tukur%20Wada%22%2C%22lastName%22%3A%22Panda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dalha%20Wada%22%2C%22lastName%22%3A%22Taura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Guyeux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Sola%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Rayner%22%7D%5D%2C%22abstractNote%22%3A%22In%20this%20article%2C%20we%20provide%20an%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20in-depth%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20analysis%20on%20the%20drug-resistance%20phenotypic%20characteristics%20of%20a%20cohort%20of%20325%20tuberculosis%20and%20characterize%20by%20Whole%20Genome%20Sequencing%2024%20isolates%20from%20Nigeria%20belonging%20to%20L4%2C%20L5%20and%20L6.%20Our%20results%20suggest%20an%20alarming%20rate%20of%20drug-resistance%20of%20the%20L4.6.2.2%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mycobacterium%20tuberculosis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20complex%20%28MTBC%29%20lineage%20and%20a%20high%20diversity%20of%20L5.%20We%20compiled%20these%20new%20Sequence%20Read%20Archives%20%28SRAs%29%20to%20previously%20published%20ones%20from%20available%20Bioprojects%20run%20in%20Nigeria.%20We%20performed%20RAxML%20phylogenetic%20reconstructions%20of%20larger%20samples%20that%20include%20public%20NCBI%20SRAs%20from%20some%20neighboring%20countries%20%28Cameroon%2C%20Ghana%29.%20To%20confront%20phylogenetic%20reconstruction%20to%20metadata%2C%20we%20used%20a%20new%20proprietary%20database%20named%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20TB-Annotator%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20We%20show%20that%20L5%20genomes%20in%20Northern%20Nigeria%20belong%20to%20new%20clades%20as%20the%20ones%20described%20until%20now%20and%20allow%20an%20update%20of%20the%20taxonomy%20of%20L5.%20In%20addition%2C%20we%20describe%20the%20L4.6.2.2%20lineage%20in%20Nigeria%2C%20Cameroon%20and%20Ghana.%20We%20provide%20computations%20on%20the%20likely%20divergence%20time%20of%20L4.6.2.2%20and%20suggest%20a%20new%20hypothesis%20concerning%20its%20origin.%20Finally%20we%20provide%20a%20short%20overview%20on%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20bovis%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20diversity%20in%20Nigeria.%20This%20study%20constitutes%20a%20baseline%20knowledge%20on%20the%20global%20genomic%20diversity%2C%20phylogeography%20and%20phylodynamics%20of%20MTBC%20in%20Nigeria%2C%20as%20well%20as%20on%20the%20natural%20history%20of%20this%20largely%20ignored%20but%20densely%20populated%20country%20of%20Africa.%20These%20results%20highlight%20the%20need%20of%20sequencing%20additional%20MTBC%20genomes%20in%20Nigeria%20and%20more%20generally%20in%20West-Africa%2C%20both%20for%20public%20health%20and%20for%20academic%20reasons.%20The%20likelihood%20of%20replacement%20of%20L5-L6%20by%20L4.6.2.2%20isolates%2C%20leave%20potentially%20little%20time%20to%20gather%20historical%20knowledge%20informative%20on%20the%20ancient%20history%20of%20tuberculosis%20in%20West-Africa.%22%2C%22date%22%3A%222023-10-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0011619%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pntd.0011619%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221935-2735%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-12-31T15%3A29%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22CUDV3QRA%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22G%5Cu00fcnther%20et%20al.%22%2C%22parsedDate%22%3A%222023-05-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BG%26%23xFC%3Bnther%2C%20G.%2C%20Guglielmetti%2C%20L.%2C%20Leu%2C%20C.%2C%20van%20Leth%2C%20F.%20and%20Lange%2C%20C.%20%282023%29.%20%26lt%3Bb%26gt%3BRelative%20cost%20of%20multidrug-resistant%20TB%20medicines%20in%20Europe%26lt%3B%5C%2Fb%26gt%3B.%20The%20International%20Journal%20of%20Tuberculosis%20and%20Lung%20Disease%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%2C%20341%26%23x2013%3B344%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.23.0026%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.23.0026%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Relative%20cost%20of%20multidrug-resistant%20TB%20medicines%20in%20Europe%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Leu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22van%20Leth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lange%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023-05-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtld.23.0026%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-06-28T12%3A40%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22CPD8NT5H%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Campbell%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCampbell%2C%20J.%20R.%2C%20Chan%2C%20E.%20D.%2C%20Anderson%2C%20L.%20F.%2C%20Bonnet%2C%20M.%2C%20Brode%2C%20S.%20K.%2C%20Cegielski%2C%20J.%20P.%2C%20Guglielmetti%2C%20L.%2C%20Singla%2C%20R.%2C%20Fox%2C%20G.%20J.%2C%20Skrahina%2C%20A.%2C%20Rodrigues%2C%20D.%2C%20Kuksa%2C%20L.%2C%20Viiklepp%2C%20P.%20and%20Menzies%2C%20D.%20%282023%29.%20%26lt%3Bb%26gt%3BAssociation%20of%20smoking%20and%20alcohol%20use%20with%20rifampin-resistant%20TB%20treatment%20outcomes%26lt%3B%5C%2Fb%26gt%3B.%20The%20International%20Journal%20of%20Tuberculosis%20and%20Lung%20Disease%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%2C%20338%26%23x2013%3B340%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.22.0678%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.22.0678%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20smoking%20and%20alcohol%20use%20with%20rifampin-resistant%20TB%20treatment%20outcomes%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20R.%22%2C%22lastName%22%3A%22Campbell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20D.%22%2C%22lastName%22%3A%22Chan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%20F.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20K.%22%2C%22lastName%22%3A%22Brode%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20P.%22%2C%22lastName%22%3A%22Cegielski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Singla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20J.%22%2C%22lastName%22%3A%22Fox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Skrahina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Rodrigues%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Kuksa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Viiklepp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Menzies%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023-04-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtld.22.0678%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-06-28T12%3A41%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22WNCRMSUT%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guthmann%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-23%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuthmann%2C%20J.-P.%2C%20Fraisse%2C%20P.%2C%20Bonnet%2C%20I.%20and%20Robert%2C%20J.%20%282023%29.%20%26lt%3Bb%26gt%3BActive%20tuberculosis%20screening%20among%20the%20displaced%20population%20fleeing%20Ukraine%2C%20France%2C%20February%20to%20October%202022%26lt%3B%5C%2Fb%26gt%3B.%20Eurosurveillance%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2807%5C%2F1560-7917.ES.2023.28.12.2300155%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2807%5C%2F1560-7917.ES.2023.28.12.2300155%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Active%20tuberculosis%20screening%20among%20the%20displaced%20population%20fleeing%20Ukraine%2C%20France%2C%20February%20to%20October%202022%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Paul%22%2C%22lastName%22%3A%22Guthmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Fraisse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%5D%2C%22abstractNote%22%3A%22Persons%20fleeing%20Ukraine%20since%20February%202022%20have%20potentially%20higher%20risk%20of%20tuberculosis%20%28TB%29%20vs%20all%20European%20Union%20countries.%20Interest%20of%20active%20TB%20screening%20among%20this%20population%20is%20debated%20and%20not%20widely%20adopted.%20In%20this%20screening%20intervention%20by%20a%20network%20of%20TB%20centres%20in%20France%2C%20the%20number%20needed%20to%20screen%20%28NNS%29%20was%20862%20to%20find%20one%20case.%20This%20experience%20shows%20that%20this%20strategy%20may%20be%20relevant%20for%20TB%20control%20in%20situations%20of%20massive%20displacement%2C%20similar%20to%20that%20following%20the%20Russian%20invasion.%22%2C%22date%22%3A%222023-03-23%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.2807%5C%2F1560-7917.ES.2023.28.12.2300155%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.eurosurveillance.org%5C%2Fcontent%5C%2F10.2807%5C%2F1560-7917.ES.2023.28.12.2300155%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221560-7917%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-03-27T15%3A02%3A22Z%22%7D%7D%2C%7B%22key%22%3A%22UJGH7XG2%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Aubry%20and%20Veziris%22%2C%22parsedDate%22%3A%222023-03-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAubry%2C%20A.%20and%20Veziris%2C%20N.%20%282023%29.%20%26lt%3Bb%26gt%3BLa%20tuberculose%2C%20l%26%23x2019%3Bune%20des%20plus%20anciennes%20maladies%20infectieuses%26%23x202F%3B%3A%20quelles%20avanc%26%23xE9%3Bes%20r%26%23xE9%3Bcentes%20majeures%26%23x202F%3B%3F%26lt%3B%5C%2Fb%26gt%3B%20Med%20Sci%20%28Paris%29%20%26lt%3Bi%26gt%3B39%26lt%3B%5C%2Fi%26gt%3B%2C%20203%26%23x2013%3B204%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1051%5C%2Fmedsci%5C%2F2023054%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1051%5C%2Fmedsci%5C%2F2023054%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22La%20tuberculose%2C%20l%5Cu2019une%20des%20plus%20anciennes%20maladies%20infectieuses%20%3A%20quelles%20avanc%5Cu00e9es%20r%5Cu00e9centes%20majeures%20%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%5D%2C%22abstractNote%22%3A%22m%26eacute%3Bdecine%5C%2Fsciences%20%28M%5C%2FS%29%2C%20revue%20internationale%20dans%20le%20domaine%20de%20la%20recherche%20biologique%2C%20m%26eacute%3Bdicale%20et%20en%20sant%26eacute%3B%22%2C%22date%22%3A%222023%5C%2F03%5C%2F01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1051%5C%2Fmedsci%5C%2F2023054%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.medecinesciences.org%5C%2Farticles%5C%2Fmedsci%5C%2Fabs%5C%2F2023%5C%2F03%5C%2Fmsc230068%5C%2Fmsc230068.html%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220767-0974%2C%201958-5381%22%2C%22language%22%3A%22fr%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-06-28T12%3A27%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22GXEAIVT5%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Masini%20et%20al.%22%2C%22parsedDate%22%3A%222023-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMasini%2C%20T.%2C%20Furin%2C%20J.%2C%20Udwadia%2C%20Z.%20and%20Guglielmetti%2C%20L.%20%282023%29.%20%26lt%3Bb%26gt%3BOptimal%20management%20of%20drug-resistant%20tuberculosis%3A%20Can%20India%20lead%20the%20way%3F%26lt%3B%5C%2Fb%26gt%3B%20Indian%20Journal%20of%20Medical%20Research%20%26lt%3Bi%26gt%3B157%26lt%3B%5C%2Fi%26gt%3B%2C%20220%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4103%5C%2Fijmr.ijmr_300_23%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4103%5C%2Fijmr.ijmr_300_23%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Optimal%20management%20of%20drug-resistant%20tuberculosis%3A%20Can%20India%20lead%20the%20way%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiziana%22%2C%22lastName%22%3A%22Masini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Furin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zarir%22%2C%22lastName%22%3A%22Udwadia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%5D%2C%22abstractNote%22%3A%22An%20abstract%20is%20unavailable.%22%2C%22date%22%3A%22Feb-Mar%202023%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.4103%5C%2Fijmr.ijmr_300_23%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.lww.com%5C%2Fijmr%5C%2FFulltext%5C%2F2023%5C%2F02000%5C%2FOptimal_management_of_drug_resistant_tuberculosis_.17.aspx%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220971-5916%20%28Print%29%22%2C%22language%22%3A%22en-US%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-06-28T12%3A40%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22Q5BS6SYV%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dom%5Cu00ednguez%20et%20al.%22%2C%22parsedDate%22%3A%222023-02-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDom%26%23xED%3Bnguez%2C%20Jos%26%23xE9%3B%2C%20Boeree%2C%20M.%20J.%2C%20Cambau%2C%20E.%2C%20Chesov%2C%20D.%2C%20Conradie%2C%20F.%2C%20Cox%2C%20V.%2C%20Dheda%2C%20K.%2C%20Dudnyk%2C%20A.%2C%20Farhat%2C%20M.%20R.%2C%20Gagneux%2C%20S.%2C%20Grobusch%2C%20M.%20P.%2C%20Gr%26%23xF6%3Bschel%2C%20M.%20I.%2C%20Guglielmetti%2C%20L.%2C%20Kontsevaya%2C%20I.%2C%20Lange%2C%20B.%2C%20van%20Leth%2C%20F.%2C%20Lienhardt%2C%20C.%2C%20Mandalakas%2C%20Anna%20M%2C%20Maurer%2C%20F.%20P.%2C%20Merker%2C%20M.%2C%20Miotto%2C%20P.%2C%20Molina-Moya%2C%20B.%2C%20Morel%2C%20F.%2C%20Niemann%2C%20S.%2C%20Veziris%2C%20N.%2C%20Whitelaw%2C%20A.%2C%20Horsburgh%2C%20Charles%20R%2C%20Lange%2C%20C.%2C%20Dom%26%23xED%3Bnguez%2C%20Jose%2C%20Boeree%2C%20M.%20J.%2C%20Cambau%2C%20E.%2C%20Chesov%2C%20D.%2C%20Conradie%2C%20F.%2C%20Cox%2C%20V.%2C%20Dheda%2C%20K.%2C%20Dudnyk%2C%20A.%2C%20Farhat%2C%20M.%20R.%2C%20Gagneux%2C%20S.%2C%20Grobusch%2C%20M.%20P.%2C%20Gr%26%23xF6%3Bschel%2C%20M.%20I.%2C%20Guglielmetti%2C%20L.%2C%20Kontsevaya%2C%20I.%2C%20Lange%2C%20B.%2C%20van%20Leth%2C%20F.%2C%20Lienhardt%2C%20C.%2C%20Mandalakas%2C%20Anna%20Maria%2C%20Maurer%2C%20F.%2C%20Merker%2C%20M.%2C%20Miotto%2C%20P.%2C%20Molina-Moya%2C%20B.%2C%20Morel%2C%20F.%2C%20Niemann%2C%20S.%2C%20Veziris%2C%20N.%2C%20Whitelaw%2C%20A.%2C%20Horsburgh%2C%20Charles%20Robert%20and%20Lange%2C%20C.%20%282023%29.%20%26lt%3Bb%26gt%3BClinical%20implications%20of%20molecular%20drug%20resistance%20testing%20for%20Mycobacterium%20tuberculosis%3A%20a%202023%20TBnet%5C%2FRESIST-TB%20consensus%20statement%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Infectious%20Diseases%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2822%2900875-1%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2822%2900875-1%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20implications%20of%20molecular%20drug%20resistance%20testing%20for%20Mycobacterium%20tuberculosis%3A%20a%202023%20TBnet%5C%2FRESIST-TB%20consensus%20statement%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%22%2C%22lastName%22%3A%22Dom%5Cu00ednguez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20J%22%2C%22lastName%22%3A%22Boeree%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dumitru%22%2C%22lastName%22%3A%22Chesov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Conradie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivian%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keertan%22%2C%22lastName%22%3A%22Dheda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrii%22%2C%22lastName%22%3A%22Dudnyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maha%20R%22%2C%22lastName%22%3A%22Farhat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Gagneux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20P%22%2C%22lastName%22%3A%22Grobusch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20I%22%2C%22lastName%22%3A%22Gr%5Cu00f6schel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irina%22%2C%22lastName%22%3A%22Kontsevaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22van%20Leth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Lienhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20M%22%2C%22lastName%22%3A%22Mandalakas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%20P%22%2C%22lastName%22%3A%22Maurer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Merker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paolo%22%2C%22lastName%22%3A%22Miotto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Molina-Moya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Whitelaw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20R%22%2C%22lastName%22%3A%22Horsburgh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%22%2C%22lastName%22%3A%22Dom%5Cu00ednguez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20J.%22%2C%22lastName%22%3A%22Boeree%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dumitru%22%2C%22lastName%22%3A%22Chesov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Conradie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivian%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keertan%22%2C%22lastName%22%3A%22Dheda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrii%22%2C%22lastName%22%3A%22Dudnyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maha%20R.%22%2C%22lastName%22%3A%22Farhat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Gagneux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20P.%22%2C%22lastName%22%3A%22Grobusch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20I.%22%2C%22lastName%22%3A%22Gr%5Cu00f6schel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irina%22%2C%22lastName%22%3A%22Kontsevaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22van%20Leth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Lienhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20Maria%22%2C%22lastName%22%3A%22Mandalakas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Maurer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Merker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paolo%22%2C%22lastName%22%3A%22Miotto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Molina-Moya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Whitelaw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20Robert%22%2C%22lastName%22%3A%22Horsburgh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%5D%2C%22abstractNote%22%3A%22Drug-resistant%20tuberculosis%20is%20a%20substantial%20health-care%20concern%20worldwide.%20Despite%20culture-based%20methods%20being%20considered%20the%20gold%20standard%20for%20drug%20susceptibility%20testing%2C%20molecular%20methods%20provide%20rapid%20information%20about%20the%20Mycobacterium%20tuberculosis%20mutations%20associated%20with%20resistance%20to%20anti-tuberculosis%20drugs.%20This%20consensus%20document%20was%20developed%20on%20the%20basis%20of%20a%20comprehensive%20literature%20search%2C%20by%20the%20TBnet%20and%20RESIST-TB%20networks%2C%20about%20reporting%20standards%20for%20the%20clinical%20use%20of%20molecular%20drug%20susceptibility%20testing.%20Review%20and%20the%20search%20for%20evidence%20included%20hand-searching%20journals%20and%20searching%20electronic%20databases.%20The%20panel%20identified%20studies%20that%20linked%20mutations%20in%20genomic%20regions%20of%20M%20tuberculosis%20with%20treatment%20outcome%20data.%20Implementation%20of%20molecular%20testing%20for%20the%20prediction%20of%20drug%20resistance%20in%20M%20tuberculosis%20is%20key.%20Detection%20of%20mutations%20in%20clinical%20isolates%20has%20implications%20for%20the%20clinical%20management%20of%20patients%20with%20multidrug-resistant%20or%20rifampicin-resistant%20tuberculosis%2C%20especially%20in%20situations%20when%20phenotypic%20drug%20susceptibility%20testing%20is%20not%20available.%20A%20multidisciplinary%20team%20including%20clinicians%2C%20microbiologists%2C%20and%20laboratory%20scientists%20reached%20a%20consensus%20on%20key%20questions%20relevant%20to%20molecular%20prediction%20of%20drug%20susceptibility%20or%20resistance%20to%20M%20tuberculosis%2C%20and%20their%20implications%20for%20clinical%20practice.%20This%20consensus%20document%20should%20help%20clinicians%20in%20the%20management%20of%20patients%20with%20tuberculosis%2C%20providing%20guidance%20for%20the%20design%20of%20treatment%20regimens%20and%20optimising%20outcomes.%22%2C%22date%22%3A%222023-02-28%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS1473-3099%2822%2900875-1%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1473309922008751%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221473-3099%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-03-10T14%3A55%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22CVEKMV76%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Barbier%20et%20al.%22%2C%22parsedDate%22%3A%222023-02-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBarbier%2C%20E.%2C%20Fouchet%2C%20T.%2C%20Hartmann%2C%20A.%2C%20Cambau%2C%20E.%2C%20Mougari%2C%20F.%2C%20Dubois%2C%20C.%2C%20Lubetzki%2C%20M.%20and%20Rochelet%2C%20M.%20%282023%29.%20%26lt%3Bb%26gt%3BRapid%20electrochemical%20detection%20of%20Mycobacterium%20tuberculosis%20in%20sputum%20by%20measuring%20Ag85%20activity%20with%20disposable%20carbon%20sensors%26lt%3B%5C%2Fb%26gt%3B.%20Talanta%20%26lt%3Bi%26gt%3B253%26lt%3B%5C%2Fi%26gt%3B%2C%20123927%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.talanta.2022.123927%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.talanta.2022.123927%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rapid%20electrochemical%20detection%20of%20Mycobacterium%20tuberculosis%20in%20sputum%20by%20measuring%20Ag85%20activity%20with%20disposable%20carbon%20sensors%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Barbier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Th%5Cu00e9o%22%2C%22lastName%22%3A%22Fouchet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Hartmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cl%5Cu00e9ment%22%2C%22lastName%22%3A%22Dubois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maurice%22%2C%22lastName%22%3A%22Lubetzki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Murielle%22%2C%22lastName%22%3A%22Rochelet%22%7D%5D%2C%22abstractNote%22%3A%22An%20electrochemical%20assay%20for%20the%20detection%20of%20the%20enzymatic%20activity%20of%20the%20antigen%2085%20%28Ag85%29%20tuberculosis%20%28TB%29%20biomarker%20was%20developed%20and%20evaluated%20for%20the%20qualitative%20detection%20of%20Mycobacterium%20tuberculosis%20in%20decontaminated%20sputum.%20For%20this%20purpose%2C%20the%20electroactive%20properties%20of%20both%20synthetic%20p-aminophenyl-6-O-octanoyl-3-d-glucopyranoside%20%28p-APOG%29%20substrate%20and%20p-aminophenyl-6-3-d-glucopyranoside%20%28p-APG%29%20product%20released%20after%20the%20removal%20of%20the%20octanoyl%20fatty%20acid%20by%20the%20Ag85%20were%20investigated%20with%20disposable%20carbon%20screen-printed%20electrodes%20by%20cyclic%20voltammetry.%20Since%20specific%20anodic%20responses%20were%20obtained%20for%20the%20p-APOG%20substrate%20and%20the%20p-APG%20product%2C%20the%20intensity%20of%20the%20oxidation%20peak%20of%20the%20p-APG%20%28E%5Cu00a0%3D%5Cu00a0%2B%200.35%5Cu00a0V%20vs.%20Ag%5C%2FAgCl%29%20was%20selected%20as%20the%20analytical%20response%20for%20the%20detection%20of%20the%20Ag85%20acyltransferase%20activity.%20Once%20the%20proof%20of%20concept%20of%20the%20Ag85%20electrochemical%20assay%20was%20validated%20with%20a%20commercially-available%20Ag85B%20protein%2C%20its%20specificity%20was%20further%20assessed%20by%20analyzing%20pure%20cultures%20of%20various%20bacteria%20including%20tuberculous%20and%20non-tuberculous%20mycobacteria%20as%20well%20as%20different%20species%20found%20in%20patients%26%23039%3B%20sputum.%20Finally%2C%20with%20a%20specificity%20of%2078%25%20and%20a%20sensitivity%20of%2089%25%2C%20the%20method%20was%20successfully%20compared%20to%20microscopy%20and%20culture%20routine%20tests%20for%20TB%20testing%20in%2036%20frozen%20fluidized%20and%20decontaminated%20sputum.%20This%20suggests%20that%20owing%20to%20its%20convenience%2C%20rapidity%2C%20low-cost%20and%20portability%2C%20the%20reported%20Ag85%20electrochemical%20assay%20is%20a%20promising%20tool%20to%20screen%20patients%20for%20TB.%22%2C%22date%22%3A%222023-02-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.talanta.2022.123927%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0039914022007238%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220039-9140%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-12-28T16%3A13%3A06Z%22%7D%7D%2C%7B%22key%22%3A%226W5JQ546%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Khan%20and%20Guglielmetti%22%2C%22parsedDate%22%3A%222023-01-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKhan%2C%20U.%20and%20Guglielmetti%2C%20L.%20%282023%29.%20%26lt%3Bb%26gt%3BTailored%20TPT%20for%20drug-resistant%20TB%20-%20promoting%20equity%20and%20access%20to%20optimal%20care%26lt%3B%5C%2Fb%26gt%3B.%20Int%20J%20Tuberc%20Lung%20Dis%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%2C%2089b%26%23x2013%3B890%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.22.0538%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.22.0538%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Tailored%20TPT%20for%20drug-resistant%20TB%20-%20promoting%20equity%20and%20access%20to%20optimal%20care%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22U.%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023-01-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtld.22.0538%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221815-7920%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-03-10T14%3A58%3A55Z%22%7D%7D%2C%7B%22key%22%3A%2227ERGIBY%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22G%5Cu00fcnther%20et%20al.%22%2C%22parsedDate%22%3A%222023-01-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BG%26%23xFC%3Bnther%2C%20G.%2C%20Guglielmetti%2C%20L.%2C%20Leu%2C%20C.%2C%20Lange%2C%20C.%2C%20van%20Leth%2C%20F.%2C%20Hasan%20Hafizi%2C%20Khachatryan%2C%20N.%2C%20Aroyan%2C%20H.%2C%20Kabasakalyan%2C%20E.%2C%20Knappik%2C%20M.%2C%20Skrahina%2C%20A.%2C%20Klimuk%2C%20D.%2C%20Nikolenka%2C%20A.%2C%20Muylle%2C%20I.%2C%20Milanov%2C%20V.%2C%20Velkovska%2C%20D.%2C%20Tarinska%2C%20N.%2C%20Bachiyska%2C%20E.%2C%20Jankovic%2C%20M.%2C%20Pieridou%2C%20D.%2C%20Adamide%2C%20T.%2C%20Nicolaou%2C%20N.%2C%20Vasakova%2C%20M.%2C%20Sukholytka%2C%20M.%2C%20Kopeck%26%23xE0%3B%2C%20E.%2C%20Folkvardsen%2C%20D.%20B.%2C%20Svensson%2C%20E.%2C%20Danilovits%2C%20M.%2C%20Kummik%2C%20T.%2C%20Vasankari%2C%20T.%2C%20Fr%26%23xE9%3Bchet-Jachym%2C%20M.%2C%20Nahmiash%2C%20A.%2C%20Togonidze%2C%20T.%2C%20Avaliani%2C%20Z.%2C%20Kinkladze%2C%20I.%2C%20Aspindzelashvili%2C%20R.%2C%20Bichashvili%2C%20T.%2C%20Losaberidze%2C%20G.%2C%20Merabishvili%2C%20T.%2C%20Kalsdorf%2C%20B.%2C%20Manika%2C%20K.%2C%20Tsiakitzis%2C%20K.%2C%20Bakos%2C%20A.%2C%20%26%23xC6%3Bgisd%26%23xF3%3Bttir%2C%20T.%20R.%2C%20Michelsen%2C%20G.%20S.%2C%20Karlsd%26%23xF3%3Bttir%2C%20K.%2C%20McLaughlin%2C%20A.-M.%2C%20Fitzgibbon%2C%20M.%2C%20Chemtob%2C%20D.%2C%20Codecasa%2C%20L.%20R.%2C%20Ferrarese%2C%20M.%2C%20Torri%2C%20S.%2C%20Gjocaj%2C%20M.%2C%20Kuksa%2C%20L.%2C%20Davidaviciene%2C%20E.%2C%20Wirtz%2C%20G.%2C%20Perrin%2C%20M.%2C%20Asciak%2C%20A.%20P.%2C%20Chesov%2C%20D.%2C%20de%20Lange%2C%20W.%2C%20Akkerman%2C%20O.%2C%20Poposka%2C%20B.%20I.%2C%20Mack%2C%20U.%2C%20Jensenius%2C%20M.%2C%20Kvalvik%2C%20L.%2C%20Mengshoel%2C%20A.%20T.%2C%20Kruczak%2C%20K.%2C%20Duarte%2C%20R.%2C%20Ribeiro%2C%20N.%2C%20Ibraim%2C%20E.%2C%20Kaluzhenina%2C%20A.%2C%20Barkanova%2C%20O.%2C%20Pesut%2C%20D.%2C%20Solovic%2C%20I.%2C%20Svetina%2C%20P.%2C%20Souza-Galv%26%23xE3%3Bo%2C%20M.-L.%20de%2C%20Millet%2C%20J.-P.%2C%20Casas%2C%20X.%2C%20Vives%2C%20M.%2C%20Bruchfeld%2C%20J.%2C%20Dalemo%2C%20P.%2C%20Jonsson%2C%20J.%2C%20Aeschbacher%2C%20K.%2C%20Keller%2C%20P.%2C%20%26%23xD6%3Bzkara%2C%20S.%2C%20Tiberi%2C%20S.%2C%20Chen%2C%20C.%2C%20Terleeva%2C%20Y.%20and%20Dudnyk%2C%20A.%20%282023%29.%20%26lt%3Bb%26gt%3BAvailability%20and%20costs%20of%20medicines%20for%20the%20treatment%20of%20tuberculosis%20in%20Europe%26lt%3B%5C%2Fb%26gt%3B.%20Clinical%20Microbiology%20and%20Infection%20%26lt%3Bi%26gt%3B29%26lt%3B%5C%2Fi%26gt%3B%2C%2077%26%23x2013%3B84%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2022.07.026%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2022.07.026%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Availability%20and%20costs%20of%20medicines%20for%20the%20treatment%20of%20tuberculosis%20in%20Europe%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claude%22%2C%22lastName%22%3A%22Leu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22van%20Leth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Hasan%20Hafizi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naira%22%2C%22lastName%22%3A%22Khachatryan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harut%22%2C%22lastName%22%3A%22Aroyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduard%22%2C%22lastName%22%3A%22Kabasakalyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Knappik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alena%22%2C%22lastName%22%3A%22Skrahina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dzmitry%22%2C%22lastName%22%3A%22Klimuk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alena%22%2C%22lastName%22%3A%22Nikolenka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inge%22%2C%22lastName%22%3A%22Muylle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vladimir%22%2C%22lastName%22%3A%22Milanov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Desislava%22%2C%22lastName%22%3A%22Velkovska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neli%22%2C%22lastName%22%3A%22Tarinska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeta%22%2C%22lastName%22%3A%22Bachiyska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mateja%22%2C%22lastName%22%3A%22Jankovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Despo%22%2C%22lastName%22%3A%22Pieridou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tonia%22%2C%22lastName%22%3A%22Adamide%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicos%22%2C%22lastName%22%3A%22Nicolaou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martina%22%2C%22lastName%22%3A%22Vasakova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariia%22%2C%22lastName%22%3A%22Sukholytka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilia%22%2C%22lastName%22%3A%22Kopeck%5Cu00e0%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dorte%20Bek%22%2C%22lastName%22%3A%22Folkvardsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22Svensson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manfred%22%2C%22lastName%22%3A%22Danilovits%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiina%22%2C%22lastName%22%3A%22Kummik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tuula%22%2C%22lastName%22%3A%22Vasankari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Fr%5Cu00e9chet-Jachym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Audrey%22%2C%22lastName%22%3A%22Nahmiash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamar%22%2C%22lastName%22%3A%22Togonidze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zaza%22%2C%22lastName%22%3A%22Avaliani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inga%22%2C%22lastName%22%3A%22Kinkladze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rusudan%22%2C%22lastName%22%3A%22Aspindzelashvili%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Teona%22%2C%22lastName%22%3A%22Bichashvili%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gulnazi%22%2C%22lastName%22%3A%22Losaberidze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tsitsino%22%2C%22lastName%22%3A%22Merabishvili%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Kalsdorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katerina%22%2C%22lastName%22%3A%22Manika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karyofyllis%22%2C%22lastName%22%3A%22Tsiakitzis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agnes%22%2C%22lastName%22%3A%22Bakos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tinna%20R%5Cu00e1n%22%2C%22lastName%22%3A%22%5Cu00c6gisd%5Cu00f3ttir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gu%5Cu00f0r%5Cu00fan%20Svanhv%5Cu00edt%22%2C%22lastName%22%3A%22Michelsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Krist%5Cu00edn%22%2C%22lastName%22%3A%22Karlsd%5Cu00f3ttir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Marie%22%2C%22lastName%22%3A%22McLaughlin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margaret%22%2C%22lastName%22%3A%22Fitzgibbon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Chemtob%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luigi%20R.%22%2C%22lastName%22%3A%22Codecasa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maurizio%22%2C%22lastName%22%3A%22Ferrarese%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefania%22%2C%22lastName%22%3A%22Torri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Majlinda%22%2C%22lastName%22%3A%22Gjocaj%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liga%22%2C%22lastName%22%3A%22Kuksa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edita%22%2C%22lastName%22%3A%22Davidaviciene%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gil%22%2C%22lastName%22%3A%22Wirtz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%22%2C%22lastName%22%3A%22Perrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Analita%20Pace%22%2C%22lastName%22%3A%22Asciak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dumitri%22%2C%22lastName%22%3A%22Chesov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wiel%22%2C%22lastName%22%3A%22de%20Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Onno%22%2C%22lastName%22%3A%22Akkerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Biljana%20Ilievska%22%2C%22lastName%22%3A%22Poposka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrich%22%2C%22lastName%22%3A%22Mack%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mogens%22%2C%22lastName%22%3A%22Jensenius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lajla%22%2C%22lastName%22%3A%22Kvalvik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20Torunn%22%2C%22lastName%22%3A%22Mengshoel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katarzyna%22%2C%22lastName%22%3A%22Kruczak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Duarte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%22%2C%22lastName%22%3A%22Ribeiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elmira%22%2C%22lastName%22%3A%22Ibraim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Kaluzhenina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Barkanova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dragica%22%2C%22lastName%22%3A%22Pesut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivan%22%2C%22lastName%22%3A%22Solovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%22%2C%22lastName%22%3A%22Svetina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria-Luiza%20de%22%2C%22lastName%22%3A%22Souza-Galv%5Cu00e3o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joan-Pau%22%2C%22lastName%22%3A%22Millet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavi%22%2C%22lastName%22%3A%22Casas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Montserrat%22%2C%22lastName%22%3A%22Vives%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%22%2C%22lastName%22%3A%22Bruchfeld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paulina%22%2C%22lastName%22%3A%22Dalemo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerker%22%2C%22lastName%22%3A%22Jonsson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katrin%22%2C%22lastName%22%3A%22Aeschbacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Keller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seref%22%2C%22lastName%22%3A%22%5Cu00d6zkara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Tiberi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christabelle%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yana%22%2C%22lastName%22%3A%22Terleeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrii%22%2C%22lastName%22%3A%22Dudnyk%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%5CnTo%20evaluate%20the%20access%20to%20comprehensive%20diagnostics%20and%20novel%20antituberculosis%20medicines%20in%20European%20countries.%5CnMethods%5CnWe%20investigated%20the%20access%20to%20genotypic%20and%20phenotypic%20Mycobacterium%20tuberculosis%20drug%20susceptibility%20testing%20and%20the%20availability%20of%20antituberculosis%20drugs%20and%20calculated%20the%20cost%20of%20drugs%20and%20treatment%20regimens%20at%20major%20tuberculosis%20treatment%20centres%20in%20countries%20of%20the%20WHO%20European%20region%20where%20rates%20of%20drug-resistant%20tuberculosis%20are%20the%20highest%20among%20all%20WHO%20regions.%20Results%20were%20stratified%20by%20middle-income%20and%20high-income%20countries.%5CnResults%5CnOverall%2C%2043%20treatment%20centres%20from%2043%20countries%20participated%20in%20the%20study.%20For%20WHO%20group%20A%20drugs%2C%20the%20frequency%20of%20countries%20with%20the%20availability%20of%20phenotypic%20drug%20susceptibility%20testing%20was%20as%20follows%3A%20%28a%29%2075%25%20%2830%5C%2F40%29%20for%20levofloxacin%2C%20%28b%29%2082%25%20%2833%5C%2F40%29%20for%20moxifloxacin%2C%20%28c%29%2048%25%20%2819%5C%2F40%29%20for%20bedaquiline%2C%20and%20%28d%29%2072%25%20%2829%5C%2F40%29%20for%20linezolid.%20Overall%2C%20of%20the%2043%20countries%2C%2036%20%2884%25%29%20and%2024%20%2856%25%29%20countries%20had%20access%20to%20bedaquiline%20and%20delamanid%2C%20respectively%2C%20whereas%20only%206%20%2814%25%29%20countries%20had%20access%20to%20rifapentine.%20The%20treatment%20of%20patients%20with%20extensively%20drug-resistant%20tuberculosis%20with%20a%20regimen%20including%20a%20carbapenem%20was%20available%20only%20in%2017%20%2840%25%29%20of%20the%2043%20countries.%20The%20median%20cost%20of%20regimens%20for%20drug-susceptible%20tuberculosis%2C%20multidrug-resistant%5C%2Frifampicin-resistant%20tuberculosis%20%28shorter%20regimen%2C%20including%20bedaquiline%20for%206%5Cu00a0months%29%2C%20and%20extensively%20drug-resistant%20tuberculosis%20%28including%20bedaquiline%2C%20delamanid%2C%20and%20a%20carbapenem%29%20were%20%5Cu20ac44%20%28minimum%5Cu2013maximum%2C%20%5Cu20ac15%5Cu2013152%29%2C%20%5Cu20ac764%20%28minimum%5Cu2013maximum%2C%20%5Cu20ac542%5Cu201315152%29%2C%20and%20%5Cu20ac8709%20%28minimum%5Cu2013maximum%2C%20%5Cu20ac7965%5Cu201311759%29%20in%20middle-income%20countries%20%28n%5Cu00a0%3D%5Cu00a012%29%20and%20%5Cu20ac280%20%28minimum%5Cu2013maximum%2C%20%5Cu20ac78%5Cu20131084%29%2C%20%5Cu20ac29765%20%28minimum%5Cu2013maximum%2C%20%5Cu20ac11116%5Cu201340584%29%2C%20and%20%5Cu20ac217591%20%28minimum%5Cu2013maximum%2C%20%5Cu20ac82827%5Cu2013320146%29%20in%20high-income%20countries%20%28n%5Cu00a0%3D%5Cu00a029%29%2C%20respectively.%5CnDiscussion%5CnIn%20countries%20of%20the%20WHO%20European%20region%2C%20there%20is%20a%20widespread%20lack%20of%20drug%20susceptibility%20testing%20capacity%20to%20new%20and%20repurposed%20antituberculosis%20drugs%2C%20lack%20of%20access%20to%20essential%20medications%20in%20several%20countries%2C%20and%20a%20high%20cost%20for%20the%20treatment%20of%20drug-resistant%20tuberculosis.%22%2C%22date%22%3A%222023-01-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2022.07.026%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1198743X22003949%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198-743X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-12-28T16%3A07%3A09Z%22%7D%7D%5D%7D
Lecorche, E., Billard-Pomares, T., Alaoui, F. M.-E., Gallois, E., Fihman, V., Carrër, A., Djamdjian, L., Camelena, F., Mougari, F., Carbonnelle, E. and Woerther, P.-L. (2026). Impact of delayed incubation on mycobacterial blood culture recovery with the BACTEC Myco/F Lytic system. Diagnostic Microbiology and Infectious Disease 114, 117217, http://doi.org/10.1016/j.diagmicrobio.2025.117217.
Saluzzo, F., Cabibbe, A. M., Anthony, R., Aubry, A., Drobniewski, F., Holicka, Y., Lillebaek, T., Macedo, R., Mansjö, M., Szél, V., Žmak, L., Cirillo, D. M. and Groenheit, R. (2026). Diagnostic algorithms for tuberculosis in Europe: insights from the European Reference Laboratory Network for Tuberculosis (ERLTB-Net). The Lancet Regional Health - Europe 60, 101516, http://doi.org/10.1016/j.lanepe.2025.101516.
Fouchet, T., Nait Chabane, M., Allam, C., Awad, Z., Mougari, F., Hartmann, A., Rochelet, M. and Cambau, E. (2025). Clinical evaluation of the diagnostic performances and treatment monitoring of the new PATHFAST TB LAM Ag assay in sputum specimens of patients with tuberculosis or with nontuberculous mycobacteria pulmonary disease Ed. Miller, M. B. J Clin Microbiol 63, e01269-25, http://doi.org/10.1128/jcm.01269-25.
Aguilar-Pérez, C., Lenaerts, A. J., Villellas, C., Guillemont, J., Dallow, J., Painter, H., Ammerman, N. C., Hassan, A., Golovkine, G., Brock, L., Sordello, S., Chauffour, A., Aubry, A., Mai, T. C., Wong, S., Clark, T. G., Nam, K., Kim, J., Choi, J., Crabbe, M., Esquivias, J., Lounis, N., Stoops, B., Amssoms, K., Bartolome-Nebreda, J. M., Gruppo, V., Robertson, G. T., Veziris, N., Upton, A. M., Nuermberger, E. L., Cox, V., Ballell, L., Baeten, B., Koul, A., Pym, A. S., Wall, R. J. and Lamprecht, D. A. (2025). The role of cytochrome bc1 inhibitors in future tuberculosis treatment regimens. Nat Commun 16, 9344, http://doi.org/10.1038/s41467-025-64427-6.
Kherabi, Y., Skouvig Pedersen, O., Lange, C., Bénézit, F., Chesov, D., Codecasa, L. R., Dudnyk, A., Kiria, N., Konstantynovska, O., Marigot-Outtandy, D., Panciu, T.-C., Poignon, C., Sasi, S., Schaub, D., Solodovnikova, V., Vasiliauskaitè, L., Yeghiazaryan, L., Günther, G., Guglielmetti, L. and TBnet/ESGMYC XDR-TB Study Group (2025). Treatment outcomes of extensively drug-resistant tuberculosis in Europe: a retrospective cohort study. Lancet Reg Health Eur 56, 101380, http://doi.org/10.1016/j.lanepe.2025.101380.
Benhard, J., Monsel, G., Dubée, V., Pavese, P., Rasoldier, V., Garrait, V., Talleux, M., Vuotto, F., Gueneau, R., Pouget-Abadie, X., Thy, M., Palacios, C., Bachir, M., Djossou, F., Tunesi, S., Jachym, M. F., Pourcher, V., Veziris, N. and Bourgarit, A. (2025). Standardized Infliximab Regimen to Treat Severe Central Nervous System Tuberculosis: A Case Series of 18 Patients. Open Forum Infectious Diseases 12, ofaf450, http://doi.org/10.1093/ofid/ofaf450.
Guglielmetti, L., Khan, U., Velásquez, G. E., Gouillou, M., Ali, M. H., Amjad, S., Kamal, F., Abubakirov, A., Ardizzoni, E., Baudin, E., Bektassov, S., Berry, C., Bonnet, M., Chavan, V., Coutisson, S., Dakenova, Z., de Jong, B. C., Dinh, L. V., Ferlazzo, G., Kirakosyan, O., Lachenal, N., Lecca, L., McIlleron, H., Mikanda, K. K., Mucching-Toscano, S., Mulders, W., Mushtaque, H., Nahid, P., Nguyen, D. V., Nguyen, N. V., Oyewusi, L., Motta, I., Panda, S., Patil, Sandip, Pham, T. H., Phan, D. T., Phan, H. T. T., Phillips, P. P. J., Ruiz, J., Rupasinghe, Praharshinie, Salahuddin, N., Sanchez-Garavito, E., Seung, K. J., Asfaw, M. T., Vargas Vasquez, D., Rich, M. L., Varaine, F., Mitnick, C. D., Arora, G., Ashara, V., Bhattacharjee, S., Borkar, R., Chincholikar, N., Choudhary, N., Davuluri, P., Desai, N., Dipika, Dhongade, S., Dulani, D., Ghule, S., Hirani, N., Hurali, P., Irani, R., Jadhav, K., Jadhav, P., Jadhav, R., Joseph, N., Joshi, A., Joshi, P., K, A., K, S., Kamble, M., Kate, R., Keer, T., S Kenche, M., Khandare, H., Koli, P., Kulkarni, A., Patra, S. K., Kuwar, A., Lande, P., Mane, N., Masalge, P., Mishra, P., Mitkari, R., More, A., Munot, P., Murgesh, R., Muthe, S., Nakashe, N., Natarajan, D., Paril, S., Patil, Supriya, Patil, V., Patwardhan, V., Posture, V., Pradeshi, A., Prasad, V., Pundir, B., Rajendran, S., Randhit, Y., Rekart, M., Samant, P., Shaikh, H., Sharma, A., Sharma, N., Sharma, S., Shinde, N., Shinde, S., Shingare, G., Shulka, A., Shriwas, A., Sonawane, L., Sudhindra, U., Suryavanshi, D., Thakare, A., Udare, D., Vaidya, G., Wagh, R., Isenova, L., Konigratbayeva, G., Nurtayeva, G., Zekeshov, N., Chenu, R., Garba, S., Tozzi, D., Yuya-Septoh, F.-J., Thi Tuyet Mai, B., Thi Hai, D., Thi Thuy, D., Thi Oanh, L., Do, B. T., Nguyen, D. T., Nguyen, P. H., Nguyen, T. M. A., Nguyen, Thi Thuy Hanh, Nguyen, T. K. N., Nguyen, T. N., Nguyen, V. K., Nog, N., Pham, T. N., Pham, T. L., Pham, T. A., Phung, T. B., Tran, B. T., Trinh, M. T., Chang, E., Coit, J., Do, J.-M., LaHood, A., O’Brien, K., Okunbor, E., Osso, E., Chávez, V., Larco, P., Mendoza, D., Robles, C., Rojas, A., Salazar, J., Santos, G., Sosa, J., Ticona, C., Carranza, S., Delgado, D., Galarza, C., Murga, G., Ramos, E., Cantaro, K., Huerta, A., Maldonado, J., Nuñez, R., Panduro, K., Rafael, R., Abdul, A., Abedin, S., Afreen, E., Ahmed, Sohail, Ahmed, U., Ali Shah, J., Ashraf, A., Aslam, F., Bashir, Z., Fayyaz, S., Hafeez, K., Hamid, M., Hassan, B., Hussain, M., Irfan, M., Omar, M., Parveen, S., Sunail, S., Farooq, M., Mazhar, B., Munir, S., Sonia, N., Yaseen, M., Zubair, M., Zehra, F., Zulfiqar, I., Abbasi, T., Akbar Abro, G., Ahmed, M., Ahmed, N., Hammad Ali, M., Ali, N., Danish, R., Farhat, A., Gill, S., Hafeez, M., Hussain, G., Inayat, H., Johnson, S., Kamal, F., Kamran, A., Kumar, Sanjeet, Maheshwari, M., Mamsa, S., Massey, S., Mehmood, A., Memon, A., Ali Mirani, A., Naz, S., Rafique Qureshi, T., Roop Moazzam Sheikh, Y., Rafi Siddiqui, M., Singh, B., Soomro, M., Ardizzoni, E., Rigouts, L., Rupasinghe, Praha, Aftab, A., Ahmed, Saman, Adnan Alamgir, M., Ali, Ayaz, Ali, Azhar, Ahmed Ali, S., Ali, S., Altaf, S., Amjad, S., Sahiba Arshad, M., Ausim, S., Basit, A., Ezik, H., Hussain, H., Hyder, S., Inayat, S., Janmohammed, A., Jaseem, K., Jawed, A., Maniar, L., Kumar, P., Kumar, Susheel, Latif, R., Liaqat, S., Ammar Nasser, M., Shakeel, M., Shaikh, S., Siddiqui, A., Singh, J., Sivan, K., Taimoor, M., Zia, N., Li, I., Otepbergenova, M., Dinh, T. H., Do, Thi Thu, Do, Thu Thuong, Le, T. N., Nguyen, K. C., Nguyen, T. T., Nguyen, V. H., Abildayeva, G., Maryash, O., Telegina, E., Tursynbekova, L., Amanzholova, Z., Bektassova, P., Belgozhanova, A., Birimkulova, N., Dyusebayeva, N., Erkut, N., Gusmanov, A., Kassenova, B., Kassym, A., Khazhidinov, K., Lee, T., Magzumova, A., Mussabayeva, M., Omarova, G., Ryapolova, N., Sagyndykova, L., Serekbay, A., Stambekova, A., Tanatarova, G., Uaisov, Z., Zhantuarova, Z., Zhumakairova, G., Arlyapova, N., Bogus, J., Cain, M., Carmona, M., Flanagan, C., McAnaw, S., Scharff, A., Soni, S., Striplin, M., Abebe, S., Alakaye, J., Bulane, A., Custodio, M., Hajison, P., Hetsa, M., Holtzman, D., Khesa, M., Lethola, M., Lebitsa, T., Mahamo, M., Makaka, J., Matoko, M., Mpinda, S., Mohoang, P., Monyaesa, D., Nkundayirazo, P., Ntsane Sesomo Mohale, M., Ntsibane, S., Phate, S., Radebe (Retsepile Tlali), M., Rakhetsi, M., Ranoosi, T., Tamirat, M., Thokoana, M., Alegre, E., Aguilar, C., Armuto, L., Barreda, N., Barreto, M., Cabrera, S., Calderon, R., Castro, M., Chavez, J., Chavez, L., Cheje, H., Cori, L., Dávalos, D., de la Gala, S., Delgadillo, K., Diaz, H., Flores, X., Galarza, J., García, D., Garcia, F., Gaspar, M., Godos, R., Gomez, P., Gonzales, L., Guerrero, L., Inga, S., Jasaycucho, J., Martel, B., Pro Martinez, A., Molina, R., Mugruza, R., Mundaca, H., Nuahan, M., Ore, K., Panduro, L., Peña, O., Perea, S., Pinedo, C., Ponce, Y., Quinte, C., Quiñones, M., Ramos, A., Ramirez, E., Reynoso, R., Reyes, C., Reyes, J., Riccio, V., Robles, B., Rojas, K., Sanabria, O., Saravia, M., Saravia, S., Senador, L., Soberon, J., Soncco, E., Soto, M., Suarez, C., Suarez, M., Suarez, V., Torpoco, E., Torres, O., Torrez, C., Tunque, G., Ugarte, A., Vaderrama, G., Valdivia, W., Valdivia, Y., Valverde, I., Vargas, C., Vargas, J., Vasquez, E., Veliz, J., Villa, D., Villafuerte, S., Villar, G., Villegas, S., Wong, M., Yataco, R., Pham, H., Truong, H., Nguyen, H., Huy, V., Nguyen, V. S., Nguyen, T. M. K., Minh, T., Bui, D. T. T., Truong, V. V., Nguyen, Thi Thu Ha, Coutisson, S., Atger, M., Nadia Baya, S., Bekhiet, M., Boissière, V., Caboclo, R., Chaudhry, M., Cloez, S., Collin, S., Delifer, C., Demaisons, S., Ducher, V., Hewison, C., Ibrahim, M., Lebeau, K., Mazmanian, M., Mirzayeva, R., Moreau, M., Moschioni, M., Pâquet, A., Perrin, C., Pichon, L., Roussel, J., Scotton, M., Austin, A. and Sun, P. (2025). Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial. The Lancet Respiratory Medicine, http://doi.org/10.1016/S2213-2600(25)00194-8.
Serge Diagbouga, P., Djibougou, A. D., Pease, C., Alcaide, A., Berthoux, A., Bruiners, N., Cirillo, D. M., Combary, A., Falchero, N., Handler, D., Kaboré, A., Lardizabal, A., Lopes, A., Loubet, M., Manivet, P., Margain, C., Meunier, V., Mougari, F., Onyuka, A., Rivoiron, S., Sagna, T., Sanvert, M., Sawadogo, L., Simporé, J., Cambau, E. and Gennaro, M. L. (2025). Preliminary performance of the VIDAS TB-IGRA as an aid in the diagnosis of individuals infected with Mycobacterium tuberculosis Ed. Miller, M. B. J Clin Microbiol 63, e01641-24, http://doi.org/10.1128/jcm.01641-24.
Seddon, J. A., Achar, J., Malik, A. A., Hughes, J., Burzynski, J., Chen, C., Denholm, J. T., Dravniece, G., Fox, G. J., Furin, J., Geliukh, E., Goncharova, O., Guglielmetti, L., Harries, A. D., Hesseling, A. C., Nguyen, B. H., Kavenga, F., Khan, U., Kherabi, Y., Kiria, N., Kock, Y., Liu, Q., Mesic, A., Moore, D. A. J., Mubanga, A., Naidoo, L., Nilsen, D., Piubello, A., Reuter, A., Rich, M. L., Satyanarayana, S., Schaaf, H. S., Schoeman, I., Skrahina, A., Udwadia, Z., Khan, P. Y., Esmail, H. and Martinez, L. (2025). Management of individuals exposed to multidrug-resistant or rifampicin-resistant tuberculosis. The Lancet Infectious Diseases, http://doi.org/10.1016/S1473-3099(25)00157-4.
Bonnet, I., Orgeur, M., Brossier, F., Sayes, F., Frigui, W., Madacki, J., Varet, H., Chauffour, A., Aubry, A., Veziris, N., Sougakoff, W., Brosch, R. and Tournebize, R. (2025). Evaluation of the role of whiB6 and kdpDE in the dominant multidrug-resistant clone Mycobacterium tuberculosis B0/W148 Ed. Doucet-Populaire, F. C. Microbiol Spectr e03224-24, http://doi.org/10.1128/spectrum.03224-24.
Sadowski, E., Pietrancosta, N., Veyron-Churlet, R., Boucher, J.-L., Pionneau, C., Clodic, G., Matheron, L., Poch, O., Mayer, C., Sachon, E. and Aubry, A. (2025). Characterization of the Orphan Cytochrome P450 CYP135B1 from Mycobacterium tuberculosis : Involvement in Metabolism but Not in the Antibacterial Activity of the Antitubercular Drug SQ109. ACS Infect Dis 11, 869–881, http://doi.org/10.1021/acsinfecdis.4c00893.
Verma, A. K., Kim, R. Q., Lamprecht, D. A., Aguilar-Pérez, C., Wong, S., Veziris, N., Aubry, A., Bartolomé-Nebreda, J. M., Carbajo, R. J., Wetzel, J. and Lamers, M. H. (2025). Structural and mechanistic study of a novel inhibitor analogue of M. tuberculosis cytochrome bc1:aa3. npj Drug Discov 2, 6, http://doi.org/10.1038/s44386-025-00008-3.
Lange, C., Bothamley, G., Günther, G., Guglielmetti, L., Kontsevaya, I., Kuksa, L., Lange, B., Lorent, N., Saluzzo, F., Sester, M., Tebruegge, M., Tunesi, S. and Tweed, C. (2025). A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2025 Update for Clinicians and Scientists. PAI 10, 1–45, http://doi.org/10.20411/pai.v10i2.791.
Kuksa, L., Andrejak, C., Haecker, B., Bothamley, G., Calcagno, A., Cirillo, D. M., Duarte, R., Fatima, R., Ferlazzo, G., Guglielmetti, L., Günther, G., Hewison, C., Horsburgh, C. R., Jäger, T., Kalancha, Y., Otto-Knapp, R., Kranzer, K., Lillebaek, T., Marks, G., Middelkoop, K., Motta, I., Rabinova, V., Sommerfeld, P., Tattevin, P. and Lange, C. (2025). Urgent request for pretomanid label expansion to align with WHO guidelines and improve treatment accessibility and efficacy. IJTLD OPEN 2, 117–119, http://doi.org/10.5588/ijtldopen.25.0152.
Guglielmetti, L., Khan, U., Velásquez, G. E., Gouillou, M., Abubakirov, A., Baudin, E., Berikova, E., Berry, C., Bonnet, M., Cellamare, M., Chavan, V., Cox, V., Dakenova, Z., De Jong, B. C., Ferlazzo, G., Karabayev, A., Kirakosyan, O., Kiria, N., Kunda, M., Lachenal, N., Lecca, L., McIlleron, H., Motta, I., Toscano, S. M., Mushtaque, H., Nahid, P., Oyewusi, L., Panda, S., Patil, S., Phillips, P. P. J., Ruiz, J., Salahuddin, N., Garavito, E. S., Seung, K. J., Ticona, E., Trippa, L., Vasquez, D. E. V., Wasserman, S., Rich, M. L., Varaine, F. and Mitnick, C. D. (2025). Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis. N Engl J Med 392, 468–482, http://doi.org/10.1056/NEJMoa2400327.
Goletti, D., Banaei, N., Batra, R., Berger, A. E., Blazevic, A., Botelho-Nevers, E., Breen, R., Bruiners, N., Cambau, E., Carbonnelle, E., Daley, C. L., Descotes-Genon, C., Gennaro, F. D., Doucet-Populaire, F., Esmail, A., Guzman, J. D. E., Fontana, L., Gennaro, M. L., Handler, D., Torres, R. M. H., Hoft, D., Ismail, N., Isnard, M., Kenny, J., Lardizabal, A., Lesage, F. X., Lopes, A., Vidal, W. L. L., Contreras, R. M., Manivet, P., Marotte, H., Méchaï, F., Medjahed-Artebasse, A., Meldau, R., Mérieux, Y., Morel, J., Mougari, F., Oelofse, S., Palmieri, F., Perrot, J. L., Petruccioli, E., Pride, D. T., Tuaillon, E., Upton, C., Vanker, N. and Dheda, K. (2025). Accuracy of VIDAS® TB-IGRA in TB patients and individuals with different thresholds of exposure. International Journal of Infectious Diseases 108318, http://doi.org/10.1016/j.ijid.2025.108318.
Soutou, M. A., Allam, C., Abi Fadel, M., Najjar, J., Guyeux, C., Cambau, E. and Sola, C. (2025). An insight into the characterization of L2 Beijing multi-drug resistant tuberculosis: Description of resistance-associated-variants and discovery of Modern 7 L2 sublineage. Infection, Genetics and Evolution 134, 105797, http://doi.org/10.1016/j.meegid.2025.105797.
Nkomo, T., Udwadia, Z., Vambe, D., Van Rie, A., Thi, S. S., Stillo, J., Stambekova, A., Sinha, A., Rich, M. L., Reuter, A., Patel, J., Otto-Knapp, R., Motta, I., Mesic, A., McKenna, L., Maru, S., Lessem, E., Lange, C., Kiria, N., Kherabi, Y., Günther, G., Guglielmetti, L., Decroo, T., Chen, L., Ashesh, A., Abubakirov, A. and Furin, J. (2025). Clinical best practices for caring for people with expanded resistance to newer TB drugs. IJTLD Open 2, 315–323, http://doi.org/10.5588/ijtldopen.25.0240.
Méchaï, F., Beugre, E., Billard-Pomares, T., Mougari, F., Wyplosz, B., Cambau, E. and Vignier, N. (2025). Usefulness of the GeneXpert MTB/RIF Ct for predicting tuberculosis infectiousness. Infectious Diseases Now 55, 105061, http://doi.org/10.1016/j.idnow.2025.105061.
Scudeller, L., Gkrania-Klotsas, E., Paño Pardo, J. R., Kostyanev, T., Langendam, M., Molina, J., Nagavci, B., Paul, M., Scudeller, L., Stahl, J. P., Sutter, S. T., Zervos, M., Cambau, E., Fitzpatrick, F., Friedland, J. S., Kantele, A., Sahin, G. Ö., Pardo, J. R. P., Skov, R. L. and Zinkernagel, A. (2025). Scope and aims of European society of clinical microbiology and infectious diseases guidelines: a white paper. Clinical Microbiology and Infection 31, 778–782, http://doi.org/10.1016/j.cmi.2024.11.033.
Guglielmetti, L., Panda, S., Abubakirov, A., Salahuddin, N., Perrin, C. and Mitnick, C. D. (2025). Equitable, personalised medicine for tuberculosis: treating patients, not diseases. The Lancet Respiratory Medicine 13, 382–385, http://doi.org/10.1016/S2213-2600(25)00080-3.
Gerussi, V., Petersen, T., Bonnet, I., Aubry, A., Bachir, M., Gyde, E., Morel, F., Poignon, C., Rached, B., Pourcher, V., Rioux, C., Vallois, D., Veziris, N., Robert, J. and Guglielmetti, L. (2025). Evaluation of High-Dose Isoniazid in Multidrug-Resistant Tuberculosis Treatment. Emerg Infect Dis 31, http://doi.org/10.3201/eid3103.241473.
Guthmann, J.-P., Robert, J., Viriot, D. and Parent Du Chatelet, I. (2025). Incidence, severity and treatment outcome of tuberculosis in the era of the COVID-19 pandemic, France, 2018–2023. Journal of Epidemiology and Population Health 73, 202795, http://doi.org/10.1016/j.jeph.2024.202795.
Kunst, H., Lange, B., Hovardovska, O., Bockey, A., Zenner, D., Andersen, A. B., Hargreaves, S., Pareek, M., Friedland, J. S., Wejse, C., Bothamley, G., Guglielmetti, L., Chesov, D., Tiberi, S., Matteelli, A., Mandalakas, A. M., Heyckendorf, J., Eimer, J., Malhotra, A., Zamora, J., Vasiliu, A., Lange, C. and for the TBnet (2024). Tuberculosis in adult migrants in Europe: a TBnet consensus statement. Eur Respir J 2401612, http://doi.org/10.1183/13993003.01612-2024.
Maitre, T., Godmer, A., Mory, C., Chauffour, A., Mai, T. C., El Helali, N., Aubry, A. and Veziris, N. (2024). Levofloxacin activity at increasing doses in a murine model of fluoroquinolone-susceptible and -resistant tuberculosis Ed. Wasserman, S. Antimicrob Agents Chemother e00583-24, http://doi.org/10.1128/aac.00583-24.
Godefroy, N., Monsel, G., Jauréguiberry, S., Henry, B., Véziris, N., Aubry, A., Robert, J., Jachym, M., Caumes, E. and Pourcher, V. (2024). Lessons learned from treating drug-resistant TB and how to apply these to drug-susceptible TB. int j tuberc lung dis 28, 357–359, http://doi.org/10.5588/ijtld.23.0548.
Rupasinghe, P., Ashraf, A., Barreda, N., Parveen, S., Zubair, M., Calderon, R., Asif, S., Hirani, N., Chingisova, L., Bulane, A., Hang, P. T., Ha, D. T., Ardizzoni, E., Kursheed, N., De Rijk, W. B., Rigouts, L., Guglielmetti, L., Mitnick, C. and De Jong, B. C. (2024). Reduced critical concentration might not have improved MGIT-based DST’s sensitivity to rifampicin Ed. Wasserman, S. Antimicrob Agents Chemother 68, e01701-23, http://doi.org/10.1128/aac.01701-23.
Paulowski, L., Filip, R., Jankovic Makek, M., Guglielmetti, L., Goletti, D., Van Ingen, J., Kranzer, K., Maurer, F. P. and on behalf of ESGMYC (2024). Impact of the COVID-19 pandemic on the real-world diagnostic infrastructure for tuberculosis—An ESGMYC collaborative study Ed. Wang, M.-S. PLoS ONE 19, e0291404, http://doi.org/10.1371/journal.pone.0291404.
Veziris, N., Aubry, A., Bonnet, I., Petersen, T., Poignon, C., Gydé, E., Guglielmetti, L. and Robert, J. (2024). Actualités sur la tuberculose à bacilles multirésistants aux antibiotiques et ses nouveaux traitements. Bull Épid Hebdo 127–131, URL: http://beh.santepubliquefrance.fr/beh/2024/6-7/2024_6-7_4.html [Accessed March 2024].
Bérot, V., Monsel, G., Lecorche, E., Halabi-Tawil, M., Maalouf, D., Pourcher, V., Aubry, A., Cambaud, E., Petit, A. and Caumes, E. (2024). Clinical relevance and prognostic impact of the classification between multibacillary and paucibacillary forms of cutaneous tuberculosis: A 24-year retrospective multicenter study. Annales de Dermatologie et de Vénéréologie 151, 103324, http://doi.org/10.1016/j.annder.2024.103324.
Guyeux, C., Senelle, G., Le Meur, A., Supply, P., Gaudin, C., Phelan, J. E., Clark, T. G., Rigouts, L., De Jong, B., Sola, C. and Refrégier, G. (2024). Newly Identified Mycobacterium africanum Lineage 10, Central Africa. Emerg Infect Dis 30, http://doi.org/10.3201/eid3003.231466.
Gedeon, A., Yab, E., Dinut, A., Sadowski, E., Capton, E., Dreneau, A., Petit, J., Gioia, B., Piveteau, C., Djaout, K., Lecat, E., Wehenkel, A. M., Gubellini, F., Mechaly, A., Alzari, P. M., Deprez, B., Baulard, A., Aubry, A., Willand, N. and Petrella, S. (2024). Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase. iScience 27, 110967, http://doi.org/10.1016/j.isci.2024.110967.
Günther, G., Guglielmetti, L., Kherabi, Y., Duarte, R. and Lange, C. (2024). Availability of drugs and resistance testing for bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL(M)) regimen for rifampicin-resistant tuberculosis in Europe. Clinical Microbiology and Infection 30, 1197.e1-1197.e4, http://doi.org/10.1016/j.cmi.2024.03.009.
Lange, C., Kherabi, Y., Guglielmetti, L., Duarte, R. and Günther, G. (2024). Availability of drugs and resistance testing for bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL(M)) regimen for rifampicin-resistant tuberculosis in Europe: author’s response. Clinical Microbiology and Infection 30, 1207–1208, http://doi.org/10.1016/j.cmi.2024.06.009.
Friesen, I., Saluzzo, F., Groenheit, R., Aubry, A., Anthony, R., Niemann, S., Mathys, V., Cirillo, D. M., Indra, A., Mathys, V., Atanasova, Y., Obrovac, M., Žmak, L., Pieridou, D., Dvořákov, V., Troels Lillebæk, Kummik, T., Klaos, K., Soini, H., Haanperä-Heikkinen, M., Mentula, S., Jérôme, R., Cambau, E., Niemann, S., Panayotis, I., Papaventsis, D., Bakos, Á., Szél, V., Lőrinczi, L. K., Fitzgibbon, M., Boyle, B., Cirillo, D. M., Giannoni, F., Pole, I., Norvaiša, I., Vasiliauskaite, L., Perrin, M., Deguara, C., Anthony, R., Mengshoel, A. T., Augustynowicz-Kopeć, E., Macedo, R., Coriu, R. M., Porvaznik, I., Klemen, Š., Herrera-León, L., Groenheit, R. and Werngren, J. (2024). Re: “Availability of drugs and resistance testing for BPaLM regimen for rifampicin-resistant tuberculosis in Europe” by Lange et al. Clinical Microbiology and Infection S1198743X24002775, http://doi.org/10.1016/j.cmi.2024.06.001.
Maitre, T., Baulard, A., Aubry, A. and Veziris, N. (2024). Optimizing the use of current antituberculosis drugs to overcome drug resistance in Mycobacterium tuberculosis. Infectious Diseases Now 54, 104807, http://doi.org/10.1016/j.idnow.2023.104807.
Maitre, T., Guglielmetti, L., Robert, J., Aubry, A. and Veziris, N. (2024). Avancées dans l’antibiothérapie de la tuberculose. Rev Prat 74, 239–244.
Campbell, J. R., Brode, S. K., Barry, P., Bastos, M. L., Bonnet, M., Guglielmetti, L., Kempker, R., Klimuk, D., Laborín, R. L., Milanov, V., Singla, R., Skrahina, A., Trajman, A., Van Der Werf, T. S., Viiklepp, P. and Menzies, D. (2023). Association of indicators of extensive disease and rifampin-resistant tuberculosis treatment outcomes: an individual participant data meta-analysis. Thorax thorax-2023-220249, http://doi.org/10.1136/thorax-2023-220249.
Du Cros, P., Greig, J., Alffenaar, J.-W. C., Cross, G. B., Cousins, C., Berry, C., Khan, U., Phillips, P. P. J., Velásquez, G. E., Furin, J., Spigelman, M., Denholm, J. T., Thi, S. S., Tiberi, S., Huang, G. K. L., Marks, G. B., Turkova, A., Guglielmetti, L., Chew, K. L., Nguyen, H. T., Ong, C. W. M., Brigden, G., Singh, K. P., Motta, I., Lange, C., Seddon, J. A., Nyang’wa, B.-T., Maug, A. K. J., Gler, M. T., Dooley, K. E., Quelapio, M., Tsogt, B., Menzies, D., Cox, V., Upton, C. M., Skrahina, A., McKenna, L., Horsburgh, C. R., Dheda, K. and Marais, B. J. (2023). Standards for clinical trials for treating TB. int j tuberc lung dis 27, 885–898, http://doi.org/10.5588/ijtld.23.0341.
Patil, S. B., Tamirat, M., Khazhidinov, K., Ardizzoni, E., Atger, M., Austin, A., Baudin, E., Bekhit, M., Bektasov, S., Berikova, E., Bonnet, M., Caboclo, R., Chaudhry, M., Chavan, V., Cloez, S., Coit, J., Coutisson, S., Dakenova, Z., De Jong, B. C., Delifer, C., Demaisons, S., Do, J. M., Dos Santos Tozzi, D., Ducher, V., Ferlazzo, G., Gouillou, M., Khan, U., Kunda, M., Lachenal, N., LaHood, A. N., Lecca, L., Mazmanian, M., McIlleron, H., Moreau, M., Moschioni, M., Nahid, P., Osso, E., Oyewusi, L., Panda, S., Pâquet, A., Thuong Huu, P., Pichon, L., Rich, M. L., Rupasinghe, P., Salahuddin, N., Sanchez Garavito, E., Seung, K. J., Velásquez, G. E., Vallet, M., Varaine, F., Yuya-Septoh, F. J., Mitnick, C. D. and Guglielmetti, L. (2023). Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial. Trials 24, 773, http://doi.org/10.1186/s13063-023-07701-6.
Sahal, M. R., Senelle, G., La, K., Panda, T. W., Taura, D. W., Guyeux, C., Cambau, E. and Sola, C. (2023). Mycobacterium tuberculosis complex drug-resistance, phylogenetics, and evolution in Nigeria: Comparison with Ghana and Cameroon Ed. Rayner, S. PLoS Negl Trop Dis 17, e0011619, http://doi.org/10.1371/journal.pntd.0011619.
Günther, G., Guglielmetti, L., Leu, C., van Leth, F. and Lange, C. (2023). Relative cost of multidrug-resistant TB medicines in Europe. The International Journal of Tuberculosis and Lung Disease 27, 341–344, http://doi.org/10.5588/ijtld.23.0026.
Campbell, J. R., Chan, E. D., Anderson, L. F., Bonnet, M., Brode, S. K., Cegielski, J. P., Guglielmetti, L., Singla, R., Fox, G. J., Skrahina, A., Rodrigues, D., Kuksa, L., Viiklepp, P. and Menzies, D. (2023). Association of smoking and alcohol use with rifampin-resistant TB treatment outcomes. The International Journal of Tuberculosis and Lung Disease 27, 338–340, http://doi.org/10.5588/ijtld.22.0678.
Guthmann, J.-P., Fraisse, P., Bonnet, I. and Robert, J. (2023). Active tuberculosis screening among the displaced population fleeing Ukraine, France, February to October 2022. Eurosurveillance 28, http://doi.org/10.2807/1560-7917.ES.2023.28.12.2300155.
Aubry, A. and Veziris, N. (2023). La tuberculose, l’une des plus anciennes maladies infectieuses : quelles avancées récentes majeures ? Med Sci (Paris) 39, 203–204, http://doi.org/10.1051/medsci/2023054.
Masini, T., Furin, J., Udwadia, Z. and Guglielmetti, L. (2023). Optimal management of drug-resistant tuberculosis: Can India lead the way? Indian Journal of Medical Research 157, 220, http://doi.org/10.4103/ijmr.ijmr_300_23.
Domínguez, José, Boeree, M. J., Cambau, E., Chesov, D., Conradie, F., Cox, V., Dheda, K., Dudnyk, A., Farhat, M. R., Gagneux, S., Grobusch, M. P., Gröschel, M. I., Guglielmetti, L., Kontsevaya, I., Lange, B., van Leth, F., Lienhardt, C., Mandalakas, Anna M, Maurer, F. P., Merker, M., Miotto, P., Molina-Moya, B., Morel, F., Niemann, S., Veziris, N., Whitelaw, A., Horsburgh, Charles R, Lange, C., Domínguez, Jose, Boeree, M. J., Cambau, E., Chesov, D., Conradie, F., Cox, V., Dheda, K., Dudnyk, A., Farhat, M. R., Gagneux, S., Grobusch, M. P., Gröschel, M. I., Guglielmetti, L., Kontsevaya, I., Lange, B., van Leth, F., Lienhardt, C., Mandalakas, Anna Maria, Maurer, F., Merker, M., Miotto, P., Molina-Moya, B., Morel, F., Niemann, S., Veziris, N., Whitelaw, A., Horsburgh, Charles Robert and Lange, C. (2023). Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement. The Lancet Infectious Diseases, http://doi.org/10.1016/S1473-3099(22)00875-1.
Barbier, E., Fouchet, T., Hartmann, A., Cambau, E., Mougari, F., Dubois, C., Lubetzki, M. and Rochelet, M. (2023). Rapid electrochemical detection of Mycobacterium tuberculosis in sputum by measuring Ag85 activity with disposable carbon sensors. Talanta 253, 123927, http://doi.org/10.1016/j.talanta.2022.123927.
Khan, U. and Guglielmetti, L. (2023). Tailored TPT for drug-resistant TB - promoting equity and access to optimal care. Int J Tuberc Lung Dis 27, 89b–890, http://doi.org/10.5588/ijtld.22.0538.
Günther, G., Guglielmetti, L., Leu, C., Lange, C., van Leth, F., Hasan Hafizi, Khachatryan, N., Aroyan, H., Kabasakalyan, E., Knappik, M., Skrahina, A., Klimuk, D., Nikolenka, A., Muylle, I., Milanov, V., Velkovska, D., Tarinska, N., Bachiyska, E., Jankovic, M., Pieridou, D., Adamide, T., Nicolaou, N., Vasakova, M., Sukholytka, M., Kopeckà, E., Folkvardsen, D. B., Svensson, E., Danilovits, M., Kummik, T., Vasankari, T., Fréchet-Jachym, M., Nahmiash, A., Togonidze, T., Avaliani, Z., Kinkladze, I., Aspindzelashvili, R., Bichashvili, T., Losaberidze, G., Merabishvili, T., Kalsdorf, B., Manika, K., Tsiakitzis, K., Bakos, A., Ægisdóttir, T. R., Michelsen, G. S., Karlsdóttir, K., McLaughlin, A.-M., Fitzgibbon, M., Chemtob, D., Codecasa, L. R., Ferrarese, M., Torri, S., Gjocaj, M., Kuksa, L., Davidaviciene, E., Wirtz, G., Perrin, M., Asciak, A. P., Chesov, D., de Lange, W., Akkerman, O., Poposka, B. I., Mack, U., Jensenius, M., Kvalvik, L., Mengshoel, A. T., Kruczak, K., Duarte, R., Ribeiro, N., Ibraim, E., Kaluzhenina, A., Barkanova, O., Pesut, D., Solovic, I., Svetina, P., Souza-Galvão, M.-L. de, Millet, J.-P., Casas, X., Vives, M., Bruchfeld, J., Dalemo, P., Jonsson, J., Aeschbacher, K., Keller, P., Özkara, S., Tiberi, S., Chen, C., Terleeva, Y. and Dudnyk, A. (2023). Availability and costs of medicines for the treatment of tuberculosis in Europe. Clinical Microbiology and Infection 29, 77–84, http://doi.org/10.1016/j.cmi.2022.07.026.

Catégories
Documents Tout le CNR-MyRMA

Publications du CNR en 2022

1368488 2022 1 heidelberg-university-faculty-of-medicine 50 creator asc year 1 241 https://cnrmyrma.fr/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%223996TQSC%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Aubry%20et%20al.%22%2C%22parsedDate%22%3A%222022-08-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAubry%2C%20A.%2C%20Sammarco%20Rosa%2C%20P.%2C%20Chauffour%2C%20A.%2C%20Fletcher%2C%20M.%20L.%2C%20Cambau%2C%20E.%20and%20Avanzi%2C%20C.%20%282022%29.%20%26lt%3Bb%26gt%3BDrug%20resistance%20in%20leprosy%3A%20An%20update%20following%2070years%20of%20chemotherapy%26lt%3B%5C%2Fb%26gt%3B.%20Infectious%20Diseases%20Now%20%26lt%3Bi%26gt%3B52%26lt%3B%5C%2Fi%26gt%3B%2C%20243%26%23x2013%3B251%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.idnow.2022.04.001%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.idnow.2022.04.001%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Drug%20resistance%20in%20leprosy%3A%20An%20update%20following%2070years%20of%20chemotherapy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Sammarco%20Rosa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Chauffour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20L.%22%2C%22lastName%22%3A%22Fletcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Avanzi%22%7D%5D%2C%22abstractNote%22%3A%22Leprosy%20is%20one%20of%20the%20oldest%20infectious%20diseases%2C%20reported%20for%20more%20than%202000years.%20Leprosy%20elimination%20goal%20as%20a%20public%20health%20problem%20set%20by%20the%20World%20Health%20Organization%2C%20aiming%20for%20a%20global%20prevalence%20rate%26lt%3B1%20patient%20in%20a%20population%20of%2010%2C000%2C%20was%20achieved%20in%202000%20mainly%20thanks%20to%20the%20worldwide%20use%20of%20leprosy%20drugs%20starting%20in%20the%201980s%20and%20their%20access%20at%20no%20cost%20for%20patients%20since%201995.%20However%2C%20around%20200%2C000%20new%20cases%20are%20still%20reported%20each%20year%2C%20particularly%20in%20India%2C%20Brazil%2C%20and%20Indonesia.%20As%20with%20other%20bacteria%20of%20medical%20interest%2C%20antimicrobial%20resistance%20is%20observed%20in%20Mycobacterium%20leprae%20strains%20in%20several%20parts%20of%20the%20world%2C%20despite%20multidrug%20therapy%20being%20the%20recommended%20standard%20leprosy%20treatment%20to%20avoid%20resistance%20selection%20since%201982.%20Therefore%2C%20identifying%20and%20monitoring%20resistance%20is%20necessary.%20We%20provide%20an%20overview%20of%20the%20historical%20facts%20that%20led%20to%20the%20current%20drug%20resistance%20situation%2C%20the%20antibiotics%20effective%20against%20M.%5Cu00a0leprae%2C%20their%20mechanisms%20of%20action%20and%20resistance%2C%20and%20resistance%20detection%20methods.%20We%20also%20discuss%20therapeutic%20management%20of%20the%20resistant%20cases%2C%20new%20genes%20with%20potential%20roles%20in%20drug%20resistance%20and%20bacterial%20adaptation%2C%20new%20drugs%20under%20investigation%2C%20and%20the%20risk%20for%20resistance%20selection%20with%20the%20chemoprophylaxis%20measures.%22%2C%22date%22%3A%222022-08-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.idnow.2022.04.001%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS2666991922000665%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222666-9919%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A26%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22PF5DMFLC%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bachir%20et%20al.%22%2C%22parsedDate%22%3A%222022-07-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBachir%2C%20M.%2C%20Guglielmetti%2C%20L.%2C%20Tunesi%2C%20S.%2C%20Billard-Pomares%2C%20T.%2C%20Chiesi%2C%20S.%2C%20Jaffr%26%23xE9%3B%2C%20J.%2C%20Langris%2C%20H.%2C%20Pourcher%2C%20V.%2C%20Schramm%2C%20F.%2C%20Lema%26%23xEE%3Btre%2C%20N.%20and%20Robert%2C%20J.%20%282022%29.%20%26lt%3Bb%26gt%3BMolecular%20detection%20of%20isoniazid%20monoresistance%20improves%20tuberculosis%20treatment%3A%20A%20retrospective%20cohort%20in%20France%26lt%3B%5C%2Fb%26gt%3B.%20Journal%20of%20Infection%20%26lt%3Bi%26gt%3B85%26lt%3B%5C%2Fi%26gt%3B%2C%2024%26%23x2013%3B30%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jinf.2022.05.017%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jinf.2022.05.017%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Molecular%20detection%20of%20isoniazid%20monoresistance%20improves%20tuberculosis%20treatment%3A%20A%20retrospective%20cohort%20in%20France%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marwa%22%2C%22lastName%22%3A%22Bachir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Tunesi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Typhaine%22%2C%22lastName%22%3A%22Billard-Pomares%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sheila%22%2C%22lastName%22%3A%22Chiesi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00e9my%22%2C%22lastName%22%3A%22Jaffr%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugo%22%2C%22lastName%22%3A%22Langris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Pourcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Schramm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%22%2C%22lastName%22%3A%22Lema%5Cu00eetre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%5CnIsoniazid-monoresistant%20tuberculosis%20%28HR-TB%29%20requires%20early%20diagnosis%20and%20adapted%20treatment%20to%20achieve%20optimal%20outcomes.%20The%20primary%20aim%20of%20the%20study%20was%20to%20assess%20the%20impact%20of%20the%20implementation%20of%20rapid%20diagnostic%20tests%20on%20HR-TB%20treatment%20in%20France.%5CnMethods%5CnWe%20designed%20a%20retrospective%20multicentre%20study%20including%20consecutive%20HR-TB%20patients%20diagnosed%20in%202016%20and%202017.%20Implementation%20of%20a%20molecular%20assay%20detecting%20isoniazid%20resistance%20directly%20on%20a%20clinical%20sample%20was%20recorded.%20The%20association%20between%20early%20implementation%20of%20such%20assays%20and%20adequate%20treatment%20was%20assessed%20by%20a%20multivariable%20Cox%20proportional%20hazards%20model.%5CnResults%5CnOverall%2C%2099%20HR-TB%20patients%20were%20included%20from%2020%20University%20Hospitals.%20Among%20all%20smear-positive%20HR-TB%20patients%2C%20only%2026%25%20beneficiated%20from%20early%20molecular%20HR%20detection.%20This%20detection%20was%20independently%20associated%20with%20shorter%20time%20to%20adequate%20treatment%20%28HR%5Cu00a0%3D%5Cu00a02.0%20%5B1.1%5Cu20133.8%5D%2C%20p%5Cu00a0%3D%5Cu00a00.03%29.%5CnConclusion%5CnIn%20our%20study%2C%20molecular%20detection%20of%20HR%20on%20an%20initial%20sample%20was%20independently%20associated%20with%20earlier%20treatment%20adaptation.%22%2C%22date%22%3A%222022-07-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jinf.2022.05.017%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0163445322003061%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220163-4453%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-06T13%3A19%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22HUBVTWEL%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bonnet%20et%20al.%22%2C%22parsedDate%22%3A%222022-06-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBonnet%2C%20I.%2C%20Haddad%2C%20E.%2C%20Guglielmetti%2C%20L.%2C%20B%26%23xE9%3Bmer%2C%20P.%2C%20Bernard%2C%20L.%2C%20Bourgoin%2C%20A.%2C%20Brault%2C%20R.%2C%20Catho%2C%20G.%2C%20Caumes%2C%20E.%2C%20Escaut%2C%20L.%2C%20Fourniols%2C%20E.%2C%20Fr%26%23xE9%3Bchet-Jachym%2C%20M.%2C%20Gaudart%2C%20A.%2C%20Guillot%2C%20H.%2C%20Lafon-Desmurs%2C%20B.%2C%20Lanoix%2C%20J.-P.%2C%20Lanotte%2C%20P.%2C%20Lemaignen%2C%20A.%2C%20Lemaire%2C%20B.%2C%20Lemaitre%2C%20N.%2C%20Michau%2C%20C.%2C%20Morand%2C%20P.%2C%20Mougari%2C%20F.%2C%20Marigot-Outtandy%2C%20D.%2C%20Patrat-Delon%2C%20S.%2C%20Perpoint%2C%20T.%2C%20Piau%2C%20C.%2C%20Pourcher%2C%20V.%2C%20Zarrouk%2C%20V.%2C%20Zeller%2C%20V.%2C%20Veziris%2C%20N.%2C%20Jaur%26%23xE9%3Bguiberry%2C%20S.%20and%20Aubry%2C%20A.%20%282022%29.%20%26lt%3Bb%26gt%3BClinical%20Features%20and%20Outcome%20of%20Multidrug-Resistant%20Osteoarticular%20Tuberculosis%3A%20A%2012-Year%20Case%20Series%20from%20France%26lt%3B%5C%2Fb%26gt%3B.%20Microorganisms%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%2C%201215%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fmicroorganisms10061215%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fmicroorganisms10061215%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20Features%20and%20Outcome%20of%20Multidrug-Resistant%20Osteoarticular%20Tuberculosis%3A%20A%2012-Year%20Case%20Series%20from%20France%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elie%22%2C%22lastName%22%3A%22Haddad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascale%22%2C%22lastName%22%3A%22B%5Cu00e9mer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Bourgoin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Brault%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaud%22%2C%22lastName%22%3A%22Catho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Caumes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9lia%22%2C%22lastName%22%3A%22Escaut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Fourniols%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Fr%5Cu00e9chet-Jachym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alice%22%2C%22lastName%22%3A%22Gaudart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Guillot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barth%5Cu00e9l%5Cu00e9my%22%2C%22lastName%22%3A%22Lafon-Desmurs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Lanoix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Lanotte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrien%22%2C%22lastName%22%3A%22Lemaignen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00e9n%5Cu00e9dicte%22%2C%22lastName%22%3A%22Lemaire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%22%2C%22lastName%22%3A%22Lemaitre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Michau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Morand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dhiba%22%2C%22lastName%22%3A%22Marigot-Outtandy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sol%5Cu00e8ne%22%2C%22lastName%22%3A%22Patrat-Delon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Perpoint%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Piau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Pourcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginie%22%2C%22lastName%22%3A%22Zarrouk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Zeller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phane%22%2C%22lastName%22%3A%22Jaur%5Cu00e9guiberry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%5D%2C%22abstractNote%22%3A%22The%20optimal%20treatment%20for%20osteoarticular%20infection%20due%20to%20multidrug-resistant%20tuberculosis%20strains%20%28MDR-OATB%29%20remains%20unclear.%20This%20study%20aims%20to%20evaluate%20the%20diagnosis%2C%20management%20and%20outcome%20of%20MDR-OATB%20in%20France.%20We%20present%20a%20case%20series%20of%20MDR-OATB%20patients%20reviewed%20at%20the%20French%20National%20Reference%20Center%20for%20Mycobacteria%20between%202007%20and%202018.%20Medical%20history%20and%20clinical%2C%20microbiological%2C%20treatment%20and%20outcome%20data%20were%20collected.%20Twenty-three%20MDR-OATB%20cases%20were%20reported%2C%20representing%203%25%20of%20all%20concurrent%20MDR-TB%20cases%20in%20France.%20Overall%2C%2017%20were%20male%2C%20and%20the%20median%20age%20was%2032%20years.%20Six%20patients%20were%20previously%20treated%20for%20TB%2C%20including%20four%20with%20first-line%20drugs.%20The%20most%20frequently%20affected%20site%20was%20the%20spine%20%28n%20%3D%2016%29.%20Bone%20and%20joint%20surgery%20were%20required%20in%2012%20patients.%20Twenty-one%20patients%20%2891%25%29%20successfully%20completed%20the%20treatment%20with%20a%20regimen%20containing%20a%20mean%20of%20four%20drugs%20%28range%2C%202%5Cu20136%29%20for%20a%20mean%20duration%20of%2020%20months%20%28range%2C%2013%5Cu201327%29.%20Overall%2C%20high%20rates%20of%20treatment%20success%20were%20achieved%20following%20WHO%20MDR-TB%20treatment%20guidelines%20and%20individualized%20patient%20management%20recommendations%20by%20the%20French%20National%20TB%20Consilium.%20However%2C%20the%20optimal%20combination%20of%20drugs%2C%20duration%20of%20treatment%20and%20role%20of%20surgery%20in%20the%20management%20of%20MDR-OATB%20remains%20to%20be%20determined.%22%2C%22date%22%3A%222022-6-14%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fmicroorganisms10061215%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9229793%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222076-2607%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-06-29T14%3A21%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22AM4AMZDJ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chaptal%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChaptal%2C%20M.%2C%20Andrejak%2C%20C.%2C%20Bonifay%2C%20T.%2C%20Beillard%2C%20E.%2C%20Guillot%2C%20G.%2C%20Guyomard-Rabenirina%2C%20S.%2C%20Demar%2C%20M.%2C%20Trombert-Paolantoni%2C%20S.%2C%20Jacomo%2C%20V.%2C%20Mosnier%2C%20E.%2C%20Veziris%2C%20N.%2C%20Djossou%2C%20F.%2C%20Epelboin%2C%20L.%20and%20Group%2C%20F.%20G.%20P.%20working%20%282022%29.%20%26lt%3Bb%26gt%3BEpidemiology%20of%20infection%20by%20pulmonary%20non-tuberculous%20mycobacteria%20in%20French%20Guiana%202008%26%23x2013%3B2018%26lt%3B%5C%2Fb%26gt%3B.%20PLOS%20Neglected%20Tropical%20Diseases%20%26lt%3Bi%26gt%3B16%26lt%3B%5C%2Fi%26gt%3B%2C%20e0010693%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0010693%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pntd.0010693%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Epidemiology%20of%20infection%20by%20pulmonary%20non-tuberculous%20mycobacteria%20in%20French%20Guiana%202008%5Cu20132018%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mil%5Cu00e8ne%22%2C%22lastName%22%3A%22Chaptal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timoth%5Cu00e9e%22%2C%22lastName%22%3A%22Bonifay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Beillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Genevi%5Cu00e8ve%22%2C%22lastName%22%3A%22Guillot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%22%2C%22lastName%22%3A%22Guyomard-Rabenirina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magalie%22%2C%22lastName%22%3A%22Demar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Trombert-Paolantoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronique%22%2C%22lastName%22%3A%22Jacomo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Mosnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%22%2C%22lastName%22%3A%22Djossou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lo%5Cu00efc%22%2C%22lastName%22%3A%22Epelboin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22French%20Guiana%20PNTM%20working%22%2C%22lastName%22%3A%22Group%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%20Unlike%20diseases%20caused%20by%20Mycobacterium%20tuberculosis%2C%20M.%20leprae%20and%20M.%20ulcerans%2C%20the%20epidemiology%20of%20pulmonary%20non-tuberculous%20mycobacteria%20%28PNTM%29%20has%20not%20received%20due%20attention%20in%20French%20Guiana.%20The%20main%20objective%20of%20the%20current%20study%20was%20to%20define%20the%20incidence%20of%20these%20PNTM%20infections%3A%20NTM%20pulmonary%20diseases%20%28NTM-PD%29%20and%20casual%20PNTM%20isolation%20%28responsible%20of%20latent%20infection%20or%20simple%20colonization%29.%20The%20secondary%20objectives%20were%20to%20determine%20species%20diversity%20and%20geographic%20distribution%20of%20these%20atypical%20mycobacteria.%20Methods%20A%20retrospective%20observational%20study%20%282008%5Cu20132018%29%20of%20French%20Guiana%20patients%20with%20at%20least%20one%20PNTM%20positive%20respiratory%20sample%20in%20culture%20was%20conducted.%20Patients%20were%20then%20classified%20into%20two%20groups%3A%20casual%20PNTM%20isolation%20or%20pulmonary%20disease%20%28NTM-PD%29%2C%20according%20to%20clinical%2C%20radiological%20and%20microbiological%20criteria%20defined%20by%20the%20American%20Thoracic%20Society%20%5C%2F%20Infectious%20Disease%20Society%20of%20America%20%28ATS%20%5C%2F%20IDSA%29%20in%202007.%20Results%20178%20patients%20were%20included%2C%20out%20of%20which%20147%20had%20casual%20PNTM%20isolation%20and%2031%20had%20NTM-PD.%20Estimated%20annual%20incidence%20rate%20of%20respiratory%20isolates%20was%206.17%20%5C%2F%20100%2C000%20inhabitants%20per%20year%20while%20that%20of%20NTM-PD%20was%201.07%20%5C%2F%20100%2C000%20inhabitants%20per%20year.%20Among%20the%20178%20patients%2C%20M.%20avium%20complex%20%28MAC%29%20was%20the%20most%20frequently%20isolated%20pathogen%20%2838%25%29%2C%20followed%20by%20M.%20fortuitum%20then%20M.%20abscessus%20%2819%25%20and%206%25%20of%20cases%20respectively%29%2C%20the%20latter%20two%20mycobacteria%20being%20mainly%20found%20in%20the%20coastal%20center%20region.%20Concerning%20NTM-PD%2C%20two%20species%20were%20mainly%20involved%3A%20MAC%20%2881%25%29%20and%20M.%20abscessus%20%2816%25%29.%20Discussion%5C%2FConclusion%20This%20is%20the%20first%20study%20on%20the%20epidemiology%20of%20PNTM%20infections%20in%20French%20Guiana.%20PNTM%5Cu2019s%20incidence%20looks%20similar%20to%20other%20contries%20and%20metropolitan%20France%20and%20NTM-PD%20is%20mostly%20due%20to%20MAC%20and%20M.abscessus.%20Although%20French%20Guiana%20is%20the%20French%20territory%20with%20the%20highest%20tuberculosis%20incidence%2C%20NTM%20should%20not%20be%20overlooked.%22%2C%22date%22%3A%229%20sept.%202022%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pntd.0010693%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.plos.org%5C%2Fplosntds%5C%2Farticle%3Fid%3D10.1371%5C%2Fjournal.pntd.0010693%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221935-2735%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A15%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22THH9Q9E6%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chiron%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChiron%2C%20R.%2C%20Hoefsloot%2C%20W.%2C%20Van%20Ingen%2C%20J.%2C%20Marchandin%2C%20H.%2C%20Kremer%2C%20L.%2C%20Morisse-Pradier%2C%20H.%2C%20Charriot%2C%20J.%2C%20Mallet%2C%20J.-P.%2C%20Herrmann%2C%20J.-L.%2C%20Caimmi%2C%20D.%2C%20Moreau%2C%20J.%2C%20Dumont%2C%20Y.%2C%20Godreuil%2C%20S.%2C%20Bergeron%2C%20A.%2C%20Drevait%2C%20M.%2C%20Bouzat-Rossigneux%2C%20E.%2C%20Terrail%2C%20N.%2C%20Andrejak%2C%20C.%2C%20Veziris%2C%20N.%2C%20Grenet%2C%20D.%2C%20Coudrat%2C%20A.%20and%20Catherinot%2C%20E.%20%282022%29.%20%26lt%3Bb%26gt%3BAmikacin%20Liposomal%20Inhalation%20Suspension%20in%20the%20Treatment%20of%20Mycobacterium%20abscessus%20Lung%20Infection%3A%20A%20French%20Observational%20Experience%26lt%3B%5C%2Fb%26gt%3B.%20Open%20Forum%20Infect%20Dis%20%26lt%3Bi%26gt%3B9%26lt%3B%5C%2Fi%26gt%3B%2C%20ofac465%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofac465%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofac465%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Amikacin%20Liposomal%20Inhalation%20Suspension%20in%20the%20Treatment%20of%20Mycobacterium%20abscessus%20Lung%20Infection%3A%20A%20French%20Observational%20Experience%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raphael%22%2C%22lastName%22%3A%22Chiron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wouter%22%2C%22lastName%22%3A%22Hoefsloot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22Van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Marchandin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Kremer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22Morisse-Pradier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Charriot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Mallet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Louis%22%2C%22lastName%22%3A%22Herrmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Davide%22%2C%22lastName%22%3A%22Caimmi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johan%22%2C%22lastName%22%3A%22Moreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Dumont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Godreuil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Bergeron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margot%22%2C%22lastName%22%3A%22Drevait%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Bouzat-Rossigneux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Terrail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Grenet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22Coudrat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Catherinot%22%7D%5D%2C%22abstractNote%22%3A%22A%20French%20observational%20cohort%20study%20investigated%20amikacin%20liposome%20inhaled%20suspension%20as%20an%20adjunct%20to%20antibiotic%20regimen%20for%20M%20abscessus%20lung%20infection.%20Sputum%20culture%20conversion%20was%20achieved%20in%2054%25%20%2814%5C%2F26%29%20of%20patients%20with%20acceptable%20safety%20profile%20after%206%20months%20of%20treatment.%22%2C%22date%22%3A%222022-9-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fofid%5C%2Fofac465%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9578164%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222328-8957%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-12-28T16%3A03%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22EBWEL99Z%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Daniau%20et%20al.%22%2C%22parsedDate%22%3A%222022-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDaniau%2C%20C.%2C%20Lecorche%2C%20E.%2C%20Mougari%2C%20F.%2C%20Benmansour%2C%20H.%2C%20Bernet%2C%20C.%2C%20Blanchard%2C%20H.%2C%20Robert%2C%20J.%2C%20Berger-Carbonne%2C%20A.%20and%20Cambau%2C%20E.%20%282022%29.%20%26lt%3Bb%26gt%3BAssociation%20of%20Healthcare%20and%20Aesthetic%20Procedures%20with%20Infections%20Caused%20by%20Nontuberculous%20Mycobacteria%2C%20France%2C%202012%26%23x2012%3B2020%26lt%3B%5C%2Fb%26gt%3B.%20Emerg%20Infect%20Dis%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%2C%20518%26%23x2013%3B526%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2803.211791%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2803.211791%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20Healthcare%20and%20Aesthetic%20Procedures%20with%20Infections%20Caused%20by%20Nontuberculous%20Mycobacteria%2C%20France%2C%202012%5Cu20122020%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00f4me%22%2C%22lastName%22%3A%22Daniau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Lecorche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faiza%22%2C%22lastName%22%3A%22Mougari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanaa%22%2C%22lastName%22%3A%22Benmansour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claude%22%2C%22lastName%22%3A%22Bernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herv%5Cu00e9%22%2C%22lastName%22%3A%22Blanchard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Berger-Carbonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22We%20describe%20nontuberculous%20mycobacteria%20%28NTM%29%20infections%20during%202012%5Cu20132020%20associated%20with%20health%20care%20and%20aesthetic%20procedures%20in%20France.%20We%20obtained%20epidemiologic%20data%20from%20the%20national%20early%20warning%20response%20system%20for%20healtcare-associated%20infections%20and%20data%20on%20NTM%20isolates%20from%20the%20National%20Reference%20Center%20for%20Mycobacteria.%20We%20compared%20clinical%20and%20environmental%20isolates%20by%20using%20whole-genome%20sequencing.%20The%2085%20original%20cases%20were%20reported%20after%20surgery%20%2848%2C%2056%25%29%2C%20other%20invasive%20procedures%20%2828%2C%2033%25%29%20and%20other%20procedures%20%289%2C%2011%25%29.%20NTM%20isolates%20belonged%20to%20rapidly%20growing%20%2873%2C%2086%25%29%20and%20slowly%20growing%20%2810%2C%2012%25%29%20species%3B%20in%202%20cases%2C%20the%20species%20was%20not%20identified.%20We%20performed%20environmental%20investigations%20for%2038%20%2845%25%29%20cases%3B%20results%20for%2012%20%2832%25%29%20were%20positive%20for%20the%20same%20NTM%20species%20as%20for%20the%20infection.%20In%2010%20cases%20that%20had%20environmental%20and%20clinical%20samples%20whose%20genomes%20were%20similar%2C%20the%20infection%20source%20was%20probably%20the%20water%20used%20in%20the%20procedures.%20NTM%20infections%20could%20be%20preventable%20by%20using%20sterile%20water%20in%20all%20invasive%20procedures.%22%2C%22date%22%3A%222022-3%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3201%5C%2Feid2803.211791%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC8888244%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221080-6040%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T21%3A35%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22FXY3SR7C%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Daniau%20et%20al.%22%2C%22parsedDate%22%3A%222022-06%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDaniau%2C%20C.%2C%20Berger-Carbonne%2C%20A.%20and%20Cambau%2C%20E.%20%282022%29.%20%26lt%3Bb%26gt%3BAssociation%20of%20Healthcare%20and%20Aesthetic%20Procedures%20with%20Infections%20Caused%20by%20Nontuberculous%20Mycobacteria%2C%20France%2C%202012%26%23x2012%3B2020%20%28response%29%26lt%3B%5C%2Fb%26gt%3B.%20Emerg%20Infect%20Dis%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%2C%201303%26%23x2013%3B1304%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2806.220686%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2806.220686%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20Healthcare%20and%20Aesthetic%20Procedures%20with%20Infections%20Caused%20by%20Nontuberculous%20Mycobacteria%2C%20France%2C%202012%5Cu20122020%20%28response%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00f4me%22%2C%22lastName%22%3A%22Daniau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Berger-Carbonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022-6%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3201%5C%2Feid2806.220686%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9155901%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221080-6040%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A28%3A15Z%22%7D%7D%2C%7B%22key%22%3A%2232L5JEUW%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22De%20Castro%20et%20al.%22%2C%22parsedDate%22%3A%222022-08-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDe%20Castro%2C%20N.%2C%20Mecha%26%23xEF%3B%2C%20F.%2C%20Bachelet%2C%20D.%2C%20Canestri%2C%20A.%2C%20Joly%2C%20V.%2C%20Vandenhende%2C%20M.%2C%20Boutoille%2C%20D.%2C%20Kerjouan%2C%20M.%2C%20Veziris%2C%20N.%2C%20Molina%2C%20J.%20M.%2C%20Grall%2C%20N.%2C%20Tattevin%2C%20P.%2C%20Laou%26%23xE9%3Bnan%2C%20C.%2C%20Yazdanpanah%2C%20Y.%20and%20for%20the%20FAST%20TB%20Study%20Group%20%282022%29.%20%26lt%3Bb%26gt%3BTreatment%20With%20a%20Three-Drug%20Regimen%20for%20Pulmonary%20Tuberculosis%20Based%20on%20Rapid%20Molecular%20Detection%20of%20Isoniazid%20Resistance%3A%20A%20Noninferiority%20Randomized%20Trial%20%28FAST-TB%29%26lt%3B%5C%2Fb%26gt%3B.%20Open%20Forum%20Infectious%20Diseases%20%26lt%3Bi%26gt%3B9%26lt%3B%5C%2Fi%26gt%3B%2C%20ofac353%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofac353%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofac353%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Treatment%20With%20a%20Three-Drug%20Regimen%20for%20Pulmonary%20Tuberculosis%20Based%20on%20Rapid%20Molecular%20Detection%20of%20Isoniazid%20Resistance%3A%20A%20Noninferiority%20Randomized%20Trial%20%28FAST-TB%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22De%20Castro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%22%2C%22lastName%22%3A%22Mecha%5Cu00ef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Bachelet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Canestri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V%22%2C%22lastName%22%3A%22Joly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%22%2C%22lastName%22%3A%22Vandenhende%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Boutoille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%22%2C%22lastName%22%3A%22Kerjouan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%20M%22%2C%22lastName%22%3A%22Molina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Grall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%22%2C%22lastName%22%3A%22Tattevin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Laou%5Cu00e9nan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y%22%2C%22lastName%22%3A%22Yazdanpanah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22for%20the%20FAST%20TB%20Study%20Group%22%7D%5D%2C%22abstractNote%22%3A%22The%20rationale%20behind%20the%20use%20of%20ethambutol%20in%20the%20standard%20tuberculosis%20treatment%20is%20to%20prevent%20the%20emergence%20of%20resistance%20to%20rifampicin%20in%20case%20of%20primary%20resistance%20to%20isoniazid.%20We%20evaluated%20whether%20early%20detection%20of%20isoniazid%20resistance%20using%20molecular%20testing%20allows%20the%20use%20an%20ethambutol-free%20regimen.FAST-TB%2C%20a%20phase%204%2C%20French%2C%20multicenter%2C%20open-label%2C%20non-inferiority%20trial%2C%20compared%202%20strategies%3A%20%281%29%20polymerase%20chain%20reaction%20%28PCR%29-based%20detection%20of%20isoniazid%20and%20rifampicin%20resistance%20at%20baseline%20using%20Genotype%20MTBDRplus%20version%202.0%20followed%20by%20ethambutol%20discontinuation%20if%20no%20resistance%20was%20detected%20%28PCR%20arm%29%20and%20%282%29%20a%20standard%204-drug%20combination%2C%20pending%20phenotypic%20drug-susceptibility%20results%20%28C%20arm%29.%20Adult%20patients%20with%20smear-positive%20pulmonary%20tuberculosis%20were%20enrolled.%20The%20primary%20endpoint%20was%20the%20proportion%20of%20patients%20with%20treatment%20success%20defined%20as%20bacteriological%20or%20clinical%20cure%20at%20the%20end%20of%20treatment.%20A%20non-inferiority%20margin%20of%2010%25%20was%20used.Two%20hundred%20three%20patients%20were%20randomized%2C%20104%20in%20the%20PCR%20arm%20and%2099%20in%20the%20C%20arm%3A%2026.6%25%20were%20female%2C%20median%20age%20was%2037%20%28interquartile%20range%2C%2028%5Cu201351%29%20years%2C%2072.4%25%20were%20born%20in%20Africa%2C%20and%205.4%25%20were%20infected%20with%20human%20immunodeficiency%20virus.%20Chest%20x-ray%20showed%20cavities%20in%2064.5%25%20of%20the%20cases.%20Overall%2C%20169%20patients%20met%20criteria%20of%20treatment%20success%3A%2087%20of%20104%20%2883.7%25%29%20in%20the%20PCR%20arm%20and%2082%20of%2099%20%2882.8%25%29%20in%20the%20C%20arm%20with%20a%20difference%20of%20%2B0.8%25%20%2890%25%20confidence%20interval%2C%20%5Cu22127.9%20to%209.6%29%2C%20meeting%20the%20noninferiority%20criteria%20in%20the%20intention-to-treat%20population%20%28P%5Cu2009%3D%5Cu2009.02%29.In%20a%20setting%20with%20low%20prevalence%20of%20primary%20isoniazid%20resistance%2C%20a%203-drug%20combination%20with%20isoniazid%2C%20rifampicin%2C%20and%20pyrazinamide%2C%20based%20on%20rapid%20detection%20of%20isoniazid%20resistance%20using%20molecular%20testing%2C%20was%20noninferior%20to%20starting%20the%20recommended%204-drug%20regimen.%22%2C%22date%22%3A%222022-08-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fofid%5C%2Fofac353%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofac353%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222328-8957%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A20%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22S6JQ4XIX%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Eimer%20et%20al.%22%2C%22parsedDate%22%3A%222022-06-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BEimer%2C%20J.%2C%20Fr%26%23xE9%3Bchet-Jachym%2C%20M.%2C%20Le%20D%26%23xFB%3B%2C%20D.%2C%20Caumes%2C%20E.%2C%20El-Helali%2C%20N.%2C%20Marigot-Outtandy%2C%20D.%2C%20Mechai%2C%20F.%2C%20Peytavin%2C%20G.%2C%20Pourcher%2C%20V.%2C%20Rioux%2C%20C.%2C%20Yazdanpanah%2C%20Y.%2C%20Robert%2C%20J.%2C%20Guglielmetti%2C%20L.%20and%20for%20the%20LZDM%20group%20%282022%29.%20%26lt%3Bb%26gt%3BIncreased%20linezolid%20plasma%20concentrations%20are%20associated%20with%20the%20development%20of%20severe%20toxicity%20in%20MDR-TB%20treatment.%26lt%3B%5C%2Fb%26gt%3B%20Clinical%20Infectious%20Diseases%20ciac485%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac485%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac485%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Increased%20linezolid%20plasma%20concentrations%20are%20associated%20with%20the%20development%20of%20severe%20toxicity%20in%20MDR-TB%20treatment.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Eimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Fr%5Cu00e9chet-Jachym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Le%20D%5Cu00fb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Caumes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Najoua%22%2C%22lastName%22%3A%22El-Helali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dhiba%22%2C%22lastName%22%3A%22Marigot-Outtandy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Mechai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Peytavin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Pourcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Rioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yazdan%22%2C%22lastName%22%3A%22Yazdanpanah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22for%20the%20LZDM%20group%22%7D%5D%2C%22abstractNote%22%3A%22Treatment%20of%20multidrug-resistant%20tuberculosis%20%28MDR-TB%29%20with%20linezolid%20is%20characterized%20by%20high%20rates%20of%20adverse%20events.%20Evidence%20on%20therapeutic%20drug%20monitoring%20to%20predict%20drug%20toxicity%20is%20scarce.%20This%20study%20aimed%20to%20evaluate%20the%20association%20of%20linezolid%20trough%20concentrations%20with%20severe%20toxicity.We%20retrospectively%20assessed%20consecutive%20patients%20started%20on%20linezolid%20for%20MDR-TB%20between%202011%20and%202017.%20The%20primary%20outcome%20was%20severe%20mitochondrial%20toxicity%20%28SMT%29%20due%20to%20linezolid%2C%20defined%20as%20neurotoxicity%20or%20myelotoxicity%20leading%20to%20drug%20discontinuation.%20The%20impact%20of%20plasma%20linezolid%20trough%20concentrations%20%26gt%3B2%5Cu2005mg%5C%2FL%20was%20assessed%20in%20multivariate%20Cox%20proportional%20hazards%20models%20including%20time-varying%20covariates.SMT%20occurred%20in%2057%20of%20146%20included%20patients%20%2839%25%29%20at%20an%20incidence%20rate%20of%200.38%20per%20person-year%20%2895%25CI%200.30-0.49%29.%20A%20maximum%20linezolid%20trough%20concentration%20%26gt%3B2%5Cu2005mg%5C%2FL%20was%20detected%20in%2052%20patients%20%2835.6%25%29%2C%20while%20the%20mean%20trough%20concentration%20was%20%26gt%3B2%5Cu2005mg%5C%2FL%20in%2022%20%2815%25%29.%20The%20adjusted%20hazard%20ratio%20for%20SMT%20was%202.35%20%2895%25CI%201.26%5Cu20134.38%2C%20p%5Cu2009%3D%5Cu20090.01%29%20in%20patients%20with%20a%20mean%20trough%20concentration%20%26gt%3B2%5Cu2005mg%5C%2FL%20and%202.63%20%2895%25CI%201.55%5Cu20134.47%2C%20p%5Cu2009%26lt%3B%5Cu20090.01%29%20for%20SMT%20after%20the%20first%20detection%20of%20a%20trough%20concentration%20%26gt%3B2%5Cu2005mg%5C%2FL.%20In%20an%20exploratory%20analysis%2C%20higher%20maximum%20trough%20concentrations%20were%20dose-dependently%20associated%20with%20toxicity%2C%20while%20lowering%20of%20elevated%20trough%20concentrations%20did%20not%20restore%20baseline%20risk.Linezolid%20trough%20concentrations%20%26gt%3B2%5Cu2005mg%5C%2FL%20are%20strongly%20associated%20with%20the%20development%20of%20severe%20treatment-emergent%20toxicity%20in%20patients%20treated%20for%20MDR-TB.%20Pending%20further%20prospective%20evidence%2C%20an%20individual%20risk-benefit%20assessment%20on%20the%20continuation%20of%20linezolid%20treatment%20is%20warranted%20in%20any%20patient%20with%20trough%20concentrations%20above%202%5Cu2005mg%5C%2FL.%22%2C%22date%22%3A%222022-06-19%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciac485%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac485%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221058-4838%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-08T13%3A02%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22QDAG4PLL%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Group%20et%20al.%22%2C%22parsedDate%22%3A%222022-04-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGroup%2C%20A.%20S.%20T.%2C%20Georghiou%2C%20S.%20B.%2C%20Rodwell%2C%20T.%20C.%2C%20Korobitsyn%2C%20A.%2C%20Abbadi%2C%20S.%20H.%2C%20Ajbani%2C%20K.%2C%20Alffenaar%2C%20J.-W.%2C%20Alland%2C%20D.%2C%20Alvarez%2C%20N.%2C%20Andres%2C%20S.%2C%20Ardizzoni%2C%20E.%2C%20Aubry%2C%20A.%2C%20Baldan%2C%20R.%2C%20Ballif%2C%20M.%2C%20Barilar%2C%20I.%2C%20B%26%23xF6%3Bttger%2C%20E.%20C.%2C%20Chakravorty%2C%20S.%2C%20Claxton%2C%20P.%20M.%2C%20Cirillo%2C%20D.%20M.%2C%20Comas%2C%20I.%2C%20Coulter%2C%20C.%2C%20Denkinger%2C%20C.%20M.%2C%20Derendinger%2C%20B.%2C%20Desmond%2C%20E.%20P.%2C%20Steenwinkel%2C%20J.%20E.%20M.%20de%2C%20Dheda%2C%20K.%2C%20Diacon%2C%20A.%20H.%2C%20Dolinger%2C%20D.%20L.%2C%20Dooley%2C%20K.%20E.%2C%20Egger%2C%20M.%2C%20Ehsani%2C%20S.%2C%20Farhat%2C%20M.%20R.%2C%20Fattorini%2C%20L.%2C%20Finci%2C%20I.%2C%20Ray%2C%20L.%20F.%20L.%2C%20Furi%26%23xF3%3B%2C%20V.%2C%20Groenheit%2C%20R.%2C%20Gumbo%2C%20T.%2C%20Heysell%2C%20S.%20K.%2C%20Hillemann%2C%20D.%2C%20Hoffmann%2C%20H.%2C%20Hsueh%2C%20P.-R.%2C%20Hu%2C%20Y.%2C%20Huang%2C%20H.%2C%20Hussain%2C%20A.%2C%20Ismail%2C%20F.%2C%20Izumi%2C%20K.%2C%20Jagielski%2C%20T.%2C%20Johnson%2C%20J.%20L.%2C%20Kambli%2C%20P.%2C%20Kaniga%2C%20K.%2C%20Karunaratne%2C%20G.%20H.%20R.%20E.%2C%20Sharma%2C%20M.%20K.%2C%20Keller%2C%20P.%20M.%2C%20Kelly%2C%20E.%20C.%2C%20Kholina%2C%20M.%2C%20Kohli%2C%20M.%2C%20Kranzer%2C%20K.%2C%20Laurenson%2C%20I.%20F.%2C%20Limberis%2C%20J.%2C%20Lin%2C%20S.-Y.%20G.%2C%20Liu%2C%20Y.%2C%20L%26%23xF3%3Bpez-Gav%26%23xED%3Bn%2C%20A.%2C%20Lyander%2C%20A.%2C%20Machado%2C%20D.%2C%20Martinez%2C%20E.%2C%20Masood%2C%20F.%2C%20Mitarai%2C%20S.%2C%20Mvelase%2C%20N.%20R.%2C%20Niemann%2C%20S.%2C%20Nikolayevskyy%2C%20V.%2C%20Maurer%2C%20F.%20P.%2C%20Merker%2C%20M.%2C%20Miotto%2C%20P.%2C%20Omar%2C%20S.%20V.%2C%20Otto-Knapp%2C%20R.%2C%20Palaci%2C%20M.%2C%20Guti%26%23xE9%3Brrez%2C%20J.%20J.%20P.%2C%20Peacock%2C%20S.%20J.%2C%20Peloquin%2C%20C.%20A.%2C%20Perera%2C%20J.%2C%20Pierre-Audigier%2C%20C.%2C%20Pholwat%2C%20S.%2C%20Posey%2C%20J.%20E.%2C%20Prammananan%2C%20T.%2C%20Rigouts%2C%20L.%2C%20Robledo%2C%20J.%2C%20Rockwood%2C%20N.%2C%20Rodrigues%2C%20C.%2C%20Salfinger%2C%20M.%2C%20Schechter%2C%20M.%20C.%2C%20Seifert%2C%20M.%2C%20Sengstake%2C%20S.%2C%20Shinnick%2C%20T.%2C%20Shubladze%2C%20N.%2C%20Sintchenko%2C%20V.%2C%20Sirgel%2C%20F.%2C%20Somasundaram%2C%20S.%2C%20Sterling%2C%20T.%20R.%2C%20Spitaleri%2C%20A.%2C%20Streicher%2C%20E.%2C%20Supply%2C%20P.%2C%20Svensson%2C%20E.%2C%20Tagliani%2C%20E.%2C%20Tahseen%2C%20S.%2C%20Takaki%2C%20A.%2C%20Theron%2C%20G.%2C%20Torrea%2C%20G.%2C%20Deun%2C%20A.%20V.%2C%20Ingen%2C%20J.%20van%2C%20Rie%2C%20A.%20V.%2C%20Soolingen%2C%20D.%20van%2C%20Jr%2C%20R.%20V.%2C%20Venter%2C%20A.%2C%20Veziris%2C%20N.%2C%20Villellas%2C%20C.%2C%20Viveiros%2C%20M.%2C%20Warren%2C%20R.%2C%20Wen%2C%20S.%2C%20Werngren%2C%20J.%2C%20Wilkinson%2C%20R.%20J.%2C%20Yang%2C%20C.%2C%20Y%26%23x131%3Blmaz%2C%20F.%20F.%2C%20Zhang%2C%20T.%2C%20Zimenkov%2C%20D.%2C%20Ismail%2C%20N.%2C%20K%26%23xF6%3Bser%2C%20C.%20U.%20and%20Sch%26%23xF6%3Bn%2C%20T.%20%282022%29.%20%26lt%3Bb%26gt%3BUpdating%20the%20approaches%20to%20define%20susceptibility%20and%20resistance%20to%20anti-tuberculosis%20agents%3A%20implications%20for%20diagnosis%20and%20treatment%26lt%3B%5C%2Fb%26gt%3B.%20European%20Respiratory%20Journal%20%26lt%3Bi%26gt%3B59%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.00166-2022%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.00166-2022%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Updating%20the%20approaches%20to%20define%20susceptibility%20and%20resistance%20to%20anti-tuberculosis%20agents%3A%20implications%20for%20diagnosis%20and%20treatment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antimycobacterial%20Susceptibility%20Testing%22%2C%22lastName%22%3A%22Group%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophia%20B.%22%2C%22lastName%22%3A%22Georghiou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20C.%22%2C%22lastName%22%3A%22Rodwell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexei%22%2C%22lastName%22%3A%22Korobitsyn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Said%20H.%22%2C%22lastName%22%3A%22Abbadi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kanchan%22%2C%22lastName%22%3A%22Ajbani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan-Willem%22%2C%22lastName%22%3A%22Alffenaar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Alland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nataly%22%2C%22lastName%22%3A%22Alvarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00f6nke%22%2C%22lastName%22%3A%22Andres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Ardizzoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rossella%22%2C%22lastName%22%3A%22Baldan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivan%22%2C%22lastName%22%3A%22Barilar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%20C.%22%2C%22lastName%22%3A%22B%5Cu00f6ttger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soumitesh%22%2C%22lastName%22%3A%22Chakravorty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pauline%20M.%22%2C%22lastName%22%3A%22Claxton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%20M.%22%2C%22lastName%22%3A%22Cirillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I%5Cu00f1aki%22%2C%22lastName%22%3A%22Comas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22Coulter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%20M.%22%2C%22lastName%22%3A%22Denkinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brigitta%22%2C%22lastName%22%3A%22Derendinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edward%20P.%22%2C%22lastName%22%3A%22Desmond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jurriaan%20E.%20M.%20de%22%2C%22lastName%22%3A%22Steenwinkel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keertan%22%2C%22lastName%22%3A%22Dheda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20H.%22%2C%22lastName%22%3A%22Diacon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20L.%22%2C%22lastName%22%3A%22Dolinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelly%20E.%22%2C%22lastName%22%3A%22Dooley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soudeh%22%2C%22lastName%22%3A%22Ehsani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maha%20R.%22%2C%22lastName%22%3A%22Farhat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lanfranco%22%2C%22lastName%22%3A%22Fattorini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%22%2C%22lastName%22%3A%22Finci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%20Fournier%20Le%22%2C%22lastName%22%3A%22Ray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victoria%22%2C%22lastName%22%3A%22Furi%5Cu00f3%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%22%2C%22lastName%22%3A%22Groenheit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tawanda%22%2C%22lastName%22%3A%22Gumbo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Scott%20K.%22%2C%22lastName%22%3A%22Heysell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Doris%22%2C%22lastName%22%3A%22Hillemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harald%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Po-Ren%22%2C%22lastName%22%3A%22Hsueh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hairong%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alamdar%22%2C%22lastName%22%3A%22Hussain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farzana%22%2C%22lastName%22%3A%22Ismail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiyohiko%22%2C%22lastName%22%3A%22Izumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tomasz%22%2C%22lastName%22%3A%22Jagielski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20L.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Priti%22%2C%22lastName%22%3A%22Kambli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kon%5Cu00e9%22%2C%22lastName%22%3A%22Kaniga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20H.%20R.%20Eranga%22%2C%22lastName%22%3A%22Karunaratne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meenu%20Kaushal%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20M.%22%2C%22lastName%22%3A%22Keller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellis%20C.%22%2C%22lastName%22%3A%22Kelly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margarita%22%2C%22lastName%22%3A%22Kholina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikashmi%22%2C%22lastName%22%3A%22Kohli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Kranzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ian%20F.%22%2C%22lastName%22%3A%22Laurenson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%22%2C%22lastName%22%3A%22Limberis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.-Y.%20Grace%22%2C%22lastName%22%3A%22Lin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yongge%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandre%22%2C%22lastName%22%3A%22L%5Cu00f3pez-Gav%5Cu00edn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Lyander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elena%22%2C%22lastName%22%3A%22Martinez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faisal%22%2C%22lastName%22%3A%22Masood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Satoshi%22%2C%22lastName%22%3A%22Mitarai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nomonde%20R.%22%2C%22lastName%22%3A%22Mvelase%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vladyslav%22%2C%22lastName%22%3A%22Nikolayevskyy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%20P.%22%2C%22lastName%22%3A%22Maurer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Merker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paolo%22%2C%22lastName%22%3A%22Miotto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaheed%20V.%22%2C%22lastName%22%3A%22Omar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralf%22%2C%22lastName%22%3A%22Otto-Knapp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mois%5Cu00e9s%22%2C%22lastName%22%3A%22Palaci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20Jos%5Cu00e9%20Palacios%22%2C%22lastName%22%3A%22Guti%5Cu00e9rrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sharon%20J.%22%2C%22lastName%22%3A%22Peacock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20A.%22%2C%22lastName%22%3A%22Peloquin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Perera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Pierre-Audigier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suporn%22%2C%22lastName%22%3A%22Pholwat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20E.%22%2C%22lastName%22%3A%22Posey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Therdsak%22%2C%22lastName%22%3A%22Prammananan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leen%22%2C%22lastName%22%3A%22Rigouts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaime%22%2C%22lastName%22%3A%22Robledo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neesha%22%2C%22lastName%22%3A%22Rockwood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camilla%22%2C%22lastName%22%3A%22Rodrigues%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%22%2C%22lastName%22%3A%22Salfinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcos%20C.%22%2C%22lastName%22%3A%22Schechter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marva%22%2C%22lastName%22%3A%22Seifert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Sengstake%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Shinnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Shubladze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vitali%22%2C%22lastName%22%3A%22Sintchenko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederick%22%2C%22lastName%22%3A%22Sirgel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sulochana%22%2C%22lastName%22%3A%22Somasundaram%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20R.%22%2C%22lastName%22%3A%22Sterling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Spitaleri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Streicher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Supply%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22Svensson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Tagliani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabira%22%2C%22lastName%22%3A%22Tahseen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akiko%22%2C%22lastName%22%3A%22Takaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Grant%22%2C%22lastName%22%3A%22Theron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Torrea%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Armand%20Van%22%2C%22lastName%22%3A%22Deun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%20van%22%2C%22lastName%22%3A%22Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annelies%20Van%22%2C%22lastName%22%3A%22Rie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dick%20van%22%2C%22lastName%22%3A%22Soolingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%20Vargas%22%2C%22lastName%22%3A%22Jr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amour%22%2C%22lastName%22%3A%22Venter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Villellas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Viveiros%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Warren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shu%27an%22%2C%22lastName%22%3A%22Wen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jim%22%2C%22lastName%22%3A%22Werngren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20J.%22%2C%22lastName%22%3A%22Wilkinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caie%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%20Ferda%22%2C%22lastName%22%3A%22Y%5Cu0131lmaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tingting%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Danila%22%2C%22lastName%22%3A%22Zimenkov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazir%22%2C%22lastName%22%3A%22Ismail%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudio%20U.%22%2C%22lastName%22%3A%22K%5Cu00f6ser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Sch%5Cu00f6n%22%7D%5D%2C%22abstractNote%22%3A%22Tweetable%20abstract%20%40ERSpublications%5Cnclick%20to%20tweetInappropriately%20high%20breakpoints%20have%20resulted%20in%20systematic%20false-susceptible%20AST%20results%20to%20anti-TB%20drugs.%20MIC%2C%20PK%5C%2FPD%20and%20clinical%20outcome%20data%20should%20be%20combined%20when%20setting%20breakpoints%20to%20minimise%20the%20emergence%20and%20spread%20of%20antimicrobial%20resistance.%20https%3A%5C%2F%5C%2Fbit.ly%5C%2F3i43wb6%22%2C%22date%22%3A%222022%5C%2F04%5C%2F01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1183%5C%2F13993003.00166-2022%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Ferj.ersjournals.com%5C%2Fcontent%5C%2F59%5C%2F4%5C%2F2200166%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220903-1936%2C%201399-3003%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-06-29T14%3A23%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22NH7XCKNV%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guglielmetti%20et%20al.%22%2C%22parsedDate%22%3A%222022-05-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuglielmetti%2C%20L.%2C%20G%26%23xFC%3Bnther%2C%20G.%2C%20Leu%2C%20C.%2C%20Cirillo%2C%20D.%2C%20Duarte%2C%20R.%2C%20Garcia-Basteiro%2C%20A.%20L.%2C%20Goletti%2C%20D.%2C%20Jankovic%2C%20M.%2C%20Kuksa%2C%20L.%2C%20Maurer%2C%20F.%20P.%2C%20M%26%23xE9%3Bcha%26%23xEF%3B%2C%20F.%2C%20Tiberi%2C%20S.%2C%20Leth%2C%20F.%20van%2C%20Veziris%2C%20N.%20and%20Lange%2C%20C.%20%282022%29.%20%26lt%3Bb%26gt%3BRifapentine%20access%20in%20Europe%3A%20growing%20concerns%20over%20key%20tuberculosis%20treatment%20component%26lt%3B%5C%2Fb%26gt%3B.%20European%20Respiratory%20Journal%20%26lt%3Bi%26gt%3B59%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.00388-2022%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.00388-2022%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rifapentine%20access%20in%20Europe%3A%20growing%20concerns%20over%20key%20tuberculosis%20treatment%20component%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claude%22%2C%22lastName%22%3A%22Leu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%22%2C%22lastName%22%3A%22Cirillo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Duarte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alberto%20L.%22%2C%22lastName%22%3A%22Garcia-Basteiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delia%22%2C%22lastName%22%3A%22Goletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mateja%22%2C%22lastName%22%3A%22Jankovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liga%22%2C%22lastName%22%3A%22Kuksa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%20P.%22%2C%22lastName%22%3A%22Maurer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22M%5Cu00e9cha%5Cu00ef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Tiberi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%20van%22%2C%22lastName%22%3A%22Leth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%5D%2C%22abstractNote%22%3A%22Tweetable%20abstract%20%40ERSpublications%5Cnclick%20to%20tweetLack%20of%20access%20to%20rifapentine%20in%20Europe%20denies%20patients%20optimal%20care%20for%20active%20tuberculosis%20and%20latent%20tuberculosis%20infection%2C%20and%20deprives%20healthcare%20providers%20of%20adequate%20tools%20to%20pursue%20tuberculosis%20control%20and%20elimination%20https%3A%5C%2F%5C%2Fbit.ly%5C%2F3jz85eh%22%2C%22date%22%3A%222022%5C%2F05%5C%2F01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1183%5C%2F13993003.00388-2022%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Ferj.ersjournals.com%5C%2Fcontent%5C%2F59%5C%2F5%5C%2F2200388%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220903-1936%2C%201399-3003%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-06-29T14%3A23%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22MY9BQ8HY%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guyeux%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuyeux%2C%20C.%2C%20Senelle%2C%20G.%2C%20Refr%26%23xE9%3Bgier%2C%20G.%2C%20Bretelle-Establet%2C%20F.%2C%20Cambau%2C%20E.%20and%20Sola%2C%20C.%20%282022%29.%20%26lt%3Bb%26gt%3BConnection%20between%20two%20historical%20tuberculosis%20outbreak%20sites%20in%20Japan%2C%20Honshu%2C%20by%20a%20new%20ancestral%20Mycobacterium%20tuberculosis%20L2%20sublineage%26lt%3B%5C%2Fb%26gt%3B.%20Epidemiology%20%26amp%3B%20Infection%20%26lt%3Bi%26gt%3B150%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1017%5C%2FS0950268822000048%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1017%5C%2FS0950268822000048%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Connection%20between%20two%20historical%20tuberculosis%20outbreak%20sites%20in%20Japan%2C%20Honshu%2C%20by%20a%20new%20ancestral%20Mycobacterium%20tuberculosis%20L2%20sublineage%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Guyeux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaetan%22%2C%22lastName%22%3A%22Senelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guislaine%22%2C%22lastName%22%3A%22Refr%5Cu00e9gier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Bretelle-Establet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Sola%22%7D%5D%2C%22abstractNote%22%3A%22By%20gathering%20680%20publicly%20available%20Sequence%20Read%20Archives%20from%20isolates%20of%20Mycobacterium%20tuberculosis%20complex%20%28MTBC%29%20including%20190%20belonging%20to%20the%20lineage%202%20Beijing%2C%20and%20using%20an%20in-house%20bioinformatical%20pipeline%2C%20the%20TB-Annotator%2C%20that%20analyses%20more%20than%2050%20000%20characters%2C%20we%20describe%20herein%20a%20new%20L2%20sublineage%20from%2020%20isolates%20found%20in%20the%20Tochigi%20province%2C%20%28Japan%29%2C%20that%20we%20designate%20as%20asia%20ancestral%205%20%28AAnc5%29.%20These%20isolates%20harbour%20a%20number%20of%20specific%20criteria%20%2842%20SNPs%29%20and%20their%20intra-cluster%20pairwise%20distance%20suggests%20historical%20and%20not%20epidemiological%20transmission.%20These%20isolates%20harbour%20a%20mutation%20in%20rpoC%2C%20and%20do%20not%20fulfil%2C%20any%20of%20the%20modern%20Beijing%20lineage%20criteria%2C%20nor%20any%20of%20the%20other%20ancestral%20Beijing%20lineages%20described%20so%20far.%20Asia%20ancestral%205%20isolates%20do%20not%20possess%20mutT2%2058%20and%20ogt%2012%20characteristics%20of%20modern%20Beijing%2C%20but%20possess%20ancestral%20Beijing%20SNPs%20characteristics.%20By%20looking%20into%20the%20literature%2C%20we%20found%20a%20reference%20isolate%20ID381%2C%20described%20in%20Kobe%20and%20Osaka%20belonging%20to%20the%20%5Cu2018G3%5Cu2019%20group%2C%20sharing%2036%20out%20of%20the%2042%20specific%20SNPs%20found%20in%20AAnc5.%20We%20also%20assessed%20the%20intermediate%20position%20of%20the%20asia%20ancestral%204%20%28AAnc4%29%20sublineage%20recently%20described%20in%20Thailand%20and%20propose%20an%20improved%20classification%20of%20the%20L2%20that%20now%20includes%20AAnc4%20and%20AAnc5.%20By%20increasing%20the%20recruitment%20into%20TB-Annotator%20to%20around%203000%20genomes%20%28including%20642%20belonging%20to%20L2%29%2C%20we%20confirmed%20our%20results%20and%20discovered%20additional%20historical%20ancestral%20L2%20branches%20that%20remain%20to%20be%20investigated%20in%20more%20detail.%20We%20also%20present%2C%20in%20addition%2C%20some%20anthropological%20and%20historical%20data%20from%20Chinese%20and%20Japan%20history%20of%20tuberculosis%2C%20as%20well%20as%20from%20Korea%2C%20that%20could%20support%20our%20results%20on%20L2%20evolution.%20This%20study%20shows%20that%20the%20reconstruction%20of%20the%20early%20history%20of%20tuberculosis%20in%20Asia%20is%20likely%20to%20reveal%20complex%20patterns%20since%20its%20emergence.%22%2C%22date%22%3A%222022%5C%2Fed%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1017%5C%2FS0950268822000048%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.cambridge.org%5C%2Fcore%5C%2Fjournals%5C%2Fepidemiology-and-infection%5C%2Farticle%5C%2Fconnection-between-two-historical-tuberculosis-outbreak-sites-in-japan-honshu-by-a-new-ancestral-mycobacterium-tuberculosis-l2-sublineage%5C%2F79482A3DD638BB99618B2CCDAA4EBC56%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220950-2688%2C%201469-4409%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-05-26T21%3A18%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22A2TD2VUD%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Holmgaard%20et%20al.%22%2C%22parsedDate%22%3A%222022-11-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHolmgaard%2C%20F.%20B.%2C%20Guglielmetti%2C%20L.%2C%20Lillebaek%2C%20T.%2C%20Andersen%2C%20%26%23xC5%3B.%20B.%2C%20Wejse%2C%20C.%20and%20Dahl%2C%20V.%20N.%20%282022%29.%20%26lt%3Bb%26gt%3BEfficacy%20and%20tolerability%20of%20concomitant%20use%20of%20bedaquiline%20and%20delamanid%20for%20multidrug-%20and%20extensively%20drug-resistant%20tuberculosis%3A%20a%20systematic%20review%20and%20meta-analysis%26lt%3B%5C%2Fb%26gt%3B.%20Clin%20Infect%20Dis%20ciac876%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac876%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac876%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Efficacy%20and%20tolerability%20of%20concomitant%20use%20of%20bedaquiline%20and%20delamanid%20for%20multidrug-%20and%20extensively%20drug-resistant%20tuberculosis%3A%20a%20systematic%20review%20and%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Freja%20Breth%22%2C%22lastName%22%3A%22Holmgaard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Troels%22%2C%22lastName%22%3A%22Lillebaek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%5Cu00c5se%20Bengaard%22%2C%22lastName%22%3A%22Andersen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Wejse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%20Naestholt%22%2C%22lastName%22%3A%22Dahl%22%7D%5D%2C%22abstractNote%22%3A%22The%20introduction%20of%20two%20novel%20drugs%2C%20bedaquiline%20and%20delamanid%2C%20has%20given%20hope%20for%20better%20and%20shorter%20treatments%20of%20drug-resistant%20tuberculosis.%20A%20systematic%20review%20was%20conducted%20to%20evaluate%20the%20efficacy%20and%20safety%20of%20concomitant%20bedaquiline%20and%20delamanid%20administration.%20Pooled%20estimates%20of%20WHO-defined%20favorable%20treatment%20outcome%20and%20significant%20QTc-interval%20prolongation%20%28QTc%20%5Cu2265500%5Cu2005ms%20or%20%5Cu226560%5Cu2005ms%20increase%20from%20baseline%29%20were%20calculated%20using%20a%20random%20effects%20model.%20Thirteen%20studies%20including%20a%20total%20of%201031%20individuals%20with%20multidrug-resistant%5C%2Frifampicin-resistant%20tuberculosis%20who%20received%20bedaquiline%20and%20delamanid%20were%20included.%20The%20pooled%20estimate%20of%20favorable%20treatment%20outcome%20was%2073.1%25%20%2895%25CI%3A%2064.3-81.8%29.%20Sputum%20culture%20conversion%20at%20six%20months%20ranged%20from%2061-95%25.%20Overall%2C%20the%20pooled%20proportion%20of%20QTc-prolongation%20was%207.8%25%20%2895%25CI%3A%204.1-11.6%29%20and%20few%20cardiac%20events%20were%20reported%20%280.8%25%2C%20n%5Cu2009%3D%5Cu20096%5C%2F798%29.%20Rates%20of%20sputum%20culture%20conversion%20and%20favorable%20treatment%20outcome%20were%20high%20in%20patients%20treated%20concomitantly%20with%20bedaquiline%20and%20delamanid%2C%20and%20the%20treatment%20seemed%20tolerable%20with%20low%20rates%20of%20clinically%20significant%20cardiac%20toxicity.%22%2C%22date%22%3A%222022-11-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciac876%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221537-6591%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-03-10T14%3A59%3A47Z%22%7D%7D%2C%7B%22key%22%3A%224ND3DBVZ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Khan%20and%20Guglielmetti%22%2C%22parsedDate%22%3A%222022-09-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKhan%2C%20U.%20and%20Guglielmetti%2C%20L.%20%282022%29.%20%26lt%3Bb%26gt%3BEvidence%20and%20ethical%20considerations%20for%20the%20treatment%20of%20contacts%20exposed%20to%20drug-resistant%20TB%26lt%3B%5C%2Fb%26gt%3B.%20The%20International%20Journal%20of%20Tuberculosis%20and%20Lung%20Disease%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%2C%20900%26%23x2013%3B901%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.22.0328%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.22.0328%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evidence%20and%20ethical%20considerations%20for%20the%20treatment%20of%20contacts%20exposed%20to%20drug-resistant%20TB%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22U.%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022-09-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtld.22.0328%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-26T13%3A17%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22YKWPDBTM%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kherabi%20et%20al.%22%2C%22parsedDate%22%3A%222022-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKherabi%2C%20Y.%2C%20Fr%26%23xE9%3Bchet-Jachym%2C%20M.%2C%20Rioux%2C%20C.%2C%20Yazdanpanah%2C%20Y.%2C%20M%26%23xE9%3Bcha%26%23xEF%3B%2C%20F.%2C%20Pourcher%2C%20V.%2C%20Robert%2C%20J.%20and%20Guglielmetti%2C%20L.%20%282022%29.%20%26lt%3Bb%26gt%3BRevised%20Definitions%20of%20Tuberculosis%20Resistance%20and%20Treatment%20Outcomes%2C%20France%2C%202006%26%23x2013%3B2019%26lt%3B%5C%2Fb%26gt%3B.%20Emerg%20Infect%20Dis%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%2C%201796%26%23x2013%3B1804%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2809.220458%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2809.220458%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Revised%20Definitions%20of%20Tuberculosis%20Resistance%20and%20Treatment%20Outcomes%2C%20France%2C%202006%5Cu20132019%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yousra%22%2C%22lastName%22%3A%22Kherabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Fr%5Cu00e9chet-Jachym%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Rioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yazdan%22%2C%22lastName%22%3A%22Yazdanpanah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22M%5Cu00e9cha%5Cu00ef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Pourcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%5D%2C%22abstractNote%22%3A%22Definitions%20of%20resistance%20in%20multidrug-resistant%20tuberculosis%20%28MDR%20TB%29%20and%20extensively%20drug-resistant%20tuberculosis%20%28XDR%20TB%29%20have%20been%20updated.%20Pre%5Cu2013XDR%20TB%2C%20defined%20as%20MDR%20TB%20with%20additional%20resistance%20to%20fluoroquinolones%2C%20and%20XDR%20TB%2C%20with%20additional%20resistance%20to%20bedaquiline%20or%20linezolid%2C%20are%20frequently%20associated%20with%20treatment%20failure%20and%20toxicity.%20We%20retrospectively%20determined%20the%20effects%20of%20pre-XDR%5C%2FXDR%20TB%20resistance%20on%20outcomes%20and%20safety%20of%20MDR%20TB%20treatment%20in%20France.%20The%20study%20included%20298%20patients%20treated%20for%20MDR%20TB%20at%203%20reference%20centers%20during%202006%5Cu20132019.%20Of%20those%2C%20205%20%2868.8%25%29%20cases%20were%20fluoroquinolone-susceptible%20MDR%20TB%20and%2093%20%2831.2%25%29%20were%20pre-XDR%5C%2FXDR%20TB.%20Compared%20with%20fluoroquinolone-susceptible%20MDR%20TB%2C%20pre-XDR%5C%2FXDR%20TB%20was%20associated%20with%20more%20cavitary%20lung%20lesions%20and%20bilateral%20disease%20and%20required%20longer%20treatment.%20Overall%2C%20202%20patients%20%2867.8%25%29%20had%20favorable%20treatment%20outcomes%2C%20with%20no%20significant%20difference%20between%20pre-XDR%5C%2FXDR%20TB%20%2867.7%25%29%20and%20fluoroquinolone-susceptible%20MDR%20TB%20%2867.8%25%3B%20p%20%3D%200.99%29.%20Pre-XDR%5C%2FXDR%20TB%20was%20not%20associated%20with%20higher%20risk%20for%20serious%20adverse%20events.%22%2C%22date%22%3A%222022-9%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3201%5C%2Feid2809.220458%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9423894%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221080-6040%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A14%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22JXJYY2QR%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kherabi%20et%20al.%22%2C%22parsedDate%22%3A%222022-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKherabi%2C%20Y.%2C%20Tunesi%2C%20S.%2C%20Kay%2C%20A.%20and%20Guglielmetti%2C%20L.%20%282022%29.%20%26lt%3Bb%26gt%3BPreventive%20Therapy%20for%20Contacts%20of%20Drug-Resistant%20Tuberculosis%26lt%3B%5C%2Fb%26gt%3B.%20Pathogens%20%26lt%3Bi%26gt%3B11%26lt%3B%5C%2Fi%26gt%3B%2C%201189%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fpathogens11101189%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fpathogens11101189%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Preventive%20Therapy%20for%20Contacts%20of%20Drug-Resistant%20Tuberculosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yousra%22%2C%22lastName%22%3A%22Kherabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Tunesi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%5D%2C%22abstractNote%22%3A%22Preventing%20the%20progression%20of%20a%20drug-resistant%20tuberculosis%20%28DR-TB%29%20infection%20to%20disease%20is%20an%20important%20pillar%20of%20the%20DR-TB%20elimination%20strategy.%20International%20guidelines%20have%20recently%20proposed%20fluoroquinolones%20for%20tuberculosis%20preventive%20therapy%20%28TPT%29%20in%20DR-TB%20contacts%2C%20although%20the%20available%20evidence%20is%20low%20quality.%20The%20pooled%20data%20from%20small%20observational%20studies%20suggest%20that%20a%20fluoroquinolone-based%20TPT%20is%20safe%2C%20effective%20and%20cost-effective%20as%20a%20preventive%20treatment%20in%20DR-TB%20contacts.%20Three%20clinical%20trials%20are%20currently%20ongoing%20to%20generate%20higher%20quality%20evidence%20on%20the%20efficacy%20of%20levofloxacin%20and%20delamanid%20as%20a%20DR-TB%20preventive%20therapy.%20Additional%20evidence%20is%20also%20needed%2C%20regarding%20TPT%20treatment%20in%20fluoroquinolone-resistant-TB%20contacts%2C%20patient%20and%20health%20care%20worker%20perceptions%20on%20DR-TB%20preventive%20therapy%20for%20contacts%2C%20and%20the%20service%20delivery%20models%20to%20increase%20DR-TPT%20access.%20This%20state-of-the-art%20review%20presents%20the%20current%20literature%20on%20TPT%20for%20contacts%20of%20DR-TB%20cases%2C%20focusing%20on%20the%20available%20evidence%20and%20international%20guidelines.%22%2C%22date%22%3A%222022%5C%2F10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fpathogens11101189%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2076-0817%5C%2F11%5C%2F10%5C%2F1189%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222076-0817%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-12-28T16%3A07%3A55Z%22%7D%7D%2C%7B%22key%22%3A%223SA6SQXF%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kilin%5Cu00e7%20et%20al.%22%2C%22parsedDate%22%3A%222022-06-24%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKilin%26%23xE7%3B%2C%20G.%2C%20Walburg%2C%20K.%20V.%2C%20Franken%2C%20K.%20L.%20M.%20C.%2C%20Valkenburg%2C%20M.%20L.%2C%20Aubry%2C%20A.%2C%20Haks%2C%20M.%20C.%2C%20Saris%2C%20A.%20and%20Ottenhoff%2C%20T.%20H.%20M.%20%282022%29.%20%26lt%3Bb%26gt%3BDevelopment%20of%20Human%20Cell-Based%20In%20Vitro%20Infection%20Models%20to%20Determine%20the%20Intracellular%20Survival%20of%20Mycobacterium%20avium%26lt%3B%5C%2Fb%26gt%3B.%20Front%20Cell%20Infect%20Microbiol%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%2C%20872361%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcimb.2022.872361%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcimb.2022.872361%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20of%20Human%20Cell-Based%20In%20Vitro%20Infection%20Models%20to%20Determine%20the%20Intracellular%20Survival%20of%20Mycobacterium%20avium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00fcl%22%2C%22lastName%22%3A%22Kilin%5Cu00e7%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kimberley%20V.%22%2C%22lastName%22%3A%22Walburg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kees%20L.%20M.%20C.%22%2C%22lastName%22%3A%22Franken%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Merel%20L.%22%2C%22lastName%22%3A%22Valkenburg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mari%5Cu00eblle%20C.%22%2C%22lastName%22%3A%22Haks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anno%22%2C%22lastName%22%3A%22Saris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%20H.%20M.%22%2C%22lastName%22%3A%22Ottenhoff%22%7D%5D%2C%22abstractNote%22%3A%22The%20Mycobacterium%20avium%20%28Mav%29%20complex%20accounts%20for%20more%20than%2080%25%20of%20all%20pulmonary%20diseases%20caused%20by%20non-tuberculous%20mycobacteria%20%28NTM%29%20infections%2C%20which%20have%20an%20alarming%20increase%20in%20prevalence%20and%20vary%20in%20different%20regions%2C%20currently%20reaching%200.3%5Cu20139.8%20per%20100%2C000%20individuals.%20Poor%20clinical%20outcomes%2C%20as%20a%20result%20of%20increasing%20microbial%20drug%20resistance%20and%20low%20treatment%20adherence%20due%20to%20drug-toxicities%2C%20emphasize%20the%20need%20for%20more%20effective%20treatments.%20Identification%20of%20more%20effective%20treatments%2C%20however%2C%20appears%20to%20be%20difficult%2C%20which%20may%20be%20due%20to%20the%20intracellular%20life%20of%20NTM%20and%20concomitant%20altered%20drug%20sensitivity%20that%20is%20not%20taken%20into%20account%20using%20traditional%20drug%20susceptibility%20testing%20screenings.%20We%20therefore%20developed%20human%20cell-based%20in%20vitro%20Mav%20infection%20models%20using%20the%20human%20MelJuSo%20cell%20line%20as%20well%20as%20primary%20human%20macrophages%20and%20a%20fluorescently%20labeled%20Mav%20strain.%20By%20testing%20a%20range%20of%20multiplicity%20of%20infection%20%28MOI%29%20and%20using%20flow%20cytometry%20and%20colony-forming%20unit%20%28CFU%29%20analysis%2C%20we%20found%20that%20an%20MOI%20of%2010%20was%20the%20most%20suitable%20for%20Mav%20infection%20in%20primary%20human%20macrophages%2C%20whereas%20an%20MOI%20of%2050%20was%20required%20to%20achieve%20similar%20results%20in%20MelJuSo%20cells.%20Moreover%2C%20by%20monitoring%20intracellular%20bacterial%20loads%20over%20time%2C%20the%20macrophages%20were%20shown%20to%20be%20capable%20of%20controlling%20the%20infection%2C%20while%20MelJuSo%20cells%20failed%20to%20do%20so.%20When%20comparing%20the%20MGIT%20system%20with%20the%20classical%20CFU%20counting%20assay%20to%20determine%20intracellular%20bacterial%20loads%2C%20MGIT%20appeared%20as%20a%20less%20labor-intensive%2C%20more%20precise%2C%20and%20more%20objective%20alternative.%20Next%2C%20using%20our%20macrophage%20Mav%20infection%20models%2C%20the%20drug%20efficacy%20of%20the%20first-line%20drug%20rifampicin%20and%20the%20more%20recently%20discovered%20bedaquiline%20on%20intracellular%20bacteria%20was%20compared%20to%20the%20activity%20on%20extracellular%20bacteria.%20The%20efficacy%20of%20the%20antibiotics%20inhibiting%20bacterial%20growth%20was%20significantly%20lower%20against%20intracellular%20bacteria%20compared%20to%20extracellular%20bacteria.%20This%20finding%20emphasizes%20the%20crucial%20role%20of%20the%20host%20cell%20during%20infection%20and%20drug%20susceptibility%20and%20highlights%20the%20usefulness%20of%20the%20models.%20Taken%20together%2C%20the%20human%20cell-based%20Mav%20infection%20models%20are%20reliable%20tools%20to%20determine%20the%20intracellular%20loads%20of%20Mav%2C%20which%20will%20enable%20researchers%20to%20investigate%20host%5Cu2013pathogen%20interactions%20and%20to%20evaluate%20the%20efficacy%20of%20%28host-directed%29%20therapeutic%20strategies%20against%20Mav.%22%2C%22date%22%3A%222022-6-24%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffcimb.2022.872361%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9263196%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222235-2988%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A31%3A19Z%22%7D%7D%2C%7B%22key%22%3A%224KRX87K9%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kraef%20et%20al.%22%2C%22parsedDate%22%3A%222022-07-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKraef%2C%20C.%2C%20Lindquist%2C%20E.%2C%20Svensson%2C%20E.%20and%20Cambau%2C%20E.%20%282022%29.%20%26lt%3Bb%26gt%3BDiagnostic%20toolkit%20for%20tuberculosis%3A%20should%20we%20include%20urine%20lipoarabinomannan%20%28LAM%29%20detection%20in%20the%20WHO%20European%20Region%3F%26lt%3B%5C%2Fb%26gt%3B%20Clinical%20Microbiology%20and%20Infection%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2022.06.022%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.cmi.2022.06.022%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Diagnostic%20toolkit%20for%20tuberculosis%3A%20should%20we%20include%20urine%20lipoarabinomannan%20%28LAM%29%20detection%20in%20the%20WHO%20European%20Region%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Kraef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilia%22%2C%22lastName%22%3A%22Lindquist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22Svensson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022-07-05%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.cmi.2022.06.022%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1198743X22003366%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221198-743X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A28%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22WWYPJGM4%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lange%20et%20al.%22%2C%22parsedDate%22%3A%222022-01-25%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLange%2C%20C.%2C%20B%26%23xF6%3Bttger%2C%20E.%20C.%2C%20Cambau%2C%20E.%2C%20Griffith%2C%20D.%20E.%2C%20Guglielmetti%2C%20L.%2C%20van%20Ingen%2C%20J.%2C%20Knight%2C%20S.%20L.%2C%20Marras%2C%20T.%20K.%2C%20Olivier%2C%20K.%20N.%2C%20Santin%2C%20M.%2C%20Stout%2C%20J.%20E.%2C%20Tortoli%2C%20E.%2C%20Wagner%2C%20D.%2C%20Winthrop%2C%20K.%2C%20Daley%2C%20C.%20L.%2C%20Lange%2C%20C.%2C%20Andrejak%2C%20C.%2C%20B%26%23xF6%3Bttger%2C%20E.%2C%20Cambau%2C%20E.%2C%20Griffith%2C%20D.%2C%20Guglielmetti%2C%20L.%2C%20van%20Ingen%2C%20J.%2C%20Knight%2C%20S.%2C%20Leitman%2C%20P.%2C%20Marras%2C%20T.%20K.%2C%20Olivier%2C%20K.%20N.%2C%20Santin%2C%20M.%2C%20Stout%2C%20J.%20E.%2C%20Tortoli%2C%20E.%2C%20Wagner%2C%20D.%2C%20Wallace%2C%20R.%20J.%2C%20Winthrop%2C%20K.%20and%20Daley%2C%20C.%20%282022%29.%20%26lt%3Bb%26gt%3BConsensus%20management%20recommendations%20for%20less%20common%20non-tuberculous%20mycobacterial%20pulmonary%20diseases%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Infectious%20Diseases%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2821%2900586-7%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS1473-3099%2821%2900586-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Consensus%20management%20recommendations%20for%20less%20common%20non-tuberculous%20mycobacterial%20pulmonary%20diseases%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%20C%22%2C%22lastName%22%3A%22B%5Cu00f6ttger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20E%22%2C%22lastName%22%3A%22Griffith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shandra%20L%22%2C%22lastName%22%3A%22Knight%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodore%20K%22%2C%22lastName%22%3A%22Marras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20N%22%2C%22lastName%22%3A%22Olivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Santin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%20E%22%2C%22lastName%22%3A%22Stout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrico%22%2C%22lastName%22%3A%22Tortoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Winthrop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20L%22%2C%22lastName%22%3A%22Daley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Andrejak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22B%5Cu00f6ttger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Griffith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakko%22%2C%22lastName%22%3A%22van%20Ingen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shandra%22%2C%22lastName%22%3A%22Knight%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Leitman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodore%20K.%22%2C%22lastName%22%3A%22Marras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20N.%22%2C%22lastName%22%3A%22Olivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Santin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%20E.%22%2C%22lastName%22%3A%22Stout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrico%22%2C%22lastName%22%3A%22Tortoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Wallace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Winthrop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Daley%22%7D%5D%2C%22abstractNote%22%3A%22The%202020%20clinical%20practice%20guideline%20for%20the%20treatment%20of%20non-tuberculous%20mycobacterial%20pulmonary%20disease%20%28NTM-PD%29%20by%20the%20American%20Thoracic%20Society%2C%20European%20Respiratory%20Society%2C%20European%20Society%20of%20Clinical%20Microbiology%20and%20Infectious%20Diseases%2C%20and%20Infectious%20Diseases%20Society%20of%20America%3B%20and%20the%202017%20management%20guideline%20by%20the%20British%20Thoracic%20Society%20covered%20pulmonary%20diseases%20in%20adults%20caused%20by%20Mycobacterium%20avium%20complex%2C%20Mycobacterium%20kansasii%2C%20Mycobacterium%20xenopi%2C%20and%20Mycobacterium%20abscessus.%20In%20order%20to%20provide%20evidence-based%20recommendations%20for%20the%20treatment%20of%20less%20common%20non-tuberculous%20mycobacterial%20%28NTM%29%20species%20in%20adult%20patients%20without%20cystic%20fibrosis%20or%20HIV%20infection%2C%20our%20expert%20panel%20group%20performed%20systematic%20literature%20searches%20to%20provide%20management%20guidance%20for%20pulmonary%20diseases%20caused%20by%20seven%20additional%20organisms%3A%20Mycobacterium%20chelonae%2C%20Mycobacterium%20fortuitum%2C%20Mycobacterium%20genavense%2C%20Mycobacterium%20gordonae%2C%20Mycobacterium%20malmoense%2C%20Mycobacterium%20simiae%2C%20and%20Mycobacterium%20szulgai.%20Treatment%20recommendations%20were%20developed%20by%20a%20structured%20consensus%20process.%20The%20evidence%20from%20the%20scientific%20literature%20published%20in%20English%20for%20treatment%20recommendations%20for%20pulmonary%20diseases%20caused%20by%20other%20NTM%20species%20was%20of%20very%20low%20quality%2C%20with%20the%20exception%20of%20M%20malmoense%2C%20and%20based%20on%20the%20evaluation%20of%20case%20reports%20and%20case%20series.%20For%20M%20malmoense%2C%20results%20from%20two%20randomised%20controlled%20trials%20and%20three%20retrospective%20cohort%20studies%20provided%20a%20better%20evidence%20base%20for%20treatment%20recommendations%2C%20although%20the%20evidence%20was%20still%20of%20low%20quality.%22%2C%22date%22%3A%222022-01-25%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS1473-3099%2821%2900586-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1473309921005867%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221473-3099%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-16T14%3A15%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22DP27S3F7%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Le%20Ray%20et%20al.%22%2C%22parsedDate%22%3A%222022-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLe%20Ray%2C%20L.%20F.%2C%20Aubry%2C%20A.%2C%20Sougakoff%2C%20W.%2C%20Revest%2C%20M.%2C%20Robert%2C%20J.%2C%20Bonnet%2C%20I.%2C%20Veziris%2C%20N.%20and%20Morel%2C%20F.%20%282022%29.%20%26lt%3Bb%26gt%3BatpE%20Mutation%20in%20Mycobacterium%20tuberculosis%20Not%20Always%20Predictive%20of%20Bedaquiline%20Treatment%20Failure%26lt%3B%5C%2Fb%26gt%3B.%20Emerg%20Infect%20Dis%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%2C%201062%26%23x2013%3B1064%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2805.212517%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3201%5C%2Feid2805.212517%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22atpE%20Mutation%20in%20Mycobacterium%20tuberculosis%20Not%20Always%20Predictive%20of%20Bedaquiline%20Treatment%20Failure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%20Fournier%22%2C%22lastName%22%3A%22Le%20Ray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wladimir%22%2C%22lastName%22%3A%22Sougakoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Revest%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Robert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Bonnet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Morel%22%7D%5D%2C%22abstractNote%22%3A%22We%20report%20the%20emergence%20of%20an%20atpE%20mutation%20in%20a%20clinical%20Mycobacterium%20tuberculosis%20strain.%20Genotypic%20and%20phenotypic%20bedaquiline%20susceptibility%20testing%20displayed%20variable%20results%20over%20time%20and%20ultimately%20were%20not%20predictive%20of%20treatment%20outcome.%20This%20observation%20highlights%20the%20limits%20of%20current%20genotypic%20and%20phenotypic%20methods%20for%20detection%20of%20bedaquiline%20resistance.%22%2C%22date%22%3A%222022-5%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3201%5C%2Feid2805.212517%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9045433%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221080-6040%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-07-06T13%3A29%3A33Z%22%7D%7D%2C%7B%22key%22%3A%22VG5PNGPC%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Maitre%20et%20al.%22%2C%22parsedDate%22%3A%222022-07%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMaitre%2C%20T.%2C%20Morel%2C%20F.%2C%20Brossier%2C%20F.%2C%20Sougakoff%2C%20W.%2C%20Jaffre%2C%20J.%2C%20Cheng%2C%20S.%2C%20Veziris%2C%20N.%2C%20Aubry%2C%20A.%20and%20on%20behalf%20of%20the%20NRC-MyRMA%20%282022%29.%20%26lt%3Bb%26gt%3BHow%20a%20PCR%20Sequencing%20Strategy%20Can%20Bring%20New%20Data%20to%20Improve%20the%20Diagnosis%20of%20Ethionamide%20Resistance%26lt%3B%5C%2Fb%26gt%3B.%20Microorganisms%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%2C%201436%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fmicroorganisms10071436%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fmicroorganisms10071436%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22How%20a%20PCR%20Sequencing%20Strategy%20Can%20Bring%20New%20Data%20to%20Improve%20the%20Diagnosis%20of%20Ethionamide%20Resistance%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Maitre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Brossier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wladimir%22%2C%22lastName%22%3A%22Sougakoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9remy%22%2C%22lastName%22%3A%22Jaffre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sokleaph%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22on%20behalf%20of%20the%20NRC-MyRMA%22%7D%5D%2C%22abstractNote%22%3A%22Ethionamide%20%28ETH%29%20is%20a%20second-line%20antituberculosis%20drug.%20ETH%20resistance%20%28ETH-R%29%20is%20mainly%20related%20to%20the%20mutations%20of%20the%20monooxygenase-activating%20ETH%20%28EthA%29%2C%20the%20ETH%20target%20%28InhA%29%2C%20and%20the%20inhA%20promoter.%20Nonetheless%2C%20diagnosing%20ETH-R%20is%20still%20challenging.%20We%20assessed%20the%20strategy%20used%20for%20detecting%20ETH-R%20at%20the%20French%20National%20Reference%20Center%20for%20Mycobacteria%20in%20497%20MDR-TB%20isolates%20received%20from%202008%20to%202016.%20The%20genotypic%20ETH%5Cu2019s%20resistance%20detection%20was%20performed%20by%20sequencing%20ethA%2C%20ethR%2C%20the%20ethA-ethR%20intergenic%20region%2C%20and%20the%20inhA%20promoter%20in%20the%20497%20multidrug-resistant%20isolates%2C%20whereas%20the%20phenotypic%20ETH%20susceptibility%20testing%20%28PST%29%20was%20performed%20using%20the%20reference%20proportion%20method.%20Mutations%20were%20found%20in%20up%20to%2076%25%20of%20the%20387%20resistant%20isolates%20and%20in%20up%20to%2028%25%20of%20the%20110%20susceptible%20isolates.%20Our%20results%20do%20not%20support%20the%20role%20of%20ethR%20mutations%20in%20ETH%20resistance.%20Altogether%2C%20the%20positive%20predictive%20value%20of%20our%20genotypic%20strategy%20to%20diagnose%20ETH-R%20was%20improved%20when%20only%20considering%20the%20variants%20included%20in%20the%20WHO%20catalogue%20and%20in%20other%20databases%2C%20such%20as%20TB-Profiler.%20Therefore%2C%20our%20work%20will%20help%20to%20update%20the%20list%20of%20mutations%20that%20could%20be%20graded%20as%20being%20associated%20with%20resistance%20to%20improve%20ETH-R%20diagnosis.%22%2C%22date%22%3A%222022%5C%2F7%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fmicroorganisms10071436%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2076-2607%5C%2F10%5C%2F7%5C%2F1436%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222076-2607%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A18%3A47Z%22%7D%7D%2C%7B%22key%22%3A%222V395TDR%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Marijke%20Braet%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMarijke%20Braet%2C%20S.%2C%20Jouet%2C%20A.%2C%20Aubry%2C%20A.%2C%20Van%20Dyck-Lippens%2C%20M.%2C%20Lenoir%2C%20E.%2C%20Assoumani%2C%20Y.%2C%20Baco%2C%20A.%2C%20Mzembaba%2C%20A.%2C%20Cambau%2C%20E.%2C%20Vasconcellos%2C%20S.%20E.%20G.%2C%20Rigouts%2C%20L.%2C%20Suffys%2C%20P.%20N.%2C%20Hasker%2C%20E.%2C%20Supply%2C%20P.%20and%20de%20Jong%2C%20B.%20C.%20%282022%29.%20%26lt%3Bb%26gt%3BInvestigating%20drug%20resistance%20of%20Mycobacterium%20leprae%20in%20the%20Comoros%3A%20an%20observational%20deep-sequencing%20study%26lt%3B%5C%2Fb%26gt%3B.%20The%20Lancet%20Microbe%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%2C%20e693%26%23x2013%3Be700%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2666-5247%2822%2900117-3%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2666-5247%2822%2900117-3%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Investigating%20drug%20resistance%20of%20Mycobacterium%20leprae%20in%20the%20Comoros%3A%20an%20observational%20deep-sequencing%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sofie%22%2C%22lastName%22%3A%22Marijke%20Braet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agathe%22%2C%22lastName%22%3A%22Jouet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magalie%22%2C%22lastName%22%3A%22Van%20Dyck-Lippens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esteban%22%2C%22lastName%22%3A%22Lenoir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Younoussa%22%2C%22lastName%22%3A%22Assoumani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdallah%22%2C%22lastName%22%3A%22Baco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aboubacar%22%2C%22lastName%22%3A%22Mzembaba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sidra%20Ezidio%20Gon%5Cu00e7alves%22%2C%22lastName%22%3A%22Vasconcellos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leen%22%2C%22lastName%22%3A%22Rigouts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20Noel%22%2C%22lastName%22%3A%22Suffys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Epco%22%2C%22lastName%22%3A%22Hasker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Supply%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bouke%20Catherine%22%2C%22lastName%22%3A%22de%20Jong%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnDespite%20strong%20leprosy%20control%20measures%2C%20including%20effective%20treatment%2C%20leprosy%20persists%20in%20the%20Comoros.%20As%20of%20May%2C%202022%2C%20no%20resistance%20to%20anti-leprosy%20drugs%20had%20been%20reported%2C%20but%20there%20are%20no%20nationally%20representative%20data.%20Post-exposure%20prophylaxis%20%28PEP%29%20with%20rifampicin%20is%20offered%20to%20contacts%20of%20patients%20with%20leprosy.%20We%20aimed%20to%20conduct%20a%20countrywide%20drug%20resistance%20survey%20and%20investigate%20whether%20PEP%20led%20to%20the%20emergence%20of%20drug%20resistance%20in%20patients%20with%20leprosy.%5CnMethods%5CnIn%20this%20observational%2C%20deep-sequencing%20analysis%20we%20assessed%20Mycobacterium%20leprae%20genomes%20from%20skin%20biopsies%20of%20patients%20in%20Anjouan%20and%20Moh%5Cu00e9li%2C%20Comoros%2C%20collected%20as%20part%20of%20the%20ComLep%20%28NCT03526718%29%20and%20PEOPLE%20%28NCT03662022%29%20studies.%20Skin%20biopsies%20that%20had%20sufficient%20M%20leprae%20DNA%20%28%26gt%3B2000%20bacilli%20in%202%20%5Cu03bcl%20of%20DNA%20extract%29%20were%20assessed%20for%20the%20presence%20of%20seven%20drug%20resistance-associated%20genes%20%28ie%2C%20rpoB%2C%20ctpC%2C%20ctpI%2C%20folP1%2C%20gyrA%2C%20gyrB%2C%20and%20nth%29%20using%20Deeplex%20Myc-Lep%20%28targeted%20next%20generation%20deep%20sequencing%29%2C%20with%20a%20limit%20of%20detection%20of%2010%25%20for%20minority%20M%20leprae%20bacterial%20populations%20bearing%20a%20polymorphism%20in%20these%20genes.%20All%20newly%20registered%20patients%20with%20leprosy%20for%20whom%20written%20informed%20consent%20was%20obtained%20were%20eligible%20for%20inclusion%20in%20the%20survey.%20Patients%20younger%20than%202%20years%20or%20with%20a%20single%20lesion%20on%20the%20face%20did%20not%20have%20biopsies%20taken.%20The%20primary%20outcome%20of%20our%20study%20was%20the%20proportion%20of%20patients%20with%20leprosy%20%28ie%2C%20new%20cases%2C%20patients%20with%20relapses%20or%20reinfections%2C%20patients%20who%20received%20single%20%28double%29%20dose%20rifampicin-PEP%2C%20or%20patients%20who%20lived%20in%20villages%20where%20PEP%20was%20distributed%29%20who%20were%20infected%20with%20M%20leprae%20with%20a%20drug-resistant%20mutation%20for%20rifampicin%2C%20fluoroquinolone%2C%20or%20dapsone%20in%20the%20Comoros.%5CnFindings%5CnBetween%20July%201%2C%202017%2C%20and%20Dec%2031%2C%202020%2C%201199%20patients%20with%20leprosy%20were%20identified%20on%20the%20basis%20of%20clinical%20criteria%2C%20of%20whom%201030%20provided%20a%20skin%20biopsy.%20Of%20these%201030%20patients%2C%20755%20%2873%5Cu00b73%25%29%20tested%20positive%20for%20the%20M%20leprae-specific%20repetitive%20element-quantitative%20PCR%20%28qPCR%29%20assay.%20Of%20these%20755%20patients%2C%20260%20%2834%5Cu00b74%25%29%20were%20eligible%20to%20be%20analysed%20using%20Deeplex%20Myc-Lep.%20251%20%2896%5Cu00b75%25%29%20were%20newly%20diagnosed%20with%20leprosy%2C%20whereas%20nine%20%283%5Cu00b74%25%29%20patients%20had%20previously%20received%20multidrug%20therapy.%2045%20%2817%5Cu00b73%25%29%20patients%20resided%20in%20villages%20where%20PEP%20had%20been%20administered%20in%202015%20or%202019%2C%20two%20%284%5Cu00b74%25%29%20of%20whom%20received%20PEP.%20All%20seven%20drug%20resistance-associated%20targets%20were%20successfully%20sequenced%20in%20216%20samples%2C%2039%20samples%20had%20incomplete%20results%2C%20and%20five%20had%20no%20results.%20No%20mutations%20were%20detected%20in%20any%20of%20the%20seven%20drug%20resistance-related%20genes%20for%20any%20patient%20with%20successfully%20sequenced%20results.%5CnInterpretation%5CnThis%20drug%20resistance%20survey%20provides%20evidence%20to%20show%20that%20M%20leprae%20is%20fully%20susceptible%20to%20rifampicin%2C%20fluoroquinolones%2C%20and%20dapsone%20in%20the%20Comoros.%20Our%20results%20also%20show%2C%20for%20the%20first%20time%2C%20the%20applicability%20of%20targeted%20sequencing%20directly%20on%20skin%20biopsies%20from%20patients%20with%20either%20paucibacillary%20or%20multibacillary%20leprosy.%20These%20data%20suggest%20that%20PEP%20had%20not%20selected%20rifampicin-resistant%20strains%2C%20although%20further%20support%20for%20this%20finding%20should%20be%20confirmed%20with%20a%20larger%20sample%20size.%5CnFunding%5CnEffect%3AHope%2C%20The%20Mission%20To%20End%20Leprosy%2C%20the%20Fonds%20Wetenschappelijk%20Onderzoek%2C%20the%20EU.%22%2C%22date%22%3A%222022-09-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2666-5247%2822%2900117-3%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS2666524722001173%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222666-5247%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-09-23T13%3A29%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22M3NEXJYZ%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Migliori%20et%20al.%22%2C%22parsedDate%22%3A%222022-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMigliori%2C%20G.%20B.%2C%20Wu%2C%20S.%20J.%2C%20Matteelli%2C%20A.%2C%20Zenner%2C%20D.%2C%20Goletti%2C%20D.%2C%20Ahmedov%2C%20S.%2C%20Al-Abri%2C%20S.%2C%20Allen%2C%20D.%20M.%2C%20Balcells%2C%20M.%20E.%2C%20Garcia-Basteiro%2C%20A.%20L.%2C%20Cambau%2C%20E.%2C%20Chaisson%2C%20R.%20E.%2C%20Chee%2C%20C.%20B.%20E.%2C%20Dalcolmo%2C%20M.%20P.%2C%20Denholm%2C%20J.%20T.%2C%20Erkens%2C%20C.%2C%20Esposito%2C%20S.%2C%20Farnia%2C%20P.%2C%20Friedland%2C%20J.%20S.%2C%20Graham%2C%20S.%2C%20Hamada%2C%20Y.%2C%20Harries%2C%20A.%20D.%2C%20Kay%2C%20A.%20W.%2C%20Kritski%2C%20A.%2C%20Manga%2C%20S.%2C%20Marais%2C%20B.%20J.%2C%20Menzies%2C%20D.%2C%20Ng%2C%20D.%2C%20Petrone%2C%20L.%2C%20Rendon%2C%20A.%2C%20Silva%2C%20D.%20R.%2C%20Schaaf%2C%20H.%20S.%2C%20Skrahina%2C%20A.%2C%20Sotgiu%2C%20G.%2C%20Thwaites%2C%20G.%2C%20Tiberi%2C%20S.%2C%20Tukvadze%2C%20N.%2C%20Zellweger%2C%20J.-P.%2C%20D%26%23x2019%3BAmbrosio%2C%20L.%2C%20Centis%2C%20R.%20and%20Ong%2C%20C.%20W.%20M.%20%282022%29.%20%26lt%3Bb%26gt%3BClinical%20standards%20for%20the%20diagnosis%2C%20treatment%20and%20prevention%20of%20TB%20infection%26lt%3B%5C%2Fb%26gt%3B.%20Int%20J%20Tuberc%20Lung%20Dis%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%2C%20190%26%23x2013%3B205%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.21.0753%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5588%5C%2Fijtld.21.0753%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20standards%20for%20the%20diagnosis%2C%20treatment%20and%20prevention%20of%20TB%20infection%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20B.%22%2C%22lastName%22%3A%22Migliori%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20J.%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Matteelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Zenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Goletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Ahmedov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Al-Abri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%20M.%22%2C%22lastName%22%3A%22Allen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20E.%22%2C%22lastName%22%3A%22Balcells%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20L.%22%2C%22lastName%22%3A%22Garcia-Basteiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Cambau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20E.%22%2C%22lastName%22%3A%22Chaisson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20B.%20E.%22%2C%22lastName%22%3A%22Chee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20P.%22%2C%22lastName%22%3A%22Dalcolmo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20T.%22%2C%22lastName%22%3A%22Denholm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Erkens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Esposito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Farnia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20S.%22%2C%22lastName%22%3A%22Friedland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Graham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Hamada%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20D.%22%2C%22lastName%22%3A%22Harries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20W.%22%2C%22lastName%22%3A%22Kay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Kritski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Manga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20J.%22%2C%22lastName%22%3A%22Marais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Menzies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Ng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Petrone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Rendon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%20R.%22%2C%22lastName%22%3A%22Silva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%20S.%22%2C%22lastName%22%3A%22Schaaf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Skrahina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Sotgiu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Thwaites%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Tiberi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Tukvadze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.-P.%22%2C%22lastName%22%3A%22Zellweger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22D%5Cu2019Ambrosio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Centis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20W.%20M.%22%2C%22lastName%22%3A%22Ong%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%5CnTuberculosis%20%28TB%29%20preventive%20therapy%20%28TPT%29%20decreases%20the%20risk%20of%20developing%20TB%20disease%20and%20its%20associated%20morbidity%20and%20mortality.%20The%20aim%20of%20these%20clinical%20standards%20is%20to%20guide%20the%20assessment%2C%20management%20of%20TB%20infection%20%28TBI%29%20and%20implementation%20of%20TPT.%5Cn%5CnMETHODS%3A%5CnA%20panel%20of%20global%20experts%20in%20the%20field%20of%20TB%20care%20was%20identified%3B%2041%20participated%20in%20a%20Delphi%20process.%20A%205-point%20Likert%20scale%20was%20used%20to%20score%20the%20initial%20standards.%20After%20rounds%20of%20revision%2C%20the%20document%20was%20approved%20with%20100%25%20agreement.%5Cn%5CnRESULTS%3A%5CnEight%20clinical%20standards%20were%20defined%3A%20Standard%201%2C%20all%20individuals%20belonging%20to%20at-risk%20groups%20for%20TB%20should%20undergo%20testing%20for%20TBI%3B%20Standard%202%2C%20all%20individual%20candidates%20for%20TPT%20%28including%20caregivers%20of%20children%29%20should%20undergo%20a%20counselling%5C%2Fhealth%20education%20session%3B%20Standard%203%2C%20testing%20for%20TBI%3A%20timing%20and%20test%20of%20choice%20should%20be%20optimised%3B%20Standard%204%2C%20TB%20disease%20should%20be%20excluded%20prior%20to%20initiation%20of%20TPT%3B%20Standard%205%2C%20all%20candidates%20for%20TPT%20should%20undergo%20a%20set%20of%20baseline%20examinations%3B%20Standard%206%2C%20all%20individuals%20initiating%20TPT%20should%20receive%20one%20of%20the%20recommended%20regimens%3B%20Standard%207%2C%20all%20individuals%20who%20have%20started%20TPT%20should%20be%20monitored%3B%20Standard%208%2C%20a%20TBI%20screening%20and%20testing%20register%20should%20be%20kept%20to%20inform%20the%20cascade%20of%20care.%5Cn%5CnCONCLUSION%3A%5CnThis%20is%20the%20first%20consensus-based%20set%20of%20Clinical%20Standards%20for%20TBI.%20This%20document%20guides%20clinicians%2C%20programme%20managers%20and%20public%20health%20officers%20in%20planning%20and%20implementing%20adequate%20measures%20to%20assess%20and%20manage%20TBI.%22%2C%22date%22%3A%222022-3%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.5588%5C%2Fijtld.21.0753%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC8886963%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221027-3719%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-05-26T21%3A18%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22EDWVUW7S%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tunesi%20et%20al.%22%2C%22parsedDate%22%3A%222022-03-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BTunesi%2C%20S.%2C%20D%26%23xFB%3B%2C%20D.%20L.%2C%20Gualano%2C%20G.%2C%20Millet%2C%20J.-P.%2C%20Skrahin%2C%20A.%2C%20Bothamley%2C%20G.%2C%20Casas%2C%20X.%2C%20Goletti%2C%20D.%2C%20Lange%2C%20C.%2C%20Musso%2C%20M.%2C%20Palmieri%2C%20F.%2C%20Pourcher%2C%20V.%2C%20Rioux%2C%20C.%2C%20Skrahina%2C%20A.%2C%20Veziris%2C%20N.%2C%20Viatushka%2C%20D.%2C%20Jachym-Fr%26%23xE9%3Bchet%2C%20M.%20and%20Guglielmetti%2C%20L.%20%282022%29.%20%26lt%3Bb%26gt%3BCo-administration%20of%20treatment%20for%20rifampicin-resistant%20TB%20and%20chronic%20HCV%20infection%3A%20a%20TBnet%20and%20ESGMYC%20study%26lt%3B%5C%2Fb%26gt%3B.%20Journal%20of%20Infection%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jinf.2022.03.004%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jinf.2022.03.004%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Co-administration%20of%20treatment%20for%20rifampicin-resistant%20TB%20and%20chronic%20HCV%20infection%3A%20a%20TBnet%20and%20ESGMYC%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Tunesi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%20Le%22%2C%22lastName%22%3A%22D%5Cu00fb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%22%2C%22lastName%22%3A%22Gualano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joan-Pau%22%2C%22lastName%22%3A%22Millet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aliaksandr%22%2C%22lastName%22%3A%22Skrahin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Graham%22%2C%22lastName%22%3A%22Bothamley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%22%2C%22lastName%22%3A%22Casas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delia%22%2C%22lastName%22%3A%22Goletti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Musso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrizio%22%2C%22lastName%22%3A%22Palmieri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%22%2C%22lastName%22%3A%22Pourcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Rioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alena%22%2C%22lastName%22%3A%22Skrahina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dzmitry%22%2C%22lastName%22%3A%22Viatushka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Jachym-Fr%5Cu00e9chet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022-03-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jinf.2022.03.004%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS016344532200130X%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220163-4453%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-16T14%3A21%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22JTCH47MP%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vongthilath-Moeung%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVongthilath-Moeung%2C%20R.%2C%20Plojoux%2C%20J.%2C%20Poncet%2C%20A.%2C%20Renzi%2C%20G.%2C%20Veziris%2C%20N.%2C%20Schrenzel%2C%20J.%20and%20Janssens%2C%20J.-P.%20%282022%29.%20%26lt%3Bb%26gt%3BNontuberculous%20Mycobacteria%20under%20Scrutiny%20in%20the%20Geneva%20Area%20%282015%26%23x2013%3B2020%29%26lt%3B%5C%2Fb%26gt%3B.%20RES%20%26lt%3Bi%26gt%3B101%26lt%3B%5C%2Fi%26gt%3B%2C%20367%26%23x2013%3B375%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1159%5C%2F000520033%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1159%5C%2F000520033%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nontuberculous%20Mycobacteria%20under%20Scrutiny%20in%20the%20Geneva%20Area%20%282015%5Cu20132020%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rechana%22%2C%22lastName%22%3A%22Vongthilath-Moeung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Plojoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Poncet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gesuele%22%2C%22lastName%22%3A%22Renzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Veziris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Schrenzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Paul%22%2C%22lastName%22%3A%22Janssens%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bb%26gt%3B%26lt%3Bi%26gt%3BBackground%3A%26lt%3B%5C%2Fi%26gt%3B%26lt%3B%5C%2Fb%26gt%3B%20Nontuberculous%20mycobacteria%20%28NTM%29%20are%20increasingly%20identified%20in%20industrialized%20countries%2C%20and%20their%20role%20as%20pathogens%20is%20more%20frequently%20recognized.%20The%20relative%20prevalence%20of%20NTM%20strains%20shows%20an%20important%20geographical%20variability.%20Thus%2C%20establishing%20the%20local%20relative%20prevalence%20of%20NTM%20strains%20is%20relevant%20and%20useful%20for%20clinicians.%20%26lt%3Bb%26gt%3B%26lt%3Bi%26gt%3BMethods%3A%26lt%3B%5C%2Fi%26gt%3B%26lt%3B%5C%2Fb%26gt%3B%20Retrospective%20analysis%20%282015%5Cu20132020%29%20of%20a%20comprehensive%20database%20was%20conducted%20including%20all%20results%20of%20cultures%20for%20mycobacteria%20in%20a%20University%20Hospital%20%28Geneva%2C%20Switzerland%29%2C%20covering%20a%20population%20of%20approximately%20500%2C000%20inhabitants.%20All%20NTM%20culture-positive%20patients%20were%20included%20in%20the%20analyses.%20Patients%5Cu2019%20characteristics%2C%20NTM%20strains%2C%20and%20time%20to%20culture%20positivity%20were%20reported.%20%26lt%3Bb%26gt%3B%26lt%3Bi%26gt%3BResults%3A%26lt%3B%5C%2Fi%26gt%3B%26lt%3B%5C%2Fb%26gt%3B%20Among%2038%2C065%20samples%20analyzed%20during%20the%20study%20period%2C%20411%20were%20culture-positive%20for%20NTM%2C%20representing%20236%20strains%2C%20and%20231%20episodes%20of%20care%20which%20occurred%20in%20222%20patients.%20Patients%20in%20whom%20NTM%20were%20identified%20were%20predominantly%20female%20%2855%25%29%2C%20with%20a%20median%20age%20of%2062%20years%2C%20and%20a%20low%20BMI%20%28median%3A%2022.6%20kg%5C%2Fm%26lt%3Bsup%26gt%3B2%26lt%3B%5C%2Fsup%26gt%3B%29.%20The%20%26lt%3Bi%26gt%3BMycobacterium%20avium%26lt%3B%5C%2Fi%26gt%3B%20complex%20%28MAC%29%20was%20the%20most%20frequently%20identified%20group%20%2837%25%20of%20strains%29%20followed%20by%20%26lt%3Bi%26gt%3BMycobacterium%20gordonae%26lt%3B%5C%2Fi%26gt%3B%20%2825%25%29%20and%20%26lt%3Bi%26gt%3BMycobacterium%20xenopi%26lt%3B%5C%2Fi%26gt%3B%20%2812%25%29%20among%20the%20slowly%20growing%20mycobacteria%20%28SGM%29%2C%20while%20the%20%26lt%3Bi%26gt%3BMycobacterium%20chelonae%5C%2Fabscessus%26lt%3B%5C%2Fi%26gt%3B%20group%20%2811%25%29%20were%20the%20most%20frequently%20identified%20rapidly%20growing%20mycobacteria%20%28RGM%29.%20Only%2019%25%20of%20all%20patients%20were%20treated%2C%20mostly%20for%20pulmonary%20infections%3A%20the%20MAC%20was%20the%20most%20frequently%20treated%20NTM%20%28%26lt%3Bi%26gt%3Bn%26lt%3B%5C%2Fi%26gt%3B%20%3D%2019%2C%2043%25%20of%20cases%20in%20patients%20treated%29%20followed%20by%20RGM%20%28%26lt%3Bi%26gt%3Bn%26lt%3B%5C%2Fi%26gt%3B%20%3D%2015%2C%2034%25%29%20and%20%26lt%3Bi%26gt%3BM.%20xenopi%26lt%3B%5C%2Fi%26gt%3B%20%28%26lt%3Bi%26gt%3Bn%26lt%3B%5C%2Fi%26gt%3B%20%3D%206%2C%2014%25%29.%20Among%20those%20treated%2C%2023%25%20were%20immunosuppressed%2C%2012%25%20had%20pulmonary%20comorbidities%2C%20and%205%25%20systemic%20comorbidities.%20Cultures%20became%20positive%20after%20a%20median%20of%2041%20days%20%28IQR%3A%2023%3B%2068%29%20for%20SGM%20and%2028%20days%20%2814%3B%2035%29%20for%20RGM.%20%26lt%3Bb%26gt%3B%26lt%3Bi%26gt%3BConclusions%3A%26lt%3B%5C%2Fi%26gt%3B%26lt%3B%5C%2Fb%26gt%3B%20In%20Western%20Switzerland%2C%20%26lt%3Bi%26gt%3BM.%20avium%26lt%3B%5C%2Fi%26gt%3B%20and%20%26lt%3Bi%26gt%3BM.%20gordonae%26lt%3B%5C%2Fi%26gt%3B%20were%20the%20most%20prevalent%20NTM%20identified.%20Positive%20cultures%20for%20NTM%20led%20to%20a%20specific%20treatment%20in%2019%25%20of%20subjects.%20Patients%20with%20a%20positive%20culture%20for%20NTM%20were%20mostly%20female%2C%20with%20a%20median%20age%20of%2062%20years%2C%20a%20low%20BMI%2C%20and%20a%20low%20prevalence%20of%20immunosuppression%20or%20associated%20severe%20comorbidities.%22%2C%22date%22%3A%222022%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1159%5C%2F000520033%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.karger.com%5C%2FArticle%5C%2FFullText%5C%2F520033%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220025-7931%2C%201423-0356%22%2C%22language%22%3A%22english%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-03-10T21%3A33%3A36Z%22%7D%7D%2C%7B%22key%22%3A%228NJBYM8Z%22%2C%22library%22%3A%7B%22id%22%3A1368488%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wetzstein%20et%20al.%22%2C%22parsedDate%22%3A%222022-10-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWetzstein%2C%20N.%2C%20Drummer%2C%20A.-P.%2C%20Bockey%2C%20A.%2C%20Herrmann%2C%20E.%2C%20K%26%23xFC%3Bpper-Tetzel%2C%20C.%20P.%2C%20Graf%2C%20C.%2C%20Koch%2C%20B.%2C%20Goetsch%2C%20U.%2C%20Vehreschild%2C%20M.%20J.%20G.%20T.%2C%20Guglielmetti%2C%20L.%2C%20Lange%2C%20B.%2C%20Wichelhaus%2C%20T.%20A.%20and%20Stephan%2C%20C.%20%282022%29.%20%26lt%3Bb%26gt%3BOccurrence%20of%20extrapulmonary%20tuberculosis%20is%20associated%20with%20geographical%20origin%3A%20spatial%20characteristics%20of%20the%20Frankfurt%20TB%20cohort%202013%26%23x2013%3B2018%26lt%3B%5C%2Fb%26gt%3B.%20Infection%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20target%3D%26%23039%3B_blank%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs15010-022-01921-9%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs15010-022-01921-9%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Occurrence%20of%20extrapulmonary%20tuberculosis%20is%20associated%20with%20geographical%20origin%3A%20spatial%20characteristics%20of%20the%20Frankfurt%20TB%20cohort%202013%5Cu20132018%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nils%22%2C%22lastName%22%3A%22Wetzstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alena-Pauline%22%2C%22lastName%22%3A%22Drummer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annabelle%22%2C%22lastName%22%3A%22Bockey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eva%22%2C%22lastName%22%3A%22Herrmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus%20Philippe%22%2C%22lastName%22%3A%22K%5Cu00fcpper-Tetzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiana%22%2C%22lastName%22%3A%22Graf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Koch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Udo%22%2C%22lastName%22%3A%22Goetsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20J.%20G.%20T.%22%2C%22lastName%22%3A%22Vehreschild%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Guglielmetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20A.%22%2C%22lastName%22%3A%22Wichelhaus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Stephan%22%7D%5D%2C%22abstractNote%22%3A%22Tuberculosis%20%28TB%29%20is%20caused%20by%20M.%20tuberculosis%20complex%20%28MTB%29%20and%20pulmonary%20tuberculosis%20%28PTB%29%20is%20its%20classical%20manifestation.%20However%2C%20in%20some%20regions%20of%20the%20world%2C%20extrapulmonary%20TB%20%28EPTB%29%20seems%20to%20be%20more%20frequent.%22%2C%22date%22%3A%222022-10-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs15010-022-01921-9%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs15010-022-01921-9%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221439-0973%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222022-12-28T16%3A07%3A36Z%22%7D%7D%5D%7D
Aubry, A., Sammarco Rosa, P., Chauffour, A., Fletcher, M. L., Cambau, E. and Avanzi, C. (2022). Drug resistance in leprosy: An update following 70years of chemotherapy. Infectious Diseases Now 52, 243–251, http://doi.org/10.1016/j.idnow.2022.04.001.
Bachir, M., Guglielmetti, L., Tunesi, S., Billard-Pomares, T., Chiesi, S., Jaffré, J., Langris, H., Pourcher, V., Schramm, F., Lemaître, N. and Robert, J. (2022). Molecular detection of isoniazid monoresistance improves tuberculosis treatment: A retrospective cohort in France. Journal of Infection 85, 24–30, http://doi.org/10.1016/j.jinf.2022.05.017.
Bonnet, I., Haddad, E., Guglielmetti, L., Bémer, P., Bernard, L., Bourgoin, A., Brault, R., Catho, G., Caumes, E., Escaut, L., Fourniols, E., Fréchet-Jachym, M., Gaudart, A., Guillot, H., Lafon-Desmurs, B., Lanoix, J.-P., Lanotte, P., Lemaignen, A., Lemaire, B., Lemaitre, N., Michau, C., Morand, P., Mougari, F., Marigot-Outtandy, D., Patrat-Delon, S., Perpoint, T., Piau, C., Pourcher, V., Zarrouk, V., Zeller, V., Veziris, N., Jauréguiberry, S. and Aubry, A. (2022). Clinical Features and Outcome of Multidrug-Resistant Osteoarticular Tuberculosis: A 12-Year Case Series from France. Microorganisms 10, 1215, http://doi.org/10.3390/microorganisms10061215.
Chaptal, M., Andrejak, C., Bonifay, T., Beillard, E., Guillot, G., Guyomard-Rabenirina, S., Demar, M., Trombert-Paolantoni, S., Jacomo, V., Mosnier, E., Veziris, N., Djossou, F., Epelboin, L. and Group, F. G. P. working (2022). Epidemiology of infection by pulmonary non-tuberculous mycobacteria in French Guiana 2008–2018. PLOS Neglected Tropical Diseases 16, e0010693, http://doi.org/10.1371/journal.pntd.0010693.
Chiron, R., Hoefsloot, W., Van Ingen, J., Marchandin, H., Kremer, L., Morisse-Pradier, H., Charriot, J., Mallet, J.-P., Herrmann, J.-L., Caimmi, D., Moreau, J., Dumont, Y., Godreuil, S., Bergeron, A., Drevait, M., Bouzat-Rossigneux, E., Terrail, N., Andrejak, C., Veziris, N., Grenet, D., Coudrat, A. and Catherinot, E. (2022). Amikacin Liposomal Inhalation Suspension in the Treatment of Mycobacterium abscessus Lung Infection: A French Observational Experience. Open Forum Infect Dis 9, ofac465, http://doi.org/10.1093/ofid/ofac465.
Daniau, C., Lecorche, E., Mougari, F., Benmansour, H., Bernet, C., Blanchard, H., Robert, J., Berger-Carbonne, A. and Cambau, E. (2022). Association of Healthcare and Aesthetic Procedures with Infections Caused by Nontuberculous Mycobacteria, France, 2012‒2020. Emerg Infect Dis 28, 518–526, http://doi.org/10.3201/eid2803.211791.
Daniau, C., Berger-Carbonne, A. and Cambau, E. (2022). Association of Healthcare and Aesthetic Procedures with Infections Caused by Nontuberculous Mycobacteria, France, 2012‒2020 (response). Emerg Infect Dis 28, 1303–1304, http://doi.org/10.3201/eid2806.220686.
De Castro, N., Mechaï, F., Bachelet, D., Canestri, A., Joly, V., Vandenhende, M., Boutoille, D., Kerjouan, M., Veziris, N., Molina, J. M., Grall, N., Tattevin, P., Laouénan, C., Yazdanpanah, Y. and for the FAST TB Study Group (2022). Treatment With a Three-Drug Regimen for Pulmonary Tuberculosis Based on Rapid Molecular Detection of Isoniazid Resistance: A Noninferiority Randomized Trial (FAST-TB). Open Forum Infectious Diseases 9, ofac353, http://doi.org/10.1093/ofid/ofac353.
Eimer, J., Fréchet-Jachym, M., Le Dû, D., Caumes, E., El-Helali, N., Marigot-Outtandy, D., Mechai, F., Peytavin, G., Pourcher, V., Rioux, C., Yazdanpanah, Y., Robert, J., Guglielmetti, L. and for the LZDM group (2022). Increased linezolid plasma concentrations are associated with the development of severe toxicity in MDR-TB treatment. Clinical Infectious Diseases ciac485, http://doi.org/10.1093/cid/ciac485.
Group, A. S. T., Georghiou, S. B., Rodwell, T. C., Korobitsyn, A., Abbadi, S. H., Ajbani, K., Alffenaar, J.-W., Alland, D., Alvarez, N., Andres, S., Ardizzoni, E., Aubry, A., Baldan, R., Ballif, M., Barilar, I., Böttger, E. C., Chakravorty, S., Claxton, P. M., Cirillo, D. M., Comas, I., Coulter, C., Denkinger, C. M., Derendinger, B., Desmond, E. P., Steenwinkel, J. E. M. de, Dheda, K., Diacon, A. H., Dolinger, D. L., Dooley, K. E., Egger, M., Ehsani, S., Farhat, M. R., Fattorini, L., Finci, I., Ray, L. F. L., Furió, V., Groenheit, R., Gumbo, T., Heysell, S. K., Hillemann, D., Hoffmann, H., Hsueh, P.-R., Hu, Y., Huang, H., Hussain, A., Ismail, F., Izumi, K., Jagielski, T., Johnson, J. L., Kambli, P., Kaniga, K., Karunaratne, G. H. R. E., Sharma, M. K., Keller, P. M., Kelly, E. C., Kholina, M., Kohli, M., Kranzer, K., Laurenson, I. F., Limberis, J., Lin, S.-Y. G., Liu, Y., López-Gavín, A., Lyander, A., Machado, D., Martinez, E., Masood, F., Mitarai, S., Mvelase, N. R., Niemann, S., Nikolayevskyy, V., Maurer, F. P., Merker, M., Miotto, P., Omar, S. V., Otto-Knapp, R., Palaci, M., Gutiérrez, J. J. P., Peacock, S. J., Peloquin, C. A., Perera, J., Pierre-Audigier, C., Pholwat, S., Posey, J. E., Prammananan, T., Rigouts, L., Robledo, J., Rockwood, N., Rodrigues, C., Salfinger, M., Schechter, M. C., Seifert, M., Sengstake, S., Shinnick, T., Shubladze, N., Sintchenko, V., Sirgel, F., Somasundaram, S., Sterling, T. R., Spitaleri, A., Streicher, E., Supply, P., Svensson, E., Tagliani, E., Tahseen, S., Takaki, A., Theron, G., Torrea, G., Deun, A. V., Ingen, J. van, Rie, A. V., Soolingen, D. van, Jr, R. V., Venter, A., Veziris, N., Villellas, C., Viveiros, M., Warren, R., Wen, S., Werngren, J., Wilkinson, R. J., Yang, C., Yılmaz, F. F., Zhang, T., Zimenkov, D., Ismail, N., Köser, C. U. and Schön, T. (2022). Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment. European Respiratory Journal 59, http://doi.org/10.1183/13993003.00166-2022.
Guglielmetti, L., Günther, G., Leu, C., Cirillo, D., Duarte, R., Garcia-Basteiro, A. L., Goletti, D., Jankovic, M., Kuksa, L., Maurer, F. P., Méchaï, F., Tiberi, S., Leth, F. van, Veziris, N. and Lange, C. (2022). Rifapentine access in Europe: growing concerns over key tuberculosis treatment component. European Respiratory Journal 59, http://doi.org/10.1183/13993003.00388-2022.
Guyeux, C., Senelle, G., Refrégier, G., Bretelle-Establet, F., Cambau, E. and Sola, C. (2022). Connection between two historical tuberculosis outbreak sites in Japan, Honshu, by a new ancestral Mycobacterium tuberculosis L2 sublineage. Epidemiology & Infection 150, http://doi.org/10.1017/S0950268822000048.
Holmgaard, F. B., Guglielmetti, L., Lillebaek, T., Andersen, Å. B., Wejse, C. and Dahl, V. N. (2022). Efficacy and tolerability of concomitant use of bedaquiline and delamanid for multidrug- and extensively drug-resistant tuberculosis: a systematic review and meta-analysis. Clin Infect Dis ciac876, http://doi.org/10.1093/cid/ciac876.
Khan, U. and Guglielmetti, L. (2022). Evidence and ethical considerations for the treatment of contacts exposed to drug-resistant TB. The International Journal of Tuberculosis and Lung Disease 26, 900–901, http://doi.org/10.5588/ijtld.22.0328.
Kherabi, Y., Fréchet-Jachym, M., Rioux, C., Yazdanpanah, Y., Méchaï, F., Pourcher, V., Robert, J. and Guglielmetti, L. (2022). Revised Definitions of Tuberculosis Resistance and Treatment Outcomes, France, 2006–2019. Emerg Infect Dis 28, 1796–1804, http://doi.org/10.3201/eid2809.220458.
Kherabi, Y., Tunesi, S., Kay, A. and Guglielmetti, L. (2022). Preventive Therapy for Contacts of Drug-Resistant Tuberculosis. Pathogens 11, 1189, http://doi.org/10.3390/pathogens11101189.
Kilinç, G., Walburg, K. V., Franken, K. L. M. C., Valkenburg, M. L., Aubry, A., Haks, M. C., Saris, A. and Ottenhoff, T. H. M. (2022). Development of Human Cell-Based In Vitro Infection Models to Determine the Intracellular Survival of Mycobacterium avium. Front Cell Infect Microbiol 12, 872361, http://doi.org/10.3389/fcimb.2022.872361.
Kraef, C., Lindquist, E., Svensson, E. and Cambau, E. (2022). Diagnostic toolkit for tuberculosis: should we include urine lipoarabinomannan (LAM) detection in the WHO European Region? Clinical Microbiology and Infection, http://doi.org/10.1016/j.cmi.2022.06.022.
Lange, C., Böttger, E. C., Cambau, E., Griffith, D. E., Guglielmetti, L., van Ingen, J., Knight, S. L., Marras, T. K., Olivier, K. N., Santin, M., Stout, J. E., Tortoli, E., Wagner, D., Winthrop, K., Daley, C. L., Lange, C., Andrejak, C., Böttger, E., Cambau, E., Griffith, D., Guglielmetti, L., van Ingen, J., Knight, S., Leitman, P., Marras, T. K., Olivier, K. N., Santin, M., Stout, J. E., Tortoli, E., Wagner, D., Wallace, R. J., Winthrop, K. and Daley, C. (2022). Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases. The Lancet Infectious Diseases, http://doi.org/10.1016/S1473-3099(21)00586-7.
Le Ray, L. F., Aubry, A., Sougakoff, W., Revest, M., Robert, J., Bonnet, I., Veziris, N. and Morel, F. (2022). atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure. Emerg Infect Dis 28, 1062–1064, http://doi.org/10.3201/eid2805.212517.
Maitre, T., Morel, F., Brossier, F., Sougakoff, W., Jaffre, J., Cheng, S., Veziris, N., Aubry, A. and on behalf of the NRC-MyRMA (2022). How a PCR Sequencing Strategy Can Bring New Data to Improve the Diagnosis of Ethionamide Resistance. Microorganisms 10, 1436, http://doi.org/10.3390/microorganisms10071436.
Marijke Braet, S., Jouet, A., Aubry, A., Van Dyck-Lippens, M., Lenoir, E., Assoumani, Y., Baco, A., Mzembaba, A., Cambau, E., Vasconcellos, S. E. G., Rigouts, L., Suffys, P. N., Hasker, E., Supply, P. and de Jong, B. C. (2022). Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study. The Lancet Microbe 3, e693–e700, http://doi.org/10.1016/S2666-5247(22)00117-3.
Migliori, G. B., Wu, S. J., Matteelli, A., Zenner, D., Goletti, D., Ahmedov, S., Al-Abri, S., Allen, D. M., Balcells, M. E., Garcia-Basteiro, A. L., Cambau, E., Chaisson, R. E., Chee, C. B. E., Dalcolmo, M. P., Denholm, J. T., Erkens, C., Esposito, S., Farnia, P., Friedland, J. S., Graham, S., Hamada, Y., Harries, A. D., Kay, A. W., Kritski, A., Manga, S., Marais, B. J., Menzies, D., Ng, D., Petrone, L., Rendon, A., Silva, D. R., Schaaf, H. S., Skrahina, A., Sotgiu, G., Thwaites, G., Tiberi, S., Tukvadze, N., Zellweger, J.-P., D’Ambrosio, L., Centis, R. and Ong, C. W. M. (2022). Clinical standards for the diagnosis, treatment and prevention of TB infection. Int J Tuberc Lung Dis 26, 190–205, http://doi.org/10.5588/ijtld.21.0753.
Tunesi, S., Dû, D. L., Gualano, G., Millet, J.-P., Skrahin, A., Bothamley, G., Casas, X., Goletti, D., Lange, C., Musso, M., Palmieri, F., Pourcher, V., Rioux, C., Skrahina, A., Veziris, N., Viatushka, D., Jachym-Fréchet, M. and Guglielmetti, L. (2022). Co-administration of treatment for rifampicin-resistant TB and chronic HCV infection: a TBnet and ESGMYC study. Journal of Infection, http://doi.org/10.1016/j.jinf.2022.03.004.
Vongthilath-Moeung, R., Plojoux, J., Poncet, A., Renzi, G., Veziris, N., Schrenzel, J. and Janssens, J.-P. (2022). Nontuberculous Mycobacteria under Scrutiny in the Geneva Area (2015–2020). RES 101, 367–375, http://doi.org/10.1159/000520033.
Wetzstein, N., Drummer, A.-P., Bockey, A., Herrmann, E., Küpper-Tetzel, C. P., Graf, C., Koch, B., Goetsch, U., Vehreschild, M. J. G. T., Guglielmetti, L., Lange, B., Wichelhaus, T. A. and Stephan, C. (2022). Occurrence of extrapulmonary tuberculosis is associated with geographical origin: spatial characteristics of the Frankfurt TB cohort 2013–2018. Infection, http://doi.org/10.1007/s15010-022-01921-9.

  • Publications – 2025 2024 2023 – 2022 – 2021 2020